DE3780329T2 - Chinoloncarbonsaeure-derivate und ihre herstellung. - Google Patents

Chinoloncarbonsaeure-derivate und ihre herstellung.

Info

Publication number
DE3780329T2
DE3780329T2 DE8787103548T DE3780329T DE3780329T2 DE 3780329 T2 DE3780329 T2 DE 3780329T2 DE 8787103548 T DE8787103548 T DE 8787103548T DE 3780329 T DE3780329 T DE 3780329T DE 3780329 T2 DE3780329 T2 DE 3780329T2
Authority
DE
Germany
Prior art keywords
chinolon
production
acid derivatives
carbonic acid
carbonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787103548T
Other languages
English (en)
Other versions
DE3780329D1 (de
Inventor
Kuniyoshi Masuzawa
Saigo Suzue
Keiji Hirai
Takayoshi Ishizaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Publication of DE3780329D1 publication Critical patent/DE3780329D1/de
Application granted granted Critical
Publication of DE3780329T2 publication Critical patent/DE3780329T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
DE8787103548T 1986-03-17 1987-03-11 Chinoloncarbonsaeure-derivate und ihre herstellung. Expired - Fee Related DE3780329T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61059016A JPS62215572A (ja) 1986-03-17 1986-03-17 キノロンカルボン酸誘導体

Publications (2)

Publication Number Publication Date
DE3780329D1 DE3780329D1 (de) 1992-08-20
DE3780329T2 true DE3780329T2 (de) 1993-03-04

Family

ID=13101068

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787103548T Expired - Fee Related DE3780329T2 (de) 1986-03-17 1987-03-11 Chinoloncarbonsaeure-derivate und ihre herstellung.

Country Status (9)

Country Link
US (1) US4894458A (de)
EP (1) EP0237955B1 (de)
JP (1) JPS62215572A (de)
KR (1) KR940009525B1 (de)
CN (1) CN1019668B (de)
AU (1) AU593873B2 (de)
CA (1) CA1327198C (de)
DE (1) DE3780329T2 (de)
HU (1) HU199453B (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
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AU577473B2 (en) * 1985-01-30 1988-09-22 Kyorin Pharmaceutical Co. Ltd. Quinolonecarboxylic acid derivative
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPH0753715B2 (ja) * 1986-02-25 1995-06-07 大塚製薬株式会社 ベンゾヘテロ環化合物
DE3702393A1 (de) * 1987-01-28 1988-08-11 Bayer Ag 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
US5290934A (en) * 1987-04-16 1994-03-01 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US5563138A (en) * 1987-04-16 1996-10-08 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
JPH0794452B2 (ja) * 1987-10-16 1995-10-11 大日本製薬株式会社 新規ピリドンカルボン酸誘導体、そのエステルおよびその塩
IL88003A (en) * 1987-10-16 1992-11-15 Dainippon Pharmaceutical Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
US5039683A (en) * 1987-10-26 1991-08-13 Pfizer Inc. Azetidinyl quinolone carboxylic acids and esters
US5173484A (en) * 1988-02-05 1992-12-22 Bayer Aktiengesellschaft Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them
JPH0219377A (ja) * 1988-07-08 1990-01-23 Kyorin Pharmaceut Co Ltd ８‐メチルキノロンカルボン酸誘導体
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
AU618823B2 (en) * 1988-07-20 1992-01-09 Sankyo Company Limited 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
EP0997466A1 (de) * 1988-10-24 2000-05-03 PROCTER & GAMBLE PHARMACEUTICALS, INC. Antimikrobielle Laktamchinolone
CA2058424A1 (en) * 1989-07-21 1991-01-22 Akihiro Shibata Quinoline carboxylic acid derivatives
US5047538A (en) * 1990-04-12 1991-09-10 Warner-Lambert Company Quinolinecarboxylic acid antibacterial agents
US5116834A (en) * 1990-04-12 1992-05-26 Warner-Lambert Company Quinolinecarboxylic acid antibacterial agents
US5256662A (en) * 1990-04-12 1993-10-26 Warner-Lambert Company Quinolinecarboxylic acid antibacterial agents
JPH03115264A (ja) * 1990-08-17 1991-05-16 Otsuka Pharmaceut Co Ltd 抗菌剤
FR2673426B1 (fr) * 1991-03-01 1993-07-16 Bouchara Sa Nouvelles quinolones, leur procede de preparation et les compositions en refermant.
FR2675144B1 (fr) * 1991-04-10 1995-06-16 Bouchara Sa Nouvelles quinolones difluorees - leur procede de preparation et les compositions pharmaceutiques en renfermant.
DE4123918A1 (de) * 1991-07-19 1993-01-21 Bayer Ag 8-vinyl- und 8-ethinyl-chinoloncarbonsaeuren
ES2036136B1 (es) * 1991-10-16 1994-03-01 Inke Sa Procedimiento para la obtencion del acido 1-(2,4-difluorofenil)-6-fluoro-7-(3-metilpiperacinil)-4-oxo-1, 4-dihidroquinolin-3-carboxilico y sus sales.
WO1993024460A1 (fr) * 1992-05-26 1993-12-09 Ss Pharmaceutical Co., Ltd. Derive d'acides-5-aminoquinolonecarboxylique et agent antibacterien contenant ce derive comme ingredient actif
FR2692577B1 (fr) * 1992-05-26 1996-02-02 Bouchara Sa Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
US5527910A (en) * 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
TW252107B (de) 1993-08-27 1995-07-21 Hokuriku Pharmacetical Co Ltd
DE4342186A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Eintopfverfahren zur Herstellung von 3-Chinoloncarbonsäurederivaten
WO1996022988A1 (fr) * 1995-01-24 1996-08-01 Hokuriku Seiyaku Co., Ltd. Derives de l'acide quiloleine carboxylique
PL339408A1 (en) * 1997-09-15 2000-12-18 Procter & Gamble Antimicrobial quinolones, agents containing them and their applications
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
EP1167344A4 (de) * 1999-03-17 2004-06-16 Daiichi Seiyaku Co Verfahren zur herstellung von 5-amino-8-alkylchinoloncarbonsäure-derivate und zwischenprodukte in ihrer herstellung
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
US6964966B2 (en) * 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
EP1453824A1 (de) * 2001-12-13 2004-09-08 Wockhardt Limited Triple-targeting chirale breitspektrumantimicrobielle piperidino-quinolon-carbonsäurederivate der neuen generation, ihre herstellung, zusammensetzungen und gebrauch als medikamente
WO2003099815A1 (en) 2002-05-28 2003-12-04 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
AU2003304460A1 (en) * 2003-09-04 2005-03-29 Wockhardt Limited Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
CA2536429C (en) 2003-09-10 2012-02-14 Kyorin Pharmaceutical Co., Ltd. 7-(4-substituted-3-cyclopropylaminomethyl-1-pyrrolidinyl) quinolonecarboxylic acid derivative
US7977327B2 (en) 2004-05-13 2011-07-12 Daiichi Sankyo Company, Limited Substituted pyrrolidine derivative
US20090156577A1 (en) * 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
TW200640899A (en) * 2005-01-21 2006-12-01 Daiichi Seiyaku Co Fluoroalkylpyrrolidine derivative
WO2007110836A1 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company A hydride reduction process for preparing quinolone intermediates
JP2009531418A (ja) 2006-03-28 2009-09-03 ザ プロクター アンド ギャンブル カンパニー キノロン中間体調製のためのカップリング方法
MX2008012328A (es) 2006-03-28 2008-10-09 Procter & Gamble Sales de malato, y polimorfos de acido (3s,5s)-7-[3-amino-5-metil- piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolinc arboxilico.
EP2149571A4 (de) * 2007-05-24 2010-09-01 Kyorin Seiyaku Kk Mutilin-derivat mit einer ringförmigen, heterozyklischen und aromatischen carboxylsäurestruktur in einem substituenten an position 14
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
US8658183B2 (en) * 2007-08-09 2014-02-25 Taigen Biotechnology Company, Ltd. Antimicrobial parenteral formulation
US8431747B2 (en) 2008-12-18 2013-04-30 E I Du Pont De Nemours And Company Process for the preparation of monomers for polybenzimidazole materials
US8183418B2 (en) 2008-12-18 2012-05-22 E. I. Du Pont De Nemours And Company Process for the synthesis of dihalodinitrotoluene
US8188317B2 (en) 2008-12-18 2012-05-29 E. I. Du Pont De Nemours And Company Integrated process for the preparation of polybenzimidazole precursors
US8163961B2 (en) 2008-12-18 2012-04-24 E. I. Du Pont De Nemours And Company Process for the preparation of monomers for polybenzimidazole materials
CN101948389A (zh) * 2010-08-16 2011-01-19 北京颖新泰康国际贸易有限公司 制备2-（5-氟-2，4-二硝基苯氧）乙酸及其酯的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS604820B2 (ja) * 1979-02-26 1985-02-06 大塚製薬株式会社 キノリンカルボン酸誘導体
JPS5630964A (en) * 1979-08-22 1981-03-28 Kyorin Pharmaceut Co Ltd Novel substituted quinolinecarboxylic acid and its preparation
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4499091A (en) * 1982-03-31 1985-02-12 Sterling Drug Inc. 1-Amino (or substituted amino)-1,4-dihydro-4-oxo-6-fluoro-7-heterylquinoline-3-carboxylic acids and their use as antibacterial agents
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
DE3248506A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4473568A (en) * 1983-03-01 1984-09-25 Warner Lambert Company Antibacterial thiazolidine or thiomorpholine substituted quinolines
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS60126271A (ja) * 1983-12-09 1985-07-05 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
DE3441788A1 (de) * 1984-11-15 1986-05-15 Bayer Ag, 5090 Leverkusen Alkyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPH0635457B2 (ja) * 1985-06-28 1994-05-11 杏林製薬株式会社 ピリドンカルボン酸誘導体およびその製造方法

Also Published As

Publication number Publication date
CA1327198C (en) 1994-02-22
EP0237955B1 (de) 1992-07-15
CN87101984A (zh) 1987-10-07
KR940009525B1 (ko) 1994-10-14
DE3780329D1 (de) 1992-08-20
CN1019668B (zh) 1992-12-30
JPS62215572A (ja) 1987-09-22
KR870008847A (ko) 1987-10-21
US4894458A (en) 1990-01-16
AU593873B2 (en) 1990-02-22
EP0237955A2 (de) 1987-09-23
EP0237955A3 (en) 1987-11-25
HU199453B (en) 1990-02-28
HUT43825A (en) 1987-12-28
AU7002687A (en) 1987-09-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee