DE3790322T1 - - Google Patents

Info

Publication number
DE3790322T1
DE3790322T1 DE19873790322 DE3790322T DE3790322T1 DE 3790322 T1 DE3790322 T1 DE 3790322T1 DE 19873790322 DE19873790322 DE 19873790322 DE 3790322 T DE3790322 T DE 3790322T DE 3790322 T1 DE3790322 T1 DE 3790322T1
Authority
DE
Germany
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19873790322
Other versions
DE3790322C2 (de
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of DE3790322T1 publication Critical patent/DE3790322T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE19873790322 1986-06-20 1987-06-12 Pending DE3790322T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/876,689 US4826811A (en) 1986-06-20 1986-06-20 Acellular red blood cell substitute

Publications (1)

Publication Number Publication Date
DE3790322T1 true DE3790322T1 (de) 1988-09-15

Family

ID=25368368

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19873790322 Pending DE3790322T1 (de) 1986-06-20 1987-06-12
DE3790322A Expired - Lifetime DE3790322C2 (de) 1986-06-20 1987-06-12 Nichtzellulares Präparat als Ersatz für rote Blutkörperchen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3790322A Expired - Lifetime DE3790322C2 (de) 1986-06-20 1987-06-12 Nichtzellulares Präparat als Ersatz für rote Blutkörperchen

Country Status (11)

Country Link
US (1) US4826811A (de)
EP (1) EP0271542B1 (de)
JP (1) JP2983544B2 (de)
CA (1) CA1298783C (de)
DE (2) DE3790322T1 (de)
FR (1) FR2600255B1 (de)
GB (2) GB8801735D0 (de)
IL (1) IL82890A0 (de)
NL (1) NL194909C (de)
PT (1) PT85133B (de)
WO (1) WO1987007832A1 (de)

Families Citing this family (87)

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US5464814A (en) * 1986-06-20 1995-11-07 Northfield Laboratories, Inc. Acellular red blood cell substitute
US5194590A (en) * 1986-06-20 1993-03-16 Northfield Laboratories, Inc. Acellular red blood cell substitute
CA1312009C (en) 1986-11-10 1992-12-29 Carl W. Rausch Extra pure semi-synthetic blood substitute
US5955581A (en) * 1986-11-10 1999-09-21 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5753616A (en) * 1986-11-10 1998-05-19 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5084558A (en) * 1987-10-13 1992-01-28 Biopure Corporation Extra pure semi-synthetic blood substitute
US5854209A (en) * 1995-03-23 1998-12-29 Biopure Corporation Method for oxygenating tissue having reduced red blood cell flow
US5449759A (en) * 1987-05-16 1995-09-12 Somatogen, Inc. Hemoglobins with intersubunit desulfide bonds
US6022849A (en) * 1987-05-16 2000-02-08 Baxter Biotech Technology Saarl Mutant recombinant hemoglobins containing heme pocket mutations
GB8711614D0 (en) * 1987-05-16 1987-06-24 Medical Res Council Proteins
JPH03501545A (ja) * 1987-12-03 1991-04-04 クローライド　サイレント　パワー　リミテッド 改良アルカル金属電池
US6204009B1 (en) 1988-05-16 2001-03-20 BAXTER BIOTECH TECHNOLOGY SàRL Nucleic acids encoding mutant recombinant hemoglobins containing heme pocket mutations
IL87707A (en) * 1988-09-08 1994-06-24 Technion Inst For Research And Hemoglobin-based blood substitute substantially similar to human blood and method for preparation thereof
IL87708A (en) * 1988-09-08 1994-04-12 Technion Inst For Research And Hemoglobin-based blood substitute possessing a colloid oncotic pressure substantially similar to human blood and method for the preparation thereof
NL8901174A (nl) * 1989-05-10 1990-12-03 Het Hoofd Van De Afdeling Mili Hemoglobine-preparaat en gebruik daarvan.
US5545727A (en) 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
US5439882A (en) * 1989-12-29 1995-08-08 Texas Tech University Health Sciences Center Blood substitute
AU9067791A (en) * 1990-11-20 1992-06-11 Enzon, Inc. Method of enhancing long-term storage stability of hemoglobin products
HUT64571A (en) * 1990-11-29 1994-01-28 Upjohn Co A method for producing hemoglobin preparatives containing imido ester cross bind
AU665599B2 (en) * 1991-11-08 1996-01-11 Hemosol Inc. Hemoglobins as drug delivery agents
US5900477A (en) * 1992-01-30 1999-05-04 Baxter International, Inc. Use of hemoglobin in the treatment of hemorrhagic shock
US5334706A (en) * 1992-01-30 1994-08-02 Baxter International Administration of low dose hemoglobin to increase perfusion
US5591457A (en) * 1992-02-07 1997-01-07 Vasogen Inc Method of inhibiting the aggregation of blood platelets and stimulating the immune systems of a human
US6669965B2 (en) 1992-02-07 2003-12-30 Vasogen Ireland Limited Method of treating atherosclerosis
GB9617611D0 (en) * 1996-08-22 1996-10-02 Vasogen Inc Treatment of autoimmune disease
US5980954A (en) 1992-02-07 1999-11-09 Vasogen Ireland Limited Treatment of autoimmune diseases
US5646252A (en) * 1992-02-10 1997-07-08 Staat Der Nederlanden, De Minister Van Defensie, Voor Deze: Het Hoofd Van De Afdeling Militair Geneeskundig Beleid Hemoglobin composition and preparation thereof
US6187744B1 (en) 1992-03-11 2001-02-13 Michael W. Rooney Methods and compositions for regulating the intravascular flow and oxygenating activity of hemoglobin in a human or animal subject
WO1995003068A1 (en) * 1993-07-23 1995-02-02 The Upjohn Company Method for administering hemoglobin
IS4198A (is) * 1993-08-13 1995-02-14 Somatogen, Inc Meðferð vegna aukaverkana sem tengjast gjöf á utanfrumublóðrauða
US5741893A (en) * 1993-08-16 1998-04-21 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5807831A (en) * 1993-08-16 1998-09-15 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5817632A (en) * 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5725839A (en) * 1993-08-16 1998-03-10 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI
US5804561A (en) * 1993-08-16 1998-09-08 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5824781A (en) * 1993-08-16 1998-10-20 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5767089A (en) * 1993-08-16 1998-06-16 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5840701A (en) * 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
TW381022B (en) 1993-08-16 2000-02-01 Hsia Jen Chang Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
US6242417B1 (en) 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US6458762B1 (en) 1994-03-28 2002-10-01 Baxter International, Inc. Therapeutic use of hemoglobin for preserving tissue viability and reducing restenosis
DE4418973A1 (de) * 1994-05-31 1995-12-14 Barnikol Wolfgang Verfahren zur Herstellung molekular-einheitlicher hyperpolymerer Hämoglobine
US6610832B1 (en) 1995-03-23 2003-08-26 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US5895810A (en) * 1995-03-23 1999-04-20 Biopure Corporation Stable polymerized hemoglobin and use thereof
US6288027B1 (en) 1995-03-23 2001-09-11 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US6271351B1 (en) 1995-03-23 2001-08-07 Biopure Corporation Method for preserving a hemoglobin blood substitute
WO1996032130A1 (en) * 1995-04-10 1996-10-17 Baxter International Inc. The use of cross-linked hemoglobin in treating subarachnoid hemorrhage
US5952470A (en) * 1995-06-07 1999-09-14 Biopure Corporation Method for separating unmodified hemoglobin from cross-linked hemoglobin
US5741894A (en) * 1995-09-22 1998-04-21 Baxter International, Inc. Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form
US5733869A (en) * 1995-10-06 1998-03-31 Baxter International, Inc. Therapeutic administration of hemoglobin in cardiac arrest
AU1083497A (en) * 1995-11-30 1997-06-19 Somatogen, Inc. Method for control of functionality during cross-linking of hemoglobins
JP2000504934A (ja) 1995-12-22 2000-04-25 バクスター バイオテク テクノロジー エス．アー．アール．エル． 結合ドメインを含むグロビン
JP2000507947A (ja) * 1996-03-28 2000-06-27 ノースフイールド ラボラトリーズ インコーポレイテツド 無細胞性赤血球代用物を製造する方法及び装置
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
ATE302019T1 (de) * 1997-02-28 2005-09-15 Univ California Verfahren und zusammensetzungen zur optimierung des sauerstofftransportes in zellfreien systemen
EP0885613A1 (de) * 1997-06-21 1998-12-23 Roche Diagnostics GmbH Verwendung von modifizierten Hämoglobinen zur Behandlung von Anämien und Kombinationspräparate umfassend Erythropoietin und modifiziertes Hämoglobin
DE19802321C2 (de) * 1998-01-23 2000-05-11 Fresenius Ag Verfahren und Vorrichtung zur Aufbereitung von intra- oder postoperativen Blutverlusten für die Autotransfusion
CA2391226A1 (en) 1999-11-12 2001-05-17 Baxter International, Inc. Reduced side-effect hemoglobin compositions
US6747132B2 (en) 2000-11-29 2004-06-08 Apex Biosciences, Inc. Methods for the synthesis of a modified hemoglobin solution
US6518010B2 (en) * 2001-02-28 2003-02-11 Biopure Corporation Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier
KR20030097834A (ko) 2001-04-18 2003-12-31 노쓰필드 라보라토리스, 인코포레이티드 안정화된 헤모글로빈 용액을 저장하기 위한 가요성 용기시스템
US20050164915A1 (en) 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
WO2003059286A2 (en) * 2002-01-11 2003-07-24 Sangart, Inc. Methods and compositions for oxygen transport comprising modified hemoglobin in plasma
US20030153491A1 (en) 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
WO2003059287A2 (en) * 2002-01-11 2003-07-24 Sangart, Inc. Methods and compositions for oxygen transport comprising an oxygen carrier and a crystalloid in hypertonic solution
SI1465643T1 (sl) 2002-01-11 2008-06-30 Sangart Inc Postopki in sestavki za transport kisika z visokoafiniteto za kisik
US7001715B2 (en) * 2002-02-28 2006-02-21 Biopure Corporation Purification of red blood cells by separation and diafiltration
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
JP2006502231A (ja) * 2002-10-03 2006-01-19 ノースフィールド ラボラトリーズ、インコーポレイテッド 大量失血を被っている患者の処置方法
US7481998B2 (en) * 2002-12-02 2009-01-27 Biovec, Llc Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
US9388427B2 (en) * 2002-12-02 2016-07-12 Biovec, Llc In vivo and ex vivo gene transfer into renal tissue using gutless adenovirus vectors
US7803365B2 (en) * 2002-12-02 2010-09-28 Biovec, Llc Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
EP1573005A2 (de) * 2002-12-02 2005-09-14 Biovec LLC Ex-vivo- und in-vivo-expression desthrombomodulin-gens zur behandlung von herz-kreislauf-erkrankungen und peripheren gefässerkrankungen
US7501114B2 (en) * 2002-12-02 2009-03-10 Biovec, Llc Ex vivo and in vivo expression of the thrombomodulin gene for the treatment of cardiovascular and peripheral vascular diseases
MXPA05007885A (es) * 2003-01-29 2005-09-21 Northfield Lab Soluciones de hemoglobina polimerizada que tienen cantidad reducida de tetramero y metodo para prepararlas.
US7135554B1 (en) 2004-01-27 2006-11-14 Biopure Corporation Method of forming a polymerized hemoglobin solution from stabilized hemoglobin
MX2007002187A (es) * 2004-08-31 2007-10-08 Sangart Inc Metodos para mejorar la estabilidad hemodinamica utilizando composiciones que contienen oxigeno.
EP1865993A2 (de) * 2005-04-05 2007-12-19 Biopure Corporation Sauerstoffangereicherte, polymerisierte hämoglobinlösungen und ihre verwendung zur sichtbarmachung von gewebe
US20070196810A1 (en) * 2006-01-24 2007-08-23 Northfield Laboratories Inc. Polymerized Hemoglobin Media and its Use in Isolation and Transplantation of Islet Cells
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
US7759306B2 (en) * 2006-05-16 2010-07-20 Simoni Jan S Methods of treating acute blood loss
US20080118572A1 (en) * 2006-10-10 2008-05-22 Harold Richard Hellstrom Methods and compositions for reducing the risk of adverse cardiovascular events associated with the administration of artificial blood
US8273857B2 (en) * 2009-09-22 2012-09-25 Jen-Chang Hsia Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine
ES2699579T3 (es) 2013-05-03 2019-02-11 Univ Washington Composición sustituta de la sangre y procedimiento de uso
WO2020080978A2 (ru) * 2018-10-19 2020-04-23 Рахимджан Ахметджанович РОЗИЕВ Cпособ получения кровезаменителя для применения в ветеринарии
CN114146165B (zh) * 2021-12-02 2022-08-12 润方（北京）生物医药研究院有限公司 一种聚合血红蛋白在制备防治呼吸衰竭药物中的应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2607706A1 (de) * 1975-02-27 1976-09-09 Alza Corp Wasserloesliches, polymerisiertes haemoglobin
US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
US4053590A (en) * 1975-02-27 1977-10-11 Alza Corporation Compositions of matter comprising macromolecular hemoglobin
DE2617822A1 (de) * 1976-04-23 1977-10-27 Biotest Serum Institut Gmbh Haemoglobinpraeparat mit erhoehter sauerstoffabgabe
US4061736A (en) * 1975-02-02 1977-12-06 Alza Corporation Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin
DE3144705A1 (de) * 1981-11-11 1983-05-19 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur herstellung eines lagerstabilen, vernetzten haemoglobinpraeparates mit hoher sauerstoff-transportkapazitaet, sowie das nach diesem verfahren hergestellte haemoglobinpraeparat
US4529719A (en) * 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
DE3412144A1 (de) * 1984-03-31 1985-10-10 Biotest Pharma GmbH, 6000 Frankfurt Verfahren zur herstellung hochgereinigter, stromafreier, hepatitissicherer human- und tierhaemoglobinloesungen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52154515A (en) * 1976-04-23 1977-12-22 Biotest Serum Institut Gmbh Hemoglobin preparation strengthening oxygen release property
US4136093A (en) * 1976-04-23 1979-01-23 Biotest-Serum-Institut Gmbh Hemoglobin preparation with increased oxygen release

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
US4061736A (en) * 1975-02-02 1977-12-06 Alza Corporation Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin
DE2607706A1 (de) * 1975-02-27 1976-09-09 Alza Corp Wasserloesliches, polymerisiertes haemoglobin
US4053590A (en) * 1975-02-27 1977-10-11 Alza Corporation Compositions of matter comprising macromolecular hemoglobin
DE2617822A1 (de) * 1976-04-23 1977-10-27 Biotest Serum Institut Gmbh Haemoglobinpraeparat mit erhoehter sauerstoffabgabe
DE3144705A1 (de) * 1981-11-11 1983-05-19 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur herstellung eines lagerstabilen, vernetzten haemoglobinpraeparates mit hoher sauerstoff-transportkapazitaet, sowie das nach diesem verfahren hergestellte haemoglobinpraeparat
US4529719A (en) * 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
DE3412144A1 (de) * 1984-03-31 1985-10-10 Biotest Pharma GmbH, 6000 Frankfurt Verfahren zur herstellung hochgereinigter, stromafreier, hepatitissicherer human- und tierhaemoglobinloesungen

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FRIEDMAN, H.I., et.al.: Surg. Gynecol. Obstet. 159, (1984) S. 429-435 *
VENUTO De F., ZEGNA, A.: J. Surg. Res., 34, (1983) S. 205-212 *

Also Published As

Publication number Publication date
NL194909B (nl) 2003-03-03
US4826811A (en) 1989-05-02
JPH01501471A (ja) 1989-05-25
FR2600255A1 (fr) 1987-12-24
EP0271542A1 (de) 1988-06-22
JP2983544B2 (ja) 1999-11-29
PT85133A (en) 1987-07-01
CA1298783C (en) 1992-04-14
IL82890A0 (en) 1987-12-20
EP0271542B1 (de) 1991-09-04
FR2600255B1 (fr) 1990-07-27
GB8801735D0 (en) 1988-03-30
NL194909C (nl) 2003-07-04
WO1987007832A1 (en) 1987-12-30
GB2200639A (en) 1988-08-10
DE3790322C2 (de) 1999-09-02
NL8720283A (nl) 1988-05-02
PT85133B (pt) 1990-03-30
GB2200639B (en) 1990-12-12

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