DE3413955C2 - - Google Patents
Info
- Publication number
- DE3413955C2 DE3413955C2 DE19843413955 DE3413955A DE3413955C2 DE 3413955 C2 DE3413955 C2 DE 3413955C2 DE 19843413955 DE19843413955 DE 19843413955 DE 3413955 A DE3413955 A DE 3413955A DE 3413955 C2 DE3413955 C2 DE 3413955C2
- Authority
- DE
- Germany
- Prior art keywords
- nifedipine
- dergocrine
- mesylate
- dergocrin
- active ingredients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims description 50
- 229960001597 nifedipine Drugs 0.000 claims description 44
- 238000002360 preparation method Methods 0.000 claims description 29
- 239000004480 active ingredient Substances 0.000 claims description 23
- 229940127291 Calcium channel antagonist Drugs 0.000 claims description 22
- 239000000480 calcium channel blocker Substances 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 13
- 230000003276 anti-hypertensive effect Effects 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 239000001257 hydrogen Substances 0.000 claims description 5
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 150000002367 halogens Chemical group 0.000 claims description 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 150000002431 hydrogen Chemical group 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- 229940124531 pharmaceutical excipient Drugs 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 239000011593 sulfur Substances 0.000 claims description 2
- GXHMMDRXHUIUMN-UHFFFAOYSA-N methanesulfonic acid Chemical compound CS(O)(=O)=O.CS(O)(=O)=O GXHMMDRXHUIUMN-UHFFFAOYSA-N 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 40
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- -1 alkoxyalkyl radical Chemical class 0.000 description 13
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- 238000000034 method Methods 0.000 description 11
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- PBKVEOSEPXMKDN-LZHUFOCISA-N chembl2311030 Chemical compound CS(O)(=O)=O.CS(O)(=O)=O.CS(O)(=O)=O.CS(O)(=O)=O.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)C(C)C)C(C)C)=C3C2=CNC3=C1.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)C(C)CC)C(C)C)=C3C2=CNC3=C1.C1=CC([C@H]2C[C@H](CN(C)[C@@H]2C2)C(=O)N[C@]3(C(=O)N4[C@H](C(N5CCC[C@H]5[C@]4(O)O3)=O)CC(C)C)C(C)C)=C3C2=CNC3=C1.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](C(N21)=O)(NC(=O)[C@H]1CN(C)[C@H]2[C@@H](C=3C=CC=C4NC=C(C=34)C2)C1)C(C)C)C1=CC=CC=C1 PBKVEOSEPXMKDN-LZHUFOCISA-N 0.000 description 9
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- ZFGOPJASRDDARH-UHFFFAOYSA-N 3-[[10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl]oxy]-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthrene Chemical compound C12CCC3(C)C(C(C)CCCC(C)C)CCC3C2CC=C(C2)C1(C)CCC2OC1CC2=CCC3C4CCC(C(C)CCCC(C)C)C4(C)CCC3C2(C)CC1 ZFGOPJASRDDARH-UHFFFAOYSA-N 0.000 description 8
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
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- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 4
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843413955 DE3413955A1 (de) | 1983-04-22 | 1984-04-13 | Pharmazeutisches praeparat enthaltend co-dergocrine und einen calcium-antagonisten |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3314607 | 1983-04-22 | ||
| DE19843413955 DE3413955A1 (de) | 1983-04-22 | 1984-04-13 | Pharmazeutisches praeparat enthaltend co-dergocrine und einen calcium-antagonisten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3413955A1 DE3413955A1 (de) | 1984-10-25 |
| DE3413955C2 true DE3413955C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-02-01 |
Family
ID=25810204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19843413955 Granted DE3413955A1 (de) | 1983-04-22 | 1984-04-13 | Pharmazeutisches praeparat enthaltend co-dergocrine und einen calcium-antagonisten |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE3413955A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE442265B (sv) * | 1978-12-21 | 1985-12-16 | Sandoz Ag | Fast, enteral-overdragen komposition i enhetsform for oral tillforsel innehallande en ergotalkaloid |
| DE2930369A1 (de) * | 1979-07-26 | 1981-02-05 | Rentschler Arzneimittel | Arzneimittelloesungen |
| US4366145A (en) * | 1981-06-24 | 1982-12-28 | Sandoz, Inc. | Soft gelatin capsule with a liquid ergot alkaloid center fill solution and method of preparation |
-
1984
- 1984-04-13 DE DE19843413955 patent/DE3413955A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE3413955A1 (de) | 1984-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| V448 | Application of spc |
Free format text: PRODUCT NAME: DIHYDROERGOCORNINMETHANSULFONAT, DIHYDROERGOCRISTINMETHANSULFONAT, ALPHA-DIHYDROERGOCRYPTINMETHANSULFONAT, BETA-DIHYDROERGOCRYPTINMETHANSULFONAT, NIFEDIPIN; REGISTRATION NO/DATE: 18292.00.00, 8751.00.00; 19900725 Spc suppl protection certif: 193 75 082 Filing date: 19930630 |
|
| V457 | Spc granted |
Free format text: PRODUCT NAME: DIHYDROERGOCORNINMETHANSULFONAT, DIHYDROERGOCRISTINMETHANSULFONAT, ALPHA-DIHYDROERGOCRYPTINMETHANSULFONAT, BETA-DIHYDROERGOCRYPTINMETHANSULFONAT, NIFEDIPIN; REGISTRATION NO/DATE: 18292.00.00, 8751.00.00; 19900725 Spc suppl protection certif: 193 75 082 Filing date: 19930630 |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: NOVARTIS AG, BASEL, CH |
|
| 8328 | Change in the person/name/address of the agent |
Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN |
|
| V464 | Spc expired |
Free format text: PRODUCT NAME: DIHYDROERGOCORNINMETHANSULFONAT, DIHYDROERGOCRISTINMETHANSULFONAT, ALPHA-DIHYDROERGOCRYPTINMETHANSULFONAT, BETA-DIHYDROERGOCRYPTINMETHANSULFONAT, NIFEDIPIN; REGISTRATION NO/DATE: 18292.00.00, 8751.00.00; 19900725 Spc suppl protection certif: 193 75 082 Filing date: 19930630 |