DE3788385D1 - Pyrimidin-Derivate. - Google Patents
Pyrimidin-Derivate.Info
- Publication number
- DE3788385D1 DE3788385D1 DE87306868T DE3788385T DE3788385D1 DE 3788385 D1 DE3788385 D1 DE 3788385D1 DE 87306868 T DE87306868 T DE 87306868T DE 3788385 T DE3788385 T DE 3788385T DE 3788385 D1 DE3788385 D1 DE 3788385D1
- Authority
- DE
- Germany
- Prior art keywords
- pyrimidine derivatives
- pyrimidine
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP61184484A JPS6339875A (ja) | 1986-08-05 | 1986-08-05 | ピリミジン誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3788385D1 true DE3788385D1 (de) | 1994-01-20 |
DE3788385T2 DE3788385T2 (de) | 1994-05-11 |
Family
ID=16153982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE87306868T Expired - Fee Related DE3788385T2 (de) | 1986-08-05 | 1987-08-03 | Pyrimidin-Derivate. |
Country Status (5)
Country | Link |
---|---|
US (1) | US4849424A (de) |
EP (1) | EP0257850B1 (de) |
JP (1) | JPS6339875A (de) |
CA (1) | CA1291757C (de) |
DE (1) | DE3788385T2 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0421266A1 (de) * | 1989-10-06 | 1991-04-10 | BASF Aktiengesellschaft | Azolylpyrimidin- und -triazinderivate und sie enthaltende Mittel |
JPH0710859B2 (ja) * | 1990-05-10 | 1995-02-08 | 日清食品株式会社 | ビスアゾリルピリミジン誘導体の製造方法 |
DE4131924A1 (de) * | 1991-09-25 | 1993-07-08 | Hoechst Ag | Substituierte 4-alkoxypyrimidine, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel |
US5318975A (en) * | 1993-02-16 | 1994-06-07 | Berlex Laboratories, Inc. | 5-pyrimdineamine derivatives |
US6432947B1 (en) | 1997-02-19 | 2002-08-13 | Berlex Laboratories, Inc. | N-heterocyclic derivatives as NOS inhibitors |
ATE345339T1 (de) * | 1997-02-19 | 2006-12-15 | Berlex Lab | N-heterocyclische derivate als nos inhibitoren |
US7037916B2 (en) | 1999-07-15 | 2006-05-02 | Pharmacopeia Drug Discovery, Inc. | Pyrimidine derivatives as IL-8 receptor antagonists |
US6525051B2 (en) | 2000-03-27 | 2003-02-25 | Schering Aktiengesellschaft | N-heterocyclic derivatives as NOS inhibitors |
JP4186484B2 (ja) * | 2002-03-12 | 2008-11-26 | 住友化学株式会社 | ピリミジン化合物およびその用途 |
US6982259B2 (en) | 2002-04-30 | 2006-01-03 | Schering Aktiengesellschaft | N-heterocyclic derivatives as NOS inhibitors |
US20050014753A1 (en) * | 2003-04-04 | 2005-01-20 | Irm Llc | Novel compounds and compositions as protein kinase inhibitors |
CN100424083C (zh) * | 2006-10-14 | 2008-10-08 | 广西民族大学 | 一种嘧啶衍生化合物及其制备方法 |
AU2010234526B2 (en) * | 2009-04-06 | 2016-07-21 | Agios Pharmaceuticals, Inc. | Pyruvate kinase M2 modulators, therapeutic compositions and related methods of use |
WO2010119878A1 (en) * | 2009-04-16 | 2010-10-21 | Sumitomo Chemical Company, Limited | Pyrimidine compound and its use for pest control |
WO2010119879A1 (en) * | 2009-04-16 | 2010-10-21 | Sumitomo Chemical Company, Limited | Pyrimidine compound and its use for pest control |
DK2448581T3 (en) | 2009-06-29 | 2017-03-13 | Agios Pharmaceuticals Inc | Therapeutic compositions and methods for their applications |
TWI598337B (zh) | 2009-06-29 | 2017-09-11 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
CA2821975A1 (en) | 2010-12-17 | 2012-06-21 | Shunqi Yan | N-(4-(azetidine-1-carbonyl)phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase m2 pkm2 modulators |
ES2569712T3 (es) | 2010-12-21 | 2016-05-12 | Agios Pharmaceuticals, Inc. | Activadores de PKM2 bicíclicos |
TWI549947B (zh) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
KR101873543B1 (ko) | 2011-05-03 | 2018-07-02 | 아지오스 파마슈티컬스 아이엔씨. | 치료에 사용하기 위한 피루베이트 키나아제 활성제 |
WO2012151440A1 (en) | 2011-05-03 | 2012-11-08 | Agios Pharmaceuticals, Inc. | Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia |
WO2013052526A1 (en) * | 2011-10-06 | 2013-04-11 | Merck Sharp & Dohme Corp. | Triazolyl pde10 inhibitors |
WO2014139144A1 (en) | 2013-03-15 | 2014-09-18 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
EP3285581B1 (de) * | 2015-03-26 | 2021-08-11 | Merck Sharp & Dohme Corp. | Pyrazolylpyrimidinonverbindungen als pde2-inhibitoren |
MD3307271T2 (ro) | 2015-06-11 | 2024-01-31 | Agios Pharmaceuticals Inc | Metode de utilizare a activatorilor de piruvat kinază |
BR112018002585A2 (pt) | 2015-08-11 | 2018-10-16 | Novartis Ag | 5-bromo-2,6-di-(1h-pirazol-1-il)pirimidin-4-amina para uso no tratamento de câncer |
BR112021020906A2 (pt) * | 2019-04-18 | 2022-04-19 | Upl Ltd | Processo para a preparação de azoxistrobina e intermediários da mesma |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3040047A (en) * | 1960-04-04 | 1962-06-19 | Takeda Pharmaceutical | 2-(pyrazol-1-yl)-pyrimidine derivatives |
US3647814A (en) * | 1969-07-03 | 1972-03-07 | Rohm & Haas | Method for preparing 4-substituted-1 2 4-triazoles |
US3914223A (en) * | 1972-10-16 | 1975-10-21 | Rohm & Haas | 1,2,4,-4H-Triazole derivatives |
JPS54115384A (en) * | 1978-02-28 | 1979-09-07 | Hokko Chem Ind Co Ltd | Ryrazolyl pyrimidine derivative, and agricultural and horticultural fungicides |
US4725600A (en) * | 1984-07-13 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent |
JP2761673B2 (ja) * | 1990-12-14 | 1998-06-04 | 株式会社テイエルブイ | 熱応動式スチ―ムトラップ |
-
1986
- 1986-08-05 JP JP61184484A patent/JPS6339875A/ja active Granted
-
1987
- 1987-08-03 DE DE87306868T patent/DE3788385T2/de not_active Expired - Fee Related
- 1987-08-03 EP EP87306868A patent/EP0257850B1/de not_active Expired - Lifetime
- 1987-08-05 CA CA000543812A patent/CA1291757C/en not_active Expired - Fee Related
- 1987-08-05 US US07/082,056 patent/US4849424A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA1291757C (en) | 1991-11-05 |
DE3788385T2 (de) | 1994-05-11 |
EP0257850B1 (de) | 1993-12-08 |
JPS6339875A (ja) | 1988-02-20 |
EP0257850A2 (de) | 1988-03-02 |
JPH0524917B2 (de) | 1993-04-09 |
EP0257850A3 (en) | 1989-08-23 |
US4849424A (en) | 1989-07-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |