DE3771362D1 - Verfahren zur herstellung von sehr reinem dermatansulfat und pharmazeutische zusammensetzungen, welche dieses enthalten. - Google Patents

Verfahren zur herstellung von sehr reinem dermatansulfat und pharmazeutische zusammensetzungen, welche dieses enthalten.

Info

Publication number
DE3771362D1
DE3771362D1 DE8787103943T DE3771362T DE3771362D1 DE 3771362 D1 DE3771362 D1 DE 3771362D1 DE 8787103943 T DE8787103943 T DE 8787103943T DE 3771362 T DE3771362 T DE 3771362T DE 3771362 D1 DE3771362 D1 DE 3771362D1
Authority
DE
Germany
Prior art keywords
mps
contain
producing
pharmaceutical compositions
ammonium salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787103943T
Other languages
German (de)
English (en)
Inventor
Bono Rinaldo Del
Ambrosi Luigi De
Gianni Ferrari
Pier Luigi Rugarli
Pier Giuseppe Pagella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mediolanum Farmaceutici SpA
Original Assignee
Mediolanum Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediolanum Farmaceutici SpA filed Critical Mediolanum Farmaceutici SpA
Application granted granted Critical
Publication of DE3771362D1 publication Critical patent/DE3771362D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE8787103943T 1986-03-25 1987-03-18 Verfahren zur herstellung von sehr reinem dermatansulfat und pharmazeutische zusammensetzungen, welche dieses enthalten. Expired - Lifetime DE3771362D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19864/86A IT1189085B (it) 1986-03-25 1986-03-25 Processo per la preparazione di dermatan solfato ad alta purezza e composizioni farmaceutiche che lo contengono

Publications (1)

Publication Number Publication Date
DE3771362D1 true DE3771362D1 (de) 1991-08-22

Family

ID=11161892

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787103943T Expired - Lifetime DE3771362D1 (de) 1986-03-25 1987-03-18 Verfahren zur herstellung von sehr reinem dermatansulfat und pharmazeutische zusammensetzungen, welche dieses enthalten.

Country Status (20)

Country Link
US (2) US4870166A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0238994B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS62236803A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR910006811B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE65250T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU599638B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1334516C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3771362D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK122187A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2029804T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI871209A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3002341T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE59878B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN163520B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1189085B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX5656A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO167676C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT84491B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
YU (1) YU44187A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA872081B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707604A (en) * 1986-11-18 1998-01-13 Access Pharmaceuticals, Inc. Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles
CA1327354C (en) * 1987-03-19 1994-03-01 David Cullis-Hill Anti-inflamatory compounds and compositions
US5668116A (en) * 1987-03-19 1997-09-16 Anthropharm Pty. Limited Anti-inflammatory compounds and compositions
US5141928B1 (en) * 1989-12-20 1995-11-14 Brujo Inc Ophthalmic medication
WO1991015217A1 (en) * 1990-04-06 1991-10-17 Washington University Anticoagulant oligosaccharides
IT1251183B (it) * 1991-08-28 1995-05-04 Opocrin Spa Dermatan solfato ad alto titolo, dotato di elevata attivita' trombolitica, e forme farmaceutiche che lo contengono.
US5801162A (en) * 1993-09-30 1998-09-01 Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) Dermatan sulfate compositions and antithrombotic compositions containing same
CA2121952A1 (en) * 1994-04-22 1995-10-23 Francesco Della Valle Topical preparations for the treatment of acne and acneiform dermatitis
US5696099A (en) * 1994-04-18 1997-12-09 Lifegroup S.P.A. Topical preparations for the treatment of acne and acneiform dermatitis
US6106866A (en) * 1995-07-31 2000-08-22 Access Pharmaceuticals, Inc. In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites
US20050164983A1 (en) * 2003-12-19 2005-07-28 Aventis Pharma S.A. Carboxyl-reduced derivatives of dermatan sulfate, preparation thereof, use thereof as a medicinal product and the pharmaceutical compositions containing them
ES2281265B1 (es) 2005-11-24 2008-08-16 Bioiberica, S.A. Composiciones para el tratamiento de la artrosis.
ES2327480B1 (es) 2007-06-15 2010-08-10 Bioiberica, S.A. "disacaridos para el tratamiento de tendones, ligamentos y huesos".
ES2440390B1 (es) 2012-07-25 2014-11-13 Bioibérica, S.A. Composiciones para el tratamiento del sobrepeso y de la obesidad
CN104448044B (zh) * 2014-12-24 2017-01-11 南京健友生化制药股份有限公司 一种肝素钠的去色与降低硫酸皮肤素含量的方法
CN105461831A (zh) * 2016-01-08 2016-04-06 东营天东制药有限公司 一种快速分离快速移动肝素与硫酸皮肤素的方法
ES2638195B1 (es) 2016-04-18 2018-08-02 Bioiberica, S.A. Composiciones para la piel

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5318520B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1972-07-05 1978-06-15
IT1189298B (it) * 1982-06-18 1988-02-04 Manetti & Roberts Italo Brit Procedimento per produrre i glicosa minoglicani dermatansolfato ed eparan-solfato sostanzialmente puri e loro impiego farmaceutico
IT1208509B (it) * 1985-03-13 1989-07-10 Mediolanum Farmaceutici Srl Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico.

Also Published As

Publication number Publication date
NO167676C (no) 1991-11-27
DK122187A (da) 1987-09-26
AU7054087A (en) 1987-10-01
US5116963A (en) 1992-05-26
IE870721L (en) 1987-09-25
US4870166A (en) 1989-09-26
NO870962L (no) 1987-09-28
GR3002341T3 (en) 1992-12-30
JPH0240681B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-09-12
PT84491B (pt) 1989-11-10
EP0238994B1 (en) 1991-07-17
CA1334516C (en) 1995-02-21
ES2029804T3 (es) 1992-10-01
NO167676B (no) 1991-08-19
IT8619864A1 (it) 1987-09-25
FI871209A7 (fi) 1987-09-26
ATE65250T1 (de) 1991-08-15
IE59878B1 (en) 1994-04-20
KR910006811B1 (ko) 1991-09-02
IT8619864A0 (it) 1986-03-25
ZA872081B (en) 1987-09-14
EP0238994A3 (en) 1988-09-21
IT1189085B (it) 1988-01-28
PT84491A (en) 1987-04-01
YU44187A (en) 1988-04-30
KR870008916A (ko) 1987-10-22
EP0238994A2 (en) 1987-09-30
JPS62236803A (ja) 1987-10-16
IN163520B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1988-10-01
DK122187D0 (da) 1987-03-10
AU599638B2 (en) 1990-07-26
NO870962D0 (no) 1987-03-09
MX5656A (es) 1993-12-01
FI871209A0 (fi) 1987-03-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MEDIOLANUM FARMACEUTICI S.P.A., MAILAND/MILANO, IT

8339 Ceased/non-payment of the annual fee