DE3446713A1 - N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel - Google Patents

N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel

Info

Publication number
DE3446713A1
DE3446713A1 DE19843446713 DE3446713A DE3446713A1 DE 3446713 A1 DE3446713 A1 DE 3446713A1 DE 19843446713 DE19843446713 DE 19843446713 DE 3446713 A DE3446713 A DE 3446713A DE 3446713 A1 DE3446713 A1 DE 3446713A1
Authority
DE
Germany
Prior art keywords
general formula
compounds
methyl
carboxylic acid
aziridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19843446713
Other languages
German (de)
English (en)
Inventor
Elmar Dr.rer.nat. 6940 Weinheim Bosies
Richard Dr.rer.nat. 6901 Wilhelmsfeld Endele
Wulf Dr. 6800 Mannheim Pahlke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE19843446713 priority Critical patent/DE3446713A1/de
Priority to DE8585115785T priority patent/DE3578563D1/de
Priority to AT85115785T priority patent/ATE54315T1/de
Priority to EP85115785A priority patent/EP0186049B1/de
Priority to IL77357A priority patent/IL77357A/xx
Priority to PH33180A priority patent/PH23039A/en
Priority to DD85284394A priority patent/DD246299A5/de
Priority to FI854985A priority patent/FI854985A7/fi
Priority to AU51265/85A priority patent/AU578335B2/en
Priority to NZ214596A priority patent/NZ214596A/xx
Priority to ZA859592A priority patent/ZA859592B/xx
Priority to JP60282177A priority patent/JPS61152678A/ja
Priority to GR853057A priority patent/GR853057B/el
Priority to DK591685A priority patent/DK591685A/da
Priority to PT81702A priority patent/PT81702B/pt
Priority to CS859547A priority patent/CS256395B2/cs
Priority to PL1985256941A priority patent/PL148867B1/pl
Priority to YU01999/85A priority patent/YU199985A/xx
Priority to HU854938A priority patent/HU194869B/hu
Priority to NO855210A priority patent/NO855210L/no
Priority to ES550285A priority patent/ES8800198A1/es
Priority to SU853991691A priority patent/SU1431676A3/ru
Priority to CN85108698A priority patent/CN85108698B/zh
Publication of DE3446713A1 publication Critical patent/DE3446713A1/de
Priority to US07/125,353 priority patent/US4826858A/en
Priority to AU49015/90A priority patent/AU625355B2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE19843446713 1984-12-21 1984-12-21 N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel Withdrawn DE3446713A1 (de)

Priority Applications (25)

Application Number Priority Date Filing Date Title
DE19843446713 DE3446713A1 (de) 1984-12-21 1984-12-21 N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel
DE8585115785T DE3578563D1 (de) 1984-12-21 1985-12-11 N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel.
AT85115785T ATE54315T1 (de) 1984-12-21 1985-12-11 N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel.
EP85115785A EP0186049B1 (de) 1984-12-21 1985-12-11 N-substituierte Aziridin-2-Carbonsäurederivate, Verfahren zu deren Herstellung sowie diese Substanzen enthaltende Arzneimittel
IL77357A IL77357A (en) 1984-12-21 1985-12-16 N-substituted aziridine-2-carboxylic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing them
PH33180A PH23039A (en) 1984-12-21 1985-12-16 N-substituted aziridine-2-carboxylic acid derivatives and pharmaceutical composition containing them
DD85284394A DD246299A5 (de) 1984-12-21 1985-12-16 Verfahren zur herstellung n-substituierter anziridin-2-carbonsaeurederivaten
FI854985A FI854985A7 (fi) 1984-12-21 1985-12-16 Menetelmä farmaseuttisesti aktiivisten N-substituoitujen atsiridiini-2-karboksyylihappojohdannaisten valmistamiseksi.
AU51265/85A AU578335B2 (en) 1984-12-21 1985-12-16 N-substituted aziridine-2-carboxylic acid derivatives
NZ214596A NZ214596A (en) 1984-12-21 1985-12-17 N-pyridinyl methyl-aziridine-carboxylic acid derivatives and pharmaceutical compositions
ZA859592A ZA859592B (en) 1984-12-21 1985-12-17 N-substituted aziridine-2-carboxylic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing them
JP60282177A JPS61152678A (ja) 1984-12-21 1985-12-17 Ｎ‐置換されたアジリジン‐２‐カルボン酸誘導体、その製法並びに該物質を含有する免疫調整剤
DK591685A DK591685A (da) 1984-12-21 1985-12-18 N-substituerede aziridin-2-carboxylsyrederivater, fremgangsmaade til fremstilling deraf samt laegemidler, der indeholder disse stoffer
GR853057A GR853057B (OSRAM) 1984-12-21 1985-12-18
PT81702A PT81702B (de) 1984-12-21 1985-12-18 N-substituierte aziridin-2-carbonsauerederivate verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel
CS859547A CS256395B2 (en) 1984-12-21 1985-12-19 Method of n-substituted aziridine-2-carboxylic acid's derivatives preparation
PL1985256941A PL148867B1 (en) 1984-12-21 1985-12-19 Method of obtaining novel n-substituted derivatives of azidrine-2-carboxylic acid
YU01999/85A YU199985A (en) 1984-12-21 1985-12-19 Process for preparation of n-substituted derivatives of azyridine -2-carboxylic acids
NO855210A NO855210L (no) 1984-12-21 1985-12-20 Fremgangsmaate ved fremstilling av n-substituerte aziridin-2-carboxylsyrederivater.
HU854938A HU194869B (en) 1984-12-21 1985-12-20 Process for production of derivatives of n-substituated aziridin-2-cyan and medical preparatives containing thereof
ES550285A ES8800198A1 (es) 1984-12-21 1985-12-20 Procedimiento para preparar derivados de acidos aziridin-2- carboxilicos substituidos en n
SU853991691A SU1431676A3 (ru) 1984-12-21 1985-12-20 Способ получени N-замещенных производных азиридин-2-карбоновой кислоты или натриевой соли кислоты
CN85108698A CN85108698B (zh) 1984-12-21 1985-12-21 N-取代氮丙啶-2-羧酸及其衍生物的制备方法
US07/125,353 US4826858A (en) 1984-12-21 1987-11-25 N-substituted aziridine-2-carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
AU49015/90A AU625355B2 (en) 1984-12-21 1990-02-01 Reagent for the detection of the presence of an allergy and for the specific detection of the allergen responsible for the allergy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843446713 DE3446713A1 (de) 1984-12-21 1984-12-21 N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
DE3446713A1 true DE3446713A1 (de) 1986-06-26

