JPS6466199A - Novel insulin-like growth factor-i derivative and its production - Google Patents

Novel insulin-like growth factor-i derivative and its production

Info

Publication number
JPS6466199A
JPS6466199A JP62222735A JP22273587A JPS6466199A JP S6466199 A JPS6466199 A JP S6466199A JP 62222735 A JP62222735 A JP 62222735A JP 22273587 A JP22273587 A JP 22273587A JP S6466199 A JPS6466199 A JP S6466199A
Authority
JP
Japan
Prior art keywords
peptide
incorporate
formula
resin
disulfide bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62222735A
Other languages
Japanese (ja)
Inventor
Tetsutaro Sajiki
Akiko Watanabe
Fumio Mitsumizo
Akihiko Osada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharmaceuticals Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Priority to JP62222735A priority Critical patent/JPS6466199A/en
Publication of JPS6466199A publication Critical patent/JPS6466199A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:A peptide of formula I (R<1> is amino, hydroxyl group; Y<1> and Y<3> incorporate to form a disulfide bond; Y<2> and Y<6> incorporate to form a disulfide bond; Y<4> and Y<5> incorporate to form a disulfide bond) and its salts. USE:A growth promoter, tissue-repairing agent. PREPARATION:For example, Boc-Ala-4-(oxymethyl)phenylacetamide resin (Boc is t-butoxycarbonyl) is used to repeat the operations of bonding of an amino- protected amino acid and deprotection from the C-terminal in accordance with the amino acid sequence of the peptide to give a peptide resin. The resin is treated with hydrogen fluoride to eliminate the peptide of formula II, then the product is oxidized with air to form disulfide bonds, resulting in the peptide of formula I.
JP62222735A 1987-09-04 1987-09-04 Novel insulin-like growth factor-i derivative and its production Pending JPS6466199A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62222735A JPS6466199A (en) 1987-09-04 1987-09-04 Novel insulin-like growth factor-i derivative and its production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62222735A JPS6466199A (en) 1987-09-04 1987-09-04 Novel insulin-like growth factor-i derivative and its production

Publications (1)

Publication Number Publication Date
JPS6466199A true JPS6466199A (en) 1989-03-13

Family

ID=16787079

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62222735A Pending JPS6466199A (en) 1987-09-04 1987-09-04 Novel insulin-like growth factor-i derivative and its production

Country Status (1)

Country Link
JP (1) JPS6466199A (en)

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