DE3772697D1 - Verfahren zur herstellung von chemisch definierten und reproduzierbaren polydeoxyribonukleotiden. - Google Patents

Verfahren zur herstellung von chemisch definierten und reproduzierbaren polydeoxyribonukleotiden.

Info

Publication number
DE3772697D1
DE3772697D1 DE8787902502T DE3772697T DE3772697D1 DE 3772697 D1 DE3772697 D1 DE 3772697D1 DE 8787902502 T DE8787902502 T DE 8787902502T DE 3772697 T DE3772697 T DE 3772697T DE 3772697 D1 DE3772697 D1 DE 3772697D1
Authority
DE
Germany
Prior art keywords
polydeoxyribonucleotides
reproducible
chemically defined
producing chemically
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787902502T
Other languages
English (en)
Inventor
Gianfranco Fedeli
Giuseppe Diamantini
Marisa Mantovani
Giuseppe Prino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gentium SRL
Original Assignee
Crinos Industria Farmacobiologica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crinos Industria Farmacobiologica SpA filed Critical Crinos Industria Farmacobiologica SpA
Application granted granted Critical
Publication of DE3772697D1 publication Critical patent/DE3772697D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE8787902502T 1986-04-17 1987-04-10 Verfahren zur herstellung von chemisch definierten und reproduzierbaren polydeoxyribonukleotiden. Expired - Lifetime DE3772697D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT20117/86A IT1190313B (it) 1986-04-17 1986-04-17 Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante
PCT/EP1987/000209 WO1987006235A1 (en) 1986-04-17 1987-04-10 A process for obtaining chemically defined and reproducible polydeoxyribonucleotides

Publications (1)

Publication Number Publication Date
DE3772697D1 true DE3772697D1 (de) 1991-10-10

Family

ID=11163944

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787902502T Expired - Lifetime DE3772697D1 (de) 1986-04-17 1987-04-10 Verfahren zur herstellung von chemisch definierten und reproduzierbaren polydeoxyribonukleotiden.

Country Status (20)

Country Link
US (1) US4985552A (de)
EP (1) EP0263155B1 (de)
JP (1) JP2581722B2 (de)
KR (1) KR880701242A (de)
CN (1) CN1018650B (de)
AR (1) AR242585A1 (de)
AT (1) ATE66927T1 (de)
AU (1) AU612976B2 (de)
BE (1) BE1002908A4 (de)
CA (1) CA1297430C (de)
CH (1) CH677114A5 (de)
DE (1) DE3772697D1 (de)
ES (1) ES2005168A6 (de)
FR (1) FR2597481B1 (de)
GR (1) GR870602B (de)
IL (1) IL82251A (de)
IT (1) IT1190313B (de)
MX (1) MX168887B (de)
WO (1) WO1987006235A1 (de)
ZA (1) ZA872755B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182269A (en) * 1987-09-23 1993-01-26 Crinos Industria Farmacobiologica Spa Composition for topical use having hair stimulating, anti-dandruff and anti-seborrhoic activity
IT1252174B (it) * 1991-12-09 1995-06-05 Crinos Industria Farmaco Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento
IT1271685B (it) * 1994-08-03 1997-06-04 Crinos Industria Farmaco Impiego dei polidesossiribonucleotidi nelle neuropati diabetiche
US7026468B2 (en) 1996-07-19 2006-04-11 Valentis, Inc. Process and equipment for plasmid purification
US7807822B2 (en) 1996-08-01 2010-10-05 Robert Bridenbaugh Methods for purifying nucleic acids
DE69928778T2 (de) * 1999-06-08 2006-07-06 Gentium S.P.A., Villa Guardia Anwendung von Komplexen von kationischen Liposomen und Polydeoxyribonukleotiden wie Arzneimitteln
JP2001078901A (ja) 1999-09-14 2001-03-27 Paloma Ind Ltd 液体加熱調理器
EP1147777A1 (de) 2000-04-18 2001-10-24 Crinos Industria Farmacobiologica S.p.A. Kombination von Defibrotid und G-CSF und ihre Verwendung zur Aktivierung der hämatopoiestischen Vorläuferzellen
WO2002065125A1 (en) * 2001-02-13 2002-08-22 Invitrogen Corporation Methods and compositions for isolation of biological macromolecules
EP1325962A1 (de) * 2001-12-17 2003-07-09 Gentium S.p.A. Methode zur Bestimmung der biologischen Aktivität von Defibrotide
CA2498518A1 (en) 2002-09-13 2004-03-25 Valentis, Inc. Apparatus and method for preparative scale purification of nucleic acids
EP2216415B2 (de) * 2003-08-01 2017-01-04 Life Technologies Corporation Zusammensetzungen und Verfahren zur Aufreinigung kurzer RNA-Moleküle und anderer Nukleinsäuren
ITMI20031714A1 (it) * 2003-09-05 2005-03-06 Gentium Spa Formazioni ad azione antitumorale.
MX2007010407A (es) * 2005-03-03 2007-10-17 Gentium Spa Formulacion con accion anti-tumor.
EP2103689A1 (de) * 2008-03-19 2009-09-23 Gentium S.p.A. Synthetische Phosphodiester-Oligonukleotide und deren therapeutische Verwendungen
CN103260627A (zh) 2010-11-12 2013-08-21 真蒂奥姆有限公司 去纤维蛋白多核苷酸用于预防和/或治疗移植物抗宿主病(gvhd)
KR102038357B1 (ko) 2012-06-22 2019-10-31 젠티엄 에스알엘 디파이브로타이드의 생물학적 활성 측정을 위한 유우글로불린에 기초한 방법
EP3026122A1 (de) 2014-11-27 2016-06-01 Gentium S.p.A. Zellenbasiertes Verfahren zur Bestimmung der Wirksamkeit von Defibrotid
CA3071544A1 (en) 2017-08-03 2019-02-07 Jazz Pharmaceuticals Ireland Limited Formulations comprising a nucleic acid in a high concentration
BR112020020865A2 (pt) 2018-04-12 2021-01-19 Jazz Pharmaceuticals, Inc. Defibrotida para prevenção e tratamento da síndrome de liberação de citocinas e neurotoxicidade associadas à imunodepleção
WO2019213053A1 (en) 2018-04-30 2019-11-07 Gentium S.R.L. Methods for treating patients having sinusoidal obstruction syndrome
US20220023533A1 (en) 2018-12-07 2022-01-27 Jazz Phrmaceticals Ireland Limited Subcutaneous delivery of high concentration formulations
EP4110287A1 (de) 2020-02-28 2023-01-04 Jazz Pharmaceuticals Ireland Limited Abgabe von niedrigviskosen formulierungen
WO2021212055A1 (en) 2020-04-17 2021-10-21 Jazz Pharmaceuticals Ireland Limited Defibrotide treatment for the prevention of organ rejection and injury
WO2022234101A1 (en) 2021-05-06 2022-11-10 Jazz Pharmaceuticals Ireland Limited Defibrotide for the treatment and prevention of acute respiratory distress syndrome

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1371944A (fr) * 1963-07-30 1964-09-11 Centre Nat Rech Scient Procédé de préparation d'acides désoxyribonucléiques hautement polymérisés
US3899481A (en) * 1970-11-03 1975-08-12 Crinos Industria Farmaco Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs
DE2154279A1 (de) * 1970-11-03 1972-05-25 Crinos Industria Farmaco Medikamente für das fibrinolytische System
IT1043823B (it) * 1970-11-03 1980-02-29 Prephar Procedimento per l estrazione di acidi nucleici da organi animali
CH617963A5 (de) * 1973-10-05 1980-06-30 Derivati Organici Lab
SU652187A1 (ru) * 1975-07-23 1979-03-15 Киевский Ордена Ленина Государственный Университет Им. Т.Г.Шевченко Способ получени дезоксирибонуклеиновой кислоты
JPS554308A (en) * 1978-06-23 1980-01-12 Yuki Gosei Yakuhin Kogyo Kk Isolation of deoxyribonucleic acid from milt of fish
IT1170215B (it) * 1983-09-12 1987-06-03 Crinos Industria Farmaco Composizione farmaceutica per il trattamento di stati di insufficienza renale acuta
IT1206341B (it) * 1984-02-16 1989-04-14 Crinos Industria Farmaco Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio.

Also Published As

Publication number Publication date
JPS63503067A (ja) 1988-11-10
IT8620117A1 (it) 1987-10-17
CN87103688A (zh) 1988-01-20
AU612976B2 (en) 1991-07-25
BE1002908A4 (fr) 1991-07-30
AU7288687A (en) 1987-11-09
ES2005168A6 (es) 1989-03-01
ZA872755B (en) 1987-10-05
CN1018650B (zh) 1992-10-14
MX168887B (es) 1993-06-14
FR2597481B1 (fr) 1990-01-12
EP0263155A1 (de) 1988-04-13
CH677114A5 (de) 1991-04-15
FR2597481A1 (fr) 1987-10-23
US4985552A (en) 1991-01-15
AR242585A1 (es) 1993-04-30
JP2581722B2 (ja) 1997-02-12
EP0263155B1 (de) 1991-09-04
IL82251A (en) 1991-05-12
IL82251A0 (en) 1987-10-30
KR880701242A (ko) 1988-07-26
WO1987006235A1 (en) 1987-10-22
CA1297430C (en) 1992-03-17
IT1190313B (it) 1988-02-16
IT8620117A0 (it) 1986-04-17
ATE66927T1 (de) 1991-09-15
GR870602B (en) 1987-08-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GENTIUM S.P.A., VILLA GUARDIA, COMO, IT