DE3888186D1 - Modulärer zusammenbau von antikörpergenen, dadurch hergestellte antikörper und deren anwendung. - Google Patents

Modulärer zusammenbau von antikörpergenen, dadurch hergestellte antikörper und deren anwendung.

Info

Publication number
DE3888186D1
DE3888186D1 DE88907510T DE3888186T DE3888186D1 DE 3888186 D1 DE3888186 D1 DE 3888186D1 DE 88907510 T DE88907510 T DE 88907510T DE 3888186 T DE3888186 T DE 3888186T DE 3888186 D1 DE3888186 D1 DE 3888186D1
Authority
DE
Germany
Prior art keywords
genens
antibody
antibodies produced
modular assembly
region modules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE88907510T
Other languages
English (en)
Other versions
DE3888186T3 (de
DE3888186T2 (de
Inventor
Randy Robinson
Alvin Liu
Arnold Horwitz
Randolph Wall
Marc Better
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xoma Corp
Original Assignee
Xoma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22138605&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3888186(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Xoma Corp filed Critical Xoma Corp
Publication of DE3888186D1 publication Critical patent/DE3888186D1/de
Application granted granted Critical
Publication of DE3888186T2 publication Critical patent/DE3888186T2/de
Publication of DE3888186T3 publication Critical patent/DE3888186T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE3888186T 1987-07-24 1988-07-25 Modulärer zusammenbau von antikörpergenen, dadurch hergestellte antikörper und deren anwendung. Expired - Lifetime DE3888186T3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7752887A 1987-07-24 1987-07-24
PCT/US1988/002514 WO1989000999A1 (en) 1987-07-24 1988-07-25 Modular assembly of antibody genes, antibodies prepared thereby and use

Publications (3)

Publication Number Publication Date
DE3888186D1 true DE3888186D1 (de) 1994-04-07
DE3888186T2 DE3888186T2 (de) 1994-09-22
DE3888186T3 DE3888186T3 (de) 2000-08-24

Family

ID=22138605

Family Applications (4)

Application Number Title Priority Date Filing Date
DE3888186T Expired - Lifetime DE3888186T3 (de) 1987-07-24 1988-07-25 Modulärer zusammenbau von antikörpergenen, dadurch hergestellte antikörper und deren anwendung.
DE200812000039 Pending DE122008000039I1 (de) 1987-07-24 1988-07-25 Modularer Zusammenbau von Antikorpergenen, dadurchhergestellte Antikorper und deren Anwendungen.
DE3856440T Ceased DE3856440T2 (de) 1987-07-24 1988-07-25 Modularer Zusammenbau von Antikörpergenen, dadurch hergestellte Antikörper und deren Anwendungen
DE3855421T Expired - Lifetime DE3855421T2 (de) 1987-07-24 1988-07-25 Modularer Zusammenbau von Antikörpergenen, dadurch hergestellte Antikörper und deren Anwendung

Family Applications After (3)

Application Number Title Priority Date Filing Date
DE200812000039 Pending DE122008000039I1 (de) 1987-07-24 1988-07-25 Modularer Zusammenbau von Antikorpergenen, dadurchhergestellte Antikorper und deren Anwendungen.
DE3856440T Ceased DE3856440T2 (de) 1987-07-24 1988-07-25 Modularer Zusammenbau von Antikörpergenen, dadurch hergestellte Antikörper und deren Anwendungen
DE3855421T Expired - Lifetime DE3855421T2 (de) 1987-07-24 1988-07-25 Modularer Zusammenbau von Antikörpergenen, dadurch hergestellte Antikörper und deren Anwendung

Country Status (8)

Country Link
EP (3) EP0371998B2 (de)
JP (1) JP2991720B2 (de)
AT (2) ATE140266T1 (de)
AU (1) AU632462B2 (de)
CA (1) CA1341235C (de)
DE (4) DE3888186T3 (de)
DK (1) DK174824B1 (de)
WO (1) WO1989000999A1 (de)

Families Citing this family (93)

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CA1341235C (en) 2001-05-22
DE3855421T2 (de) 1997-03-06
JPH03501321A (ja) 1991-03-28
AU632462B2 (en) 1993-01-07
EP0550400B1 (de) 1996-07-10
EP0371998B1 (de) 1994-03-02
DE3856440D1 (de) 2000-12-07
DE3888186T3 (de) 2000-08-24
EP0731167A1 (de) 1996-09-11
WO1989000999A1 (en) 1989-02-09
DE3888186T2 (de) 1994-09-22
DK19290D0 (da) 1990-01-24
EP0731167B1 (de) 2000-11-02
EP0371998A4 (en) 1991-11-21
DE3855421D1 (de) 1996-08-14
DK174824B1 (da) 2003-12-08
JP2991720B2 (ja) 1999-12-20
EP0550400A2 (de) 1993-07-07
ATE197315T1 (de) 2000-11-15
EP0371998B2 (de) 1999-11-03
EP0550400A3 (en) 1993-10-06
DE122008000039I1 (de) 2011-12-01
ATE140266T1 (de) 1996-07-15
DK19290A (da) 1990-03-23
EP0371998A1 (de) 1990-06-13
DE3856440T2 (de) 2001-06-13
AU2324488A (en) 1989-03-01

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