DE3627448C2 - - Google Patents
Info
- Publication number
- DE3627448C2 DE3627448C2 DE3627448A DE3627448A DE3627448C2 DE 3627448 C2 DE3627448 C2 DE 3627448C2 DE 3627448 A DE3627448 A DE 3627448A DE 3627448 A DE3627448 A DE 3627448A DE 3627448 C2 DE3627448 C2 DE 3627448C2
- Authority
- DE
- Germany
- Prior art keywords
- laser
- cuvette
- volume
- detector
- channel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000005855 radiation Effects 0.000 claims description 32
- 238000004440 column chromatography Methods 0.000 claims description 9
- 230000001105 regulatory effect Effects 0.000 claims description 8
- 238000006073 displacement reaction Methods 0.000 claims description 4
- 239000007788 liquid Substances 0.000 description 17
- 239000000126 substance Substances 0.000 description 11
- 230000035945 sensitivity Effects 0.000 description 7
- 238000004587 chromatography analysis Methods 0.000 description 5
- 239000010453 quartz Substances 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 230000033228 biological regulation Effects 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 239000003480 eluent Substances 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 108010063955 thrombin receptor peptide (42-47) Proteins 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 241000826860 Trapezium Species 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 238000001307 laser spectroscopy Methods 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6402—Atomic fluorescence; Laser induced fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/85—Investigating moving fluids or granular solids
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Optical Measuring Cells (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Silicon Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU853893760A SU1376042A1 (ru) | 1985-05-12 | 1985-05-12 | Лазерный флуориметрический детектор дл микроколоночной хроматографии |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3627448A1 DE3627448A1 (de) | 1988-02-18 |
| DE3627448C2 true DE3627448C2 (enExample) | 1990-02-22 |
Family
ID=21176583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19863627448 Granted DE3627448A1 (de) | 1985-05-12 | 1986-08-13 | Fluorimetrischer laserdetektor fuer die mikrosaeulenchromatografie |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4822167A (enExample) |
| AT (1) | AT390841B (enExample) |
| CS (1) | CS268787B1 (enExample) |
| DD (1) | DD270643A3 (enExample) |
| DE (1) | DE3627448A1 (enExample) |
| FR (1) | FR2603106B1 (enExample) |
| GB (1) | GB2193571B (enExample) |
| HU (1) | HU201155B (enExample) |
| SE (1) | SE458156B (enExample) |
| SU (1) | SU1376042A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6830731B1 (en) * | 1998-01-05 | 2004-12-14 | Biosite, Inc. | Immunoassay fluorometer |
| US6195214B1 (en) * | 1999-07-30 | 2001-02-27 | Etec Systems, Inc. | Microcolumn assembly using laser spot welding |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4031399A (en) * | 1975-02-24 | 1977-06-21 | Beckman Instruments, Inc. | Fluorometer |
| US3999861A (en) * | 1975-06-30 | 1976-12-28 | Technicon Instruments Corporation | Flow cell |
| FR2348486A1 (fr) * | 1976-04-15 | 1977-11-10 | Commissariat Energie Atomique | Procede et dispositif d'analyse d'echantillon par spectrographie d'emission utilisant un faisceau laser |
| US4203670A (en) * | 1977-04-21 | 1980-05-20 | Bromberg Nathan S | System and method of fluorescence polarimetry |
| US4284355A (en) * | 1979-10-29 | 1981-08-18 | Ortho Diagnostics, Inc. | Automated method for cell volume determination |
| US4350892A (en) * | 1980-07-31 | 1982-09-21 | Research Corporation | X'-, Y'-, Z'- axis multidimensional slit-scan flow system |
| DD159566A1 (de) * | 1981-06-10 | 1983-03-16 | Hartmut Lucht | Spektralfluorometer |
| DE3208919A1 (de) * | 1982-03-12 | 1983-09-22 | Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München | Anordnung zur messung der fluoreszenzpolarisation |
| US4537861A (en) * | 1983-02-03 | 1985-08-27 | Elings Virgil B | Apparatus and method for homogeneous immunoassay |
| US4555177A (en) * | 1983-12-22 | 1985-11-26 | The United States Of America As Represented By The Secretary Of The Navy | Method and apparatus for detecting singlet state resonance fluorescence |
| US4643566A (en) * | 1984-07-20 | 1987-02-17 | Canon Kabushiki Kaisha | Particle analyzing apparatus |
| SE455646B (sv) * | 1984-10-22 | 1988-07-25 | Radians Innova Ab | Fluorescensanordning |
-
1985
- 1985-05-12 SU SU853893760A patent/SU1376042A1/ru active
-
1986
- 1986-04-25 CS CS863008A patent/CS268787B1/cs unknown
- 1986-05-05 DD DD28988586A patent/DD270643A3/de not_active IP Right Cessation
- 1986-08-04 AT AT0209286A patent/AT390841B/de not_active IP Right Cessation
- 1986-08-07 GB GB8619282A patent/GB2193571B/en not_active Expired - Lifetime
- 1986-08-13 DE DE19863627448 patent/DE3627448A1/de active Granted
- 1986-08-13 HU HU863578A patent/HU201155B/hu not_active IP Right Cessation
- 1986-08-20 FR FR8611901A patent/FR2603106B1/fr not_active Expired
- 1986-08-27 SE SE8603622A patent/SE458156B/sv not_active IP Right Cessation
- 1986-09-05 US US06/903,650 patent/US4822167A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FR2603106B1 (fr) | 1988-12-09 |
| CS268787B1 (en) | 1990-04-11 |
| US4822167A (en) | 1989-04-18 |
| DE3627448A1 (de) | 1988-02-18 |
| HU201155B (en) | 1990-09-28 |
| FR2603106A1 (fr) | 1988-02-26 |
| AT390841B (de) | 1990-07-10 |
| SE458156B (sv) | 1989-02-27 |
| SU1376042A1 (ru) | 1988-02-23 |
| GB8619282D0 (en) | 1986-09-17 |
| CS300886A1 (en) | 1989-06-13 |
| GB2193571B (en) | 1990-07-04 |
| SE8603622D0 (sv) | 1986-08-27 |
| DD270643A3 (de) | 1989-08-09 |
| GB2193571A (en) | 1988-02-10 |
| HUT44652A (en) | 1988-03-28 |
| ATA209286A (de) | 1989-12-15 |
| SE8603622L (sv) | 1988-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8125 | Change of the main classification |
Ipc: G01N 30/74 |
|
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |