NZ207378A - Leu 27 - and nle 27 -grf (human growth hormone releasing factor), preparation and pharmaceutical composition - Google Patents
Leu 27 - and nle 27 -grf (human growth hormone releasing factor), preparation and pharmaceutical compositionInfo
- Publication number
- NZ207378A NZ207378A NZ207378A NZ20737884A NZ207378A NZ 207378 A NZ207378 A NZ 207378A NZ 207378 A NZ207378 A NZ 207378A NZ 20737884 A NZ20737884 A NZ 20737884A NZ 207378 A NZ207378 A NZ 207378A
- Authority
- NZ
- New Zealand
- Prior art keywords
- grf
- leu
- growth hormone
- human growth
- hormone releasing
- Prior art date
Links
- 101000825742 Homo sapiens Somatoliberin Proteins 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 101710142969 Somatoliberin Proteins 0.000 abstract 2
- 102100022831 Somatoliberin Human genes 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 1
- 239000007791 liquid phase Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
1. Claims for the Contracting States : BE CH DE FR GB IT LI LU NL SE Polypeptides of the general formula (Leu**27 )-GRF wherein GRF represents at least the first 28 amino acids of the full sequence of natural human growth hormone releasing factor and wherein the carboxyl terminus of the molecule is present in free form or as the amide. 1. Claims for the Contracting State : AT A method for the preparation of polypeptides of the general formula (Leu**27 )-GRF wherein GRF represents at least the first 28 amino acids of the full sequence of natural human growth hormone releasing factor and wherein the carboxyl terminus of the molecule is present in free form or as the amide, characterized in that (a) the protecting groups of a protected polypeptide of corresponding amino acid sequence, which has been synthetized according to the liquid phase method, are cleaved off in a manner known per se, or (b) a carrier resin-bound protected polypeptide of corresponding amino acid sequence, which has been synthetized according to the solid phase method, is treated with anhydrous liquid HF.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47270083A | 1983-03-07 | 1983-03-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ207378A true NZ207378A (en) | 1989-05-29 |
Family
ID=23876594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ207378A NZ207378A (en) | 1983-03-07 | 1984-03-05 | Leu 27 - and nle 27 -grf (human growth hormone releasing factor), preparation and pharmaceutical composition |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0121764B1 (en) |
| JP (1) | JPH0786120B2 (en) |
| AT (1) | ATE53220T1 (en) |
| AU (1) | AU574064B2 (en) |
| CA (1) | CA1254000A (en) |
| DE (1) | DE3482387D1 (en) |
| DK (1) | DK162130C (en) |
| IE (1) | IE57097B1 (en) |
| IL (1) | IL71150A (en) |
| NZ (1) | NZ207378A (en) |
| ZA (1) | ZA841638B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4518586A (en) * | 1983-01-13 | 1985-05-21 | The Salk Institute For Biological Studies | GRF Analogs III |
| IL70530A (en) * | 1983-01-13 | 1986-09-30 | Salk Inst For Biological Studi | Synthetic peptides having growth hormone releasing factor activity and compositions containing them |
| BG49718A3 (en) * | 1983-07-15 | 1992-01-15 | Bio- Technology General Corp | Method for preparing of polypeptid with superoxiddismutasne activitty |
| DE3327007A1 (en) * | 1983-07-27 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | PRODUCTION OF POLYPEPTIDES WITH AN ACID-CARBOXYTERMINUS |
| AU575843B2 (en) * | 1983-08-10 | 1988-08-11 | The Administrators Of The Tulane Eductional Fund | Growth hormone releasing peptides |
| US4617149A (en) * | 1983-09-21 | 1986-10-14 | Eli Lilly And Company | Growth hormone release factor analogs |
| CA1340265C (en) * | 1985-01-18 | 1998-12-15 | Kirston E. Koths | Oxidation resistant muteins |
| US4734399A (en) * | 1985-08-06 | 1988-03-29 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
| ZA866026B (en) * | 1985-08-12 | 1988-04-27 | Syntex Inc | Bovine growth hormone releasing factor derivative |
| EP0448513A3 (en) * | 1990-03-21 | 1991-12-27 | Japat Ltd | Process for production of peptidylglycine alpha-hydroxylating monooxygenase and use thereof |
| CA2085362A1 (en) * | 1990-06-29 | 1991-12-30 | Arthur M. Felix | Histidine substituted growth hormone releasing factor analogs |
| DK0490249T3 (en) * | 1990-12-10 | 1995-05-29 | Hoffmann La Roche | Process for Enzymatic Preparation of GRF (1-44) -NH2 |
| CA2084061A1 (en) * | 1991-04-09 | 1992-10-10 | Arthur M. Felix | Growth hormone releasing factor analogs |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL70530A (en) * | 1983-01-13 | 1986-09-30 | Salk Inst For Biological Studi | Synthetic peptides having growth hormone releasing factor activity and compositions containing them |
| US4617149A (en) * | 1983-09-21 | 1986-10-14 | Eli Lilly And Company | Growth hormone release factor analogs |
-
1984
- 1984-03-05 DK DK151884A patent/DK162130C/en not_active IP Right Cessation
- 1984-03-05 EP EP84102383A patent/EP0121764B1/en not_active Expired - Lifetime
- 1984-03-05 AT AT84102383T patent/ATE53220T1/en not_active IP Right Cessation
- 1984-03-05 IL IL71150A patent/IL71150A/en not_active IP Right Cessation
- 1984-03-05 ZA ZA841638A patent/ZA841638B/en unknown
- 1984-03-05 DE DE8484102383T patent/DE3482387D1/en not_active Expired - Fee Related
- 1984-03-05 CA CA000448864A patent/CA1254000A/en not_active Expired
- 1984-03-05 NZ NZ207378A patent/NZ207378A/en unknown
- 1984-03-05 AU AU25268/84A patent/AU574064B2/en not_active Ceased
- 1984-03-06 IE IE537/84A patent/IE57097B1/en not_active IP Right Cessation
- 1984-03-06 JP JP59041481A patent/JPH0786120B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IE840537L (en) | 1984-09-07 |
| EP0121764A2 (en) | 1984-10-17 |
| DK162130C (en) | 1992-03-02 |
| JPH0786120B2 (en) | 1995-09-20 |
| DK151884D0 (en) | 1984-03-05 |
| EP0121764A3 (en) | 1985-12-04 |
| IL71150A0 (en) | 1984-06-29 |
| CA1254000A (en) | 1989-05-09 |
| ZA841638B (en) | 1984-10-31 |
| EP0121764B1 (en) | 1990-05-30 |
| IL71150A (en) | 1987-02-27 |
| JPS59176238A (en) | 1984-10-05 |
| DK151884A (en) | 1984-09-08 |
| AU574064B2 (en) | 1988-06-30 |
| IE57097B1 (en) | 1992-04-22 |
| DE3482387D1 (en) | 1990-07-05 |
| DK162130B (en) | 1991-09-23 |
| AU2526884A (en) | 1984-09-13 |
| ATE53220T1 (en) | 1990-06-15 |
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