DE3681528D1 - Verfahren zur reinigung eines rohen gewebeplasminogenaktivators. - Google Patents

Verfahren zur reinigung eines rohen gewebeplasminogenaktivators.

Info

Publication number
DE3681528D1
DE3681528D1 DE8686305919T DE3681528T DE3681528D1 DE 3681528 D1 DE3681528 D1 DE 3681528D1 DE 8686305919 T DE8686305919 T DE 8686305919T DE 3681528 T DE3681528 T DE 3681528T DE 3681528 D1 DE3681528 D1 DE 3681528D1
Authority
DE
Germany
Prior art keywords
cleaning
plasminogen activator
tissue plasminogen
raw tissue
raw
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686305919T
Other languages
English (en)
Inventor
Mitsuyoshi Morii
Masaharu Ohoka
Nobuhiro Kawashimi
Noriko Morii
Toshihiko Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Application granted granted Critical
Publication of DE3681528D1 publication Critical patent/DE3681528D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DE8686305919T 1985-08-01 1986-08-01 Verfahren zur reinigung eines rohen gewebeplasminogenaktivators. Expired - Fee Related DE3681528D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60168601A JPS6229975A (ja) 1985-08-01 1985-08-01 粗ｔＰＡの精製法

Publications (1)

Publication Number Publication Date
DE3681528D1 true DE3681528D1 (de) 1991-10-24

Family

ID=15871078

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686305919T Expired - Fee Related DE3681528D1 (de) 1985-08-01 1986-08-01 Verfahren zur reinigung eines rohen gewebeplasminogenaktivators.

Country Status (9)

Country Link
US (1) US5110736A (de)
EP (1) EP0210870B1 (de)
JP (1) JPS6229975A (de)
CA (1) CA1314833C (de)
DE (1) DE3681528D1 (de)
DK (1) DK369686A (de)
FI (1) FI87793C (de)
NO (1) NO172396C (de)
ZA (1) ZA865536B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU597908B2 (en) * 1985-10-04 1990-06-14 Implico B.V. A protein reagent having the ability to bind tissue plasminogen activator in its two chain form and/or its single chain form
JPS6463378A (en) * 1986-08-11 1989-03-09 Mitsui Toatsu Chemicals Separation of single stranded tpa and double standard tpa
HUT51901A (en) * 1987-06-22 1990-06-28 Genetics Inst Process for production of new trombolitic ensimes
US5411864A (en) * 1987-11-05 1995-05-02 Genentech, Inc. Method of purifying recombinant proteins from corresponding host cell proteins
DE3832898A1 (de) * 1988-09-28 1990-04-12 Boehringer Mannheim Gmbh Praeparat von in prokaryonten exprimiertem plasminogenaktivator
WO2001038560A2 (en) * 1999-11-22 2001-05-31 American Red Cross Active enzyme detection using immobilized enzyme inhibitors
US7200993B2 (en) * 2005-03-31 2007-04-10 Caterpillar Inc Electro-hydraulic steering control system
CN114426962A (zh) * 2021-12-21 2022-05-03 佛山汉腾生物科技有限公司 t-PA纯化方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3382389D1 (de) * 1982-12-14 1991-10-02 South African Inventions Plasminogenaktivator.
PH22337A (en) * 1983-11-21 1988-08-12 Ciba Geigy Ag Synthesis of fibrinolytic agents by yeast

Also Published As

Publication number Publication date
JPS6229975A (ja) 1987-02-07
CA1314833C (en) 1993-03-23
FI87793B (fi) 1992-11-13
EP0210870A3 (en) 1988-01-07
EP0210870B1 (de) 1991-09-18
NO172396B (no) 1993-04-05
NO863095L (no) 1987-02-02
NO863095D0 (no) 1986-07-31
DK369686A (da) 1987-02-02
FI863111A (fi) 1987-02-02
FI863111A0 (fi) 1986-07-30
ZA865536B (en) 1987-03-25
NO172396C (no) 1993-07-14
DK369686D0 (da) 1986-08-01
EP0210870A2 (de) 1987-02-04
FI87793C (fi) 1993-02-25
US5110736A (en) 1992-05-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee