DE3471689D1 - Immobilized nucleic acid probe and solid support for nucleic acids - Google Patents

Immobilized nucleic acid probe and solid support for nucleic acids

Info

Publication number
DE3471689D1
DE3471689D1 DE8484107266T DE3471689T DE3471689D1 DE 3471689 D1 DE3471689 D1 DE 3471689D1 DE 8484107266 T DE8484107266 T DE 8484107266T DE 3471689 T DE3471689 T DE 3471689T DE 3471689 D1 DE3471689 D1 DE 3471689D1
Authority
DE
Germany
Prior art keywords
solid support
acid probe
nucleic acid
nucleic acids
immobilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484107266T
Other languages
English (en)
Inventor
Nanibhushan Dattagupta
Donald M Crothers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular Diagnostics Inc
Original Assignee
Molecular Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/511,064 external-priority patent/US4542102A/en
Application filed by Molecular Diagnostics Inc filed Critical Molecular Diagnostics Inc
Application granted granted Critical
Publication of DE3471689D1 publication Critical patent/DE3471689D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/548—Carbohydrates, e.g. dextran
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DE8484107266T 1983-07-05 1984-06-25 Immobilized nucleic acid probe and solid support for nucleic acids Expired DE3471689D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/511,064 US4542102A (en) 1983-07-05 1983-07-05 Coupling of nucleic acids to solid support by photochemical methods
US06/611,667 US4713326A (en) 1983-07-05 1984-05-18 Coupling of nucleic acids to solid support by photochemical methods

Publications (1)

Publication Number Publication Date
DE3471689D1 true DE3471689D1 (en) 1988-07-07

Family

ID=27057111

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484107266T Expired DE3471689D1 (en) 1983-07-05 1984-06-25 Immobilized nucleic acid probe and solid support for nucleic acids

Country Status (7)

Country Link
US (1) US4713326A (de)
EP (1) EP0130523B1 (de)
JP (1) JPH075628B2 (de)
AU (1) AU563558B2 (de)
DE (1) DE3471689D1 (de)
ES (1) ES8607387A1 (de)
IL (1) IL72278A (de)

Families Citing this family (185)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4737454A (en) * 1983-07-14 1988-04-12 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US4849077A (en) * 1984-08-06 1989-07-18 Akademie Der Wissenschaften Der Ddr Process for solid phase-sequencing of nucleic acid fragments
GB8432118D0 (en) * 1984-12-19 1985-01-30 Malcolm A D B Sandwich hybridisation technique
GB2179448B (en) * 1984-12-19 1989-06-07 Blair Malcolm A D Improved sandwich hybridisation technique for the detection of nucleotide sequences
EP0216860B1 (de) * 1985-03-15 1992-10-28 SUMMERTON, James Stereoregulare polynukleotiden bindende polymere
US4882269A (en) * 1985-12-13 1989-11-21 Princeton University Amplified hybridization assay
EP0259453A1 (de) * 1986-03-04 1988-03-16 Cambridge Biotech Corporation Nachweis von nukleinsäure durch partikel-agglutination
US5348855A (en) * 1986-03-05 1994-09-20 Miles Inc. Assay for nucleic acid sequences in an unpurified sample
FR2606155B1 (fr) * 1986-11-05 1990-07-20 Pasteur Institut Reactif immunologique pour la determination de la sequence d'un acide nucleique, son procede de preparation et methode immunologique de determination de la sequence d'un acide nucleique a l'aide de ce reactif
FR2606154B1 (fr) * 1986-11-05 1990-05-11 Pasteur Institut Procede de detection et de dosage immunologique des acides nucleiques presents dans les milieux biologiques
US5599667A (en) * 1987-03-02 1997-02-04 Gen-Probe Incorporated Polycationic supports and nucleic acid purification separation and hybridization
JPH01125395A (ja) * 1987-07-29 1989-05-17 Life Technol Inc 核酸浦獲試薬
US4942124A (en) * 1987-08-11 1990-07-17 President And Fellows Of Harvard College Multiplex sequencing
DK641487A (da) * 1987-12-07 1989-06-08 Gluetech Aps Fremgangsmaade til modificering af polymeroverflader
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US7811751B2 (en) 1988-05-03 2010-10-12 Oxford Gene Technology Limited Analysing polynucleotide sequences
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US6054270A (en) * 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
AU632494B2 (en) * 1988-05-20 1993-01-07 F. Hoffmann-La Roche Ag Immobilized sequence-specific probes
WO1990001563A1 (en) * 1988-08-01 1990-02-22 Cimino George D Identification of allele specific nucleic acid sequences by hybridization with crosslinkable oligonucleotide probes
US5985327A (en) * 1988-10-05 1999-11-16 Flinders Technologies Pty. Ltd. Solid medium and method for DNA storage
US6627226B2 (en) 1988-10-05 2003-09-30 Whatman, Inc. Dry solid medium for storage and analysis of genetic material
US5972386A (en) * 1995-12-19 1999-10-26 Flinders Technologies Pty, Ltd. Dry solid medium for storage and analysis of genetic material
US6447804B1 (en) 1988-10-05 2002-09-10 Whatman, Plc Dry solid medium for storage and analysis of genetic material
WO1990003959A1 (en) * 1988-10-05 1990-04-19 The Flinders University Of South Australia Solid medium and method for dna storage
US5807527A (en) * 1991-05-29 1998-09-15 Flinders Technologies Pty. Ltd. Solid medium and method for DNA storage
US5756126A (en) * 1991-05-29 1998-05-26 Flinders Technologies Pty. Ltd. Dry solid medium for storage and analysis of genetic material
US5496562A (en) * 1988-10-05 1996-03-05 Flinders Technologies Pty Ltd Solid medium and method for DNA storage
ATE155821T1 (de) * 1989-03-10 1997-08-15 Vysis Inc Interferenzverhinderung mit affinitätseinfangschemas
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6379895B1 (en) 1989-06-07 2002-04-30 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6919211B1 (en) 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US6955915B2 (en) 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US5871928A (en) * 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US5925525A (en) * 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
CA2031659A1 (en) * 1990-01-26 1991-07-27 John B. Findlay Water-insoluble reagent, nucleic acid probe, test kit and diagnostic and purification methods
US6506558B1 (en) 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
AU1248292A (en) 1990-12-06 1992-07-08 Affymax Technologies N.V. Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides
CA2065719A1 (en) 1991-04-30 1992-10-31 John B. Findlay Nucleic acid amplification and detection methods using rapid polymerase chain reaction cycle
US5639603A (en) * 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
EP0604552B1 (de) * 1991-09-18 1997-02-12 Affymax Technologies N.V. Verfahren zur synthese der verschiedenen sammlungen von oligomeren
US6864101B1 (en) 1991-11-22 2005-03-08 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US6468740B1 (en) 1992-11-05 2002-10-22 Affymetrix, Inc. Cyclic and substituted immobilized molecular synthesis
US6943034B1 (en) 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
EP0649532B1 (de) 1992-07-06 1997-11-12 Biomira, Inc. Photoaktivierung von proteinen zu konjugationszwecken
DE69429338T2 (de) * 1993-04-13 2002-08-14 Naxcor, Menlo Park Nicht-nucleosidische cumarin-derivate als reagenzien zum crosslinking von polynucleotiden
US6277570B1 (en) 1993-04-13 2001-08-21 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US5767259A (en) 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
US6495676B1 (en) * 1993-04-13 2002-12-17 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
US6165778A (en) * 1993-11-02 2000-12-26 Affymax Technologies N.V. Reaction vessel agitation apparatus
US5503805A (en) * 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US7323298B1 (en) * 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US7625697B2 (en) * 1994-06-17 2009-12-01 The Board Of Trustees Of The Leland Stanford Junior University Methods for constructing subarrays and subarrays made thereby
US5622822A (en) 1994-09-13 1997-04-22 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using polyethyleneimine and an anionic phosphate ester surfactant and amplification of same
US5582988A (en) 1994-09-15 1996-12-10 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same
US5747256A (en) * 1995-12-19 1998-05-05 Beckman Instruments, Inc. Homogeneous DNA probe titration assay
US20070178475A1 (en) * 1998-09-17 2007-08-02 Nehls Michael C Novel human polynucleotides and polypeptides encoded thereby
US6545264B1 (en) 1998-10-30 2003-04-08 Affymetrix, Inc. Systems and methods for high performance scanning
US6303799B1 (en) 1998-11-10 2001-10-16 Naxcor Polynucleotide crosslinking agents
US20010034438A1 (en) * 2000-01-12 2001-10-25 Walke D. Wade Novel human membrane protein and polynucleotides encoding the same
US6570003B1 (en) * 2001-01-09 2003-05-27 Lexion Genetics Incorporated Human 7TM proteins and polynucleotides encoding the same
US20020110809A1 (en) * 1999-04-30 2002-08-15 Nehls Michael C. Novel human polynucleotides and polypeptides encoded thereby
WO2000066783A2 (en) * 1999-05-04 2000-11-09 Ortho-Clinical Diagnostics, Inc. Rapid and efficient capture of dna from sample without using cell lysing reagent
US20020095031A1 (en) * 1999-05-04 2002-07-18 Nehls Michael C. Novel human polynucleotides and polypeptides encoded thereby
US20020049312A1 (en) * 2000-05-23 2002-04-25 Turner C. Alexander Noel human thrombospondin-like proteins and polynucleotides encoding the same
US6716614B1 (en) 1999-09-02 2004-04-06 Lexicon Genetics Incorporated Human calcium dependent proteases, polynucleotides encoding the same, and uses thereof
US20030050464A1 (en) * 2000-07-28 2003-03-13 Yi Hu Novel human proteases and polynucleotides encoding the same
