DE3786229D1 - Prolinalderivate. - Google Patents

Prolinalderivate.

Info

Publication number
DE3786229D1
DE3786229D1 DE8787116613T DE3786229T DE3786229D1 DE 3786229 D1 DE3786229 D1 DE 3786229D1 DE 8787116613 T DE8787116613 T DE 8787116613T DE 3786229 T DE3786229 T DE 3786229T DE 3786229 D1 DE3786229 D1 DE 3786229D1
Authority
DE
Germany
Prior art keywords
prolinal derivatives
prolinal
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787116613T
Other languages
English (en)
Other versions
DE3786229T2 (de
Inventor
Masaaki Toda
Shuichi Ohuchida
Hiroyuki Ohno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE3786229D1 publication Critical patent/DE3786229D1/de
Publication of DE3786229T2 publication Critical patent/DE3786229T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
DE87116613T 1986-11-20 1987-11-10 Prolinalderivate. Expired - Fee Related DE3786229T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27537586 1986-11-20
JP22845287 1987-09-14

Publications (2)

Publication Number Publication Date
DE3786229D1 true DE3786229D1 (de) 1993-07-22
DE3786229T2 DE3786229T2 (de) 1993-10-07

Family

ID=26528260

Family Applications (1)

Application Number Title Priority Date Filing Date
DE87116613T Expired - Fee Related DE3786229T2 (de) 1986-11-20 1987-11-10 Prolinalderivate.

Country Status (6)

Country Link
US (3) US4956380A (de)
EP (1) EP0268190B1 (de)
JP (1) JPH064583B2 (de)
KR (1) KR950013849B1 (de)
DE (1) DE3786229T2 (de)
ES (1) ES2058089T3 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0268190B1 (de) * 1986-11-20 1993-06-16 Ono Pharmaceutical Co., Ltd. Prolinalderivate
US5262431A (en) * 1986-12-29 1993-11-16 Ono Pharmaceutical Co., Ltd. Prolinal derivatives and pharmaceutical compositions thereof
EP0275482B1 (de) * 1986-12-29 1993-01-20 Ono Pharmaceutical Co., Ltd. Prolin-Derivate
EP0277588B1 (de) * 1987-02-04 1993-03-24 Ono Pharmaceutical Co., Ltd. Prolinalderivate
US5053414A (en) * 1988-04-08 1991-10-01 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
US5212191A (en) * 1988-04-08 1993-05-18 Ono Pharmaceutical Co., Ltd. Heterocyclic compounds
EP0419683A4 (en) * 1989-04-13 1992-03-11 Japan Tobacco Inc. New amino acid derivatives having prolylendopeptidase inhibitor activity
EP0536163A1 (de) * 1990-06-04 1993-04-14 Pfizer Inc. Aromatische pyrrolidin- und thiazolidinamide
EP0468469A2 (de) * 1990-07-27 1992-01-29 Japan Tobacco Inc. Prolinderivate
US5506256A (en) * 1990-07-27 1996-04-09 Yoshitomi Pharmaceutical Industries, Ltd. Proline derivatives possessing prolyl endopeptidase-inhibitory activity
FR2703050B1 (fr) * 1993-03-24 1995-04-28 Adir Nouveaux dérivés bicycliques azotés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
EP1120408A1 (de) * 1998-10-02 2001-08-01 Ono Pharmaceutical Co., Ltd. Heilmittel für motorische dysfunktion und inhibitoren der gapdh-expression
US6121311A (en) * 1999-04-28 2000-09-19 Japan Tobacco Inc. Method for treating cocainism
EP1496838B1 (de) 2002-03-12 2010-11-03 Merck Sharp & Dohme Corp. Substituierte amide
ATE462432T1 (de) 2003-05-05 2010-04-15 Probiodrug Ag Glutaminylcyclase-hemmer
AU2004290499C1 (en) 2003-11-03 2011-02-24 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
EP1824846A2 (de) 2003-11-03 2007-08-29 Probiodrug AG Neue verbindungen zur behandlung neurologischer erkrankungen
BRPI0507485A (pt) 2004-02-05 2007-07-10 Probiodrug Ag inibidores novos de glutaminil ciclase
EP2089383B1 (de) 2006-11-09 2015-09-16 Probiodrug AG 3-hydroxy-1,5-dihydropyrrol-2-one derivate als inhibitoren von glutaminylcyclase zur behandlung von geschwüren, krebs und anderen krankheiten
JP5523107B2 (ja) 2006-11-30 2014-06-18 プロビオドルグ エージー グルタミニルシクラーゼの新規阻害剤
ZA200905537B (en) 2007-03-01 2010-10-27 Probiodrug Ag New use of glutaminyl cyclase inhibitors
ES2533484T3 (es) 2007-04-18 2015-04-10 Probiodrug Ag Derivados de tiourea como inhibidores de la glutaminil ciclasa
DK2475428T3 (en) 2009-09-11 2015-09-28 Probiodrug Ag Heterocyclic derivatives as glutaminylcyklaseinhibitorer
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
CN102791704B (zh) 2010-03-10 2015-11-25 前体生物药物股份公司 谷氨酰胺酰环化酶(qc, ec 2.3.2.5)的杂环抑制剂
JP5945532B2 (ja) 2010-04-21 2016-07-05 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
EP3461819B1 (de) 2017-09-29 2020-05-27 Probiodrug AG Hemmer der glutaminylcyclase

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0080822A1 (de) * 1981-11-27 1983-06-08 Beecham Group Plc Antihypertensive auf Prolin basierende Peptide
JPS60188317A (ja) * 1984-03-09 1985-09-25 Yakult Honsha Co Ltd 抗健忘症剤
JPS6137764A (ja) * 1984-07-31 1986-02-22 Suntory Ltd 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
JPH0680077B2 (ja) * 1985-02-08 1994-10-12 サントリー株式会社 プロリンエンドペプチダ−ゼインヒビタ−活性を有する新規ペプチド化合物
JPH0623190B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
US4772587A (en) * 1985-04-16 1988-09-20 Suntory Limited Dipeptide derivative of fatty acid
DE3680578D1 (de) * 1985-04-16 1991-09-05 Suntory Ltd Dipeptid-derivate, verfahren zur herstellung, pharmazeutische zusammensetzungen und ihre anwendung.
JPH0623191B2 (ja) * 1985-04-16 1994-03-30 サントリー株式会社 ペプチダ−ゼ阻害活性化合物およびその製法ならびに用途
EP0268190B1 (de) * 1986-11-20 1993-06-16 Ono Pharmaceutical Co., Ltd. Prolinalderivate
JP2589163B2 (ja) * 1988-09-28 1997-03-12 日東化成株式会社 非対称トリオルガノ錫ハライドの製法

Also Published As

Publication number Publication date
KR880006190A (ko) 1988-07-22
DE3786229T2 (de) 1993-10-07
KR950013849B1 (ko) 1995-11-17
JPH01156957A (ja) 1989-06-20
JPH064583B2 (ja) 1994-01-19
US5340832A (en) 1994-08-23
US5100904A (en) 1992-03-31
ES2058089T3 (es) 1994-11-01
EP0268190B1 (de) 1993-06-16
EP0268190A1 (de) 1988-05-25
US4956380A (en) 1990-09-11

Similar Documents

Publication Publication Date Title
DE3786229D1 (de) Prolinalderivate.
MX8358A (es) Derivados de sacarosa.
IT8619169A0 (it) Azolilderivati fungicidi.
DE3787815D1 (de) Azetidinonderivate.
FI871632A0 (fi) Heterocykliska karboxamider.
DE3777997D1 (de) Piperidinderivate.
DE3761308D1 (de) 18-phenylestrane-derivate.
DE3872153D1 (de) 25-hydroxy-vitamin-d3-derivate.
FI883963A0 (fi) Isoxazol- -karbolinderivat.
DE3778624D1 (de) Glucosylmoranoline-derivate.
DE3881755D1 (de) Pyrrolidin-derivate.
IT8622828A0 (it) Azolilderivati fungicidi.
DE3780338T2 (de) Indenopyrimidin-derivate.
DE3781831D1 (de) Aralkylimidazolderivate.
DE3774759D1 (de) Alkenamid-derivate.
DE3861208D1 (de) Hydroxyalkyl-triazolyl-derivate.
DE3785480T2 (de) Macrolid-derivate.
DE3769757D1 (de) Hydrofluoren-derivate.
DE3866371D1 (de) Diphenylaethylen-derivate.
ATE90670T1 (de) Prolinalderivate.
DE3784837D1 (de) Pseudo-uridin-derivate.
DE3775818D1 (de) Dihalogen-substituierte thiocyanopyrimidin-derivate.
DE3777385D1 (de) Alpha-acyloxyketon-derivate.
DE3863447D1 (de) Aminoethylphosphinsaeure-derivate.
DE3881146D1 (de) Thiazetidin-derivate.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee