AU586839B2 - Substituted imidazole derivatives and their preparation and use - Google Patents

Substituted imidazole derivatives and their preparation and use

Info

Publication number
AU586839B2
AU586839B2 AU50083/85A AU5008385A AU586839B2 AU 586839 B2 AU586839 B2 AU 586839B2 AU 50083/85 A AU50083/85 A AU 50083/85A AU 5008385 A AU5008385 A AU 5008385A AU 586839 B2 AU586839 B2 AU 586839B2
Authority
AU
Australia
Prior art keywords
och3
preparation
ch2ch3
hal
imidazole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU50083/85A
Other languages
English (en)
Other versions
AU5008385A (en
Inventor
Arja Leena Karjalainen
Arto Johannes Karjalainen
Kauko Oiva Antero Kurkela
Raimo Einari Virtanen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orion Oyj
Original Assignee
Farmos Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmos Yhtyma Oy filed Critical Farmos Yhtyma Oy
Publication of AU5008385A publication Critical patent/AU5008385A/en
Application granted granted Critical
Publication of AU586839B2 publication Critical patent/AU586839B2/en
Assigned to ORION-YHTYMA OY reassignment ORION-YHTYMA OY Alteration of Name(s) in Register under S187 Assignors: FARMOS-YHTYMA OY
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Lubricants (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Resins (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Dental Preparations (AREA)
  • Golf Clubs (AREA)
AU50083/85A 1984-11-23 1985-11-20 Substituted imidazole derivatives and their preparation and use Expired AU586839B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB08429578A GB2167408B (en) 1984-11-23 1984-11-23 Substituted imidazole derivatives and their preparation and use
GB8429578 1984-11-23

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU33329/89A Division AU3332989A (en) 1984-11-23 1989-04-21 Substituted imidazole derivatives and their preparation and use

Publications (2)

Publication Number Publication Date
AU5008385A AU5008385A (en) 1986-05-29
AU586839B2 true AU586839B2 (en) 1989-07-27

Family

ID=10570140

Family Applications (2)

Application Number Title Priority Date Filing Date
AU50083/85A Expired AU586839B2 (en) 1984-11-23 1985-11-20 Substituted imidazole derivatives and their preparation and use
AU33329/89A Abandoned AU3332989A (en) 1984-11-23 1989-04-21 Substituted imidazole derivatives and their preparation and use

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU33329/89A Abandoned AU3332989A (en) 1984-11-23 1989-04-21 Substituted imidazole derivatives and their preparation and use

Country Status (26)

Country Link
US (1) US4689339A (OSRAM)
EP (2) EP0183492B1 (OSRAM)
JP (1) JPH064597B2 (OSRAM)
KR (1) KR930004673B1 (OSRAM)
AT (2) ATE85050T1 (OSRAM)
AU (2) AU586839B2 (OSRAM)
BG (1) BG60762B2 (OSRAM)
CA (1) CA1268770C (OSRAM)
DD (1) DD258230A1 (OSRAM)
DE (2) DE3587045T2 (OSRAM)
DK (2) DK164903C (OSRAM)
ES (2) ES8704462A1 (OSRAM)
FI (1) FI80264C (OSRAM)
GB (1) GB2167408B (OSRAM)
GR (1) GR852817B (OSRAM)
HK (1) HK3592A (OSRAM)
HU (1) HU195189B (OSRAM)
IE (1) IE58165B1 (OSRAM)
IL (1) IL77111A (OSRAM)
NO (1) NO166585C (OSRAM)
NZ (1) NZ214258A (OSRAM)
PH (1) PH22016A (OSRAM)
PT (1) PT81542B (OSRAM)
SG (1) SG106891G (OSRAM)
SU (1) SU1424736A3 (OSRAM)
ZA (1) ZA858942B (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU600725B2 (en) * 1986-05-15 1990-08-23 Orion-Yhtyma Oy 4(5)-substituted imidazole derivatives, and intermediates and processes for their preparation
AU634556B2 (en) * 1986-05-15 1993-02-25 Orion-Yhtyma Oy 4(5)-substituted imidazole derivatives, and intermediates and processes for their preparation

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252162A4 (en) * 1986-01-28 1988-07-29 Mitsui Petrochemical Ind PROCESS FOR THE PREPARATION OF NON-SUBSTITUTED 2-IMIDAZOLES.
JP2576493B2 (ja) * 1987-03-20 1997-01-29 アイシン精機株式会社 原稿読取り装置に用いられる原稿トレ−
FR2621327B1 (fr) * 1987-10-06 1990-01-05 Commissariat Energie Atomique Procede de production et d'extraction de polysaccharides a partir d'une culture de porphyridium cruentum et dispositif pour la mise en oeuvre du procede
GB2225782A (en) * 1988-12-09 1990-06-13 Farmos Group Limited Imidazole derivatives useful for treatment of diabetes
GB8903437D0 (en) * 1989-02-15 1989-04-05 Erba Carlo Spa Imidazolyl derivatives of 3,4-dihydro-2h-1-benzothiopyran
CA1321751C (en) * 1989-02-21 1993-08-31 Eugene C. Crichlow Mechanism mediating ruminal stasis in ruminal lactic acidosis
DK344489D0 (da) * 1989-07-12 1989-07-12 Novo Nordisk As Substituerede 2-imidazoliner og fremstilling og anvendelse deraf
GB2244431A (en) * 1990-05-31 1991-12-04 Farmos Oy Treatment of age related memory impairment and other cognitive disorders
GB2256135B (en) 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
US5541211A (en) * 1991-06-18 1996-07-30 Orion-Yhtyma Oy Administration of atipamezole to elicit a yohimbine-like alpha-adrenoreceptor antagonistic noradrenergic transmission
ES2164054T3 (es) * 1991-11-05 2002-02-16 Smithkline Beecham Corp Antagonistas de receptores de endotelina.
GB9127050D0 (en) * 1991-12-20 1992-02-19 Orion Yhtymae Oy Substituted imidazole derivatives and their preparation and use
GB9127430D0 (en) * 1991-12-27 1992-02-19 Scras Benzofuranylimidazole derivatives
GB9312669D0 (en) * 1993-06-18 1993-08-04 Orion Yhtymae Oy New opticla isomers
GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles
FR2733983B1 (fr) * 1995-05-10 1997-08-01 Pf Medicament Procede de preparation d'un derive d'acide benzofurane carboxylque optiquement pur et son utilisation pour preparer l'efaroxan
GB9520150D0 (en) * 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
FR2754709B1 (fr) 1996-10-23 1999-03-05 Sanofi Sa Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
WO1998055439A1 (en) * 1997-06-05 1998-12-10 Venantius Limited Indane compounds and their pharmaceutical use
WO1999051593A1 (en) * 1998-04-02 1999-10-14 Ortho-Mcneil Pharmaceutical, Inc. 4-thionaphthyl-1h-imidazoles with alpha-2-adrenergic activity
FR2784989B1 (fr) * 1998-09-10 2002-09-27 Fabre Pierre Sante Derive d'ester d'acide 2-ethyl-2,3-dihydrobenzofurane- carboxylique, procede de preparation et utilisation pour la preparation de derives de l'efaroxan
WO2000042023A1 (en) * 1999-01-18 2000-07-20 Novo Nordisk A/S Substituted imidazoles, their preparation and use
US6388090B2 (en) 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
US6593324B2 (en) 2000-03-01 2003-07-15 Orion Corporation Dervatives of quinoline as alpha-2 antagonists
ATE302757T1 (de) 2000-05-08 2005-09-15 Orion Corp Neue polyzyklische indanylimidazole mit alpha2 adrenergik aktivität
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US6543389B2 (en) 2001-06-26 2003-04-08 Pfizer Inc. Insecticidal pet collar
CA2480695A1 (en) 2002-04-03 2003-10-09 Orion Corporation Polycyclic compounds as potent alpha2-adrenoceptor antagonists
US8188126B2 (en) 2002-05-16 2012-05-29 Pierre Fabre Medicament Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
FI116292B (fi) * 2003-01-08 2005-10-31 Juvantia Pharma Ltd Oy Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita
ES2315740T3 (es) * 2003-11-04 2009-04-01 Intervet International Bv Formulaciones ectoparasiticidas de espinosinas y pesticidas de azol.
FI20050657A0 (fi) * 2005-06-17 2005-06-17 Orion Corp Atipametsolin kiteytysmenetelmä
CA2624788C (en) 2005-10-12 2011-04-19 Unimed Pharmaceuticals, Llc Improved testosterone gel and method of use
US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
WO2008017591A1 (en) * 2006-08-08 2008-02-14 Intervet International B.V. Composition for enhanced antiparasitic activity
TWI457122B (zh) 2007-07-20 2014-10-21 Orion Corp 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3-二氫苯並[1,4]戴奧辛-2-基甲基衍生物
CL2008003553A1 (es) * 2007-12-05 2009-11-27 Grindeks Jsc Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
CR20160214A (es) 2013-11-05 2016-10-11 3M Innovative Properties Co Formulaciones de inyección con base en aceite de sésamo
TWI704145B (zh) 2015-06-05 2020-09-11 芬蘭商奧利安公司 新醫藥化合物
EP3370718B1 (en) 2015-11-05 2021-01-27 University Of Louisville Research Foundation, Inc. Local and regional anesthesia and analgesia
JP2019519582A (ja) 2016-06-29 2019-07-11 オリオン コーポレーション ベンゾジオキサン誘導体およびその医薬用途
CN113194750A (zh) 2018-12-21 2021-07-30 雀巢产品有限公司 用于在婴儿或幼儿中引起饱腹感、更好的睡眠和/或限制夜间觉醒的营养组合物
CN111978254A (zh) * 2019-05-22 2020-11-24 南京康德祥医药科技有限公司 一种阿替美唑盐酸盐的制备工艺
CN111925330A (zh) * 2020-09-07 2020-11-13 上海阿达玛斯试剂有限公司 一种阿替美唑的制备方法
EP4658639A1 (en) 2023-02-01 2025-12-10 Univerza V Ljubljani N,n-dialkyl-4-(2-ethylindan-2-yl)-1h-imidazole-1-carboxamides and related compounds for treatment of neurodegenerative diseases
LU103072B1 (en) 2023-02-15 2024-08-19 Univ Ljubljani N,N-DIALKYL-4-(2-ETHYLINDAN-2-YL)-lH-IMIDAZOLE-l-CARBOXAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2933962A1 (de) * 1979-08-22 1981-03-26 Hoechst Ag, 65929 Frankfurt Verfahren zur herstellung von 4,5-dichlor-imidazolen.
US4342775A (en) * 1980-03-04 1982-08-03 Farmitalia Carlo Erba S.P.A. 3-(1-Imidazolyl)-derivatives of 2,3-dihydro-4H-1-benzopyran
US4302469A (en) * 1980-09-10 1981-11-24 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
NZ201219A (en) * 1981-07-28 1984-10-19 Reckitt & Colmann Prod Ltd Dihydrobenzofuranyl-2-imidazolines and pharmaceutical compositions
ES8503669A1 (es) * 1982-07-05 1985-03-01 Erba Farmitalia Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
FR2539415B1 (fr) * 1983-01-14 1985-09-13 Adir Derives de la d-2 imidazoline, leur preparation et leur application en therapeutique
FR2542738A1 (fr) * 1983-03-18 1984-09-21 Synthelabo Indanyl-2 d2-imidazoline, procede pour la preparer, et compositions pharmaceutiques qui la contiennent

