DE3770113D1 - Mitomycin-derivate. - Google Patents

Mitomycin-derivate.

Info

Publication number
DE3770113D1
DE3770113D1 DE8787307454T DE3770113T DE3770113D1 DE 3770113 D1 DE3770113 D1 DE 3770113D1 DE 8787307454 T DE8787307454 T DE 8787307454T DE 3770113 T DE3770113 T DE 3770113T DE 3770113 D1 DE3770113 D1 DE 3770113D1
Authority
DE
Germany
Prior art keywords
mitomycin derivatives
mitomycin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787307454T
Other languages
English (en)
Inventor
Motomichi Kono
Makoto Morimoto
Masaji Kasai
Tadashi Ashizawa
Yutaka Saito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of DE3770113D1 publication Critical patent/DE3770113D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE8787307454T 1986-08-26 1987-08-24 Mitomycin-derivate. Expired - Lifetime DE3770113D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61199519A JPS6354380A (ja) 1986-08-26 1986-08-26 マイトマイシン誘導体

Publications (1)

Publication Number Publication Date
DE3770113D1 true DE3770113D1 (de) 1991-06-20

Family

ID=16409175

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787307454T Expired - Lifetime DE3770113D1 (de) 1986-08-26 1987-08-24 Mitomycin-derivate.

Country Status (4)

Country Link
US (1) US4820824A (de)
EP (1) EP0265050B1 (de)
JP (1) JPS6354380A (de)
DE (1) DE3770113D1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4874779A (en) * 1988-06-29 1989-10-17 Bristol-Myers Company Mitomycin phosphate derivatives
JPH04500513A (ja) * 1988-08-23 1992-01-30 ジョージタウン・ユニバーシティー 低骨髄毒性マイトマイシン誘導体、その製造方法およびその使用
US5091523A (en) * 1990-04-25 1992-02-25 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1523128A (fr) * 1965-11-12 1968-05-03 Kyowa Hakko Kogyo Kk Procédé de préparation de dérivés phosphorés de la mitomycine c
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes
FR2571373A1 (fr) * 1984-10-09 1986-04-11 Bristol Myers Co Procede de preparation de derives n7-substitues de la mitomycine c
JPS61176590A (ja) * 1985-01-31 1986-08-08 Kyowa Hakko Kogyo Co Ltd ７−ｎ−アミノメチレンマイトマイシン誘導体、製造法及び抗腫瘍剤
US4652644A (en) * 1985-04-29 1987-03-24 Bristol-Myers Company Process for preparation of N7 -amidino substituted mitomycin C derivatives

Also Published As

Publication number Publication date
JPS6354380A (ja) 1988-03-08
US4820824A (en) 1989-04-11
EP0265050B1 (de) 1991-05-15
EP0265050A1 (de) 1988-04-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee