DE3617763A1 - Verfahren zur durchfuehrung immunologischer bestimmungen und dafuer geeignete vorrichtung - Google Patents

Verfahren zur durchfuehrung immunologischer bestimmungen und dafuer geeignete vorrichtung

Info

Publication number
DE3617763A1
DE3617763A1 DE19863617763 DE3617763A DE3617763A1 DE 3617763 A1 DE3617763 A1 DE 3617763A1 DE 19863617763 DE19863617763 DE 19863617763 DE 3617763 A DE3617763 A DE 3617763A DE 3617763 A1 DE3617763 A1 DE 3617763A1
Authority
DE
Germany
Prior art keywords
light guide
face
light
sample
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19863617763
Other languages
German (de)
English (en)
Other versions
DE3617763C2 (US20030220297A1-20031127-C00009.png
Inventor
Nobutaka Hachioji Tokio/Tokyo Kaneko
Takashi Kokubunji Tokio/Tokyo Tabara
Takeo Hachioji Tokio/Tokyo Takahashi
Takashi Sagamihara Kanagawa Yamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olympus Corp
Original Assignee
Olympus Optical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP60113055A external-priority patent/JPH0746110B2/ja
Priority claimed from JP60113052A external-priority patent/JP2533845B2/ja
Application filed by Olympus Optical Co Ltd filed Critical Olympus Optical Co Ltd
Publication of DE3617763A1 publication Critical patent/DE3617763A1/de
Application granted granted Critical
Publication of DE3617763C2 publication Critical patent/DE3617763C2/de
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N2021/1748—Comparative step being essential in the method
    • G01N2021/1751—Constructive features therefore, e.g. using two measurement cells
    • G01N2021/1755—Constructive features therefore, e.g. using two measurement cells and using two apparatus or two probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N21/8507—Probe photometers, i.e. with optical measuring part dipped into fluid sample
    • G01N2021/8514—Probe photometers, i.e. with optical measuring part dipped into fluid sample with immersed mirror
    • G01N2021/8521—Probe photometers, i.e. with optical measuring part dipped into fluid sample with immersed mirror with a combination mirror cell-cuvette
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE19863617763 1985-05-28 1986-05-27 Verfahren zur durchfuehrung immunologischer bestimmungen und dafuer geeignete vorrichtung Granted DE3617763A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP60113055A JPH0746110B2 (ja) 1985-05-28 1985-05-28 免疫学的測定方法
JP60113052A JP2533845B2 (ja) 1985-05-28 1985-05-28 免疫学的分析方法

Publications (2)

Publication Number Publication Date
DE3617763A1 true DE3617763A1 (de) 1986-12-04
DE3617763C2 DE3617763C2 (US20030220297A1-20031127-C00009.png) 1989-08-17

Family

ID=26452083

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19863617763 Granted DE3617763A1 (de) 1985-05-28 1986-05-27 Verfahren zur durchfuehrung immunologischer bestimmungen und dafuer geeignete vorrichtung

Country Status (2)

Country Link
US (1) US4980278A (US20030220297A1-20031127-C00009.png)
DE (1) DE3617763A1 (US20030220297A1-20031127-C00009.png)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0348191A1 (en) * 1988-06-23 1989-12-27 Syntex (U.S.A.) Inc. Multiparameter particle analysis
WO1991002975A1 (en) * 1989-08-21 1991-03-07 The Board Of Regents Of The University Of Washington Multiple-probe diagnostic sensor
WO1992005429A1 (en) * 1990-09-20 1992-04-02 Battelle Memorial Institute Optical immunoassay
EP0584721A1 (de) * 1992-08-21 1994-03-02 Roche Diagnostics GmbH Analyseelement zur Analyse einer flüssigen Probe
EP0585744A1 (de) * 1992-08-21 1994-03-09 Boehringer Mannheim Gmbh Licht leitendes Analyseelement zur Bestimmung eines Analyts
EP0685730A1 (en) * 1994-06-04 1995-12-06 Orbisphere Laboratories Neuchatel Sa Luminoscopic analytic device and method
US6231733B1 (en) 1993-04-17 2001-05-15 Kurt Nilsson Immobilized carbohydrate biosensor

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032730A (en) * 1989-10-02 1991-07-16 Fuji Photo Film Co., Ltd. Immunoassay apparatus
JP3107649B2 (ja) * 1991-12-20 2000-11-13 イビデン株式会社 蛍光免疫測定装置
US5489980A (en) * 1992-03-18 1996-02-06 Anthony; Michael Apparatus for rapid and accurate analysis of the composition of samples
DE4216980C2 (de) * 1992-05-19 1994-04-21 Eppendorf Geraetebau Netheler Immunosensorisches Nachweisverfahren
DE69431873T2 (de) * 1994-06-04 2003-11-13 Orbisphere Lab Photoakustisches Analysegerät
US5577137A (en) * 1995-02-22 1996-11-19 American Research Corporation Of Virginia Optical chemical sensor and method using same employing a multiplicity of fluorophores contained in the free volume of a polymeric optical waveguide or in pores of a ceramic waveguide
US6356676B1 (en) 1996-03-19 2002-03-12 University Of Utah Research Foundation Lens and associatable flow cell
EP0928416A4 (en) * 1996-03-19 2000-03-29 Univ Utah Res Found LENS AND RELATED FLOW CELL
US6115061A (en) * 1996-04-10 2000-09-05 The United States Of America As Represented By The Secretary Of The Navy In situ microscope imaging system for examining subsurface environments
US5958704A (en) 1997-03-12 1999-09-28 Ddx, Inc. Sensing system for specific substance and molecule detection
CA2298459A1 (en) * 1997-06-10 1999-01-14 Howard P. Groger Detection of chemical agent materials using a sorbent polymer and fluorescent probe
US6139797A (en) * 1997-08-20 2000-10-31 Suzuki Motor Corporation Immunoassay apparatus
US6300638B1 (en) 1998-11-12 2001-10-09 Calspan Srl Corporation Modular probe for total internal reflection fluorescence spectroscopy
KR100816799B1 (ko) * 1999-12-24 2008-03-26 로셰 디아그노스틱스 게엠베하 테스트 부재 분석 시스템 및 그 분석 시스템을 이용한 분석 조사 방법
WO2002032567A1 (de) * 2000-10-17 2002-04-25 Febit Ag Verfahren und vorrichtung zur integrierten synthese und analytbestimmung an einem träger
US6974673B2 (en) * 2001-09-24 2005-12-13 Veridian Systems Division Coupled capillary fiber based waveguide biosensor
WO2005073697A1 (en) * 2004-01-20 2005-08-11 The Curators Of The University Of Missouri Local flow and shear stress sensor based on molecular rotors
DE102008050109B4 (de) * 2008-07-21 2010-06-17 Ancosys Gmbh Optischer Sensor
CN102445375A (zh) * 2010-09-30 2012-05-09 广州阳普医疗科技股份有限公司 加样皿装置
WO2020216913A1 (en) * 2019-04-25 2020-10-29 Trinamix Gmbh Container lid allowing spectroscopy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2550420A1 (de) * 1974-11-11 1976-05-13 Monsanto Co Optische analyseneinrichtung und analysenverfahren
DE3246873C2 (de) * 1981-12-17 1986-04-24 Olympus Optical Co., Ltd., Tokio/Tokyo Mit immunologischer Agglutinationsreaktion arbeitendes Analysiergerät

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4050895A (en) * 1975-09-26 1977-09-27 Monsanto Research Corporation Optical analytical device, waveguide and method
US4279992A (en) * 1978-03-13 1981-07-21 Miles Laboratories, Inc. Specific binding assay employing an enzyme-cleavable substrate as label
US4272245A (en) * 1978-12-04 1981-06-09 Transidyne General Corporation Method and apparatus for electro-chemical measurement
JPS57100349A (en) * 1980-12-16 1982-06-22 Amano Pharmaceut Co Ltd Measuring method for enzyme immunity of antibody immunoglobulin using regeneratable immune adsorption body
JPS57131062A (en) * 1981-02-05 1982-08-13 Amano Pharmaceut Co Ltd Quantitative determination of antigen using enzyme- labelled antigen and second antibody insolubilizing carrier
EP0084216A1 (en) * 1981-10-26 1983-07-27 Dainichi-Nippon Cables, Ltd. Image guide
US4582809A (en) * 1982-06-14 1986-04-15 Myron J. Block Apparatus including optical fiber for fluorescence immunoassay
US4490473A (en) * 1983-03-28 1984-12-25 Panab Labeled antibodies and methods
US4657869A (en) * 1984-05-18 1987-04-14 E. I. Du Pont De Nemours And Company Self-contained device for carrying out specific binding assays
US4647544A (en) * 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
US4737343A (en) * 1986-01-21 1988-04-12 The Regents Of The University Of California Gas-sensing optrode

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2550420A1 (de) * 1974-11-11 1976-05-13 Monsanto Co Optische analyseneinrichtung und analysenverfahren
DE3246873C2 (de) * 1981-12-17 1986-04-24 Olympus Optical Co., Ltd., Tokio/Tokyo Mit immunologischer Agglutinationsreaktion arbeitendes Analysiergerät

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0348191A1 (en) * 1988-06-23 1989-12-27 Syntex (U.S.A.) Inc. Multiparameter particle analysis
WO1991002975A1 (en) * 1989-08-21 1991-03-07 The Board Of Regents Of The University Of Washington Multiple-probe diagnostic sensor
WO1992005429A1 (en) * 1990-09-20 1992-04-02 Battelle Memorial Institute Optical immunoassay
EP0584721A1 (de) * 1992-08-21 1994-03-02 Roche Diagnostics GmbH Analyseelement zur Analyse einer flüssigen Probe
EP0585744A1 (de) * 1992-08-21 1994-03-09 Boehringer Mannheim Gmbh Licht leitendes Analyseelement zur Bestimmung eines Analyts
US6231733B1 (en) 1993-04-17 2001-05-15 Kurt Nilsson Immobilized carbohydrate biosensor
US6887689B2 (en) 1993-04-19 2005-05-03 Kurt Nilsson Immobilized carbohydrate biosensor
US7244582B1 (en) 1993-04-19 2007-07-17 Kurt Nilsson Immobilized carbohydrate biosensor
US7625722B2 (en) 1993-04-19 2009-12-01 Kurt Nilsson Immobilized carbohydrate biosensor
EP0685730A1 (en) * 1994-06-04 1995-12-06 Orbisphere Laboratories Neuchatel Sa Luminoscopic analytic device and method

Also Published As

Publication number Publication date
DE3617763C2 (US20030220297A1-20031127-C00009.png) 1989-08-17
US4980278A (en) 1990-12-25

Similar Documents

Publication Publication Date Title
DE3617763C2 (US20030220297A1-20031127-C00009.png)
DE3033869C2 (de) Verfahren zum Nachweis einer immunologischen Agglutinationsreaktion
DE3783847T2 (de) Verfahren und apparat fuer immunoassay.
DE3226332C2 (de) Analyseverfahren
EP0126450B1 (de) Partikel sowie Verfahren zum Nachweis von Antigenen und/oder Antikörpern unter Verwendung der Partikel
DE3531891C2 (US20030220297A1-20031127-C00009.png)
DE3618101C2 (US20030220297A1-20031127-C00009.png)
DE60018537T2 (de) Teststreifen zur Bestimmung eines Analyts in eine flüssige Probe
DE69835142T2 (de) VORRICHTUNG zur Bestimmung VON STÖRENDEN SUBSTANZEN im PLASMA
DE2607903C2 (de) Analyseverfahren, das mit einfacher oder komplexer Agglutinationsreaktion arbeitet, und Verfahren zu dessen Durchführung
DE3214939C2 (US20030220297A1-20031127-C00009.png)
EP0699906A2 (de) Verfahren zum Nachweis der Kontamination einer Oberfläche mit einem Analyten
DE2409273A1 (de) Verfahren und vorrichtung zum messen von antigen-antikoerper-reaktionen
EP0034156A1 (de) Verfahren und vorrichtung zur bestimmung von glucose im serum oder im harn.
DE19747572C1 (de) Vorrichtung und Verfahren zur Durchführung von Fluoreszenzimmuntests
DE3344019A1 (de) Anordnung zur optischen messung von stoffkonzentrationen
DE3343176A1 (de) Automatisiertes analysengeraet
DE60013243T2 (de) Immunochromatographisches teststück und chromatographische analysenmethode
DE4040463A1 (de) Messverfahren zur bestimmung von harzteilchen in papierstoffen
DE3643108C2 (US20030220297A1-20031127-C00009.png)
DE69636211T2 (de) Verfahren für die optische Messung einer Flüssigkeit in einem porösen Material
WO1997036168A1 (de) System zur quantitativen ortsaufgelösten auswertung von testelementen
DE4024350C2 (de) Immunologisches Multiplex-Testsystem
DE4113255C2 (de) Verfahren zum immunologischen Messen von Antigenen oder Antikörpern
DE202020004776U1 (de) Optisches Detektionssystem

Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee