DE3790581B4 - Verfahren zur selektiven Vernichtung von hypoxischen Tumorzellen - Google Patents

Verfahren zur selektiven Vernichtung von hypoxischen Tumorzellen Download PDF

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Publication number
DE3790581B4
DE3790581B4 DE3790581A DE3790581A DE3790581B4 DE 3790581 B4 DE3790581 B4 DE 3790581B4 DE 3790581 A DE3790581 A DE 3790581A DE 3790581 A DE3790581 A DE 3790581A DE 3790581 B4 DE3790581 B4 DE 3790581B4
Authority
DE
Germany
Prior art keywords
amino
benzotriazine
hydroxy
dioxide
oxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3790581A
Other languages
German (de)
English (en)
Other versions
DE3790581T1 (enExample
Inventor
William W. Palo Alto Lee
J. Martin Stanford Brown
Edward W. Palo Alto Grange
Abelardo P. San Jose Martinez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Priority to DE3745196A priority Critical patent/DE3745196B4/de
Application granted granted Critical
Publication of DE3790581B4 publication Critical patent/DE3790581B4/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE3790581A 1986-09-25 1987-06-16 Verfahren zur selektiven Vernichtung von hypoxischen Tumorzellen Expired - Lifetime DE3790581B4 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE3745196A DE3745196B4 (de) 1986-09-25 1987-06-16 Verbindungen und deren Verwendung zur selektiven Vernichtung von hypoxischen Tumorzellen

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91190686A 1986-09-25 1986-09-25
US911906 1986-09-25
PCT/US1987/001412 WO1988002366A1 (en) 1986-09-25 1987-06-16 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents

Publications (1)

Publication Number Publication Date
DE3790581B4 true DE3790581B4 (de) 2004-12-23

Family

ID=25431084

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3790581A Expired - Lifetime DE3790581B4 (de) 1986-09-25 1987-06-16 Verfahren zur selektiven Vernichtung von hypoxischen Tumorzellen
DE19873790581 Pending DE3790581T1 (enExample) 1986-09-25 1987-06-16

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE19873790581 Pending DE3790581T1 (enExample) 1986-09-25 1987-06-16

Country Status (5)

Country Link
JP (1) JP2668232B2 (enExample)
CA (1) CA1338445C (enExample)
DE (2) DE3790581B4 (enExample)
GB (1) GB2203151B (enExample)
WO (1) WO1988002366A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175287A (en) * 1986-09-25 1992-12-29 S R I International Process for preparing 1,2,4-benzotriazine oxides
US5616584A (en) 1986-09-25 1997-04-01 Sri International 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents
IE62911B1 (en) * 1988-03-18 1995-03-08 Stanford Res Inst Int 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents
GR1000941B (el) * 1989-03-17 1993-03-16 Stanford Res Inst Int Μεθοδος παρασκευης οξειδιων 1,2,4,βενζοτριαζινης.
EP0478545B1 (en) * 1989-09-18 1999-08-11 Sri International 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents
US5672702A (en) * 1995-12-04 1997-09-30 Sanofi Process for preparing 3 amino 1, 2, 4-benzotriazine dioxide
JP2015500295A (ja) * 2011-12-07 2015-01-05 エスアールアイ インターナショナルＳＲＩ Ｉｎｔｅｒｎａｔｉｏｎａｌ ヒト結核菌を標的とする医薬としてのベンゾトリアジンオキサイド類
US10981953B2 (en) 2013-12-26 2021-04-20 Toagosei Co, Ltd. Method for promoting expression of calreticulin, and synthetic peptide for use in method for promoting expression of calreticulin
JP6872713B2 (ja) 2015-05-29 2021-05-19 東亞合成株式会社 腫瘍細胞の放射線感受性を増大させる合成ペプチド及びその利用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2489352A (en) * 1946-04-10 1949-11-29 Merck & Co Inc Halogen compounds of 3 aminobenzotriazine 1, 2, 4 oxide-1
US3697518A (en) * 1968-11-16 1972-10-10 Bayer Ag Phosphorus acid esters of 3-hydroxy-benzo-1,2,4-triazine -1-n-oxide
US4206212A (en) * 1977-09-10 1980-06-03 Bayer Aktiengesellschaft Combating plant pathogenic bacteria with 3-halogeno-benzotriazine 1-oxides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2489359A (en) * 1947-01-10 1949-11-29 Merck & Co Inc Benzotriazines
CH487171A (de) * 1963-10-22 1970-03-15 Siegfried Ag Verfahren zur Herstellung therapeutisch wirksamer 1,2-Dihydro-1,2,4-benztriazine
IE38778B1 (en) * 1973-02-02 1978-05-24 Ciba Geigy New 1,2,4-benzotriazine derivatives
DE2538179C2 (de) * 1975-08-27 1986-05-28 Bayer Ag, 5090 Leverkusen 3-Alkoxy-benzo-1,2,4-triazine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2489352A (en) * 1946-04-10 1949-11-29 Merck & Co Inc Halogen compounds of 3 aminobenzotriazine 1, 2, 4 oxide-1
US3697518A (en) * 1968-11-16 1972-10-10 Bayer Ag Phosphorus acid esters of 3-hydroxy-benzo-1,2,4-triazine -1-n-oxide
US4206212A (en) * 1977-09-10 1980-06-03 Bayer Aktiengesellschaft Combating plant pathogenic bacteria with 3-halogeno-benzotriazine 1-oxides

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
C.A., 106, 95684v (1987) *
C.A., 44, 3536i (1950) *
J. Am. Chem. Soc., 05.Juli 1954, S. 3551-3553 *
J. Chem. Soc (B), 1970, S. 911-916 *
J. Pharm. Sci., 69/7, 789-793(1980) *

Also Published As

Publication number Publication date
JP2668232B2 (ja) 1997-10-27
JPH01500826A (ja) 1989-03-23
WO1988002366A1 (en) 1988-04-07
GB8810634D0 (en) 1988-07-06
DE3790581T1 (enExample) 1988-08-25
CA1338445C (en) 1996-07-09
GB2203151B (en) 1991-05-29
GB2203151A (en) 1988-10-12

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