AU2526884A - Growth hormone releasing factor analogues - Google Patents

Growth hormone releasing factor analogues

Info

Publication number
AU2526884A
AU2526884A AU25268/84A AU2526884A AU2526884A AU 2526884 A AU2526884 A AU 2526884A AU 25268/84 A AU25268/84 A AU 25268/84A AU 2526884 A AU2526884 A AU 2526884A AU 2526884 A AU2526884 A AU 2526884A
Authority
AU
Australia
Prior art keywords
grf
growth hormone
hormone releasing
releasing factor
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU25268/84A
Other versions
AU574064B2 (en
Inventor
Arthur Martin Felix
Edgar Philip Heimer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU2526884A publication Critical patent/AU2526884A/en
Application granted granted Critical
Publication of AU574064B2 publication Critical patent/AU574064B2/en
Assigned to F. HOFFMANN-LA ROCHE AG reassignment F. HOFFMANN-LA ROCHE AG Alteration of Name(s) in Register under S187 Assignors: F. HOFFMANN-LA ROCHE AG
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth-hormone releasing factors (GH-RF) (Somatoliberin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1. Claims for the Contracting States : BE CH DE FR GB IT LI LU NL SE Polypeptides of the general formula (Leu**27 )-GRF wherein GRF represents at least the first 28 amino acids of the full sequence of natural human growth hormone releasing factor and wherein the carboxyl terminus of the molecule is present in free form or as the amide. 1. Claims for the Contracting State : AT A method for the preparation of polypeptides of the general formula (Leu**27 )-GRF wherein GRF represents at least the first 28 amino acids of the full sequence of natural human growth hormone releasing factor and wherein the carboxyl terminus of the molecule is present in free form or as the amide, characterized in that (a) the protecting groups of a protected polypeptide of corresponding amino acid sequence, which has been synthetized according to the liquid phase method, are cleaved off in a manner known per se, or (b) a carrier resin-bound protected polypeptide of corresponding amino acid sequence, which has been synthetized according to the solid phase method, is treated with anhydrous liquid HF.
AU25268/84A 1983-03-07 1984-03-05 Growth hormone releasing factor analogues Ceased AU574064B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47270083A 1983-03-07 1983-03-07
US472700 1983-03-07

Publications (2)

Publication Number Publication Date
AU2526884A true AU2526884A (en) 1984-09-13
AU574064B2 AU574064B2 (en) 1988-06-30

Family

ID=23876594

Family Applications (1)

Application Number Title Priority Date Filing Date
AU25268/84A Ceased AU574064B2 (en) 1983-03-07 1984-03-05 Growth hormone releasing factor analogues

Country Status (11)

Country Link
EP (1) EP0121764B1 (en)
JP (1) JPH0786120B2 (en)
AT (1) ATE53220T1 (en)
AU (1) AU574064B2 (en)
CA (1) CA1254000A (en)
DE (1) DE3482387D1 (en)
DK (1) DK162130C (en)
IE (1) IE57097B1 (en)
IL (1) IL71150A (en)
NZ (1) NZ207378A (en)
ZA (1) ZA841638B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU568146B2 (en) * 1983-09-21 1987-12-17 Eli Lilly And Company (hse)27, (met(0)27 & (met(s-me))27 growth hormone release factor analogues
AU572171B2 (en) * 1983-07-27 1988-05-05 Hoechst A.G. Polypeptides
AU577057B2 (en) * 1983-09-13 1988-09-15 Salk Institute For Biological Studies, The Grf analogues

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL70530A (en) * 1983-01-13 1986-09-30 Salk Inst For Biological Studi Synthetic peptides having growth hormone releasing factor activity and compositions containing them
BG49718A3 (en) * 1983-07-15 1992-01-15 Bio Technology General Corp Method for preparing of polypeptid with superoxiddismutasne activitty
AU575843B2 (en) * 1983-08-10 1988-08-11 The Administrators Of The Tulane Eductional Fund Growth hormone releasing peptides
CA1340265C (en) * 1985-01-18 1998-12-15 Kirston E. Koths Oxidation resistant muteins
US4734399A (en) * 1985-08-06 1988-03-29 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
ES2001203A6 (en) * 1985-08-12 1988-05-01 Syntex Inc Bovine growth hormone releasing factor derivative.
EP0448513A3 (en) * 1990-03-21 1991-12-27 Japat Ltd Process for production of peptidylglycine alpha-hydroxylating monooxygenase and use thereof
AU656144B2 (en) * 1990-06-29 1995-01-27 F. Hoffmann-La Roche Ag Histidine substituted growth hormone releasing factor analogs
DE69108192T2 (en) * 1990-12-10 1995-07-20 Hoffmann La Roche Process for the enzymatic production of GRF (1-44) NH2.
CA2084061A1 (en) * 1991-04-09 1992-10-10 Arthur M. Felix Growth hormone releasing factor analogs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL70530A (en) * 1983-01-13 1986-09-30 Salk Inst For Biological Studi Synthetic peptides having growth hormone releasing factor activity and compositions containing them
US4617149A (en) * 1983-09-21 1986-10-14 Eli Lilly And Company Growth hormone release factor analogs

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU572171B2 (en) * 1983-07-27 1988-05-05 Hoechst A.G. Polypeptides
AU577057B2 (en) * 1983-09-13 1988-09-15 Salk Institute For Biological Studies, The Grf analogues
AU568146B2 (en) * 1983-09-21 1987-12-17 Eli Lilly And Company (hse)27, (met(0)27 & (met(s-me))27 growth hormone release factor analogues

Also Published As

Publication number Publication date
JPS59176238A (en) 1984-10-05
DK151884D0 (en) 1984-03-05
AU574064B2 (en) 1988-06-30
EP0121764B1 (en) 1990-05-30
DK162130C (en) 1992-03-02
JPH0786120B2 (en) 1995-09-20
ZA841638B (en) 1984-10-31
CA1254000A (en) 1989-05-09
IE57097B1 (en) 1992-04-22
DE3482387D1 (en) 1990-07-05
IL71150A0 (en) 1984-06-29
IE840537L (en) 1984-09-07
DK151884A (en) 1984-09-08
IL71150A (en) 1987-02-27
ATE53220T1 (en) 1990-06-15
NZ207378A (en) 1989-05-29
DK162130B (en) 1991-09-23
EP0121764A3 (en) 1985-12-04
EP0121764A2 (en) 1984-10-17

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