JPS6450899A - Novel insulin-like growth factor-i derivative and production thereof - Google Patents

Novel insulin-like growth factor-i derivative and production thereof

Info

Publication number
JPS6450899A
JPS6450899A JP62209080A JP20908087A JPS6450899A JP S6450899 A JPS6450899 A JP S6450899A JP 62209080 A JP62209080 A JP 62209080A JP 20908087 A JP20908087 A JP 20908087A JP S6450899 A JPS6450899 A JP S6450899A
Authority
JP
Japan
Prior art keywords
formula
disulfide bond
peptide
expressed
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62209080A
Other languages
Japanese (ja)
Inventor
Tetsutaro Sajiki
Akiko Watanabe
Fumio Mitsumizo
Akihiko Osada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharmaceuticals Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Priority to JP62209080A priority Critical patent/JPS6450899A/en
Publication of JPS6450899A publication Critical patent/JPS6450899A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:A peptide(salt) expressed by formula I (X is amino acid sequence expressed by formula II; R1 and R2 are amino group or hydroxyl group; Y<1> and Y<4> are together disulfide bond; Y<2> and Y<6> are together disulfide bond; Y<3> and Y<5> are together disulfide bond). USE:A growth promoting agent, tissue repairing agent and remedy for diabetes. PREPARATION:For example, an amino acid having C end is successively linked with an amino acid by a solid phase method using methylbenzhydrylamine resin and peptide chain is stretched to give a peptide resin and oxidation reaction is carried out in order to form disulfide bond between chain peptides expressed by formula III (R<3> and R<4> are H or protecting group) and formula IV (R<5> is H or protecting group) synthesized by eliminating the resultant peptide from the resin to provide the novel insulin-like growth factor-I derivative expressed by formula I.
JP62209080A 1987-08-21 1987-08-21 Novel insulin-like growth factor-i derivative and production thereof Pending JPS6450899A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62209080A JPS6450899A (en) 1987-08-21 1987-08-21 Novel insulin-like growth factor-i derivative and production thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62209080A JPS6450899A (en) 1987-08-21 1987-08-21 Novel insulin-like growth factor-i derivative and production thereof

Publications (1)

Publication Number Publication Date
JPS6450899A true JPS6450899A (en) 1989-02-27

Family

ID=16566933

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62209080A Pending JPS6450899A (en) 1987-08-21 1987-08-21 Novel insulin-like growth factor-i derivative and production thereof

Country Status (1)

Country Link
JP (1) JPS6450899A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009529036A (en) * 2006-03-06 2009-08-13 ケアジェン シーオー エルティーディー Peptide having insulin-like growth factor-1 activity and use thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009529036A (en) * 2006-03-06 2009-08-13 ケアジェン シーオー エルティーディー Peptide having insulin-like growth factor-1 activity and use thereof
EP2270039A1 (en) * 2006-03-06 2011-01-05 Caregen Co., Ltd. Peptides having activities of insulin like growth factor-1 and their uses

Similar Documents

Publication Publication Date Title
DE3428942C2 (en) (H-PTH) PEPTIDE DERIVATIVES
DE3583824D1 (en) PRECURSOR OF INSULIN, METHOD FOR THE PRODUCTION THEREOF AND METHOD FOR THE PRODUCTION OF HUMANINSULIN FROM SUCH PRECURSORS OF THE INSULIN.
KR870002165A (en) Insulin analog and its manufacturing method
AU630951B2 (en) Enzymatic removal of a protein amino-terminal sequence
KR840009069A (en) Method for producing psychotropic peptides
DE3614833A1 (en) PEPTIDES WITH VASORELAXING, NATRIURETIC AND DIURETIC EFFECTS, METHOD FOR THE PRODUCTION THEREOF, THE AGENTS CONTAINING THEM AND THEIR USE
AU4683489A (en) Tgf-beta 1/beta 2: a novel chimeric transforming growth factor-beta
US3883500A (en) Process for the manufacture of insulin, analogs and derivatives thereof
CA2202390A1 (en) Keratinocyte growth factor analogs
FI892185A (en) A process for the preparation of therapeutically useful peptide compounds
DE2252157B2 (en) INTERMEDIATE PRODUCTS FOR THE MANUFACTURE OF INSULIN, INSULIN ANALOGS AND DERIVATIVES AND PROCESSES FOR THE MANUFACTURING OF INSULIN, INSULIN ANALOGS AND DERIVATIVES
JPS6450899A (en) Novel insulin-like growth factor-i derivative and production thereof
GB2125799A (en) Novel polypeptides processes for their production pharmaceutical compositions comprising said polypeptides and their use
US3917581A (en) Derivatives of somatostatin and process therefor
EP0001449B1 (en) Analogues of somatostatin, pharmaceutical compositions containing them and their preparation
JPS5795950A (en) Novel hexapeptide, manufacture, use as drug and composition
EP0288272A2 (en) Process for selective peptide bond cleavage
US4020157A (en) Shortened analogs of somatostatin
Brandenburg et al. Crosslinked insulins: preparation, properties, and applications
JPS6466199A (en) Novel insulin-like growth factor-i derivative and its production
JPS6466198A (en) Novel insulin-like growth factor-i derivative and its production
JPS6463597A (en) Novel insulin-like growth factor-i derivative and production thereof
EP0001075B1 (en) Partially protected human insulin-a chain and process for its preparation
CA1047028A (en) Somatostatin, derivatives thereof, and process therefor
DE602004001590T2 (en) Improved process for the synthesis of diamide derivatives of the tripeptide KPV