DE3471940D1 - Homologues from aprotinine whose lys 15 amino acid is substituted by other amino acids, process for their preparation and their use as medicaments - Google Patents

Homologues from aprotinine whose lys 15 amino acid is substituted by other amino acids, process for their preparation and their use as medicaments

Info

Publication number
DE3471940D1
DE3471940D1 DE8484108293T DE3471940T DE3471940D1 DE 3471940 D1 DE3471940 D1 DE 3471940D1 DE 8484108293 T DE8484108293 T DE 8484108293T DE 3471940 T DE3471940 T DE 3471940T DE 3471940 D1 DE3471940 D1 DE 3471940D1
Authority
DE
Germany
Prior art keywords
cooh
lys
homologues
amino acids
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484108293T
Other languages
German (de)
English (en)
Inventor
Harald Prof Dr Tschesche
Herbert Dr Wenzel
Rainer Dr Schmuck
Eugen Dr Schnabel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19833339693 external-priority patent/DE3339693A1/de
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE8484108293T priority Critical patent/DE3471940D1/de
Application granted granted Critical
Publication of DE3471940D1 publication Critical patent/DE3471940D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DE8484108293T 1983-07-28 1984-07-14 Homologues from aprotinine whose lys 15 amino acid is substituted by other amino acids, process for their preparation and their use as medicaments Expired DE3471940D1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE8484108293T DE3471940D1 (en) 1983-07-28 1984-07-14 Homologues from aprotinine whose lys 15 amino acid is substituted by other amino acids, process for their preparation and their use as medicaments

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE3327277 1983-07-28
DE19833339693 DE3339693A1 (de) 1983-11-03 1983-11-03 Homologe des aprotinin mit anderen aminosaeuren in position 15 anstelle von lysin, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE8484108293T DE3471940D1 (en) 1983-07-28 1984-07-14 Homologues from aprotinine whose lys 15 amino acid is substituted by other amino acids, process for their preparation and their use as medicaments

Publications (1)

Publication Number Publication Date
DE3471940D1 true DE3471940D1 (en) 1988-07-14

Family

ID=25812701

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484108293T Expired DE3471940D1 (en) 1983-07-28 1984-07-14 Homologues from aprotinine whose lys 15 amino acid is substituted by other amino acids, process for their preparation and their use as medicaments

Country Status (14)

Country Link
US (1) US4595674A (forum.php)
EP (1) EP0132732B1 (forum.php)
JP (1) JPH0686479B2 (forum.php)
KR (1) KR890004784B1 (forum.php)
AU (1) AU560584B2 (forum.php)
CA (1) CA1238000A (forum.php)
DE (1) DE3471940D1 (forum.php)
DK (2) DK171895B1 (forum.php)
ES (1) ES8601858A1 (forum.php)
GR (1) GR82265B (forum.php)
HU (1) HU199880B (forum.php)
IE (1) IE57628B1 (forum.php)
IL (1) IL72494A (forum.php)
NZ (1) NZ209001A (forum.php)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291662B1 (en) 1984-12-05 2001-09-18 Amgen Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences
US5871956A (en) * 1984-12-06 1999-02-16 Amgen Inc. Recombinant methods for production of serine inhibitors and DNA sequences useful for same
DE3587526T3 (de) * 1984-12-06 2002-08-08 Amgen Inc.(N.D.Ges D. Staates Delaware), Thousand Oaks Serinproteaseinhibitoren und isolierungsverfahren dazu.
US6132990A (en) * 1984-12-06 2000-10-17 Amgen Boulder Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences useful for same
US5900400A (en) * 1984-12-06 1999-05-04 Amgen Inc. Serine protease inhibitor analogs
FI854634A0 (fi) * 1985-11-22 1985-11-22 Labsystems Oy Foerfarande foer bestaemning av proteolytisk aktivitet.
GB2188322A (en) * 1986-03-26 1987-09-30 Bayer Ag Aprotinin and analogues thereof produced by a recombinant host
GB2188933A (en) * 1986-04-10 1987-10-14 Bayer Ag Expression vectors for production of polypeptides, method for enhanced expression of polypeptides, hosts containing the expression vectors, products manufactured thereby
US5223482A (en) * 1986-11-17 1993-06-29 Scios Nova Inc. Recombinant Alzheimer's protease inhibitory amyloid protein and method of use
US5187153A (en) * 1986-11-17 1993-02-16 Scios Nova Inc. Methods of treatment using Alzheimer's amyloid polypeptide derivatives
US5220013A (en) * 1986-11-17 1993-06-15 Scios Nova Inc. DNA sequence useful for the detection of Alzheimer's disease
GB2199582A (en) * 1987-01-07 1988-07-13 Bayer Ag Analogues of pancreatic secretory trypsin inhibitor
US5032573A (en) * 1987-03-23 1991-07-16 Bayer Aktiengesellschaft Homologs of aprotinin produced from a recombinant host, process, expression vector and recombinant host therefor and pharmaceutical use thereof
JP2656944B2 (ja) * 1987-04-30 1997-09-24 クーパー ラボラトリーズ タンパク質性治療剤のエアロゾール化
DE3724570A1 (de) * 1987-06-27 1989-01-05 Bayer Ag Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist
GB2208511A (en) * 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
DK225488D0 (da) * 1988-04-26 1988-04-26 Novo Industri As Polypeptid
US5591603A (en) * 1987-08-28 1997-01-07 Novo Nordisk A/S Process for preparing aprotinin and aprotinin analogs in yeast cells
US20060134087A1 (en) * 1988-09-02 2006-06-22 Dyax Corp. ITI-D1 Kunitz domain mutants as hNE inhibitors
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US4994367A (en) * 1988-10-07 1991-02-19 East Carolina University Extended shelf life platelet preparations and process for preparing the same
US5866413A (en) * 1989-03-06 1999-02-02 Board Of Regents Of The University Of Texas System Pai-1 mutants
ES2185529T3 (es) * 1989-03-06 2003-05-01 Univ Texas T-pa resistente a la serpina; mutante; genes.
DE59007737D1 (de) * 1989-05-13 1995-01-05 Bayer Ag Proteinaseninhibitoren, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel.
US7413537B2 (en) * 1989-09-01 2008-08-19 Dyax Corp. Directed evolution of disulfide-bonded micro-proteins
AU8740491A (en) * 1990-09-28 1992-04-28 Protein Engineering Corporation Proteinaceous anti-dental plaque agents
DE69233760D1 (de) * 1991-03-01 2009-06-25 Dyax Corp Inhibitoren der menschlichen Elastase von Neutrophilen
WO1992015677A1 (en) * 1991-03-01 1992-09-17 Protein Engineering Corporation Process for the development of binding mini-proteins
WO1994001461A1 (en) * 1992-07-13 1994-01-20 Corvas International, Inc. BOVINE PANCREATIC TRYPSIN INHIBITOR DERIVED INHIBITORS OF FACTOR Xa
US6869925B1 (en) * 1992-09-09 2005-03-22 Amgen Inc. Inhibition of retrovirus infection
TW492975B (en) * 1993-07-26 2002-07-01 Novartis Ag Tryptase inhibitor
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
DE69533544T2 (de) * 1994-01-11 2006-02-23 Dyax Corp., Cambridge Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
US6017880A (en) * 1994-03-09 2000-01-25 Amgen Inc. Inhibition of retrovirus infection
DE4417353A1 (de) * 1994-05-18 1996-01-25 Bayer Ag Verfahren zur Herstellung von rekombinantem Aprotinin und rekombinanten Aprotinin Varianten mit der natürlichen N-terminlaen Sequenz
DE19629982A1 (de) 1996-07-25 1998-01-29 Bayer Ag Aprotinin-Varianten mit verbesserten Eigenschaften
GB0103765D0 (en) * 2001-02-15 2001-04-04 Affitech As Assay
KR20040004562A (ko) * 2001-03-27 2004-01-13 어웨어, 인크. 수신기 투과성 ｑ-모드
CA2453264A1 (en) * 2001-07-10 2003-04-24 Omnio Ab Novel drug targets for arthritis
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
WO2003103475A2 (en) 2002-06-07 2003-12-18 Dyax Corp. Prevention and reduction of blood loss
JP2005537006A (ja) 2002-08-28 2005-12-08 ダイアックス、コープ 臓器及び組織の保存方法
ES2362424T3 (es) * 2003-01-07 2011-07-05 Dyax Corporation Biblioteca del dominio kunitz.
US6989369B2 (en) * 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
US7432238B2 (en) * 2004-04-16 2008-10-07 Stc.Unm Human Kunitz-type inhibitor with enhanced antifibrinolytic activity
US7910550B2 (en) * 2004-04-16 2011-03-22 Stc.Unm Human kunitz-type inhibitor with enhanced antifibrinolytic activity
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US20060118491A1 (en) * 2004-12-03 2006-06-08 Gjerde Douglas T Method and device for desalting an analyte
US20090223893A1 (en) * 2005-12-01 2009-09-10 Gjerde Douglas T Method and Device for Desalting an Analyte
ES2594607T3 (es) 2005-12-29 2016-12-21 The Regents Of The University Of California Procedimientos y composiciones relacionadas con el dominio Kunitz I mutante de TFPI-2
WO2008110301A1 (de) * 2007-03-13 2008-09-18 Bayer Schering Pharma Aktiengesellschaft Aprotinin-varianten mit verbesserten eigenschaften
AU2010203712A1 (en) * 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
EP3459564B1 (en) 2010-01-06 2021-10-27 Takeda Pharmaceutical Company Limited Plasma kallikrein binding proteins
CN105713092B (zh) 2011-01-06 2019-09-10 戴埃克斯有限公司 血浆前激肽释放酶结合蛋白
JP6719384B2 (ja) 2014-03-27 2020-07-15 ダイアックス コーポレーション 糖尿病黄斑浮腫の治療のための組成物および方法
CN116077648A (zh) 2015-12-11 2023-05-09 武田药品工业株式会社 血浆激肽释放酶抑制剂及其治疗遗传性血管性水肿发作的用途

Also Published As

Publication number Publication date
DK171441B1 (da) 1996-10-28
AU560584B2 (en) 1987-04-09
NZ209001A (en) 1989-02-24
IE841954L (en) 1985-01-28
AU3000184A (en) 1985-01-31
KR890004784B1 (ko) 1989-11-27
KR850001288A (ko) 1985-03-18
GR82265B (forum.php) 1984-12-13
DK60993A (da) 1993-05-27
HUT34515A (en) 1985-03-28
IL72494A (en) 1988-02-29
EP0132732A2 (de) 1985-02-13
DK369284A (da) 1985-01-29
IE57628B1 (en) 1993-02-10
CA1238000A (en) 1988-06-14
ES534659A0 (es) 1985-11-16
ES8601858A1 (es) 1985-11-16
HU199880B (en) 1990-03-28
US4595674A (en) 1986-06-17
DK60993D0 (da) 1993-05-27
IL72494A0 (en) 1984-11-30
DK369284D0 (da) 1984-07-27
DK171895B1 (da) 1997-08-04
EP0132732A3 (en) 1986-02-05
EP0132732B1 (de) 1988-06-08
JPH0686479B2 (ja) 1994-11-02
JPS6056999A (ja) 1985-04-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee