DE3433329C2 - - Google Patents

Info

Publication number
DE3433329C2
DE3433329C2 DE3433329A DE3433329A DE3433329C2 DE 3433329 C2 DE3433329 C2 DE 3433329C2 DE 3433329 A DE3433329 A DE 3433329A DE 3433329 A DE3433329 A DE 3433329A DE 3433329 C2 DE3433329 C2 DE 3433329C2
Authority
DE
Germany
Prior art keywords
defibrotide
treatment
patients
acute renal
thrombotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3433329A
Other languages
German (de)
English (en)
Other versions
DE3433329A1 (de
Inventor
Vittorio Prof. Bologna It Bonomini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CRINOS INDUSTRIA FARMACOBIOLOGICA SpA VILLA GUARDIA COMO IT
Original Assignee
CRINOS INDUSTRIA FARMACOBIOLOGICA SpA VILLA GUARDIA COMO IT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CRINOS INDUSTRIA FARMACOBIOLOGICA SpA VILLA GUARDIA COMO IT filed Critical CRINOS INDUSTRIA FARMACOBIOLOGICA SpA VILLA GUARDIA COMO IT
Publication of DE3433329A1 publication Critical patent/DE3433329A1/de
Application granted granted Critical
Publication of DE3433329C2 publication Critical patent/DE3433329C2/de
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE19843433329 1983-09-12 1984-09-11 Pharmazeutische zusammensetzung zur behandlung der stadien akuter niereninsuffizienz Granted DE3433329A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22856/83A IT1170215B (it) 1983-09-12 1983-09-12 Composizione farmaceutica per il trattamento di stati di insufficienza renale acuta

Publications (2)

Publication Number Publication Date
DE3433329A1 DE3433329A1 (de) 1985-03-28
DE3433329C2 true DE3433329C2 (enExample) 1993-07-22

Family

ID=11201234

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19843433329 Granted DE3433329A1 (de) 1983-09-12 1984-09-11 Pharmazeutische zusammensetzung zur behandlung der stadien akuter niereninsuffizienz

Country Status (8)

Country Link
US (1) US4649134A (enExample)
EP (1) EP0137542B1 (enExample)
JP (1) JPH0647546B2 (enExample)
AT (1) ATE65696T1 (enExample)
BE (1) BE900563A (enExample)
CH (1) CH661871A5 (enExample)
DE (1) DE3433329A1 (enExample)
IT (1) IT1170215B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1170214B (it) * 1983-09-12 1987-06-03 Crinos Industria Farmaco Composizione farmaceutica per la cura delle arteriopatie periferiche
US5223609A (en) * 1986-04-17 1993-06-29 Crinos Industria Farmacobiologica S.P.A. Process for obtaining chemically defined and reproducible polydeoxyribonucleotides
IT1190313B (it) * 1986-04-17 1988-02-16 Crinos Industria Farmaco Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante
IT1223322B (it) * 1987-10-23 1990-09-19 Crinos Industria Farmaco Metodo per prevenire la formazione di coaguli sanguigni nel circuito extracorporeo di apparecchi di dialisi a composizione utile per esso
IT1231509B (it) * 1989-09-07 1991-12-07 Crinos Industria Farmaco Composizione farmceutica ad uso topico per la terapia della fragilita' capillare.
US6699985B2 (en) * 1991-08-21 2004-03-02 Arsinur Burcoglu Method of treating HIV infection and related secondary infections thereof
US5977083A (en) * 1991-08-21 1999-11-02 Burcoglu; Arsinur Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states
US5624912A (en) * 1991-08-21 1997-04-29 Burcoglu; Arsinur Method of treating HIV infection and related secondary infections with defibrotide
CA2153778C (en) * 1993-01-13 2004-07-06 Arsinur Burcoglu Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states
HK1044896A1 (zh) * 1997-04-28 2002-11-08 Burcoglu Arsinur 治疗hiv感染和与之有关的继发感染的方法
EP1325962A1 (en) * 2001-12-17 2003-07-09 Gentium S.p.A. A method for determining the biological activity of defibrotide
EP1872787A1 (en) * 2006-06-27 2008-01-02 Gentium S.p.A. Use of defibrotide for the inhibition of heparanase
EP1982722A1 (en) * 2007-04-16 2008-10-22 Gentium S.p.A. Use of oligotide for the treatment of renal diseases
US8515557B2 (en) 2007-11-19 2013-08-20 Cochlear Limited Electrode array for a cochlear implant
EP2103689A1 (en) * 2008-03-19 2009-09-23 Gentium S.p.A. Synthetic phosphodiester oligonucleotides and therapeutical uses thereof
IT1406068B1 (it) 2010-07-22 2014-02-06 Medestea Int Spa Polidesossiribonucleotidi (pdrn) per l'impiego nel trattamento di condizioni di acidosi e composizioni a base di polidesossiribonucleotidi per il suddetto impiego
EP2637672B1 (en) 2010-11-12 2018-08-22 Gentium S.r.l. Defibrotide for use in prophylaxis and/or treatment of graft versus host disease (gvhd).
DK2864496T4 (da) * 2012-06-22 2021-01-04 Gentium S R L Euglobulin-baseret fremgangsmåde til bestemmelse af den biologiske aktivitet af defibrotid
EP3026122A1 (en) 2014-11-27 2016-06-01 Gentium S.p.A. Cellular-based method for determining the potency of defibrotide
RU2766143C2 (ru) * 2017-07-26 2022-02-08 Джентиум С.Р.Л. Жидкая композиция дефибротида для лечения и профилактики веноокклюзионной болезни
MX2020001337A (es) * 2017-08-03 2020-09-09 Jazz Pharmaceuticals Ireland Ltd Formulaciones que comprenden un acido nucleico en una alta concentracion.
KR20210008478A (ko) 2018-04-12 2021-01-22 재즈 파마슈티칼즈, 인코포레이티드 면역고갈과 관련된 사이토카인 방출 증후군 및 신경독성의 예방 및 치료를 위한 데피브로타이드
WO2021212055A1 (en) 2020-04-17 2021-10-21 Jazz Pharmaceuticals Ireland Limited Defibrotide treatment for the prevention of organ rejection and injury
WO2022234101A1 (en) 2021-05-06 2022-11-10 Jazz Pharmaceuticals Ireland Limited Defibrotide for the treatment and prevention of acute respiratory distress syndrome

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB879622A (en) * 1959-07-13 1961-10-11 Farmaceutici Italia Steroids
DE1202439B (de) * 1959-11-24 1965-10-07 Cediap Centrale De Destributio Verfahren zur Herstellung von Praeparaten mit hohem Gehalt an freien Desoxyribonucleinsaeuren aus Fischmilch
FR2575M (fr) * 1962-03-19 1964-06-08 Cediap Centrale De Distrib D A Procédé de préparation d'un médicament a base d'adn (acide désoxyribonucléique) en milieu vital d'origine et produit nouveau en résultant.
DE2154279A1 (de) * 1970-11-03 1972-05-25 Crinos Industria Farmaco Medikamente für das fibrinolytische System
IT1043823B (it) * 1970-11-03 1980-02-29 Prephar Procedimento per l estrazione di acidi nucleici da organi animali
US3899481A (en) * 1970-11-03 1975-08-12 Crinos Industria Farmaco Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs

Also Published As

Publication number Publication date
JPH0647546B2 (ja) 1994-06-22
ATE65696T1 (de) 1991-08-15
IT8322856A0 (it) 1983-09-12
JPS6084224A (ja) 1985-05-13
CH661871A5 (it) 1987-08-31
EP0137542B1 (en) 1991-07-31
IT1170215B (it) 1987-06-03
EP0137542A2 (en) 1985-04-17
US4649134A (en) 1987-03-10
BE900563A (fr) 1985-01-02
DE3433329A1 (de) 1985-03-28
EP0137542A3 (en) 1987-09-02

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Free format text: BARZ, P., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 80803 MUENCHEN

8339 Ceased/non-payment of the annual fee