DE3485860D1 - Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate. - Google Patents
Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.Info
- Publication number
- DE3485860D1 DE3485860D1 DE8484116421T DE3485860T DE3485860D1 DE 3485860 D1 DE3485860 D1 DE 3485860D1 DE 8484116421 T DE8484116421 T DE 8484116421T DE 3485860 T DE3485860 T DE 3485860T DE 3485860 D1 DE3485860 D1 DE 3485860D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- pharmaceutical preparations
- cephalosporine compounds
- cephalosporine
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
- C07D239/40—One sulfur atom as doubly bound sulfur atom or as unsubstituted mercapto radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58247251A JPS60142987A (ja) | 1983-12-29 | 1983-12-29 | セフアロスポリン誘導体 |
JP59249193A JPS61126089A (ja) | 1984-11-26 | 1984-11-26 | セフアロスポリン誘導体、その製法およびそれらを含有する抗菌剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3485860D1 true DE3485860D1 (de) | 1992-09-10 |
DE3485860T2 DE3485860T2 (de) | 1993-01-14 |
Family
ID=26538169
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE198484116421T Pending DE150507T1 (de) | 1983-12-29 | 1984-12-28 | Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate. |
DE8484116421T Expired - Fee Related DE3485860T2 (de) | 1983-12-29 | 1984-12-28 | Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE198484116421T Pending DE150507T1 (de) | 1983-12-29 | 1984-12-28 | Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate. |
Country Status (3)
Country | Link |
---|---|
US (1) | US5064953A (de) |
EP (1) | EP0150507B1 (de) |
DE (2) | DE150507T1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61267583A (ja) * | 1985-01-21 | 1986-11-27 | Sankei Yakuhin Kk | 新規なβ−ラクタム抗生物質 |
NZ215527A (en) * | 1985-04-01 | 1989-06-28 | Mochida Pharm Co Ltd | Cephalosporin derivatives and pharmaceutical compositions |
US4840945A (en) * | 1985-04-01 | 1989-06-20 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
EP0359291A1 (de) * | 1985-04-01 | 1990-03-21 | Mochida Pharmaceutical Co., Ltd. | Cephalosporinderivate |
DE3689762T2 (de) * | 1985-12-13 | 1994-08-18 | Takeda Chemical Industries Ltd | Antibakterielle Verbindungen, ihre Herstellung und Verwendung. |
EP0228061A3 (de) * | 1985-12-23 | 1988-12-14 | Takeda Chemical Industries, Ltd. | Cephem-Verbindungen |
EP0229369A3 (de) * | 1985-12-26 | 1988-12-21 | Takeda Chemical Industries, Ltd. | Cephalosporinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate |
FI872879A (fi) * | 1986-07-21 | 1988-01-22 | Sankei Yakuhin Kk | --laktamfoerening, foerfarande foer dess framstaellning, denna innehaollande laekemedelskomposition foer behandling av sjukdom med bakterieinfektion samt mellanprodukter foer dess syntes. |
AT392969B (de) * | 1986-11-17 | 1991-07-25 | Sankei Yakuhin Kk | Beta-lactamverbindungen, verfahren zu ihrer herstellung, dieselben enthaltende pharmazeutischepraeparate zur behandlung von durch bakterien verursachte infektionskrankheiten |
US4880798A (en) * | 1986-11-25 | 1989-11-14 | Mochida Pharmaceutical Co., Ltd. | Cephalosporin derivatives |
JPS63132893A (ja) * | 1986-11-25 | 1988-06-04 | Mochida Pharmaceut Co Ltd | 新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤 |
MC1921A1 (fr) * | 1987-04-10 | 1989-04-06 | Sankei Yakuhin Kk | Derives acyles |
DK170088A (da) * | 1987-04-10 | 1988-10-11 | Hoffmann La Roche | Acylderivater |
NZ225383A (en) * | 1987-08-07 | 1990-03-27 | Sankei Yakuhin Kk | Cephalosporin derivatives and pharmaceutical compositions |
US5138066A (en) * | 1987-08-14 | 1992-08-11 | Hoffmann-La Roche, Inc. | Intermediates for cephalosporins with sulfur-containing oxyimino side chain |
US5073550A (en) * | 1987-08-14 | 1991-12-17 | Hoffmann-La Roche Inc. | Cephalosphorins with sulfur-containing oxyimino side chain |
EP0303172A3 (de) * | 1987-08-14 | 1991-05-15 | F. Hoffmann-La Roche Ag | Oxyimino-Cephalosporine |
EP0333082A3 (de) * | 1988-03-15 | 1991-05-02 | Takeda Chemical Industries, Ltd. | Cephemverbindungen, ihre Herstellung und Anwendung |
JPH02191285A (ja) * | 1988-06-28 | 1990-07-27 | Ajinomoto Co Inc | アミド化合物の製造方法 |
HU208694B (en) * | 1991-02-22 | 1993-12-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing 1,2,4-triazolo (1,5-a) pyridine derivatives and their carbocycle-, tetrahydro-thio furane-, tetrahydro - thiopyrane-, or tetrahydro-pyridine-condensated derivatives |
US5155221A (en) * | 1992-03-06 | 1992-10-13 | Dowelanco | Process for the preparation of 2-alkylthio-4-hydrazino-5-fluoropyrimidines |
EP0582261A1 (de) * | 1992-08-01 | 1994-02-09 | Lucky Ltd. | Cephalosporine und Verfahren für ihre Herstellung |
EP2142551B1 (de) * | 2007-04-17 | 2015-10-14 | Bristol-Myers Squibb Company | KONDENSIERTE HETEROCYCLISCHE Verbindungen als Hemmer der BETA-HYDROXYSTEROID-DEHYDROGENASE -TYP I |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE566543A (de) * | 1957-04-09 | |||
JPS503170B1 (de) * | 1970-06-11 | 1975-01-31 | ||
GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
HU165117B (de) * | 1971-08-12 | 1974-06-28 | ||
US3907786A (en) * | 1973-09-04 | 1975-09-23 | Bristol Myers Co | 7-{8 {60 -(2-aminomethyl-1,4-cyclohexadienyl)acetamido{9 -3-heterocyclic-thiomethyl-3-cephem-4-carboxylic acids and salts |
DK154939C (da) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
AU1303576A (en) * | 1975-04-21 | 1977-10-20 | Erba Carlo Spa | Cephalosporins |
NZ189245A (en) * | 1976-01-23 | 1979-12-11 | Roussel Uclaf | Substituted 2-(2-amino-4-thiazoyl)-2-hydroxyimino-acetic acid derivatives |
GB1576625A (en) * | 1976-04-12 | 1980-10-08 | Fujisawa Pharmaceutical Co | Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof |
SE439312B (sv) * | 1977-03-25 | 1985-06-10 | Roussel Uclaf | Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra |
DE2716677C2 (de) * | 1977-04-15 | 1985-10-10 | Hoechst Ag, 6230 Frankfurt | Cephemderivate und Verfahren zu ihrer Herstellung |
DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
FR2400519A1 (fr) * | 1977-08-17 | 1979-03-16 | Roussel Uclaf | Forme cristalline du sel de sodium d'un derive oximine de l'acide 7-amino-thiazolyl acetamido cephalosporanique, son procede de preparation et son application comme medicament |
FR2432521A1 (fr) * | 1978-03-31 | 1980-02-29 | Roussel Uclaf | Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
AR229882A1 (es) * | 1978-05-26 | 1983-12-30 | Glaxo Group Ltd | Procedimiento para preparar antibioticos de cefalosporina |
US4372952A (en) * | 1978-07-31 | 1983-02-08 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
US4331666A (en) * | 1979-05-11 | 1982-05-25 | Farmitalia Carlo Erba S.P.A. | 3-[(8-Carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid |
US4271157A (en) * | 1980-02-28 | 1981-06-02 | E. R. Squibb & Sons, Inc. | Imidazole derivatives of 7-[(2-amino-4-thiazolyl)-oximino] cephalosporins |
EP0037380B1 (de) * | 1980-03-28 | 1984-09-12 | BIOCHEMIE Gesellschaft m.b.H. | Verfahren zum Herstellen von Cephalosporin-Antibiotika und Zwischenprodukte zur Verwendung in diesem Verfahren und ihre Herstellung |
US4316024A (en) * | 1980-09-15 | 1982-02-16 | Bristol-Myers Company | Dioxo piperazine compounds |
JPS6011917B2 (ja) * | 1981-04-09 | 1985-03-28 | 山之内製薬株式会社 | 新規なセファロスポリン化合物 |
US4436912A (en) * | 1981-09-08 | 1984-03-13 | Eli Lilly And Company | 7-[2-(2-Aminooxazol-4-yl)-2-(oximino)acetamido cephalosporin antibiotics and intermediates therefor |
JPS5849382A (ja) * | 1981-09-18 | 1983-03-23 | Kyowa Hakko Kogyo Co Ltd | β−ラクタム化合物 |
US4526977A (en) * | 1981-10-07 | 1985-07-02 | American Home Products Corporation | 2-(3-Amino-5-isoxazolyl)-2-oxyimino-acetic acids |
US4594417A (en) * | 1981-10-30 | 1986-06-10 | Eli Lilly Company | Crystalline antibiotic salt |
DE3143537A1 (de) * | 1981-11-03 | 1983-05-11 | Hoechst Ag, 6230 Frankfurt | Kristalline salze von cefodizim und verfahren zu ihrer herstellung |
FR2517309A1 (fr) * | 1981-12-01 | 1983-06-03 | Sanofi Sa | Nouveaux derives de cephalosporines substitues en position 3 par un groupe heterocycle thiomethyl; procede de preparation desdits composes et compositions pharmaceutiques en contenant |
EP0081971A3 (de) * | 1981-12-08 | 1984-09-26 | Tanabe Seiyaku Co., Ltd. | Cephalosporinderivate und Verfahren zu ihrer Herstellung |
EP0082501A1 (de) * | 1981-12-18 | 1983-06-29 | Kyowa Hakko Kogyo Co., Ltd | Beta-Lactam-Verbindung und sie enthaltende pharmazeutische Zusammensetzung |
DE3207840A1 (de) * | 1982-03-04 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | "cephalosporinderivate und verfahren zu ihrer herstellung" |
US4500526A (en) * | 1982-06-28 | 1985-02-19 | Bristol-Myers Company | Cephalosporin derivatives |
US4616081A (en) * | 1982-07-07 | 1986-10-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Cephalosporin compounds |
JPS5946292A (ja) * | 1982-09-09 | 1984-03-15 | Otsuka Chem Co Ltd | 2−置換セフエム誘導体の製造法 |
JPS5973575A (ja) * | 1982-10-05 | 1984-04-25 | Shionogi & Co Ltd | プロピニルアミノイソオキサゾ−ル誘導体 |
DE3248281A1 (de) * | 1982-12-28 | 1984-06-28 | Hoechst Ag, 6230 Frankfurt | Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung |
JPS59155391A (ja) * | 1983-02-22 | 1984-09-04 | Tanabe Seiyaku Co Ltd | 新規セファロスポリン誘導体 |
JPS59167576A (ja) * | 1983-03-15 | 1984-09-21 | Kyowa Hakko Kogyo Co Ltd | β−ラクタム化合物 |
DE3330605A1 (de) * | 1983-08-25 | 1985-03-14 | Hoechst Ag, 6230 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
JPS6066987A (ja) * | 1983-09-20 | 1985-04-17 | Takeda Chem Ind Ltd | 抗生物質taν−547,その製造法および微生物 |
US4600773A (en) * | 1983-12-01 | 1986-07-15 | Eli Lilly And Company | Crystalline cephalexin hydrochloride monohydrate |
JPS61126089A (ja) * | 1984-11-26 | 1986-06-13 | Mochida Pharmaceut Co Ltd | セフアロスポリン誘導体、その製法およびそれらを含有する抗菌剤 |
JPS61267583A (ja) * | 1985-01-21 | 1986-11-27 | Sankei Yakuhin Kk | 新規なβ−ラクタム抗生物質 |
NZ215527A (en) * | 1985-04-01 | 1989-06-28 | Mochida Pharm Co Ltd | Cephalosporin derivatives and pharmaceutical compositions |
-
1984
- 1984-12-28 DE DE198484116421T patent/DE150507T1/de active Pending
- 1984-12-28 DE DE8484116421T patent/DE3485860T2/de not_active Expired - Fee Related
- 1984-12-28 EP EP84116421A patent/EP0150507B1/de not_active Expired - Lifetime
-
1989
- 1989-09-26 US US07/412,992 patent/US5064953A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0150507A3 (en) | 1986-08-13 |
EP0150507B1 (de) | 1992-08-05 |
DE3485860T2 (de) | 1993-01-14 |
DE150507T1 (de) | 1987-02-26 |
US5064953A (en) | 1991-11-12 |
EP0150507A2 (de) | 1985-08-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |