DE3888441T2 - Benzoxazin-Verbindungen und ihre pharmazeutische Anwendung. - Google Patents

Benzoxazin-Verbindungen und ihre pharmazeutische Anwendung.

Info

Publication number
DE3888441T2
DE3888441T2 DE3888441T DE3888441T DE3888441T2 DE 3888441 T2 DE3888441 T2 DE 3888441T2 DE 3888441 T DE3888441 T DE 3888441T DE 3888441 T DE3888441 T DE 3888441T DE 3888441 T2 DE3888441 T2 DE 3888441T2
Authority
DE
Germany
Prior art keywords
benzoxazine compounds
pharmaceutical application
compounds
benzoxazine
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3888441T
Other languages
English (en)
Other versions
DE3888441D1 (de
Inventor
Tetsuya Tahara
Takeshi Kawakita
Mitsuyoshi Yasumoto
Takemi Fukuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP63005415A external-priority patent/JPH01207290A/ja
Application filed by Welfide Corp filed Critical Welfide Corp
Publication of DE3888441D1 publication Critical patent/DE3888441D1/de
Application granted granted Critical
Publication of DE3888441T2 publication Critical patent/DE3888441T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE3888441T 1987-10-22 1988-10-21 Benzoxazin-Verbindungen und ihre pharmazeutische Anwendung. Expired - Fee Related DE3888441T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP26795387 1987-10-22
JP33125987 1987-12-25
JP63005415A JPH01207290A (ja) 1987-10-22 1988-01-13 ベンズオキサジン化合物

Publications (2)

Publication Number Publication Date
DE3888441D1 DE3888441D1 (de) 1994-04-21
DE3888441T2 true DE3888441T2 (de) 1994-10-20

Family

ID=27276738

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3888441T Expired - Fee Related DE3888441T2 (de) 1987-10-22 1988-10-21 Benzoxazin-Verbindungen und ihre pharmazeutische Anwendung.

Country Status (9)

Country Link
US (1) US4892872A (de)
EP (1) EP0313393B1 (de)
JP (1) JPH0228182A (de)
KR (1) KR910000439B1 (de)
AT (1) ATE102943T1 (de)
CA (1) CA1304082C (de)
DE (1) DE3888441T2 (de)
ES (1) ES2061684T3 (de)
HK (1) HK1007143A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5122528A (en) * 1983-12-22 1992-06-16 Erbamont, Inc. Analgesic use of benzobicyclic carboxamides
US4933445A (en) * 1988-11-29 1990-06-12 Rorer Pharmaceutical Corporation Heteroazabenzobicyclic carboxamide 5-HT3 antagonists
US5185333A (en) * 1989-07-03 1993-02-09 Yoshitomi Pharmaceutical Industries, Ltd. Benzazine compounds and pharmaceutical uses thereof
ATE137501T1 (de) * 1989-07-03 1996-05-15 Yoshitomi Pharmaceutical Benzazin-verbindungen und deren pharmazeutische verwendungen
JP3122671B2 (ja) * 1990-05-23 2001-01-09 協和醗酵工業株式会社 複素環式化合物
GB9120628D0 (en) * 1991-09-27 1991-11-06 Fujisawa Pharmaceutical Co Pyrrolobenzoxazine derivatives and process for preparation thereof
JP2699794B2 (ja) * 1992-03-12 1998-01-19 三菱化学株式会社 チエノ〔３，２−ｂ〕ピリジン誘導体
KR100188318B1 (ko) * 1993-04-28 1999-06-01 고오야 마사시 안정화된 주사제 및 주사제의 안정화법
GB9309716D0 (en) * 1993-05-12 1993-06-23 Zeneca Ltd Heterocyclic derivatives
JP3266998B2 (ja) * 1993-09-07 2002-03-18 三菱ウェルファーマ株式会社 １，４−ベンズオキサジン化合物の工業的な製造法
US5723103A (en) * 1994-12-09 1998-03-03 Vanderbilt University Substituted benzamides and radioligand analogs and methods of use
CA2460075A1 (en) * 2001-09-12 2003-03-20 Donn Gregory Wishka Substituted 7-aza[2.2.1] bicycloheptanes for the treatment of diseases
NZ541009A (en) 2003-01-13 2007-09-28 Dynogen Pharmaceuticals Inc Method of treating nausea, vomiting, retching or any combination thereof
KR100879636B1 (ko) * 2007-08-22 2009-01-21 한국과학기술연구원 세로토닌 ５―ｈｔ₃ａ 길항적 효과를 갖는 퀴나졸린유도체 함유 약제 조성물
EP2253316B1 (de) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin-5-HT3-Rezeptorantagonisten zur Verwendung bei der Behandlung oder Prävention einer Innenohr-Pathologie mit Vestibularisdefiziten
LT2432467T (lt) 2009-05-20 2018-04-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonino 5-ht3 receptoriaus antagonistai, skirti panaudoti pažeidimų sukeltų vestibiuliarinių sutrikimų gydymui
CN101786963B (zh) * 2010-03-03 2013-05-08 山东众诚药业股份有限公司 阿扎司琼中间体的合成方法
CN102329313B (zh) * 2011-07-15 2012-09-26 海南灵康制药有限公司 一种盐酸阿扎司琼化合物及其制法
WO2014130587A1 (en) * 2013-02-19 2014-08-28 Roger Linington Novel small molecule inhibitors of biofilm formation and the novel use of previously identified compounds for inhibition of biofilm formation and applications for drug therapy and medical device coating
CN103351386B (zh) * 2013-07-26 2016-05-18 南京正大天晴制药有限公司 一种盐酸阿扎司琼的合成方法
CN103467465B (zh) * 2013-09-02 2016-06-01 扬子江药业集团四川海蓉药业有限公司 一种盐酸阿扎司琼的合成方法
CN104557907B (zh) * 2015-01-21 2016-06-01 扬子江药业集团四川海蓉药业有限公司 一种盐酸阿扎司琼的制备方法
CN104557906A (zh) * 2015-01-21 2015-04-29 扬子江药业集团四川海蓉药业有限公司 一种盐酸阿扎司琼的制备方法
WO2016184900A1 (en) * 2015-05-18 2016-11-24 Sensorion Calcineurin inhibitors of the setron family for the treatment of hearing loss
CN105001178B (zh) * 2015-06-29 2019-04-02 上海信谊万象药业股份有限公司 盐酸阿扎司琼中间体的合成方法
WO2017044693A1 (en) 2015-09-11 2017-03-16 Chase Pharmaceuticals Corporation Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
MX2018012587A (es) 2016-04-14 2019-03-07 Sensorion (+)-azasetron para uso en el tratamiento de trastornos del oido.
SG11201809004PA (en) 2016-04-14 2018-11-29 Sensorion (+)-azasetron for use in the treatment of ear disorders
WO2021014014A1 (en) 2019-07-25 2021-01-28 Sensorion Treatment and/or prevention of lesions in the central auditory nervous system
TW202400180A (zh) 2022-03-16 2024-01-01 法商聖索瑞恩公司 阿扎司瓊用於處置突發性感覺神經性聽力喪失
CN115160341B (zh) * 2022-07-18 2023-07-18 中国医学科学院医学实验动物研究所 苯并噁嗪类化合物及其药物用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2509155A1 (de) * 1975-03-03 1976-09-09 Hoechst Ag 1,4-benzoxazinderivate und verfahren zu ihrer herstellung
FR2531083B1 (fr) * 1982-06-29 1986-11-28 Sandoz Sa Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
US4888353A (en) * 1986-02-28 1989-12-19 Erbamont, Inc. Carboxamides useful as antiemetic or antipsychotic agents
KR920003064B1 (ko) * 1984-01-25 1992-04-13 글락소 그룹 리미티드 헤테로시클릭 화합물의 제조방법
US4717563A (en) * 1986-03-05 1988-01-05 A. H. Robins Company, Inc. 2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenzamides in a method for alleviating emesis caused by non-platinum anticancer drugs

Also Published As

Publication number Publication date
JPH0228182A (ja) 1990-01-30
ATE102943T1 (de) 1994-04-15
EP0313393A2 (de) 1989-04-26
EP0313393A3 (de) 1991-02-06
EP0313393B1 (de) 1994-03-16
HK1007143A1 (en) 1999-04-01
KR890006642A (ko) 1989-06-15
KR910000439B1 (ko) 1991-01-25
JPH0573752B2 (de) 1993-10-15
CA1304082C (en) 1992-06-23
DE3888441D1 (de) 1994-04-21
US4892872A (en) 1990-01-09
ES2061684T3 (es) 1994-12-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: WELFIDE CORP., OSAKA, JP

8328 Change in the person/name/address of the agent

Free format text: STREHL, SCHUEBEL-HOPF & PARTNER, 80538 MUENCHEN

8339 Ceased/non-payment of the annual fee