DE376516T1 - Verfahren zur herstellung von nabumeton. - Google Patents

Verfahren zur herstellung von nabumeton.

Info

Publication number
DE376516T1
DE376516T1 DE198989312781T DE89312781T DE376516T1 DE 376516 T1 DE376516 T1 DE 376516T1 DE 198989312781 T DE198989312781 T DE 198989312781T DE 89312781 T DE89312781 T DE 89312781T DE 376516 T1 DE376516 T1 DE 376516T1
Authority
DE
Germany
Prior art keywords
process according
catalyst
nabumetone
producing
triphenylphosphine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE198989312781T
Other languages
English (en)
Inventor
Mohammad Corpus Christi Texas Aslam
Kenneth G. North Kingstown Rhode Island Davenport
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CNA Holdings LLC
Original Assignee
Hoechst Celanese Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Celanese Corp filed Critical Hoechst Celanese Corp
Publication of DE376516T1 publication Critical patent/DE376516T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/512—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Semiconductor Lasers (AREA)
  • Developing Agents For Electrophotography (AREA)

Claims (8)

ANSPRÜCHE:
1. Verfahren zur Herstellung von Nabumetone, bei dem 2-Brom-6-methoxynaphthalin mit 3-Buten-2-ol in Gegenwart eines Katalysators umgesetzt wird.
2. Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß der Katalysator eine Palladiumverbindung in Kombination mit einem Liganden enthält, der dreiwertigen Phosphor enthält.
3. Verfahren nach Anspruch 2, dadurch gekennzeichnet, daß der Katalysator Palladium(II)-acetat ist in Kombination mit Triphenylphosphin.
4. Verfahren nach Anspruch 2, dadurch gekennzeichnet, daß der Katalysator ein Bis(triphenylphosphin)dichlorpalladium(II)-Komplex ist.
5. Verfahren nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, daß die Reaktionstemperatur im Bereich von 120 °C bis 150 "C liegt.
6. Verfahren nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, daß die Reaktionszeit im Bereich von 0,25 bis 10 Stunden liegt.
7. Verfahren nach einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, daß die Reaktion in Gegenwart eines Lösungsmittels durchgeführt wird.
8. Verfahren nach Anspruch 7, dadurch gekennzeichnet, daß das Lösungsmittel N-Methy!pyrrolidon ist.
DE198989312781T 1988-12-08 1989-12-07 Verfahren zur herstellung von nabumeton. Pending DE376516T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28270988A 1988-12-08 1988-12-08

Publications (1)

Publication Number Publication Date
DE376516T1 true DE376516T1 (de) 1991-03-21

Family

ID=23082783

Family Applications (2)

Application Number Title Priority Date Filing Date
DE198989312781T Pending DE376516T1 (de) 1988-12-08 1989-12-07 Verfahren zur herstellung von nabumeton.
DE8989312781T Expired - Fee Related DE68904888T2 (de) 1988-12-08 1989-12-07 Verfahren zur herstellung von nabumeton.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8989312781T Expired - Fee Related DE68904888T2 (de) 1988-12-08 1989-12-07 Verfahren zur herstellung von nabumeton.

Country Status (6)

Country Link
EP (1) EP0376516B1 (de)
JP (1) JPH02231446A (de)
AT (1) ATE85600T1 (de)
CA (1) CA2004042C (de)
DE (2) DE376516T1 (de)
GR (2) GR910300056T1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1223157A1 (de) * 1995-06-07 2002-07-17 Hoechst Celanese Corporation Verwendung von 4-substituierten 2-butanonen zur Herstellung von Nabumetone
US5600009A (en) * 1996-04-09 1997-02-04 Hoechst Celanese Corporation Use of 4-substituted 2-butanones to prepare nabumetone
IT1283638B1 (it) * 1996-07-29 1998-04-23 Archimica Spa Procedimento per la preparazione di un naftilbutanone
US5756851A (en) * 1996-10-21 1998-05-26 Albemarle Corporation Production of nabumetone or precursors thereof
AU5656698A (en) * 1996-12-03 1998-06-29 Recordati S.A. Chemical And Pharmaceutical Company A process for the preparation of nabumetone
US5741938A (en) * 1997-02-21 1998-04-21 Albemarle Corporation Production of alkyl aralkyl keones from allylic-aralkenyl secondary alcohols
US5847225A (en) * 1997-04-25 1998-12-08 Albemarle Corporation Production of naphthyl-substituted ketones from naphthaldehydes
US5861538A (en) * 1997-08-04 1999-01-19 Albemarle Corporation Production of alkoxynaphthyl-substituted ketones from naphthaldehydes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3922299A (en) * 1974-03-05 1975-11-25 Univ Delaware Vinylic substitution reactions
GB1476721A (en) * 1974-08-20 1977-06-16 Beecham Group Ltd 4-6-methoxy-2-naphthyl-butan-2-one
US4070374A (en) * 1975-06-16 1978-01-24 Givaudan Corporation Process for the preparation of aryl substituted aldehydes, ketones and alcohols
NL8803088A (nl) * 1987-12-19 1989-07-17 Beecham Group Plc Werkwijze voor de bereiding van een butanonderivaat.

Also Published As

Publication number Publication date
CA2004042C (en) 1999-11-02
EP0376516A1 (de) 1990-07-04
EP0376516B1 (de) 1993-02-10
JPH02231446A (ja) 1990-09-13
GR3010337T3 (de) 1994-04-29
DE68904888T2 (de) 1993-05-27
CA2004042A1 (en) 1990-06-08
DE68904888D1 (de) 1993-03-25
GR910300056T1 (en) 1991-11-15
ATE85600T1 (de) 1993-02-15

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