DE3876836T2 - Aminochinolinderivate gegen malaria, verfahren zur herstellung und diese enthaltende pharmazeutische zusammensetzung. - Google Patents

Aminochinolinderivate gegen malaria, verfahren zur herstellung und diese enthaltende pharmazeutische zusammensetzung.

Info

Publication number
DE3876836T2
DE3876836T2 DE8888400683T DE3876836T DE3876836T2 DE 3876836 T2 DE3876836 T2 DE 3876836T2 DE 8888400683 T DE8888400683 T DE 8888400683T DE 3876836 T DE3876836 T DE 3876836T DE 3876836 T2 DE3876836 T2 DE 3876836T2
Authority
DE
Germany
Prior art keywords
derivatives
new
pharmaceutical composition
amino acid
free amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888400683T
Other languages
English (en)
Other versions
DE3876836D1 (de
Inventor
Jean-Bernard Falmagne
Philippe Pirson
Jacques Quivy
Andre Trouet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
La Region Wallonne
Original Assignee
La Region Wallonne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by La Region Wallonne filed Critical La Region Wallonne
Application granted granted Critical
Publication of DE3876836D1 publication Critical patent/DE3876836D1/de
Publication of DE3876836T2 publication Critical patent/DE3876836T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE8888400683T 1987-03-24 1988-03-22 Aminochinolinderivate gegen malaria, verfahren zur herstellung und diese enthaltende pharmazeutische zusammensetzung. Expired - Fee Related DE3876836T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8704079A FR2612778B1 (fr) 1987-03-24 1987-03-24 Nouveaux derives d'aminoquinoleine antimalarique, procede de preparation et composition pharmaceutique en contenant

Publications (2)

Publication Number Publication Date
DE3876836D1 DE3876836D1 (de) 1993-02-04
DE3876836T2 true DE3876836T2 (de) 1993-05-06

Family

ID=9349368

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888400683T Expired - Fee Related DE3876836T2 (de) 1987-03-24 1988-03-22 Aminochinolinderivate gegen malaria, verfahren zur herstellung und diese enthaltende pharmazeutische zusammensetzung.

Country Status (8)

Country Link
EP (1) EP0286491B1 (de)
JP (1) JPS63255265A (de)
AT (1) ATE83771T1 (de)
CA (1) CA1336528C (de)
DE (1) DE3876836T2 (de)
ES (1) ES2052752T3 (de)
FR (1) FR2612778B1 (de)
GR (1) GR3006982T3 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2644462B1 (fr) * 1988-09-23 1993-07-09 Ire Celltarg Sa Nouveaux composes actifs sur les formes tissulaires de la malaria et procede de preparation
CA2133620A1 (en) * 1993-10-28 1995-04-29 Werner Hofheinz Aminoquinoline derivatives
DK0907363T3 (da) * 1996-03-29 2007-09-24 Univ Mississippi Lægemiddel, der omfatter (-)-8-[(4-amino-1-methylbutyl)amino]-5-(3,4-dichlorphenoxy)-6-methoxy-4-methylquinolin, til behandling af parasitiske og opportunistiske infektioner
WO2004085402A1 (en) * 2003-03-27 2004-10-07 Council Of Scientific And Industrial Research Ring-substituted 8-aminoqunoline derivates as antimalarial agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0037388B1 (de) * 1980-03-31 1984-12-12 Institut International De Pathologie Cellulaire Et Moleculaire Pharmazeutische Stoffe, deren Herstellung und Präparate in denen diese enthalten sind

Also Published As

Publication number Publication date
ES2052752T3 (es) 1994-07-16
JPS63255265A (ja) 1988-10-21
DE3876836D1 (de) 1993-02-04
CA1336528C (fr) 1995-08-01
EP0286491A1 (de) 1988-10-12
FR2612778B1 (fr) 1991-10-18
EP0286491B1 (de) 1992-12-23
GR3006982T3 (de) 1993-06-30
FR2612778A1 (fr) 1988-09-30
ATE83771T1 (de) 1993-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee