DE3784484T2 - Hepatitis nanb-viraler stoff, antigen und immunologisches reagenz. - Google Patents

Hepatitis nanb-viraler stoff, antigen und immunologisches reagenz.

Info

Publication number
DE3784484T2
DE3784484T2 DE8787402519T DE3784484T DE3784484T2 DE 3784484 T2 DE3784484 T2 DE 3784484T2 DE 8787402519 T DE8787402519 T DE 8787402519T DE 3784484 T DE3784484 T DE 3784484T DE 3784484 T2 DE3784484 T2 DE 3784484T2
Authority
DE
Germany
Prior art keywords
antigen
immunological reagent
nanb viral
hepatitis nanb
hepatitis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787402519T
Other languages
English (en)
Other versions
DE3784484D1 (de
Inventor
Jacques Pillot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur de Lille
Original Assignee
Institut Pasteur de Lille
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8615625A external-priority patent/FR2606515B1/fr
Priority claimed from FR8701738A external-priority patent/FR2609807B2/fr
Application filed by Institut Pasteur de Lille filed Critical Institut Pasteur de Lille
Application granted granted Critical
Publication of DE3784484D1 publication Critical patent/DE3784484D1/de
Publication of DE3784484T2 publication Critical patent/DE3784484T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24221—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE8787402519T 1986-11-07 1987-11-06 Hepatitis nanb-viraler stoff, antigen und immunologisches reagenz. Expired - Fee Related DE3784484T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8615625A FR2606515B1 (fr) 1986-11-07 1986-11-07 Procede pour l'isolement d'un nouvel agent viral et de l'antigene qui lui est associe, agent viral et antigene obtenus par ce procede et procede de detection dudit antigene a l'aide d'un reactif immunologique approprie
FR8701738A FR2609807B2 (fr) 1987-02-11 1987-02-11 Reactifs immunologiques pour la detection de l'hepatite virale nanb, leurs procedes de preparation et leurs applications dans des procedes de detection de l'hepatite virale nanb et en tant qu'agents therapeutiques

Publications (2)

Publication Number Publication Date
DE3784484D1 DE3784484D1 (de) 1993-04-08
DE3784484T2 true DE3784484T2 (de) 1993-07-01

Family

ID=26225574

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787402519T Expired - Fee Related DE3784484T2 (de) 1986-11-07 1987-11-06 Hepatitis nanb-viraler stoff, antigen und immunologisches reagenz.

Country Status (7)

Country Link
EP (1) EP0277437B1 (de)
JP (1) JP2602517B2 (de)
AU (1) AU611402B2 (de)
DE (1) DE3784484T2 (de)
ES (1) ES2054696T3 (de)
NZ (1) NZ222465A (de)
WO (1) WO1988003410A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714596A (en) * 1987-11-18 1998-02-03 Chiron Corporation NANBV diagnostics: polynucleotides useful for screening for hepatitis C virus
GB2212511B (en) * 1987-11-18 1992-01-22 Chiron Corp Hepatitis c virus
US5712088A (en) * 1987-11-18 1998-01-27 Chiron Corporation Methods for detecting Hepatitis C virus using polynucleotides specific for same
US5698390A (en) 1987-11-18 1997-12-16 Chiron Corporation Hepatitis C immunoassays
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
US6171782B1 (en) 1987-11-18 2001-01-09 Chiron Corporation Antibody compositions to HCV and uses thereof
US6861212B1 (en) 1987-11-18 2005-03-01 Chiron Corporation NANBV diagnostics and vaccines
JPH02500880A (ja) * 1987-11-18 1990-03-29 カイロン　コーポレイション Ｎａｎｂｖの診断用薬およびワクチン
US5789559A (en) * 1988-06-17 1998-08-04 Genelabs Technologies, Inc. DNA sequences of enterically transmitted non-A/non-B hepatitis viral agent
US5824649A (en) * 1988-06-17 1998-10-20 Genelabs Technologies, Inc. DNA sequences of enterically transmitted non-A/non-B hepatitis viral agent and characteristic epitopes thereof
DE3837616A1 (de) * 1988-11-05 1990-05-10 Behringwerke Ag Einschritt-immuntest zur bestimmung von antigen-spezifischen antikoerpern aller immunglobulin-klassen und dazu geeignetes mittel
US6027729A (en) * 1989-04-20 2000-02-22 Chiron Corporation NANBV Diagnostics and vaccines
LU87861A1 (fr) 1989-12-18 1991-10-08 Wellcome Found Agent viral
US7166287B1 (en) 1989-12-18 2007-01-23 Glaxo Wellcome Inc. Viral agent
EP0447984A1 (de) * 1990-03-20 1991-09-25 Abbott Laboratories Hyperimmunglobulin gegen Hepatitis-C-Virus und Verfahren zur Herstellung
US5846805A (en) * 1991-08-26 1998-12-08 Boehringer Ingelheim Animal Health, Inc. Culture of swine infertility and respiratory syndrome virus in simian cells
CA2116348C (en) * 1991-08-26 2001-07-03 James E. Collins Sirs vaccine and diagnosis method
US6080570A (en) * 1991-08-26 2000-06-27 Boehringer Ingelheim Vetmedica, Inc. Method of producing a vaccine for Swine Infertility and Respiratory Syndrome
US6982160B2 (en) 1991-08-26 2006-01-03 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions that include SIRS virus
AU2696792A (en) * 1991-09-16 1993-04-27 David A Benfield Vaccine for mystery swine disease and method for diagnosis thereof
EP0839912A1 (de) 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Ansteckende Klone von RNA-Viren und darauf basierende Impfstoffe und diagnostisches Verfahren
PL204373B1 (pl) 1999-03-08 2010-01-29 Boehringer Ingelheim Vetemendi Replikony zespołu reprodukcyjnego i oddechowego świń (PRRSV), zastosowanie replikonów PRRSV, szczepionki zawierające replikony PRRSV i zastosowanie tych szczepionek
JP4778620B2 (ja) 1999-04-22 2011-09-21 ユナイテッド ステイツ デパートメント オブ アグリカルチャー 分離株ｊａ−１４２に基づく、豚繁殖・呼吸障害症候群ワクチン
WO2006009880A2 (en) 2004-06-18 2006-01-26 Regents Of The University Of Minnesota Identifying virally infected and vaccinated organisms
US7632636B2 (en) 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
ES2386973T3 (es) 2005-06-24 2012-09-10 Regents Of The University Of Minnesota Virus PRRS, clones infecciosos, mutantes de los mismos, y métodos de utilización
AR078253A1 (es) 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
ES2553879T3 (es) 2011-02-17 2015-12-14 Boehringer Ingelheim Vetmedica Gmbh Procedimiento para la producción a escala comercial de PRRSV
DK2675475T3 (en) 2011-02-17 2015-09-14 Boehringer Ingelheim Vetmed NEW EUROPEAN PRRSV TRIAL
WO2013017570A1 (en) 2011-07-29 2013-02-07 Boehringer Ingelheim Vetmedica Gmbh Novel prrs virus inducing type i interferon in susceptible cells
US9187731B2 (en) 2011-07-29 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh PRRS virus inducing type I interferon in susceptible cells
EP2968513A2 (de) 2013-03-15 2016-01-20 Boehringer Ingelheim Vetmedica, Inc. Prrs-virus, zusammensetzungen, impfstoff und verfahren zur verwendung
EP3083947B1 (de) 2013-12-20 2019-04-03 Boehringer Ingelheim Vetmedica GmbH Prrs-virusvariante, cdna-klon des europäischen prrs-virus und verwendungen davon

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4356164A (en) * 1979-05-21 1982-10-26 Govt. of the U.S., as represented by the Secretary, Dept. of Health & Human Services Detection of non-A, non-B hepatitis associated antigen
AU540153B2 (en) * 1979-05-21 1984-11-01 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Detection of non-a, non-b hepatitis associated antigen
EP0071640B1 (de) * 1981-02-11 1986-06-04 Connaught Laboratories Incorporated Nicht-a, nicht-b hepatitisvirus
US4542016A (en) * 1981-03-27 1985-09-17 Institut Merieux Non-a non-b hepatitis surface antigen useful for the preparation of vaccines and methods of use
FR2502154A1 (fr) * 1981-03-30 1982-09-24 Trepo Christian Procede de preparation d'antigenes de l'hepatite virale nanb, et application a la realisation d'un reactif permettant le diagnostic et le pronostic des infections provoquees par les virus des hepatites virales
JPS57198867A (en) * 1981-06-02 1982-12-06 Eisai Co Ltd Non-a, non-b hepatitis related antigen and diagnostic therefor
JPS58753A (ja) * 1981-06-25 1983-01-05 Eisai Co Ltd 非ａ非ｂ型肝炎関連抗体および検出試薬
JPS58183629A (ja) * 1982-04-21 1983-10-26 Eisai Co Ltd 非ａ非ｂ型肝炎関連モノクロナ−ル抗体および診断薬
EP0093438B1 (de) * 1982-05-05 1988-07-20 Louisiana State University and Agricultural and Mechanical College Nicht-A, nicht-B Hepatitis-Antigen
FR2597606B1 (fr) * 1986-04-16 1989-10-06 Pasteur Institut Nouveau reactif pour la detection d'hepatites virales non a non b et procede de diagnostic de telles hepatites par voie immunoenzymatique

Also Published As

Publication number Publication date
AU8273487A (en) 1988-06-01
ES2054696T3 (es) 1994-08-16
EP0277437A1 (de) 1988-08-10
JPH01501205A (ja) 1989-04-27
NZ222465A (en) 1992-11-25
DE3784484D1 (de) 1993-04-08
WO1988003410A1 (fr) 1988-05-19
JP2602517B2 (ja) 1997-04-23
EP0277437B1 (de) 1993-03-03
AU611402B2 (en) 1991-06-13

Similar Documents

Publication Publication Date Title
DE3784484T2 (de) Hepatitis nanb-viraler stoff, antigen und immunologisches reagenz.
EP0058676A4 (de) Non-a, non-b hepatitisprobe und impfstoff.
NZ236491A (en) Post-transfusional non-a non-b hepatitis viral polypeptides, dna, antigenic polypeptides and antibodies to the polypeptides
PT86640A (pt) Hepatitis b virus surface antigens and hybrid antigens containing them
DK643387D0 (da) T-celle-epitoper af hepatitis b-virus-nucleocapsid-protein
DE68912441D1 (de) Nichtessentielle Geflügelpockenvirus-Regionen.
NO873164D0 (no) Muse-humane kimaere antistoffer.
DE3879452T2 (de) Chimaere antikoerper.
DE3872754T2 (de) Nachweis von antikoerpern humaner immundefizienz-viren.
DE3378301D1 (en) Non-a, non-b hepatitis-associated monoclonal antibody and diagnostic reagent
DE3788806D1 (de) Kugelförmige hybrid-hiv-antigene.
FI880802A (fi) T- och b-cellepitoper av pre-s-regionen av hepatitis b-virusytantigen.
FI861691A (fi) En ny tumoerassocierad antigen.
DE3780256T2 (de) Anti-pci-monoklonaler antikoerper.
NO870174L (no) Modifisert b2-mikroglobulin.
DE3377401D1 (de) Non-a, non-b hepatitis antigen
FI872154A0 (fi) Inaktivering av virus.
DE3580482D1 (de) Monoklonale antikoerper und immunisierung damit.
ATE86120T1 (de) Hepatitis nanb-viraler stoff, antigen und immunologisches reagenz.
NO873488D0 (no) Monoklonale antistoffer.
DK375388A (da) Nanb hepatitisvirusmiddel, antigen og immunologisk reagens
TR23713A (tr) Suebstituye edilmis tiouereler,izotiouereler ve korbadiimetiller
DE3175439D1 (en) Non-a, non-b hepatitis assay and vaccine
DE3784437D1 (de) Spinnloesung und daraus hergestellte artikel.
GB8621578D0 (en) Hepatitis b viral antigens

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee