DE3783693D1 - Verfahren zur reinigung des gewebeplasminogenaktivators. - Google Patents

Verfahren zur reinigung des gewebeplasminogenaktivators.

Info

Publication number
DE3783693D1
DE3783693D1 DE8787308391T DE3783693T DE3783693D1 DE 3783693 D1 DE3783693 D1 DE 3783693D1 DE 8787308391 T DE8787308391 T DE 8787308391T DE 3783693 T DE3783693 T DE 3783693T DE 3783693 D1 DE3783693 D1 DE 3783693D1
Authority
DE
Germany
Prior art keywords
cleaning
plasminogen activator
tissue plasminogen
tissue
activator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787308391T
Other languages
English (en)
Other versions
DE3783693T2 (de
Inventor
Mitsuyoshi Morii
Masaharu Ohoka
Toshihiko Suzuki
Katsuyuki Suzuki
Nobuhiro Kawashima
Noriko Mitsui Toatsu Apa Morii
Kunizou Mitsui Toatsu Iij Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Application granted granted Critical
Publication of DE3783693D1 publication Critical patent/DE3783693D1/de
Publication of DE3783693T2 publication Critical patent/DE3783693T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE8787308391T 1986-09-22 1987-09-22 Verfahren zur reinigung des gewebeplasminogenaktivators. Expired - Fee Related DE3783693T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61222111A JPS6379591A (ja) 1986-09-22 1986-09-22 ｔＰＡの精製方法

Publications (2)

Publication Number Publication Date
DE3783693D1 true DE3783693D1 (de) 1993-03-04
DE3783693T2 DE3783693T2 (de) 1993-05-13

Family

ID=16777317

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787308391T Expired - Fee Related DE3783693T2 (de) 1986-09-22 1987-09-22 Verfahren zur reinigung des gewebeplasminogenaktivators.

Country Status (10)

Country Link
US (1) US4985362A (de)
EP (1) EP0261941B1 (de)
JP (1) JPS6379591A (de)
AU (1) AU586355B2 (de)
CA (1) CA1302929C (de)
DE (1) DE3783693T2 (de)
DK (1) DK497487A (de)
FI (1) FI874116A (de)
NO (1) NO873943L (de)
ZA (1) ZA877088B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3512910A1 (de) * 1985-04-11 1986-10-16 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung von plasminogenaktivatoren
JP2507339B2 (ja) * 1986-08-11 1996-06-12 三井東圧化学株式会社 粗ｔＰＡの精製方法
DE3726655A1 (de) * 1987-08-11 1989-02-23 Hoechst Ag Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
WO1990001333A1 (en) * 1988-08-02 1990-02-22 Invitron Corporation METHOD FOR PREPARING tPA COMPOSITIONS
JPH0824578B2 (ja) * 1988-09-05 1996-03-13 三井東圧化学株式会社 ｔＰＡの精製方法
WO1991013976A1 (en) * 1990-03-14 1991-09-19 Yamanouchi Pharmaceutical Co., Ltd. Process for producing purified tissue plasminogen activator or its derivative
DK82592D0 (da) * 1992-06-23 1992-06-23 Novo Nordisk As Fremstilling af proteiner

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5980613A (ja) * 1982-10-29 1984-05-10 Mitsui Toatsu Chem Inc 新規なプラスミノ−ゲン・アクチベ−タ及びその製造方法
CH660742A5 (de) * 1982-10-29 1987-06-15 Mitsui Toatsu Chemicals Plasminogen-aktivator, verfahren zu seiner herstellung und diesen enthaltendes thrombolytisches agens.
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
EP0156169B1 (de) * 1984-02-29 1991-12-18 Asahi Kasei Kogyo Kabushiki Kaisha Wässrige Lösung eines darin in erhöhter Konzentration aufgelösten Gewebe-Plasminogen-Aktivators und Herstellungsverfahren
EP0163751B1 (de) * 1984-06-05 1989-09-20 Asahi Kasei Kogyo Kabushiki Kaisha Verfahren zur Herstellung eines Plasminogenaktivators
WO1987001389A1 (en) * 1985-09-06 1987-03-12 Codon Methods for the recovery of tissue plasminogen activator
JPH01500563A (ja) * 1986-07-16 1989-03-01 セルテック　リミテッド 精製方法

Also Published As

Publication number Publication date
EP0261941A3 (en) 1988-06-08
US4985362A (en) 1991-01-15
DE3783693T2 (de) 1993-05-13
NO873943L (no) 1988-03-23
DK497487D0 (da) 1987-09-22
DK497487A (da) 1988-03-23
EP0261941A2 (de) 1988-03-30
AU586355B2 (en) 1989-07-06
FI874116A0 (fi) 1987-09-21
FI874116A (fi) 1988-03-23
NO873943D0 (no) 1987-09-21
JPS6379591A (ja) 1988-04-09
CA1302929C (en) 1992-06-09
AU7865287A (en) 1988-03-24
ZA877088B (en) 1988-03-29
EP0261941B1 (de) 1993-01-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee