JP5412078B2 - 皮膚外用剤 - Google Patents
皮膚外用剤 Download PDFInfo
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- JP5412078B2 JP5412078B2 JP2008259201A JP2008259201A JP5412078B2 JP 5412078 B2 JP5412078 B2 JP 5412078B2 JP 2008259201 A JP2008259201 A JP 2008259201A JP 2008259201 A JP2008259201 A JP 2008259201A JP 5412078 B2 JP5412078 B2 JP 5412078B2
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- extract
- skin
- oil
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- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 9
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Landscapes
- Cosmetics (AREA)
Description
即ち本発明は、(A)水素添加リン脂質を含むリポソーム、(B)ホスファチジルイノシトール、(C)2−メタクリロイルオキシエチルホスホリルコリンを構成単位とする高分子、(D)保湿剤とを含有することを特徴とする皮膚外用剤である。
また、リポソームの粒径は小さいほうが好ましく、平均粒径が30から100nmのものが特に好適である。
に塗布したとき皮膜形成能が高い。この形成された保護膜により配合されている、リポソーム及び保湿剤がトラップされ皮膚上で徐々に放出され保湿効果が持続する。
本発明の皮膚外用剤の形態は特に限定されず、クリーム状、ジェル状等が挙げられるが、特に本来の目的である保湿効果の持続性等の点から、ジェル状とする場合に本発明の効果が顕著である。また、ジェル状とする場合は、水溶性高分子を配合することが好ましい。
次に、リポソームの調製例を挙げる。表1に掲げた成分を用いて以下の方法でリポソームを製造した。表1には使用した各成分の割合を重量%(配合量合計100重量%)で示している。
(調製法)
(1)配合全成分をそれぞれ量り込み、撹拌しながら分散させた。
(2)その後、70〜80℃に加温して、ホモミキサーで高速撹拌し、分散を高めた。
(3)次いで、前項(2)の分散液を高圧ミキサー(マイクロフルイダイザー)により微細に分散させてリポソームを形成させた。
(4)次いで、この分散液を室温まで冷却してリポソーム分散液を得た。
得られたリポソームの平均粒径は40〜100nmであり、電子顕微鏡の観察において多層リポソームであることが確認できた。
表2に示す成分、配合量の処方(配合量合計100重量%)の皮膚外用剤を以下の方法で調製した。
(調製法)
アクリレーツ/アクリル酸アルキル(C10-30)クロスポリマーを水に溶解して水酸化カリウムを加え攪拌して中和する。
スクワランにセラミド及びフィトスフィンゴシンを添加して溶解する。
形成されたゲルに、1,3−ブチレングリコール、グリセリン、加水分解酵母エキス、スクワランに溶解したセラミドとフィトスフィンゴシン、アセチルヒドロキシプロリン、加水分解ヒアルロン酸を添加撹拌して均一にする。
◎:非常に効果が高い
○:効果が高い
△:変化がない
×:変化がなく、使用感が悪い
Claims (4)
- (A)水素添加リン脂質を含むリポソーム、
(B)ホスファチジルイノシトール、
(C)2−メタクリロイルオキシエチルホスホリルコリンを構成単位とする高分子
(D)保湿剤とを含有することを特徴とする皮膚外用剤であって、(A)のリポソームを1〜50重量%、(B)のホスファチジルイノシトールを0.1〜5重量%及び(C)の高分子を1〜20重量%含有する、皮膚外用剤。 - (A)のリポソームが、水素添加リン脂質を1〜8重量%含有し、平均粒径が30から100nmのものである請求項1の皮膚外用剤。
- (A)のリポソームが、ホスファチジルコリン含有量が50重量%以上の水素添加リン脂質を用いたものである請求項1又は2記載の皮膚外用剤。
- (D)の保湿剤が、加水分解酵母エキス、セラミド、フィトスフィンゴシン、アセチルヒドロキシプロリン及び加水分解ヒアルロン酸から選ばれる1種又は2種以上である請求項1〜3の何れか1項記載の皮膚外用剤。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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JP2008259201A JP5412078B2 (ja) | 2008-10-06 | 2008-10-06 | 皮膚外用剤 |
Applications Claiming Priority (1)
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JP2008259201A JP5412078B2 (ja) | 2008-10-06 | 2008-10-06 | 皮膚外用剤 |
Publications (2)
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