GB879622A - Steroids - Google Patents

Steroids

Info

Publication number
GB879622A
GB879622A GB24050/59A GB2405059A GB879622A GB 879622 A GB879622 A GB 879622A GB 24050/59 A GB24050/59 A GB 24050/59A GB 2405059 A GB2405059 A GB 2405059A GB 879622 A GB879622 A GB 879622A
Authority
GB
United Kingdom
Prior art keywords
nortestosterone
cyclopentylpropionate
epoxy
hydroxy
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB24050/59A
Inventor
Bruno Camerino
Bianco Patelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Priority to GB24050/59A priority Critical patent/GB879622A/en
Priority to CH784360A priority patent/CH387624A/en
Priority to AT532360A priority patent/AT241704B/en
Priority to FR832738A priority patent/FR54M/fr
Publication of GB879622A publication Critical patent/GB879622A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Abstract

The invention comprises 4-hydroxy-19-nortestosterone 17-b - cyclopentylpropionate and the preparation thereof by treating 4,5-epoxy-19-nortestosterone 17-b -cyclopentylpropionate with sulphuric acid in an organic solvent, e.g. acetic acid. The above process may be modified in that the 4,5-epoxy-19-nortestosterone 17-b -cyclopentylpropionate is prepared by acylating 4,5-epoxy-19-nortestosterone with a b -cyclopentylpropionic acid halide such as the chloride, in the presence of a tertiary amine, and the 4,5-epoxy-19-nortestosterone may be prepared by treating 19-nortestosterone with hydrogen peroxide in an alkaline medium. Detailed examples are given.ALSO:A therapeutic composition comprises 4-hydroxy - 19 - nortestosterone 17 - b - cyclopentylpropionate and compatible pharmaceutically acceptable carrier. The composition may be in the form of a solution in a fluid vehicle in the form of a gel or in the form of a microcrystalline suspension in an aqueous medium.
GB24050/59A 1959-07-13 1959-07-13 Steroids Expired GB879622A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB24050/59A GB879622A (en) 1959-07-13 1959-07-13 Steroids
CH784360A CH387624A (en) 1959-07-13 1960-07-09 Process for the preparation of 4-hydroxy-19-nortestosterone-17-cyclopentyl propionate
AT532360A AT241704B (en) 1959-07-13 1960-07-11 Process for the preparation of 4-hydroxy-19-nortestosterone-17-cyclopentyl propionate
FR832738A FR54M (en) 1959-07-13 1960-07-12

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB24050/59A GB879622A (en) 1959-07-13 1959-07-13 Steroids

Publications (1)

Publication Number Publication Date
GB879622A true GB879622A (en) 1961-10-11

Family

ID=10205577

Family Applications (1)

Application Number Title Priority Date Filing Date
GB24050/59A Expired GB879622A (en) 1959-07-13 1959-07-13 Steroids

Country Status (4)

Country Link
AT (1) AT241704B (en)
CH (1) CH387624A (en)
FR (1) FR54M (en)
GB (1) GB879622A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1170215B (en) * 1983-09-12 1987-06-03 Crinos Industria Farmaco PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF STATES OF ACUTE RENAL INSUFFICIENCY

Also Published As

Publication number Publication date
AT241704B (en) 1965-08-10
FR54M (en) 1961-01-09
CH387624A (en) 1965-02-15

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