DE3803972A1 - Ultraschallkontrastmittel - Google Patents

Ultraschallkontrastmittel

Info

Publication number
DE3803972A1
DE3803972A1 DE3803972A DE3803972A DE3803972A1 DE 3803972 A1 DE3803972 A1 DE 3803972A1 DE 3803972 A DE3803972 A DE 3803972A DE 3803972 A DE3803972 A DE 3803972A DE 3803972 A1 DE3803972 A1 DE 3803972A1
Authority
DE
Germany
Prior art keywords
acid
ultrasound contrast
necessary
solution
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE3803972A
Other languages
German (de)
English (en)
Other versions
DE3803972C2 (https=
Inventor
Michael Dr Stein
Dieter Heldmann
Thomas Dr Fritzsch
Joachim Dr Siegert
Georg Dr Roessling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acusphere Inc
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE3803972A priority Critical patent/DE3803972A1/de
Application filed by Schering AG filed Critical Schering AG
Priority to JP1501696A priority patent/JP2907911B2/ja
Priority to EP93112378A priority patent/EP0586875A1/de
Priority to AT89901933T priority patent/ATE109663T1/de
Priority to HU9601731A priority patent/HU9601731D0/hu
Priority to PCT/DE1989/000069 priority patent/WO1989006978A1/de
Priority to DE58908194T priority patent/DE58908194D1/de
Priority to AU30351/89A priority patent/AU635200B2/en
Priority to EP89901933A priority patent/EP0398935B1/de
Priority to HU055/89A priority patent/HU221485B/hu
Priority to EP89730021A priority patent/EP0327490A1/de
Priority to KR1019890701826A priority patent/KR0133132B1/ko
Priority to ES89901933T priority patent/ES2068917T3/es
Priority to IE34389A priority patent/IE66912B1/en
Priority to PT89635A priority patent/PT89635B/pt
Priority to CA000590059A priority patent/CA1336164C/en
Priority to IE940809A priority patent/IE940809L/xx
Priority to IL89175A priority patent/IL89175A/xx
Priority to CN89100726A priority patent/CN1033840C/zh
Priority to MYPI89000146A priority patent/MY105856A/en
Priority to NZ237900A priority patent/NZ237900A/xx
Priority to NZ227869A priority patent/NZ227869A/xx
Publication of DE3803972A1 publication Critical patent/DE3803972A1/de
Application granted granted Critical
Publication of DE3803972C2 publication Critical patent/DE3803972C2/de
Priority to US07/536,373 priority patent/US6264959B1/en
Priority to FI903865A priority patent/FI99086C/fi
Priority to DK199001864A priority patent/DK175832B1/da
Priority to NO903443A priority patent/NO301260B1/no
Priority to US08/072,748 priority patent/US5425366A/en
Priority to US08/477,642 priority patent/US6071496A/en
Priority to US08/474,468 priority patent/US6177062B1/en
Priority to JP7306254A priority patent/JP3027326B2/ja
Priority to NO970732A priority patent/NO304412B1/no
Granted legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/228—Host-guest complexes, clathrates, chelates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE3803972A 1988-02-05 1988-02-05 Ultraschallkontrastmittel Granted DE3803972A1 (de)

Priority Applications (31)

Application Number Priority Date Filing Date Title
DE3803972A DE3803972A1 (de) 1988-02-05 1988-02-05 Ultraschallkontrastmittel
EP93112378A EP0586875A1 (de) 1988-02-05 1989-02-01 Ultraschallkontrastmittel, Verfahren zu deren Herstellung und deren Verwendung als Diagnostika und Therapeutika
AT89901933T ATE109663T1 (de) 1988-02-05 1989-02-01 Ultraschallkontrastmittel, verfahren zu deren herstellung und deren verwendung als diagnostika und therapeutika.
HU9601731A HU9601731D0 (en) 1988-02-05 1989-02-01 Ultrasonic contrastmaterials, process for producing them and their use as diagnostics and therapeutical materials
JP1501696A JP2907911B2 (ja) 1988-02-05 1989-02-01 超音波造影剤、その製造方法及び該超音波造影剤からなる診断又は治療用製剤
DE58908194T DE58908194D1 (de) 1988-02-05 1989-02-01 Ultraschallkontrastmittel, verfahren zu deren herstellung und deren verwendung als diagnostika und therapeutika.
AU30351/89A AU635200B2 (en) 1988-02-05 1989-02-01 Ultrasonic contrast agents, process for producing them and their use as diagnostic and therapeutic agents
EP89901933A EP0398935B1 (de) 1988-02-05 1989-02-01 Ultraschallkontrastmittel, verfahren zu deren herstellung und deren verwendung als diagnostika und therapeutika
HU055/89A HU221485B (en) 1988-02-05 1989-02-01 Ultrasound contrast media consisting of microparticles and process for producing the same
EP89730021A EP0327490A1 (de) 1988-02-05 1989-02-01 Ultraschallkontrastmittel, Verfahren zu deren Herstellung und deren Verwendung als Diagnostika und Therapeutika
KR1019890701826A KR0133132B1 (ko) 1988-02-05 1989-02-01 초음파 조영제, 이의 제법 및 이의 진단제로서의 용도
ES89901933T ES2068917T3 (es) 1988-02-05 1989-02-01 Medios de contraste por ultrasonido, procedimiento para su obtencion y utilizacion de los mismos como productos de diagnostico y terapeuticos.
IE34389A IE66912B1 (en) 1988-02-05 1989-02-01 Ultrasonic contrast agents process for their preparation and their use as diagnostic and therapeutic agents
PCT/DE1989/000069 WO1989006978A1 (fr) 1988-02-05 1989-02-01 Agents de contraste ultrasonores, procede pour leur fabrication et leur emploi a titre d'agents diagnostiques et therapeutiques
IL89175A IL89175A (en) 1988-02-05 1989-02-03 Ultrasonic contrast agents and processes for the preparation thereof
CA000590059A CA1336164C (en) 1988-02-05 1989-02-03 Ultrasonic contrast agents, process for their preparation and their use as a diagnostic and therapeutic agent
PT89635A PT89635B (pt) 1988-02-05 1989-02-03 Processo para a preparacao de contrastes para ultrassons
IE940809A IE940809L (en) 1988-02-05 1989-02-03 Ultrasonic contrast agents, process for their preparation¹and their use as diagnostic and therapeutic agents
CN89100726A CN1033840C (zh) 1988-02-05 1989-02-04 制备用于超声造影的微粒和超声波造影剂的方法
MYPI89000146A MY105856A (en) 1988-02-05 1989-02-04 Ultra sonic contrast agents, process for their preparation and their use as diagnostic and therapeutic agents.
NZ237900A NZ237900A (en) 1988-02-05 1989-02-07 Microparticles suitable as ultrasonic contrast agent comprising biodegradable polymers; preparation thereof
NZ227869A NZ227869A (en) 1988-02-05 1989-02-07 Ultrasonic contrast agents containing amylose microparticles
US07/536,373 US6264959B1 (en) 1988-02-05 1990-06-11 Ultrasonic contrast agents, process for their preparation and their use as a diagnostic and therapeutic agent
DK199001864A DK175832B1 (da) 1988-02-05 1990-08-03 Ultrasoniske kontrastmidler og fremgangsmåde til fremstilling deraf samt deres anvendelse
FI903865A FI99086C (fi) 1988-02-05 1990-08-03 Ultraäänivarjoaineita, menetelmä niiden valmistamiseksi ja niiden käyttö diagnostisina aineina
NO903443A NO301260B1 (no) 1988-02-05 1990-08-06 Ultrasoniske kontrastmidler samt anvendelse av slike ved fremstilling av et preparat for ultralyddiagnostikk
US08/072,748 US5425366A (en) 1988-02-05 1993-06-07 Ultrasonic contrast agents for color Doppler imaging
US08/477,642 US6071496A (en) 1988-02-05 1995-06-07 Polyalkylcyanoacrylate agents and methods for enhancing contrast in ultrasound imaging
US08/474,468 US6177062B1 (en) 1988-02-05 1995-06-07 Agents and methods for enhancing contrast in ultrasound imaging
JP7306254A JP3027326B2 (ja) 1988-02-05 1995-11-24 超音波造影剤及び超音波診断用製剤
NO970732A NO304412B1 (no) 1988-02-05 1997-02-17 Ultrasonisk kontrastmiddel samt anvendelse derav ved fremstilling av et preparat for ultralyddiagnostikk

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3803972A DE3803972A1 (de) 1988-02-05 1988-02-05 Ultraschallkontrastmittel

Publications (2)

Publication Number Publication Date
DE3803972A1 true DE3803972A1 (de) 1989-08-10
DE3803972C2 DE3803972C2 (https=) 1989-11-02

Family

ID=6347027

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3803972A Granted DE3803972A1 (de) 1988-02-05 1988-02-05 Ultraschallkontrastmittel

Country Status (1)

Country Link
DE (1) DE3803972A1 (https=)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5425366A (en) * 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
WO1996013213A3 (de) * 1994-11-01 1996-08-01 Schering Ag Ultraschallverfahren und schaltungen zur durchführung dieser verfahren
US6592846B1 (en) 1991-05-03 2003-07-15 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure resistant gas-filled microvesicles and methods for thereof preparation thereof
WO2004048585A3 (de) * 2002-11-22 2004-08-05 Basf Ag Enzymatische synthese von polyolacrylaten
US6998107B2 (en) 1991-04-05 2006-02-14 Bristol-Myers Squibb Pharma Comapany Composition comprising low density microspheres
US7078015B2 (en) 1989-12-22 2006-07-18 Imarx Therapeutics, Inc. Ultrasound imaging and treatment
US7105151B2 (en) 1997-06-18 2006-09-12 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US7329402B2 (en) 1995-06-07 2008-02-12 Imarx Pharmaceutical Corp. Methods of imaging and treatment
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US8084056B2 (en) 1998-01-14 2011-12-27 Lantheus Medical Imaging, Inc. Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US10022460B2 (en) 2014-12-31 2018-07-17 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
US10588988B2 (en) 2016-05-04 2020-03-17 Lantheus Medical Imaging, Inc. Methods and devices for preparation of ultrasound contrast agents

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
WO1997040679A1 (en) 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122624A2 (de) * 1983-04-15 1984-10-24 Schering Aktiengesellschaft Mikropartikel und Gasbläschen enthaltendes Ultraschallkontrastmittel
EP0123235A2 (de) * 1983-04-15 1984-10-31 Schering Aktiengesellschaft Mikropartikel und Gasblächen enthaltendes Ultraschall-Kontrastmittel
EP0131540A2 (de) * 1983-07-06 1985-01-16 Schering Aktiengesellschaft Ultraschallkontrastmittel sowie dessen Herstellung
EP0224934A2 (en) * 1985-12-05 1987-06-10 Steven B. Feinstein Contrast agent, process for its preparation and its use for ultrasonic imaging

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122624A2 (de) * 1983-04-15 1984-10-24 Schering Aktiengesellschaft Mikropartikel und Gasbläschen enthaltendes Ultraschallkontrastmittel
EP0123235A2 (de) * 1983-04-15 1984-10-31 Schering Aktiengesellschaft Mikropartikel und Gasblächen enthaltendes Ultraschall-Kontrastmittel
EP0131540A2 (de) * 1983-07-06 1985-01-16 Schering Aktiengesellschaft Ultraschallkontrastmittel sowie dessen Herstellung
EP0224934A2 (en) * 1985-12-05 1987-06-10 Steven B. Feinstein Contrast agent, process for its preparation and its use for ultrasonic imaging

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ROELAND, J.: Ultrasound Med. Biol. 8, 471-492, 1982 *

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5425366A (en) * 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
US7078015B2 (en) 1989-12-22 2006-07-18 Imarx Therapeutics, Inc. Ultrasound imaging and treatment
EP0580726B2 (en) † 1991-04-05 2008-08-20 Imarx Pharmaceutical Corp. Low density microspheres and their use as contrast agents for computed tomography
US6998107B2 (en) 1991-04-05 2006-02-14 Bristol-Myers Squibb Pharma Comapany Composition comprising low density microspheres
US6592846B1 (en) 1991-05-03 2003-07-15 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure resistant gas-filled microvesicles and methods for thereof preparation thereof
WO1996013213A3 (de) * 1994-11-01 1996-08-01 Schering Ag Ultraschallverfahren und schaltungen zur durchführung dieser verfahren
US7329402B2 (en) 1995-06-07 2008-02-12 Imarx Pharmaceutical Corp. Methods of imaging and treatment
US7105151B2 (en) 1997-06-18 2006-09-12 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US8084056B2 (en) 1998-01-14 2011-12-27 Lantheus Medical Imaging, Inc. Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US8658205B2 (en) 1998-01-14 2014-02-25 Lantheus Medical Imaging, Inc. Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US8685441B2 (en) 1998-01-14 2014-04-01 Lantheus Medical Imaging, Inc. Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US8747892B2 (en) 1998-01-14 2014-06-10 Lantheus Medical Imaging, Inc. Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US9545457B2 (en) 1998-01-14 2017-01-17 Lantheus Medical Imaging, Inc. Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
WO2004048585A3 (de) * 2002-11-22 2004-08-05 Basf Ag Enzymatische synthese von polyolacrylaten
US12296029B2 (en) 2014-12-31 2025-05-13 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
US10022460B2 (en) 2014-12-31 2018-07-17 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
US11395856B2 (en) 2014-12-31 2022-07-26 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
US10583207B2 (en) 2014-12-31 2020-03-10 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
US10588988B2 (en) 2016-05-04 2020-03-17 Lantheus Medical Imaging, Inc. Methods and devices for preparation of ultrasound contrast agents
US12097270B2 (en) 2016-05-04 2024-09-24 Lantheus Medical Imaging, Inc. Methods and devices for preparation of ultrasound contrast agents
US9913919B2 (en) 2016-07-06 2018-03-13 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US11266749B2 (en) 2016-07-06 2022-03-08 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US11266750B2 (en) 2016-07-06 2022-03-08 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US11344636B2 (en) 2016-07-06 2022-05-31 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US10583208B2 (en) 2016-07-06 2020-03-10 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US11529431B2 (en) 2016-07-06 2022-12-20 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US11857646B2 (en) 2016-07-06 2024-01-02 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US11925695B2 (en) 2016-07-06 2024-03-12 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US10220104B2 (en) 2016-07-06 2019-03-05 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US12161730B2 (en) 2016-07-06 2024-12-10 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents

Also Published As

Publication number Publication date
DE3803972C2 (https=) 1989-11-02

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
D2 Grant after examination
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: SCHERING AG, 13353 BERLIN, DE

8365 Fully valid after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: ACUSPHERE, INC., WATERTOWN, MASS., US

8328 Change in the person/name/address of the agent

Representative=s name: HOFFMANN & EITLE, 81925 MUENCHEN