DE3574252D1 - Substituted imidazole derivatives and their preparation and use - Google Patents

Substituted imidazole derivatives and their preparation and use

Info

Publication number
DE3574252D1
DE3574252D1 DE8585308491T DE3574252T DE3574252D1 DE 3574252 D1 DE3574252 D1 DE 3574252D1 DE 8585308491 T DE8585308491 T DE 8585308491T DE 3574252 T DE3574252 T DE 3574252T DE 3574252 D1 DE3574252 D1 DE 3574252D1
Authority
DE
Germany
Prior art keywords
och3
preparation
ch2ch3
hal
imidazole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8585308491T
Other languages
German (de)
English (en)
Inventor
Arto Johannes Karjalainen
Raimo Einari Virtanen
Arja Leena Karjalainen
Kauko Oiva Antero Kurkela
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Farmos Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmos Yhtyma Oy filed Critical Farmos Yhtyma Oy
Application granted granted Critical
Publication of DE3574252D1 publication Critical patent/DE3574252D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Lubricants (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Resins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Dental Preparations (AREA)
  • Golf Clubs (AREA)
DE8585308491T 1984-11-23 1985-11-21 Substituted imidazole derivatives and their preparation and use Expired DE3574252D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB08429578A GB2167408B (en) 1984-11-23 1984-11-23 Substituted imidazole derivatives and their preparation and use

Publications (1)

Publication Number Publication Date
DE3574252D1 true DE3574252D1 (en) 1989-12-21

Family

ID=10570140

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8585308491T Expired DE3574252D1 (en) 1984-11-23 1985-11-21 Substituted imidazole derivatives and their preparation and use
DE8888106210T Expired - Fee Related DE3587045T2 (de) 1984-11-23 1985-11-21 Substituierte imidazol-derivate und verfahren zu deren herstellung und deren anwendung.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8888106210T Expired - Fee Related DE3587045T2 (de) 1984-11-23 1985-11-21 Substituierte imidazol-derivate und verfahren zu deren herstellung und deren anwendung.

Country Status (26)

Country Link
US (1) US4689339A (OSRAM)
EP (2) EP0310745B1 (OSRAM)
JP (1) JPH064597B2 (OSRAM)
KR (1) KR930004673B1 (OSRAM)
AT (2) ATE47997T1 (OSRAM)
AU (2) AU586839B2 (OSRAM)
BG (1) BG60762B2 (OSRAM)
CA (1) CA1268770C (OSRAM)
DD (1) DD258230A1 (OSRAM)
DE (2) DE3574252D1 (OSRAM)
DK (2) DK164903C (OSRAM)
ES (2) ES8704462A1 (OSRAM)
FI (1) FI80264C (OSRAM)
GB (1) GB2167408B (OSRAM)
GR (1) GR852817B (OSRAM)
HK (1) HK3592A (OSRAM)
HU (1) HU195189B (OSRAM)
IE (1) IE58165B1 (OSRAM)
IL (1) IL77111A (OSRAM)
NO (1) NO166585C (OSRAM)
NZ (1) NZ214258A (OSRAM)
PH (1) PH22016A (OSRAM)
PT (1) PT81542B (OSRAM)
SG (1) SG106891G (OSRAM)
SU (1) SU1424736A3 (OSRAM)
ZA (1) ZA858942B (OSRAM)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987004431A1 (fr) * 1986-01-28 1987-07-30 Mitsui Petrochemical Industries, Ltd. Procede de preparation de 2-imidazoles non substitues
FI862039A0 (fi) * 1986-05-15 1986-05-15 Farmos Oy Nytt foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat.
FI81092C (fi) * 1986-05-15 1990-09-10 Farmos Oy Foerfarande foer framstaellning av terapeutiskt aktiva 4(5)-(2,3-dihydro-1h-inden-2-yl)-imidazolderivat.
JP2576493B2 (ja) * 1987-03-20 1997-01-29 アイシン精機株式会社 原稿読取り装置に用いられる原稿トレ−
FR2621327B1 (fr) * 1987-10-06 1990-01-05 Commissariat Energie Atomique Procede de production et d'extraction de polysaccharides a partir d'une culture de porphyridium cruentum et dispositif pour la mise en oeuvre du procede
GB2225782A (en) * 1988-12-09 1990-06-13 Farmos Group Limited Imidazole derivatives useful for treatment of diabetes
GB8903437D0 (en) * 1989-02-15 1989-04-05 Erba Carlo Spa Imidazolyl derivatives of 3,4-dihydro-2h-1-benzothiopyran
CA1321751C (en) * 1989-02-21 1993-08-31 Eugene C. Crichlow Mechanism mediating ruminal stasis in ruminal lactic acidosis
DK344489D0 (da) * 1989-07-12 1989-07-12 Novo Nordisk As Substituerede 2-imidazoliner og fremstilling og anvendelse deraf
GB2244431A (en) * 1990-05-31 1991-12-04 Farmos Oy Treatment of age related memory impairment and other cognitive disorders
GB2256135B (en) 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
US5541211A (en) * 1991-06-18 1996-07-30 Orion-Yhtyma Oy Administration of atipamezole to elicit a yohimbine-like alpha-adrenoreceptor antagonistic noradrenergic transmission
AU669866B2 (en) * 1991-11-05 1996-06-27 Smithkline Beecham Corporation Endothelin receptor antagonists
GB9127050D0 (en) * 1991-12-20 1992-02-19 Orion Yhtymae Oy Substituted imidazole derivatives and their preparation and use
GB9127430D0 (en) * 1991-12-27 1992-02-19 Scras Benzofuranylimidazole derivatives
GB9312669D0 (en) * 1993-06-18 1993-08-04 Orion Yhtymae Oy New opticla isomers
GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles
FR2733983B1 (fr) * 1995-05-10 1997-08-01 Pf Medicament Procede de preparation d'un derive d'acide benzofurane carboxylque optiquement pur et son utilisation pour preparer l'efaroxan
GB9520150D0 (en) 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
FR2754709B1 (fr) 1996-10-23 1999-03-05 Sanofi Sa Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
WO1998055439A1 (en) * 1997-06-05 1998-12-10 Venantius Limited Indane compounds and their pharmaceutical use
WO1999051593A1 (en) * 1998-04-02 1999-10-14 Ortho-Mcneil Pharmaceutical, Inc. 4-thionaphthyl-1h-imidazoles with alpha-2-adrenergic activity
FR2784989B1 (fr) * 1998-09-10 2002-09-27 Fabre Pierre Sante Derive d'ester d'acide 2-ethyl-2,3-dihydrobenzofurane- carboxylique, procede de preparation et utilisation pour la preparation de derives de l'efaroxan
AU3033100A (en) * 1999-01-18 2000-08-01 Boehringer Ingelheim International Gmbh Substituted imidazoles, their preparation and use
US6388090B2 (en) * 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
US6593324B2 (en) 2000-03-01 2003-07-15 Orion Corporation Dervatives of quinoline as alpha-2 antagonists
US6362211B2 (en) 2000-05-08 2002-03-26 Orion Corporation Polycyclic indanylimidazoles with alpha2 adrenergic activity
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US6543389B2 (en) 2001-06-26 2003-04-08 Pfizer Inc. Insecticidal pet collar
CA2480695A1 (en) 2002-04-03 2003-10-09 Orion Corporation Polycyclic compounds as potent alpha2-adrenoceptor antagonists
US8188126B2 (en) 2002-05-16 2012-05-29 Pierre Fabre Medicament Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
FI116292B (fi) * 2003-01-08 2005-10-31 Juvantia Pharma Ltd Oy Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita
DE602004017347D1 (de) * 2003-11-04 2008-12-04 Intervet Int Bv Azol-pestiziden
FI20050657A0 (fi) * 2005-06-17 2005-06-17 Orion Corp Atipametsolin kiteytysmenetelmä
SI1937276T1 (sl) 2005-10-12 2013-04-30 Unimed Pharmaceuticals, Llc C/O Abbott Laboratoires 100 Abbott Park Road Izboljšani testosteronski gel in postopek uporabe
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
DE602007005143D1 (de) * 2006-08-08 2010-04-15 Intervet Int Bv Zusammensetzung für verstärkte antiparasitische wirksamkeit
TWI457122B (zh) 2007-07-20 2014-10-21 Orion Corp 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
CL2008003553A1 (es) * 2007-12-05 2009-11-27 Grindeks Jsc Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
WO2015069535A1 (en) 2013-11-05 2015-05-14 3M Innovative Properties Company Sesame oil based injection formulations
AR104882A1 (es) 2015-06-05 2017-08-23 Orion Corp DERIVADOS DE 2-(1-HETEROARILPIPERAZIN-4-IL)METIL-1,4-BENZODIOXANO COMO ANTAGONISTAS DE a2C
JP7002756B2 (ja) * 2015-11-05 2022-01-20 ユニバーシティー オブ ルイヴィル リサーチ ファウンデーション，インコーポレーテッド 局所と局部の麻酔と鎮痛
KR20190020343A (ko) 2016-06-29 2019-02-28 오리온 코포레이션 벤조디옥산 유도체 및 이의 약제학적 용도
EP3897214A1 (en) 2018-12-21 2021-10-27 Société des Produits Nestlé S.A. Nutritional composition for inducing a feeling of satiety, a better sleep and/or limiting nocturnal awaking in infants or young children
CN111978254A (zh) * 2019-05-22 2020-11-24 南京康德祥医药科技有限公司 一种阿替美唑盐酸盐的制备工艺
CN111925330A (zh) * 2020-09-07 2020-11-13 上海阿达玛斯试剂有限公司 一种阿替美唑的制备方法
EP4658639A1 (en) 2023-02-01 2025-12-10 Univerza V Ljubljani N,n-dialkyl-4-(2-ethylindan-2-yl)-1h-imidazole-1-carboxamides and related compounds for treatment of neurodegenerative diseases
LU103072B1 (en) 2023-02-15 2024-08-19 Univ Ljubljani N,N-DIALKYL-4-(2-ETHYLINDAN-2-YL)-lH-IMIDAZOLE-l-CARBOXAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES
CN117186010A (zh) * 2023-08-15 2023-12-08 厦门欧瑞捷生物科技有限公司 一种盐酸阿替美唑的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2933962A1 (de) * 1979-08-22 1981-03-26 Hoechst Ag, 65929 Frankfurt Verfahren zur herstellung von 4,5-dichlor-imidazolen.
US4342775A (en) * 1980-03-04 1982-08-03 Farmitalia Carlo Erba S.P.A. 3-(1-Imidazolyl)-derivatives of 2,3-dihydro-4H-1-benzopyran
US4302469A (en) * 1980-09-10 1981-11-24 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
NZ201219A (en) * 1981-07-28 1984-10-19 Reckitt & Colmann Prod Ltd Dihydrobenzofuranyl-2-imidazolines and pharmaceutical compositions
ES523609A0 (es) * 1982-07-05 1985-03-01 Erba Farmitalia Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
FR2539415B1 (fr) * 1983-01-14 1985-09-13 Adir Derives de la d-2 imidazoline, leur preparation et leur application en therapeutique
FR2542738A1 (fr) * 1983-03-18 1984-09-21 Synthelabo Indanyl-2 d2-imidazoline, procede pour la preparer, et compositions pharmaceutiques qui la contiennent

Also Published As

Publication number Publication date
AU5008385A (en) 1986-05-29
GB2167408A (en) 1986-05-29
DK540485D0 (da) 1985-11-22
EP0310745A2 (en) 1989-04-12
IL77111A0 (en) 1986-04-29
AU3332989A (en) 1989-08-10
JPS61143366A (ja) 1986-07-01
NZ214258A (en) 1989-02-24
FI854335A7 (fi) 1986-05-24
NO166585C (no) 1991-08-21
EP0310745A3 (en) 1989-10-11
EP0183492A1 (en) 1986-06-04
FI80264C (fi) 1990-05-10
DK164903B (da) 1992-09-07
GB8429578D0 (en) 1985-01-03
GR852817B (OSRAM) 1986-03-21
KR930004673B1 (ko) 1993-06-03
SG106891G (en) 1992-02-14
DK58292D0 (da) 1992-05-04
HK3592A (en) 1992-01-17
ATE47997T1 (de) 1989-12-15
ES549178A0 (es) 1987-04-01
FI80264B (fi) 1990-01-31
CA1268770C (en) 1990-05-08
NO166585B (no) 1991-05-06
PT81542A (en) 1985-12-01
DK58292A (da) 1992-05-04
US4689339A (en) 1987-08-25
ATE85050T1 (de) 1993-02-15
GB2167408B (en) 1988-05-25
AU586839B2 (en) 1989-07-27
ES8801248A1 (es) 1987-12-16
ZA858942B (en) 1986-08-27
IE852929L (en) 1986-05-23
DD258230A1 (de) 1988-07-13
JPH064597B2 (ja) 1994-01-19
EP0310745B1 (en) 1993-01-27
IE58165B1 (en) 1993-07-28
ES557268A0 (es) 1987-12-16
DE3587045D1 (de) 1993-03-11
ES8704462A1 (es) 1987-04-01
NO854671L (no) 1986-05-26
PH22016A (en) 1988-05-13
IL77111A (en) 1989-09-28
EP0183492B1 (en) 1989-11-15
HUT38913A (en) 1986-07-28
KR860004028A (ko) 1986-06-16
CA1266669A1 (en) 1990-03-13
DK164903C (da) 1993-01-25
BG60762B2 (bg) 1996-02-29
DK540485A (da) 1986-05-24
HU195189B (en) 1988-04-28
FI854335A0 (fi) 1985-11-05
SU1424736A3 (ru) 1988-09-15
DE3587045T2 (de) 1993-06-03
PT81542B (pt) 1988-03-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ORION-YHTYMAE OY, ESPOO, FI

8328 Change in the person/name/address of the agent

Representative=s name: PRUFER & PARTNER GBR, 81545 MUENCHEN