DE3750846D1 - Mitomycin-derivate. - Google Patents

Mitomycin-derivate.

Info

Publication number
DE3750846D1
DE3750846D1 DE3750846T DE3750846T DE3750846D1 DE 3750846 D1 DE3750846 D1 DE 3750846D1 DE 3750846 T DE3750846 T DE 3750846T DE 3750846 T DE3750846 T DE 3750846T DE 3750846 D1 DE3750846 D1 DE 3750846D1
Authority
DE
Germany
Prior art keywords
mitomycin derivatives
mitomycin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3750846T
Other languages
English (en)
Other versions
DE3750846T2 (de
Inventor
Motomichi Kono
Yutaka Saito
Yutaka Kanda
Masaji - - Kasai
Akira Sato
Makoto Morimoto
Tadashi Ashizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of DE3750846D1 publication Critical patent/DE3750846D1/de
Application granted granted Critical
Publication of DE3750846T2 publication Critical patent/DE3750846T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
DE3750846T 1986-08-29 1987-08-28 Mitomycin-derivate. Expired - Fee Related DE3750846T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20323086 1986-08-29
PCT/JP1987/000640 WO1988001622A1 (en) 1986-08-29 1987-08-28 Mitomycin derivatives

Publications (2)

Publication Number Publication Date
DE3750846D1 true DE3750846D1 (de) 1995-01-19
DE3750846T2 DE3750846T2 (de) 1995-05-11

Family

ID=16470603

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3750846T Expired - Fee Related DE3750846T2 (de) 1986-08-29 1987-08-28 Mitomycin-derivate.

Country Status (5)

Country Link
US (1) US5103018A (de)
EP (1) EP0280741B1 (de)
DE (1) DE3750846T2 (de)
HK (1) HK1001329A1 (de)
WO (1) WO1988001622A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629427A (en) * 1993-08-26 1997-05-13 Peterson; Dwight M. 2,7-diaminomitosene analogues
US7875612B2 (en) 2001-04-24 2011-01-25 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
SE0101702D0 (sv) 2001-05-15 2001-05-15 Ardenia Investments Ltd Novel potentiating compounds
AUPR644301A0 (en) * 2001-07-17 2001-08-09 Unisearch Limited Method and composition for treatment of cancer
ATE426414T1 (de) 2002-05-15 2009-04-15 Endocyte Inc Vitamin-mitomycin-konjugate
TWI367096B (en) 2003-01-27 2012-07-01 Endocyte Inc Vitamin-receptor binding drug delivery conjugates and pharmaceutical compositions
WO2006012527A1 (en) 2004-07-23 2006-02-02 Endocyte, Inc. Bivalent linkers and conjugates thereof
CN101175757B (zh) 2005-03-16 2012-11-14 恩多塞特公司 蝶酸及其缀合物的合成和纯化
KR20130113543A (ko) 2005-08-19 2013-10-15 엔도사이트, 인코포레이티드 복수-약제 리간드 공액체
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
EP2481427A1 (de) 2007-03-14 2012-08-01 Endocyte, Inc. Folat-Tubulysin Konjugate
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
RU2523909C2 (ru) 2007-06-25 2014-07-27 Эндосайт, Инк. Конъюгаты, содержащие гидрофильные спейсеры линкеров
JP2010536790A (ja) 2007-08-17 2010-12-02 パーデュー・リサーチ・ファウンデーション Ｐｓｍａ結合性リガンド−リンカー結合体及び使用方法
US9187521B2 (en) 2007-10-25 2015-11-17 Endocyte, Inc. Tubulysins and processes for preparing
US9951324B2 (en) 2010-02-25 2018-04-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
EA201590622A1 (ru) 2012-10-16 2015-10-30 Эндосайт, Инк. Конъюгаты для доставки лекарственного средства, содержащие не встречающиеся в природе аминокислоты, и способы применения
BR112015011118B1 (pt) 2012-11-15 2022-12-13 Endocyte, Inc Conjugado; composição farmacêutica; e uso de um conjugado
TN2016000137A1 (en) 2013-10-18 2017-10-06 Deutsches Krebsforsch Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer.
US10188759B2 (en) 2015-01-07 2019-01-29 Endocyte, Inc. Conjugates for imaging

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59104386A (ja) * 1982-12-07 1984-06-16 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
JPS59175493A (ja) * 1983-03-25 1984-10-04 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
KR840008362A (ko) * 1983-04-11 1984-12-14 사무엘 제이. 두보프 아미노 이황산염
JPS60255789A (ja) * 1984-06-01 1985-12-17 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体，その製造法および抗腫瘍剤
US4927943A (en) * 1984-09-04 1990-05-22 Bristol-Myers Company Substituted 7-oxomitosanes

Also Published As

Publication number Publication date
US5103018A (en) 1992-04-07
EP0280741A1 (de) 1988-09-07
DE3750846T2 (de) 1995-05-11
EP0280741A4 (de) 1990-02-21
WO1988001622A1 (en) 1988-03-10
HK1001329A1 (en) 1998-06-12
EP0280741B1 (de) 1994-12-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee