DE3439843A1 - Plasmide zur erhoehten produktion von penicillin g-amidase - Google Patents

Plasmide zur erhoehten produktion von penicillin g-amidase

Info

Publication number
DE3439843A1
DE3439843A1 DE3439843A DE3439843A DE3439843A1 DE 3439843 A1 DE3439843 A1 DE 3439843A1 DE 3439843 A DE3439843 A DE 3439843A DE 3439843 A DE3439843 A DE 3439843A DE 3439843 A1 DE3439843 A1 DE 3439843A1
Authority
DE
Germany
Prior art keywords
plasmid
fragment
penicillin
gene
amidase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE3439843A
Other languages
German (de)
English (en)
Inventor
Peter Dr.rer.nat. 8131 Bernried Buckel
Gunter Dr.Rer.Nat. Schumacher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE3439843A priority Critical patent/DE3439843A1/de
Priority to CA000494287A priority patent/CA1283068C/en
Priority to JP60241775A priority patent/JPS61181383A/ja
Priority to PT81403A priority patent/PT81403B/pt
Priority to EP85113875A priority patent/EP0180225B1/de
Priority to AT85113875T priority patent/ATE64153T1/de
Priority to DE8585113875T priority patent/DE3583107D1/de
Priority to ES548457A priority patent/ES8802248A1/es
Priority to DK501185A priority patent/DK501185A/da
Priority to CS857794A priority patent/CS275831B6/cs
Publication of DE3439843A1 publication Critical patent/DE3439843A1/de
Priority to US07/303,097 priority patent/US5053335A/en
Priority to LVP-93-467A priority patent/LV10498B/lv
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE3439843A 1984-10-31 1984-10-31 Plasmide zur erhoehten produktion von penicillin g-amidase Withdrawn DE3439843A1 (de)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DE3439843A DE3439843A1 (de) 1984-10-31 1984-10-31 Plasmide zur erhoehten produktion von penicillin g-amidase
CA000494287A CA1283068C (en) 1984-10-31 1985-10-30 Plasmid for expression of penicillin g amidase
JP60241775A JPS61181383A (ja) 1984-10-31 1985-10-30 ペニシリン−ｇ−アミダ−ゼの発現に好適なプラスミドそれを有する微生物及び該プラスミドの製法
PT81403A PT81403B (pt) 1984-10-31 1985-10-30 Processo de preparacao de plasmideos para a producao aumentada de penicilina-g-amidase
AT85113875T ATE64153T1 (de) 1984-10-31 1985-10-31 Plasmide zur erhoehten produktion von penicillin g-amidase.
EP85113875A EP0180225B1 (de) 1984-10-31 1985-10-31 Plasmide zur erhöhten Produktion von Penicillin G-Amidase
DE8585113875T DE3583107D1 (de) 1984-10-31 1985-10-31 Plasmide zur erhoehten produktion von penicillin g-amidase.
ES548457A ES8802248A1 (es) 1984-10-31 1985-10-31 Procedimiento para la preparacion de penicilin-g-amidasa por expresion de la enzima en el seno de un microorganismo.
DK501185A DK501185A (da) 1984-10-31 1985-10-31 Plasmider til foroeget produktion af penicillin g-amidase
CS857794A CS275831B6 (en) 1984-10-31 1985-10-31 Process for preparing penicillin-g-amidase
US07/303,097 US5053335A (en) 1984-10-31 1989-01-27 Plasmids for the increased production of penicillin g amidase
LVP-93-467A LV10498B (lv) 1984-10-31 1993-06-02 Plazmīdas iegūšanas paņēmiens, mikroorganisms

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3439843A DE3439843A1 (de) 1984-10-31 1984-10-31 Plasmide zur erhoehten produktion von penicillin g-amidase

Publications (1)

Publication Number Publication Date
DE3439843A1 true DE3439843A1 (de) 1986-04-30

Family

ID=6249194

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3439843A Withdrawn DE3439843A1 (de) 1984-10-31 1984-10-31 Plasmide zur erhoehten produktion von penicillin g-amidase
DE8585113875T Expired - Lifetime DE3583107D1 (de) 1984-10-31 1985-10-31 Plasmide zur erhoehten produktion von penicillin g-amidase.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8585113875T Expired - Lifetime DE3583107D1 (de) 1984-10-31 1985-10-31 Plasmide zur erhoehten produktion von penicillin g-amidase.

Country Status (10)

Country Link
US (1) US5053335A (https=)
EP (1) EP0180225B1 (https=)
JP (1) JPS61181383A (https=)
AT (1) ATE64153T1 (https=)
CA (1) CA1283068C (https=)
CS (1) CS275831B6 (https=)
DE (2) DE3439843A1 (https=)
DK (1) DK501185A (https=)
ES (1) ES8802248A1 (https=)
PT (1) PT81403B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516679A (en) * 1994-12-23 1996-05-14 Bristol-Myers Squibb Company Penicillin V amidohydrolase gene from Fusarium oxysporum
WO1998020120A1 (en) * 1996-11-05 1998-05-14 Bristol-Myers Squibb Company Mutant penicillin g acylases
US6068991A (en) * 1997-12-16 2000-05-30 Bristol-Myers Squibb Company High expression Escherichia coli expression vector
UA100692C2 (ru) 2007-05-02 2013-01-25 Мериал Лимитед Днк-плазмиды, имеющие повышенную экспрессию и стабильность

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3330003A1 (de) * 1982-10-21 1984-10-31 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Dna-sequenz und dna-strukturen und sie verwendendes verfahren zur herstellung von penicillin-acylase
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4554250A (en) * 1983-06-30 1985-11-19 E. R. Squibb & Sons, Inc. Method of increased production of penicillin acylase and plasmid employed therein

Also Published As

Publication number Publication date
EP0180225A2 (de) 1986-05-07
EP0180225B1 (de) 1991-06-05
EP0180225A3 (en) 1988-01-07
PT81403A (de) 1985-11-01
JPS61181383A (ja) 1986-08-14
CS275831B6 (en) 1992-03-18
DK501185A (da) 1986-05-01
CA1283068C (en) 1991-04-16
JPH0521552B2 (https=) 1993-03-24
ES548457A0 (es) 1988-05-01
DE3583107D1 (de) 1991-07-11
ES8802248A1 (es) 1988-05-01
PT81403B (pt) 1987-11-11
US5053335A (en) 1991-10-01
DK501185D0 (da) 1985-10-31
ATE64153T1 (de) 1991-06-15

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Legal Events

Date Code Title Description
8141 Disposal/no request for examination