Family

ID=6253432

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19843446713 Withdrawn DE3446713A1 (de) 1984-12-21 1984-12-21 N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel
DE8585115785T Expired - Lifetime DE3578563D1 (de) 1984-12-21 1985-12-11 N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8585115785T Expired - Lifetime DE3578563D1 (de) 1984-12-21 1985-12-11 N-substituierte aziridin-2-carbonsaeurederivate, verfahren zu deren herstellung sowie diese substanzen enthaltende arzneimittel.

Country Status (23)

Country Link
US (1) US4826858A (OSRAM)
EP (1) EP0186049B1 (OSRAM)
JP (1) JPS61152678A (OSRAM)
CN (1) CN85108698B (OSRAM)
AT (1) ATE54315T1 (OSRAM)
AU (2) AU578335B2 (OSRAM)
CS (1) CS256395B2 (OSRAM)
DD (1) DD246299A5 (OSRAM)
DE (2) DE3446713A1 (OSRAM)
DK (1) DK591685A (OSRAM)
ES (1) ES8800198A1 (OSRAM)
FI (1) FI854985A7 (OSRAM)
GR (1) GR853057B (OSRAM)
HU (1) HU194869B (OSRAM)
IL (1) IL77357A (OSRAM)
NO (1) NO855210L (OSRAM)
NZ (1) NZ214596A (OSRAM)
PH (1) PH23039A (OSRAM)
PL (1) PL148867B1 (OSRAM)
PT (1) PT81702B (OSRAM)
SU (1) SU1431676A3 (OSRAM)
YU (1) YU199985A (OSRAM)
ZA (1) ZA859592B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8404679B2 (en) 2008-06-16 2013-03-26 Hoffmann-La Roche Inc. Pyrrolidine derivatives as NK2 receptor antagonists

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100738229B1 (ko) * 2001-12-31 2007-07-12 한국화학연구원 신규한 피롤리디닐피리딘 유도체
CA2547600A1 (en) * 2003-12-12 2005-06-30 Syngenta Participations Ag Novel herbicides
CN105272896A (zh) * 2015-10-19 2016-01-27 山东国润生物医药有限公司 (（2s）-2-氮丙啶基)二苯基甲醇的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2833986A1 (de) * 1978-08-03 1980-02-21 Boehringer Mannheim Gmbh Immunstimulierende n-substituierte aziridin-2-carbonsaeurederivate, verfahren zu ihrer herstellung sowie arzneimittel, die diese substanzen enthalten
DE3211254A1 (de) * 1982-03-26 1983-09-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8404679B2 (en) 2008-06-16 2013-03-26 Hoffmann-La Roche Inc. Pyrrolidine derivatives as NK2 receptor antagonists

Also Published As

Publication number Publication date
EP0186049A1 (de) 1986-07-02
YU199985A (en) 1987-12-31
HUT40107A (en) 1986-11-28
FI854985L (fi) 1986-06-22
DE3578563D1 (de) 1990-08-09
ES550285A0 (es) 1987-11-01
AU5126585A (en) 1986-06-26
JPS61152678A (ja) 1986-07-11
PL148867B1 (en) 1989-12-30
CN85108698A (zh) 1986-07-23
SU1431676A3 (ru) 1988-10-15
US4826858A (en) 1989-05-02
PL256941A1 (en) 1986-10-07
ZA859592B (en) 1986-09-24
PH23039A (en) 1989-03-10
FI854985A7 (fi) 1986-06-22
AU4901590A (en) 1990-08-02
AU578335B2 (en) 1988-10-20
DK591685D0 (da) 1985-12-18
PT81702A (de) 1986-01-02
PT81702B (de) 1987-08-10
FI854985A0 (fi) 1985-12-16
NO855210L (no) 1986-06-23
CN85108698B (zh) 1988-09-07
DK591685A (da) 1986-06-22
GR853057B (OSRAM) 1986-04-15
CS954785A2 (en) 1987-08-13
IL77357A (en) 1989-08-15
EP0186049B1 (de) 1990-07-04
NZ214596A (en) 1988-10-28
HU194869B (en) 1988-03-28
AU625355B2 (en) 1992-07-09
CS256395B2 (en) 1988-04-15
ES8800198A1 (es) 1987-11-01
DD246299A5 (de) 1987-06-03
ATE54315T1 (de) 1990-07-15

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee