ZA877088B - Purification process of tpa - Google Patents

Purification process of tpa

Info

Publication number
ZA877088B
ZA877088B ZA877088A ZA877088A ZA877088B ZA 877088 B ZA877088 B ZA 877088B ZA 877088 A ZA877088 A ZA 877088A ZA 877088 A ZA877088 A ZA 877088A ZA 877088 B ZA877088 B ZA 877088B
Authority
ZA
South Africa
Prior art keywords
tpa
purification process
purification
Prior art date
Application number
ZA877088A
Other languages
English (en)
Inventor
Morii Mitsuyoshi
Ohoka Masaharu
Suzuki Toshihiko
Suzuki Katsuyuki
Kawashima Nobuhiro
Morii Noriko
Mori Kunizou
Original Assignee
Mitsui Toatsu Chemicals, Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals, Incorporated filed Critical Mitsui Toatsu Chemicals, Incorporated
Publication of ZA877088B publication Critical patent/ZA877088B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/814—Enzyme separation or purification
    • Y10S435/815—Enzyme separation or purification by sorption

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA877088A 1986-09-22 1987-09-21 Purification process of tpa ZA877088B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61222111A JPS6379591A (ja) 1986-09-22 1986-09-22 ｔＰＡの精製方法

Publications (1)

Publication Number Publication Date
ZA877088B true ZA877088B (en) 1988-03-29

Family

ID=16777317

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA877088A ZA877088B (en) 1986-09-22 1987-09-21 Purification process of tpa

Country Status (10)

Country Link
US (1) US4985362A (xx)
EP (1) EP0261941B1 (xx)
JP (1) JPS6379591A (xx)
AU (1) AU586355B2 (xx)
CA (1) CA1302929C (xx)
DE (1) DE3783693T2 (xx)
DK (1) DK497487A (xx)
FI (1) FI874116A (xx)
NO (1) NO873943L (xx)
ZA (1) ZA877088B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3512910A1 (de) * 1985-04-11 1986-10-16 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung von plasminogenaktivatoren
JP2507339B2 (ja) * 1986-08-11 1996-06-12 三井東圧化学株式会社 粗ｔＰＡの精製方法
DE3726655A1 (de) * 1987-08-11 1989-02-23 Hoechst Ag Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
WO1990001333A1 (en) * 1988-08-02 1990-02-22 Invitron Corporation METHOD FOR PREPARING tPA COMPOSITIONS
JPH0824578B2 (ja) * 1988-09-05 1996-03-13 三井東圧化学株式会社 ｔＰＡの精製方法
WO1991013976A1 (en) * 1990-03-14 1991-09-19 Yamanouchi Pharmaceutical Co., Ltd. Process for producing purified tissue plasminogen activator or its derivative
DK82592D0 (da) * 1992-06-23 1992-06-23 Novo Nordisk As Fremstilling af proteiner

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0124613B1 (en) * 1982-10-29 1992-12-30 MITSUI TOATSU CHEMICALS, Inc. Novel plasminogen activator derived from human kidneys, process for its preparation, and thrombolytic drug containing the same
JPS5980613A (ja) * 1982-10-29 1984-05-10 Mitsui Toatsu Chem Inc 新規なプラスミノ−ゲン・アクチベ−タ及びその製造方法
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
DE3584902D1 (de) * 1984-02-29 1992-01-30 Asahi Chemical Ind Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren.
DE3479814D1 (en) * 1984-06-05 1989-10-26 Asahi Chemical Ind Process for the preparation of a plasminogen activator
WO1987001389A1 (en) * 1985-09-06 1987-03-12 Codon Methods for the recovery of tissue plasminogen activator
WO1988000615A1 (en) * 1986-07-16 1988-01-28 Celltech Limited Process for purifying a plasminogen activator

Also Published As

Publication number Publication date
EP0261941A3 (en) 1988-06-08
DK497487A (da) 1988-03-23
FI874116A (fi) 1988-03-23
JPS6379591A (ja) 1988-04-09
DK497487D0 (da) 1987-09-22
NO873943D0 (no) 1987-09-21
FI874116A0 (fi) 1987-09-21
DE3783693T2 (de) 1993-05-13
AU586355B2 (en) 1989-07-06
EP0261941B1 (en) 1993-01-20
US4985362A (en) 1991-01-15
AU7865287A (en) 1988-03-24
EP0261941A2 (en) 1988-03-30
CA1302929C (en) 1992-06-09
NO873943L (no) 1988-03-23
DE3783693D1 (de) 1993-03-04

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