DE3872741T - - Google Patents
Info
- Publication number
- DE3872741T DE3872741T DE19883872741 DE3872741T DE3872741T DE 3872741 T DE3872741 T DE 3872741T DE 19883872741 DE19883872741 DE 19883872741 DE 3872741 T DE3872741 T DE 3872741T DE 3872741 T DE3872741 T DE 3872741T
- Authority
- DE
- Germany
- Prior art keywords
- fluid compositions
- magnetic fluid
- superparamagnetic particles
- medicine
- substances
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011553 magnetic fluid Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
- G01N2446/90—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids characterised by small molecule linker used to couple immunoreagents to magnetic particles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Inorganic Chemistry (AREA)
- Radiology & Medical Imaging (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Lubricants (AREA)
- Soft Magnetic Materials (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE8888730073T DE3872741D1 (de) | 1987-03-24 | 1988-03-23 | Magnetische fluessigkeitszusammensetzungen. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873709851 DE3709851A1 (de) | 1987-03-24 | 1987-03-24 | Nmr-diagnostische fluessigkeitszusammensetzungen |
| DE8888730073T DE3872741D1 (de) | 1987-03-24 | 1988-03-23 | Magnetische fluessigkeitszusammensetzungen. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3872741T true DE3872741T (forum.php) | 1992-08-20 |
| DE3872741D1 DE3872741D1 (de) | 1992-08-20 |
Family
ID=6323973
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19873709851 Withdrawn DE3709851A1 (de) | 1987-03-24 | 1987-03-24 | Nmr-diagnostische fluessigkeitszusammensetzungen |
| DE8888730073T Expired - Lifetime DE3872741D1 (de) | 1987-03-24 | 1988-03-23 | Magnetische fluessigkeitszusammensetzungen. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19873709851 Withdrawn DE3709851A1 (de) | 1987-03-24 | 1987-03-24 | Nmr-diagnostische fluessigkeitszusammensetzungen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5160725A (forum.php) |
| EP (1) | EP0284549B1 (forum.php) |
| JP (1) | JP2663976B2 (forum.php) |
| AT (1) | ATE78175T1 (forum.php) |
| DE (2) | DE3709851A1 (forum.php) |
| ES (1) | ES2052766T3 (forum.php) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5612019A (en) * | 1988-12-19 | 1997-03-18 | Gordon, Deceased; David | Diagnosis and treatment of HIV viral infection using magnetic metal transferrin particles |
| US5385707A (en) * | 1988-12-28 | 1995-01-31 | Stefan Miltenyi | Metal matrices for use in high gradient magnetic separation of biological materials and method for coating the same |
| US5114703A (en) * | 1989-05-30 | 1992-05-19 | Alliance Pharmaceutical Corp. | Percutaneous lymphography using particulate fluorocarbon emulsions |
| GB8916782D0 (en) * | 1989-07-21 | 1989-09-06 | Nycomed As | Compositions |
| GB8916780D0 (en) * | 1989-07-21 | 1989-09-06 | Nycomed As | Compositions |
| GB8916781D0 (en) * | 1989-07-21 | 1989-09-06 | Nycomed As | Compositions |
| US5547682A (en) * | 1989-12-22 | 1996-08-20 | Bioquest, Incorporated | Preparation and use of novel injectable RES avoiding inorganic particles for medical application |
| US5368840A (en) * | 1990-04-10 | 1994-11-29 | Imarx Pharmaceutical Corp. | Natural polymers as contrast media for magnetic resonance imaging |
| US5358702A (en) * | 1990-04-10 | 1994-10-25 | Unger Evan C | Methoxylated gel particle contrast media for improved diagnostic imaging |
| EP0693288B1 (en) * | 1990-04-10 | 1999-10-13 | Imarx Pharmaceutical Corp. | Polymers as contrast media for magnetic resonance |
| US5240626A (en) * | 1990-09-21 | 1993-08-31 | Minnesota Mining And Manufacturing Company | Aqueous ferrofluid |
| US5370901A (en) * | 1991-02-15 | 1994-12-06 | Bracco International B.V. | Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients |
| US5179955A (en) * | 1991-02-22 | 1993-01-19 | Molecular Biosystems, Inc. | Method of abdominal ultrasound imaging |
| DE4117782C2 (de) * | 1991-05-28 | 1997-07-17 | Diagnostikforschung Inst | Nanokristalline magnetische Eisenoxid-Partikel, Verfahren zu ihrer Herstellung sowie diagnostische und/oder therapeutische Mittel |
| US5407659A (en) * | 1991-10-22 | 1995-04-18 | Mallinckrodt Medical, Inc. | Treated calcium/oxyanion-containing particles for medical diagnostic imaging |
| US5342609A (en) * | 1991-10-22 | 1994-08-30 | Mallinckrodt Medical, Inc. | Microfluidization of calcium/oxyanion-containing particles |
| US5344640A (en) * | 1991-10-22 | 1994-09-06 | Mallinckrodt Medical, Inc. | Preparation of apatite particles for medical diagnostic imaging |
| EP0614527A4 (en) * | 1991-11-19 | 1998-06-03 | Evan C Unger | CONTRAST AGENTS BASED ON GEL-SHAPED PARTICLES FOR IMPROVED IMAGE GENERATION. |
| US5324503A (en) * | 1992-02-06 | 1994-06-28 | Mallinckrodt Medical, Inc. | Iodo-phenylated chelates for x-ray contrast |
| JPH05262673A (ja) * | 1992-03-19 | 1993-10-12 | Nippon Paint Co Ltd | 超音波診断用造影剤 |
| DE69207589T2 (de) * | 1992-06-01 | 1996-05-23 | Basf Ag | Anwendung von Dispersionen von magneto-ionischen Partikeln in MRI-Kontrast-Mitteln |
| US5464696A (en) * | 1992-08-13 | 1995-11-07 | Bracco International B.V. | Particles for NMR imaging |
| ES2199226T3 (es) * | 1992-09-04 | 2004-02-16 | The General Hospital Corporation | Polimeros biocompatibles que contienen mitades diagnosticas o terapeuticas. |
| US5871710A (en) * | 1992-09-04 | 1999-02-16 | The General Hospital Corporation | Graft co-polymer adducts of platinum (II) compounds |
| FI951210A7 (fi) * | 1992-09-16 | 1995-05-10 | Nycomed Imaging As | Varjoaineisiin liittyviä parannuksia |
| US5336923A (en) * | 1992-12-31 | 1994-08-09 | Honeywell, Inc. | Varactor diode having a stepped capacitance-voltage profile |
| US5916539A (en) * | 1993-03-02 | 1999-06-29 | Silica Gel Ges. M.B.H. | Superparamagnetic particles, process for producing the same and their use |
| DE4309333A1 (de) * | 1993-03-17 | 1994-09-22 | Silica Gel Gmbh | Superparamagnetische Teilchen, Verfahren zu ihrer Herstellung und Verwendung derselben |
| US5605672A (en) * | 1993-06-09 | 1997-02-25 | The General Hospital Corporation | Blood pool imaging composition and method of its use |
| US5411730A (en) * | 1993-07-20 | 1995-05-02 | Research Corporation Technologies, Inc. | Magnetic microparticles |
| US5928958A (en) * | 1994-07-27 | 1999-07-27 | Pilgrimm; Herbert | Superparamagnetic particles, process for their manufacture and usage |
| DE4428851C2 (de) * | 1994-08-04 | 2000-05-04 | Diagnostikforschung Inst | Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie |
| US5520904A (en) * | 1995-01-27 | 1996-05-28 | Mallinckrodt Medical, Inc. | Calcium/oxyanion-containing particles with a polymerical alkoxy coating for use in medical diagnostic imaging |
| DE19514515C2 (de) * | 1995-04-12 | 1997-03-20 | Dirk Dipl Chem Guenther | Magnetisierbare Dispersionen |
| JPH11507027A (ja) * | 1995-06-07 | 1999-06-22 | シェリング アクチェンゲゼルシャフト | 特定の標的構造に特異的に結合するフェライト及びオリゴヌクレオチドのコンジュゲート |
| JP4280304B2 (ja) * | 1996-01-10 | 2009-06-17 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
| GB9600427D0 (en) * | 1996-01-10 | 1996-03-13 | Nycomed Imaging As | Contrast media |
| DE19602930A1 (de) * | 1996-01-18 | 1997-07-24 | Schering Ag | Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung |
| DE19612001A1 (de) * | 1996-03-18 | 1997-09-25 | Silica Gel Gmbh Adsorptions Te | Superparamagnetische Teilchen mit vergrößerter R¶1¶-Relaxivität, Verfahren zur Herstellung und deren Verwendung |
| US5855868A (en) * | 1996-04-01 | 1999-01-05 | Nycomed Imaging As | Method of T1 -weighted resonance imaging of RES organs |
| US6306384B1 (en) * | 1996-10-01 | 2001-10-23 | E-L Management Corp. | Skin battery cosmetic composition |
| JP2001513568A (ja) * | 1997-08-29 | 2001-09-04 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 肺疾患を治療するためのウリジン5’−ジホスフェートとその類似体の使用 |
| GB2372703A (en) * | 1999-10-19 | 2002-09-04 | Kimberly Clark Co | Selective removal of contaminants from a surface using magnets |
| US6841393B2 (en) | 1999-10-19 | 2005-01-11 | Kimberly-Clark Worldwide, Inc. | Selective removal of contaminants from a surface using colored particles and articles having magnets |
| US6503761B1 (en) * | 1999-10-19 | 2003-01-07 | Kimberly-Clark Worldwide, Inc. | Selective removal of contaminants from a surface using articles having magnets |
| EP1397243B1 (en) * | 2001-04-13 | 2011-08-31 | Cornell Research Foundation, Inc. | Superparamagnetic nanostructured materials |
| US20030022203A1 (en) * | 2001-04-23 | 2003-01-30 | Rajan Kumar | Cellular Arrays |
| DE10154016B4 (de) * | 2001-10-26 | 2004-02-12 | Berlin Heart Ag | Magnetflüssigkeit und Verfahren zur ihrer Herstellung |
| BR0105499F1 (pt) * | 2001-11-05 | 2018-01-09 | Univ Minas Gerais | processo de obtenção de nanocompósitos ferrita/ciclodextrina e uso como dispositivos de descontaminação magneticamente dirigível |
| US20030185757A1 (en) * | 2002-03-27 | 2003-10-02 | Mayk Kresse | Iron-containing nanoparticles with double coating and their use in diagnosis and therapy |
| DE10222481A1 (de) * | 2002-05-22 | 2003-12-04 | Eucro Europe Contract Res Gmbh | Kontrastmittel für die Verwendung in bildgebenden Verfahren |
| AU2002347076A1 (en) * | 2002-10-09 | 2004-05-04 | Ferropharm Gmbh Forschungslabor | Stabilized superparamagnetic particles |
| US6887295B2 (en) * | 2002-10-25 | 2005-05-03 | Hoeganaes Corporation | Powder metallurgy lubricants, compositions, and methods for using the same |
| DE10331439B3 (de) * | 2003-07-10 | 2005-02-03 | Micromod Partikeltechnologie Gmbh | Magnetische Nanopartikel mit verbesserten Magneteigenschaften |
| US7723311B2 (en) * | 2003-06-18 | 2010-05-25 | Nanobiomagnetics, Inc. | Delivery of bioactive substances to target cells |
| US7344491B1 (en) | 2003-11-26 | 2008-03-18 | Nanobiomagnetics, Inc. | Method and apparatus for improving hearing |
| US8651113B2 (en) * | 2003-06-18 | 2014-02-18 | Swr&D Inc. | Magnetically responsive nanoparticle therapeutic constructs and methods of making and using |
| JPWO2006028129A1 (ja) * | 2004-09-10 | 2008-05-08 | 東レ株式会社 | 医薬品製剤 |
| EP1866155A2 (en) * | 2005-04-05 | 2007-12-19 | Bar-Ilan University | New core and core-shell nanoparticles containing iodine for x-ray imaging |
| US20070036026A1 (en) * | 2005-05-16 | 2007-02-15 | Laibinis Paul E | Magnetic Particle Systems and Methods |
| JP5321772B2 (ja) * | 2005-06-15 | 2013-10-23 | 戸田工業株式会社 | 磁性粒子含有医薬用原薬 |
| US20070098642A1 (en) * | 2005-11-02 | 2007-05-03 | General Electric Company | Nanoparticle-based imaging agents for X-ray/computed tomography |
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| KR101489830B1 (ko) * | 2006-12-18 | 2015-02-04 | 콜로로삐아 이탈리아 에스.피.에이 | 발열요법에 적용하기 위한 자성 나노 입자, 그의 제조 및 약리 적용을 갖는 구조체에의 용도 |
| FR2921837B1 (fr) * | 2007-10-05 | 2015-07-31 | Guerbet Sa | Nouveau procede de preparation de nanoparticules recouvertes d'une couche stabilisatrice organique couplee a des ligands de ciblage |
| KR20110124353A (ko) | 2009-03-04 | 2011-11-16 | 루브리졸 어드밴스드 머티어리얼스, 인코포레이티드 | 분산제 조성물 |
| GB2472446A (en) * | 2009-08-07 | 2011-02-09 | Ct Fuer Angewandte Nanotechnologie | Metal oxide particles coated with polyethylene glycol and their synthesis |
| JP2011057473A (ja) * | 2009-09-07 | 2011-03-24 | Univ Of Miyazaki | マグネタイト微粒子の製造方法 |
| US9205155B2 (en) * | 2009-10-30 | 2015-12-08 | General Electric Company | Treating water insoluble nanoparticles with hydrophilic alpha-hydroxyphosphonic acid conjugates, the so modified nanoparticles and their use as contrast agents |
| US20110217379A1 (en) * | 2010-03-08 | 2011-09-08 | Davis Llp | Magnetic nanomaterials and methods for chemoembolisation |
| CA2792399A1 (en) * | 2010-04-01 | 2011-10-06 | Hoeganaes Corporation | Magnetic powder metallurgy materials |
| JP5608851B2 (ja) * | 2010-04-08 | 2014-10-15 | サンノプコ株式会社 | 金属酸化物粒子分散体 |
| DE102010020784A1 (de) * | 2010-05-18 | 2011-11-24 | Siemens Aktiengesellschaft | Verfahren zum Erkennen von magnetisch gekennzeichneten Objekten sowie entsprechende Vorrichtung |
| JP5723978B2 (ja) | 2010-08-05 | 2015-05-27 | ハンファ ケミカル コーポレーション | 極小かつ均一な大きさの酸化鉄系常磁性ナノ粒子の製造方法及びこれを用いるmrit1造影剤 |
| KR101805873B1 (ko) * | 2011-08-03 | 2018-01-10 | 한화케미칼 주식회사 | 단당류 인산 또는 그 유도체로 표면이 개질된 친수성 나노입자, 그의 콜로이드 용액 및 그 용도 |
| US8895068B2 (en) | 2010-12-15 | 2014-11-25 | General Electric Company | Nanoparticle composition and associated methods thereof |
| US8889103B2 (en) | 2010-12-15 | 2014-11-18 | General Electric Company | Diagnostic agent composition and associated methods thereof |
| KR101303567B1 (ko) * | 2011-03-08 | 2013-09-23 | 주식회사 인트론바이오테크놀로지 | 카르복실기가 도입된 만난으로 코팅된 자기공명영상 조영제 및 그것의 제조 방법 |
| CN102924977A (zh) * | 2012-11-06 | 2013-02-13 | 广东工业大学 | 一种磁性Fe3O4 纳米粒子表面改性的方法 |
| WO2014145509A1 (en) * | 2013-03-15 | 2014-09-18 | The Regents Of The University Of California | Enteric ct contrast material based on low-z atoms |
| ES2965620T3 (es) * | 2014-04-01 | 2024-04-16 | Centre Nat Rech Scient | Nanopartículas de óxido metálico dendronizado, un procedimiento de preparación de las mismas y sus usos |
| FR3031063B1 (fr) | 2014-12-30 | 2017-02-10 | Biomerieux Sa | Complexe multicouches, procede de fabrication et utilisation du complexe |
| CN107551271B (zh) * | 2017-08-28 | 2020-11-27 | 上海长海医院 | 一种磁性-ros双重智能靶向纳米粒及其制备方法 |
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|---|---|---|---|---|
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| US4423158A (en) * | 1983-01-27 | 1983-12-27 | Gelinnovation Handelsaktiebolag | Ion adsorbent for metals having a coordination number greater than two |
| DE3316703A1 (de) * | 1983-05-04 | 1984-11-08 | Schering AG, 1000 Berlin und 4709 Bergkamen | Orales kontrastmittel fuer die kernspintomographie und dessen herstellung |
| US4554088A (en) * | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| FR2550449B1 (fr) * | 1983-08-12 | 1986-01-31 | Commissariat Energie Atomique | Agents de relaxation specifiques d'organes ou de pathologies, utilisables pour modifier les contrastes en imagerie medicale par resonance magnetique nucleaire |
| CA1243602A (en) * | 1983-08-25 | 1988-10-25 | Hong-Ning Yeung | Methods for enhancing the contrast in nmr imaging |
| US4615879A (en) * | 1983-11-14 | 1986-10-07 | Vanderbilt University | Particulate NMR contrast agents for gastrointestinal application |
| SE463651B (sv) * | 1983-12-21 | 1991-01-07 | Nycomed As | Diagnostikum och kontrastmedel |
| GB8408127D0 (en) * | 1984-03-29 | 1984-05-10 | Nyegaard & Co As | Contrast agents |
| US4728575A (en) * | 1984-04-27 | 1988-03-01 | Vestar, Inc. | Contrast agents for NMR imaging |
| GB8413772D0 (en) * | 1984-05-30 | 1984-07-04 | Nyegaard & Co As | Chemical compounds |
| GB8413849D0 (en) * | 1984-05-31 | 1984-07-04 | Amersham Int Plc | Nmr contrast agents |
| CA1268208A (en) * | 1984-08-10 | 1990-04-24 | Truman Brown | Magnetic micro-particles as contrast agents in nuclear magnetic resonance imaging |
| US4749560A (en) * | 1984-08-13 | 1988-06-07 | Research Corporation | Metal organo phosphorous compounds for NMR analysis |
| US4639365A (en) * | 1984-10-18 | 1987-01-27 | The Board Of Regents, The University Of Texas System | Gadolinium chelates as NMR contrast agents |
| DE3577185D1 (de) * | 1984-11-01 | 1990-05-23 | Nycomed As | Paramagnetische kontrastmittel fuer die anwendung in "in vivo" nmr-diagnostischen methoden und die herstellung davon. |
| SE465907B (sv) * | 1984-11-01 | 1991-11-18 | Nyegaard & Co As | Diagnosticeringsmedel innehaallande en paramagnetisk metall |
| DE3443252A1 (de) * | 1984-11-23 | 1986-05-28 | Schering AG, 1000 Berlin und 4709 Bergkamen | Dextran-magnetit-komplexe fuer die nmr-diagnostik |
| DE3508000A1 (de) * | 1985-03-04 | 1986-09-04 | Schering AG, Berlin und Bergkamen, 1000 Berlin | Ferromagnetische partikel fuer die nmr-diagnostik |
| PT81498B (pt) * | 1984-11-23 | 1987-12-30 | Schering Ag | Processo para a preparacao de composicoes para diagnostico contendo particulas magneticas |
| DE3443251C2 (de) * | 1984-11-23 | 1998-03-12 | Schering Ag | Eisenoxid-Komplexe für die NMR-Diagnostik, diese Verbindungen enthaltende diagnostische Mittel, ihre Verwendung und Verfahren zu deren Herstellung |
| US4656026A (en) * | 1984-12-10 | 1987-04-07 | University Of Iowa Research Foundation | Magnetic resonance (MR) image enhancement compounds for specific areas of the brain |
| EP0184849A1 (de) * | 1984-12-12 | 1986-06-18 | Rainer Bauer | Aufnahmeeinrichtung für elektronische Bauelemente |
| US4637929A (en) * | 1985-01-04 | 1987-01-20 | Salutar, Inc. | Ferrioxamine-paramagnetic contrast agents for MR imaging, composition, apparatus and use |
| US4675173A (en) * | 1985-05-08 | 1987-06-23 | Molecular Biosystems, Inc. | Method of magnetic resonance imaging of the liver and spleen |
| DE3518267A1 (de) * | 1985-05-17 | 1986-11-20 | Martin Prof. Dr. 1000 Berlin Wenzel | Mittel zur kontrast-erhoehung bei der kernspin-tomographie |
| GB8518300D0 (en) * | 1985-07-19 | 1985-08-29 | Amersham Int Plc | Contrast agent |
| GB8522535D0 (en) * | 1985-09-11 | 1985-10-16 | Amersham Int Plc | Contrast agent |
| US4795698A (en) * | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
-
1987
- 1987-03-24 DE DE19873709851 patent/DE3709851A1/de not_active Withdrawn
-
1988
- 1988-03-23 AT AT88730073T patent/ATE78175T1/de not_active IP Right Cessation
- 1988-03-23 DE DE8888730073T patent/DE3872741D1/de not_active Expired - Lifetime
- 1988-03-23 ES ES88730073T patent/ES2052766T3/es not_active Expired - Lifetime
- 1988-03-23 EP EP88730073A patent/EP0284549B1/de not_active Expired - Lifetime
- 1988-03-24 JP JP63068349A patent/JP2663976B2/ja not_active Expired - Fee Related
-
1991
- 1991-01-04 US US07/638,134 patent/US5160725A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPS63255237A (ja) | 1988-10-21 |
| DE3709851A1 (de) | 1988-10-06 |
| ATE78175T1 (de) | 1992-08-15 |
| EP0284549A3 (en) | 1989-09-13 |
| JP2663976B2 (ja) | 1997-10-15 |
| EP0284549B1 (de) | 1992-07-15 |
| US5160725A (en) | 1992-11-03 |
| EP0284549A2 (de) | 1988-09-28 |
| ES2052766T3 (es) | 1994-07-16 |
| DE3872741D1 (de) | 1992-08-20 |
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|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8330 | Complete renunciation |