IL71150A0 - Polypeptides,their preparation and pharmaceutical compositions containing them - Google Patents

Polypeptides,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL71150A0
IL71150A0 IL71150A IL7115084A IL71150A0 IL 71150 A0 IL71150 A0 IL 71150A0 IL 71150 A IL71150 A IL 71150A IL 7115084 A IL7115084 A IL 7115084A IL 71150 A0 IL71150 A0 IL 71150A0
Authority
IL
Israel
Prior art keywords
grf
polypeptides
preparation
leu
amide
Prior art date
Application number
IL71150A
Other versions
IL71150A (en
Original Assignee
Sparamedica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sparamedica Ag filed Critical Sparamedica Ag
Publication of IL71150A0 publication Critical patent/IL71150A0/en
Publication of IL71150A publication Critical patent/IL71150A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1. Claims for the Contracting States : BE CH DE FR GB IT LI LU NL SE Polypeptides of the general formula (Leu**27 )-GRF wherein GRF represents at least the first 28 amino acids of the full sequence of natural human growth hormone releasing factor and wherein the carboxyl terminus of the molecule is present in free form or as the amide. 1. Claims for the Contracting State : AT A method for the preparation of polypeptides of the general formula (Leu**27 )-GRF wherein GRF represents at least the first 28 amino acids of the full sequence of natural human growth hormone releasing factor and wherein the carboxyl terminus of the molecule is present in free form or as the amide, characterized in that (a) the protecting groups of a protected polypeptide of corresponding amino acid sequence, which has been synthetized according to the liquid phase method, are cleaved off in a manner known per se, or (b) a carrier resin-bound protected polypeptide of corresponding amino acid sequence, which has been synthetized according to the solid phase method, is treated with anhydrous liquid HF.
IL71150A 1983-03-07 1984-03-05 Growth hormone releasing factor analogs,their preparation and pharmaceutical compositions containing them IL71150A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47270083A 1983-03-07 1983-03-07

Publications (2)

Publication Number Publication Date
IL71150A0 true IL71150A0 (en) 1984-06-29
IL71150A IL71150A (en) 1987-02-27

Family

ID=23876594

Family Applications (1)

Application Number Title Priority Date Filing Date
IL71150A IL71150A (en) 1983-03-07 1984-03-05 Growth hormone releasing factor analogs,their preparation and pharmaceutical compositions containing them

Country Status (11)

Country Link
EP (1) EP0121764B1 (en)
JP (1) JPH0786120B2 (en)
AT (1) ATE53220T1 (en)
AU (1) AU574064B2 (en)
CA (1) CA1254000A (en)
DE (1) DE3482387D1 (en)
DK (1) DK162130C (en)
IE (1) IE57097B1 (en)
IL (1) IL71150A (en)
NZ (1) NZ207378A (en)
ZA (1) ZA841638B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518586A (en) * 1983-01-13 1985-05-21 The Salk Institute For Biological Studies GRF Analogs III
IL70530A (en) * 1983-01-13 1986-09-30 Salk Inst For Biological Studi Synthetic peptides having growth hormone releasing factor activity and compositions containing them
BG49718A3 (en) * 1983-07-15 1992-01-15 Bio- Technology General Corp Method for preparing of polypeptid with superoxiddismutasne activitty
DE3327007A1 (en) * 1983-07-27 1985-02-07 Hoechst Ag, 6230 Frankfurt PRODUCTION OF POLYPEPTIDES WITH AN ACID-CARBOXYTERMINUS
AU575843B2 (en) * 1983-08-10 1988-08-11 The Administrators Of The Tulane Eductional Fund Growth hormone releasing peptides
US4617149A (en) * 1983-09-21 1986-10-14 Eli Lilly And Company Growth hormone release factor analogs
CA1340265C (en) * 1985-01-18 1998-12-15 Kirston E. Koths Oxidation resistant muteins
US4734399A (en) * 1985-08-06 1988-03-29 Hoffmann-La Roche Inc. Growth hormone releasing factor analogs
ZA866026B (en) * 1985-08-12 1988-04-27 Syntex Inc Bovine growth hormone releasing factor derivative
EP0448513A3 (en) * 1990-03-21 1991-12-27 Japat Ltd Process for production of peptidylglycine alpha-hydroxylating monooxygenase and use thereof
CA2085362A1 (en) * 1990-06-29 1991-12-30 Arthur M. Felix Histidine substituted growth hormone releasing factor analogs
DK0490249T3 (en) * 1990-12-10 1995-05-29 Hoffmann La Roche Process for Enzymatic Preparation of GRF (1-44) -NH2
CA2084061A1 (en) * 1991-04-09 1992-10-10 Arthur M. Felix Growth hormone releasing factor analogs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL70530A (en) * 1983-01-13 1986-09-30 Salk Inst For Biological Studi Synthetic peptides having growth hormone releasing factor activity and compositions containing them
US4617149A (en) * 1983-09-21 1986-10-14 Eli Lilly And Company Growth hormone release factor analogs

Also Published As

Publication number Publication date
IE840537L (en) 1984-09-07
EP0121764A2 (en) 1984-10-17
DK162130C (en) 1992-03-02
JPH0786120B2 (en) 1995-09-20
DK151884D0 (en) 1984-03-05
EP0121764A3 (en) 1985-12-04
CA1254000A (en) 1989-05-09
NZ207378A (en) 1989-05-29
ZA841638B (en) 1984-10-31
EP0121764B1 (en) 1990-05-30
IL71150A (en) 1987-02-27
JPS59176238A (en) 1984-10-05
DK151884A (en) 1984-09-08
AU574064B2 (en) 1988-06-30
IE57097B1 (en) 1992-04-22
DE3482387D1 (en) 1990-07-05
DK162130B (en) 1991-09-23
AU2526884A (en) 1984-09-13
ATE53220T1 (en) 1990-06-15

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Legal Events

Date Code Title Description
RH Patent void