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU600725B2 (en) * 1986-05-15 1990-08-23 Orion-Yhtyma Oy 4(5)-substituted imidazole derivatives, and intermediates and processes for their preparation
AU634556B2 (en) * 1986-05-15 1993-02-25 Orion-Yhtyma Oy 4(5)-substituted imidazole derivatives, and intermediates and processes for their preparation

Also Published As

Publication number Publication date
JPH064597B2 (ja) 1994-01-19
FI854335A7 (fi) 1986-05-24
EP0183492A1 (en) 1986-06-04
EP0310745B1 (en) 1993-01-27
HK3592A (en) 1992-01-17
ATE47997T1 (de) 1989-12-15
BG60762B2 (bg) 1996-02-29
KR860004028A (ko) 1986-06-16
ATE85050T1 (de) 1993-02-15
ZA858942B (en) 1986-08-27
SU1424736A3 (ru) 1988-09-15
CA1268770C (en) 1990-05-08
AU5008385A (en) 1986-05-29
GB2167408A (en) 1986-05-29
PT81542B (pt) 1988-03-03
ES549178A0 (es) 1987-04-01
HU195189B (en) 1988-04-28
IL77111A (en) 1989-09-28
FI854335A0 (fi) 1985-11-05
DK58292D0 (da) 1992-05-04
ES557268A0 (es) 1987-12-16
NO166585C (no) 1991-08-21
DK540485A (da) 1986-05-24
US4689339A (en) 1987-08-25
EP0183492B1 (en) 1989-11-15
NO166585B (no) 1991-05-06
CA1266669A1 (en) 1990-03-13
GB2167408B (en) 1988-05-25
KR930004673B1 (ko) 1993-06-03
AU3332989A (en) 1989-08-10
EP0310745A3 (en) 1989-10-11
GB8429578D0 (en) 1985-01-03
GR852817B (OSRAM) 1986-03-21
DK58292A (da) 1992-05-04
HUT38913A (en) 1986-07-28
EP0310745A2 (en) 1989-04-12
ES8801248A1 (es) 1987-12-16
ES8704462A1 (es) 1987-04-01
IL77111A0 (en) 1986-04-29
DE3587045D1 (de) 1993-03-11
IE58165B1 (en) 1993-07-28
DK164903B (da) 1992-09-07
NZ214258A (en) 1989-02-24
DK540485D0 (da) 1985-11-22
FI80264B (fi) 1990-01-31
JPS61143366A (ja) 1986-07-01
IE852929L (en) 1986-05-23
DE3587045T2 (de) 1993-06-03
PT81542A (en) 1985-12-01
NO854671L (no) 1986-05-26
PH22016A (en) 1988-05-13
FI80264C (fi) 1990-05-10
DK164903C (da) 1993-01-25
SG106891G (en) 1992-02-14
DD258230A1 (de) 1988-07-13
DE3574252D1 (en) 1989-12-21

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