US6649399B2 (en) 1999-12-09 2003-11-18 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same
US20050153323A1 (en) * 2000-07-28 2005-07-14 Yi Hu Novel human proteases and polynucleotides encoding the same
US6448388B1 (en) 2000-08-16 2002-09-10 Lexicon Genetics Incorporated Human proteases and polynucleotides encoding the same
US20080003673A1 (en) * 1999-09-02 2008-01-03 Alejandro Abuin Novel human proteases and polynucleotides encoding the same
US6867291B1 (en) * 2000-09-15 2005-03-15 Lexicon Genetics Incorporated Human hemicentin proteins and polynucleotides encoding the same
US6790660B1 (en) 2001-09-18 2004-09-14 Lexicon Genetics Incorporated Human kielin-like proteins and polynucleotides encoding the same
US20020107382A1 (en) * 2000-09-27 2002-08-08 Friddle Carl Johan Novel human protease inhibitor proteins and polynucleotides encoding the same
US6541252B1 (en) 2000-05-19 2003-04-01 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
US6586230B1 (en) * 2000-10-27 2003-07-01 Lexicon Genetics Incorporated Human kinase and polynucleotides encoding the same
US6841377B1 (en) * 2001-06-13 2005-01-11 Lexicon Genetics Incorporated Human kinase and polynucleotides encoding the same
US6602698B2 (en) * 1999-12-07 2003-08-05 Lexicon Genetics Incorporated Human kinase proteins and polynucleotides encoding the same
US6511840B1 (en) 2000-06-15 2003-01-28 Lexicon Genetics Incorporated Human kinase proteins and polynucleotides encoding the same
US6734009B2 (en) 2000-12-27 2004-05-11 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
US6797510B1 (en) * 2001-05-24 2004-09-28 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
US20080050809A1 (en) * 1999-09-28 2008-02-28 Alejandro Abuin Novel human kinases and polynucleotides encoding the same
US20080213878A1 (en) * 1999-10-19 2008-09-04 Gregory Donoho Novel human membrane proteins and polynucleotides encoding the same
JP2003527838A (ja) * 1999-12-07 2003-09-24 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒト膜タンパクおよびそれをコードするポリヌクレオチド
WO2001042477A1 (en) * 1999-12-13 2001-06-14 Lexicon Genetics Incorporated Novel human transferase proteins and polynucleotides encoding the same
CA2395247A1 (en) * 1999-12-22 2001-06-28 Lexicon Genetics Incorporated Novel human membrane proteins and polynucleotides encoding the same
WO2001046407A1 (en) * 1999-12-22 2001-06-28 Lexicon Genetics Incorporated Polynucleotides encoding human protease homologs
AU783923B2 (en) * 2000-01-06 2005-12-22 Lexicon Genetics Incorporated Novel human proteases and polynucleotides encoding the same
EP1254222A1 (de) * 2000-01-18 2002-11-06 Lexicon Genetics Incorporated Menschliche gaba-rezeptor proteine und dafür kodierende polynukleotide
JP2004504804A (ja) * 2000-01-18 2004-02-19 レキシコン・ジェネティクス・インコーポレーテッド ヒト新規キナーゼタンパクおよびそれをコードするポリヌクレオチド
AU2001253117B8 (en) * 2000-01-26 2006-08-03 Lexicon Pharmaceuticals, Inc. Human neurexin-like proteins and polynucleotides encoding the same
WO2001094566A2 (en) * 2000-01-28 2001-12-13 Lexicon Genetics Incorporated Human enzymes and polynucleotides encoding the same
EP1250433A1 (de) * 2000-01-28 2002-10-23 Lexicon Genetics Incorporated Menschliche membranproteine und dafür kodierende polynukleotide
CA2399663A1 (en) * 2000-02-04 2001-08-09 Lexicon Genetics Incorporated Novel human enzymes and polynucleotides encoding the same
DE60139458D1 (de) * 2000-02-04 2009-09-17 Lexicon Pharmaceuticals Inc Neue menschliche g-protein gekoppelten rezeptoren und dafür kodierende polynucleotide
EP1255843A1 (de) 2000-02-11 2002-11-13 Lexicon Genetics Incorporated Menschliche protease und dafür kodierende polynukleotide
AU2001238503A1 (en) * 2000-02-17 2001-08-27 Lexicon Genetics Incorporated Novel human thrombospondin repeat proteins and polynucleotides encoding the same
US6555669B2 (en) 2000-02-29 2003-04-29 Lexicon Genetics Incorporated Human transferase proteins and polynucleotides encoding the same
CA2401645A1 (en) 2000-02-29 2001-09-07 Lexicon Genetics Incorporated Novel human transporter proteins and polynucleotides encoding the same
US20020082405A1 (en) * 2000-03-06 2002-06-27 Gregory Donoho Novel human transporter proteins and polynucleotides encoding the same
EP1263967A2 (de) 2000-03-10 2002-12-11 Lexicon Genetics Incorporated Humane g-protein gekoppelte rezeptorkinasen und dafür kodierende polynucleotide
AU2001247395B2 (en) * 2000-03-13 2006-08-31 Lexicon Pharmaceuticals, Inc. Novel human phospholipases and polynucleotides encoding the same
CA2403636A1 (en) * 2000-03-20 2001-09-27 Lexicon Genetics Incorporated Human secreted proteins and polynucleotides encoding the same
CA2404896A1 (en) * 2000-04-03 2001-10-11 Lexicon Genetics Incorporated Human ion channel protein and polynucleotides encoding the same
CA2405729A1 (en) * 2000-04-12 2001-10-25 Lexicon Genetics Incorporated Human metalloprotease and polynucleotides encoding the same
JP2004511205A (ja) 2000-04-25 2004-04-15 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトキナーゼプロテインおよびそれをコードするポリヌクレオチド
US7262006B1 (en) 2000-05-01 2007-08-28 Ortho-Clinical Diagnostics, Inc. Rapid and efficient capture of DNA from sample without using cell lysing reagent
US20020107375A1 (en) * 2000-05-12 2002-08-08 Brian Mathur Novel human lipocalin homologs and polynucleotides encoding the same
WO2001088133A2 (en) 2000-05-18 2001-11-22 Lexicon Genetics Incorporated Human semaphorin homologs and polynucleotides encoding the same
US6790667B1 (en) 2000-05-30 2004-09-14 Lexicon Genetics Incorporated Human mitochondrial proteins and polynucleotides encoding the same
AU2001275337A1 (en) * 2000-06-07 2001-12-17 Lexicon Genetics Incorporated Novel human transporter proteins and polynucleotides encoding the same
US20040168209A1 (en) * 2000-06-12 2004-08-26 Alejandro Abuin Novel murine polynucleotide sequences and mutant cells and mutant animals defined thereby
AU2001271516B2 (en) * 2000-06-27 2006-08-03 Lexicon Pharmaceuticals, Inc. Novel human gaba receptors and polynucleotides encoding the same
AU2002224553A1 (en) * 2000-07-21 2002-02-05 Incyte Genomics, Inc. Human proteases
US6887685B1 (en) * 2000-07-25 2005-05-03 Lexicon Genetics Incorporated Human thymosin protein and polynucleotides encoding the same
US20020076780A1 (en) * 2000-08-16 2002-06-20 Turner C. Alexander Novel human ion channel proteins and polynucleotides encoding the same
JP2004531201A (ja) * 2000-08-22 2004-10-14 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトプロテアーゼ及び該プロテアーゼをコードするポリヌクレオチド
EP1311676A2 (de) * 2000-08-22 2003-05-21 Lexicon Genetics Incorporated Menschliche 7tm-proteine und dafür kodierende polynukleotide
AU2001285326A1 (en) * 2000-08-31 2002-03-13 Lexicon Genetics Incorporated Human kinase proteins and polynucleotides encoding the same
WO2002020753A2 (en) * 2000-09-01 2002-03-14 Lexicon Genetics Incorporated Human gaba transporter protein and polynucleotides encoding the same
ATE326533T1 (de) * 2000-09-27 2006-06-15 Lexicon Genetics Inc Menschliche ionenaustauschproteine und dafür kodierende polynukleotiden
US6777232B1 (en) * 2000-10-02 2004-08-17 Lexicon Genetics Incorporated Human membrane proteins and polynucleotides encoding the same
WO2002031129A2 (en) 2000-10-12 2002-04-18 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
US7001763B1 (en) 2000-10-17 2006-02-21 Lexicon Genetics Incorporated Human semaphorin proteins and polynucleotides encoding the same
EP1409674A2 (de) * 2000-10-27 2004-04-21 Lexicon Genetics Incorporated Humane 7tm proteine und dafür kodierende polynukleotide
JP2004531209A (ja) * 2000-10-30 2004-10-14 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒト７ｔｍタンパクおよびそれをコードするポリヌクレオチド
AU2002230875B2 (en) * 2000-11-01 2007-03-01 Lexicon Pharmaceuticals, Inc. Novel human proteases and polynucleotides encoding the same
WO2002050278A2 (en) * 2000-11-15 2002-06-27 Lexicon Genetics Incorporated Novel human secreted proteins and polynucleotides encoding the same
WO2002042438A2 (en) 2000-11-20 2002-05-30 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
US6384979B1 (en) 2000-11-30 2002-05-07 The University Of British Columbia Color filtering and absorbing total internal reflection image display
CA2431007A1 (en) * 2000-12-11 2002-07-18 Lexicon Genetics Incorporated Novel human kinase and polynucleotides encoding the same
CA2431210A1 (en) * 2000-12-12 2002-06-20 Lexicon Genetics Incorporated Novel human kinases and uses thereof
US6583269B1 (en) 2000-12-18 2003-06-24 Lexicon Genetics Incorporated Human protease inhibitor and polynucleotides encoding the same
CA2432737A1 (en) * 2000-12-20 2002-06-27 Lexicon Genetics Incorporated Human ion channel protein and polynucleotides encoding the same
US6852844B1 (en) 2000-12-20 2005-02-08 Lexicon Genetics Incorporated Human protocadherin proteins and polynucleotides encoding the same
WO2002068626A2 (en) * 2000-12-28 2002-09-06 Lexicon Genetics Incorporated Novel human ion channel-related proteins and polynucleotides encoding the same
WO2002053753A2 (en) * 2001-01-05 2002-07-11 Lexicon Genetics Incorporated Novel human lipase and polynucleotides encoding the same
WO2002053754A2 (en) * 2001-01-08 2002-07-11 Lexicon Genetics Incorporated Human protease and polynucleotides encoding the same
EP1407029A2 (de) * 2001-01-23 2004-04-14 Lexicon Genetics Incorporated Neuartige menschliche kinasen und polynukleotiden die dafür kodieren
US20020115846A1 (en) * 2001-01-24 2002-08-22 Xuanchuan (Sean) Yu Novel human lipase and polynucleotides encoding the same
WO2002063002A2 (en) * 2001-02-02 2002-08-15 Lexicon Genetics Incorporated Novel human transporter protein and polynucleotides encoding the same
WO2002066624A2 (en) * 2001-02-20 2002-08-29 Lexicon Genetics Incorporated Novel human protease and polynucleotides encoding the same
JP3929250B2 (ja) * 2001-03-08 2007-06-13 株式会社ルネサステクノロジ 半導体装置
AU2002306696B2 (en) * 2001-03-12 2007-12-20 Lexicon Pharmaceuticals, Inc. Novel human EGF-family proteins and polynucleotides encoding the same
AU2002252296A1 (en) * 2001-03-12 2002-09-24 Lexicon Genetics Incorporated Novel human transporter proteins and polynucleotides encoding the same
US7252990B2 (en) * 2001-03-12 2007-08-07 Lexicon Genetics Incorporated Human dectin proteins and polynucleotides encoding the same
US6994995B1 (en) * 2001-03-16 2006-02-07 Lexicon Genetics Incorporated Human synaptotagmin and polynucleotides encoding the same
WO2002074932A2 (en) 2001-03-20 2002-09-26 Lexicon Genetics Incorporated Novel human kinase and polynucleotides encoding the same
JP2004524043A (ja) * 2001-04-06 2004-08-12 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトキナーゼ及び該キナーゼをコードするポリヌクレオチド
WO2002081671A1 (en) 2001-04-06 2002-10-17 Lexicon Genetics Incorporated Novel human kinase and polynucleotides encoding the same
US6644173B2 (en) * 2001-04-11 2003-11-11 Keuring, Incorporated Beverage filter cartridge holder
US6607895B2 (en) * 2001-04-16 2003-08-19 Lexicon Genetics Incorporated Human adenylsuccinate synthetase and polynucleotides encoding the same
WO2002088313A2 (en) * 2001-04-30 2002-11-07 Lexicon Genetics Incorporated Novel human nuclear transporters and polynucleotides encoding the same
DE10121201B4 (de) * 2001-04-30 2007-07-12 Molecular Machines & Industries Gmbh Photoaktivierbare Polysaccharidderivate für die Immobilisierung von Biomolekülen
EP1463749A4 (de) * 2001-05-09 2005-04-13 Lexicon Genetics Inc Neue menschliche kinasen und diese codierende polynukleotide
WO2002097095A1 (en) * 2001-05-25 2002-12-05 Lexicon Genetics Incorporated Novel human transporter proteins and polynucleotides encoding the same
CA2448347C (en) 2001-05-29 2010-09-21 Lexicon Genetics Incorporated Novel human hydroxylases and polynucleotides encoding the same
JP2004531268A (ja) * 2001-06-14 2004-10-14 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトトランスポータータンパクおよびそれをコードするポリヌクレオチド
AU2002318186A1 (en) * 2001-07-03 2003-01-21 Lexicon Genetics Incorporated Novel human kielin-like proteins and polynucleotides encoding the same
JP2005500060A (ja) * 2001-08-14 2005-01-06 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトコラーゲンタンパクおよびそれをコードするポリヌクレオチド
US20040106109A1 (en) * 2001-10-02 2004-06-03 Belly Robert T Detection of ras mutations
DE10154291B4 (de) * 2001-11-05 2005-05-19 Hain Lifescience Gmbh Verfahren zum Nachweis von Nukleinsäuren in Form eines Trockenschnelltestes
JP3447009B1 (ja) * 2002-10-29 2003-09-16 實 平垣 構築物用構成体およびその製造方法
SE527200C2 (sv) * 2003-06-19 2006-01-17 Microdrug Ag Inhalatoranordning samt kombinerade doser av formaterol och fluticason
US20120202710A1 (en) 2003-09-09 2012-08-09 Integrigen, Inc. Methods and compositions for generation of germline human antibody genes
ATE497837T1 (de) 2004-04-09 2011-02-15 Vivebio Llc Vorrichtungen und verfahren für abnahme, lagerung und transport von biologischen proben
KR100745750B1 (ko) * 2005-01-25 2007-08-02 삼성전자주식회사 인터컬레이터를 이용한 핵산의 분리 방법
US7402730B1 (en) 2005-02-03 2008-07-22 Lexicon Pharmaceuticals, Inc. Knockout animals manifesting hyperlipidemia
US7312079B1 (en) 2005-10-06 2007-12-25 Lexicon Pharmaceuticals, Inc. Variants of FAM3C
US20080004410A1 (en) * 2006-06-30 2008-01-03 Yu-Chin Lai Hydrophilic macromonomers having alpha,beta-conjugated carboxylic terminal group and medical devices incorporating same
WO2008056837A1 (en) * 2006-11-07 2008-05-15 Korea Research Institute Of Bioscience And Biotechnology Method for fabricating a biomaterial array using photoreaction
US20090312406A1 (en) * 2008-06-12 2009-12-17 Hsing-Pang Hsieh Coumarin compounds and their use for treating viral infection
US8058427B2 (en) * 2008-06-12 2011-11-15 National Health Research Institutes Coumarin compounds and their use for treating cancer
US9428792B2 (en) 2013-03-14 2016-08-30 Certirx Corporation Nucleic acid-based authentication and identification codes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2334107A1 (fr) * 1975-12-05 1977-07-01 Pasteur Institut Procede de couplage de substances biologiques par des liaisons covalentes
US4169204A (en) * 1976-10-20 1979-09-25 Regents Of The University Of California Psoralens
DD148955A1 (de) * 1980-02-04 1981-06-17 Hunger Hans Dieter Verfahren zur kopplung von nukleinsaeuren an traegermaterialien
CA1180647A (en) * 1981-07-17 1985-01-08 Cavit Akin Light-emitting polynucleotide hybridization diagnostic method
US4542102A (en) * 1983-07-05 1985-09-17 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
US4737454A (en) * 1983-07-14 1988-04-12 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US4582789A (en) * 1984-03-21 1986-04-15 Cetus Corporation Process for labeling nucleic acids using psoralen derivatives

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AU563558B2 (en) 1987-07-16
EP0130523B1 (de) 1988-06-01
US4713326A (en) 1987-12-15
IL72278A (en) 1989-07-31
EP0130523A3 (en) 1986-07-23
ES8607387A1 (es) 1986-05-16
EP0130523A2 (de) 1985-01-09
AU3025684A (en) 1985-01-10
JPH075628B2 (ja) 1995-01-25
JPS6036496A (ja) 1985-02-25
ES534025A0 (es) 1986-05-16

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