DE3411225C2 - - Google Patents
Info
- Publication number
- DE3411225C2 DE3411225C2 DE3411225A DE3411225A DE3411225C2 DE 3411225 C2 DE3411225 C2 DE 3411225C2 DE 3411225 A DE3411225 A DE 3411225A DE 3411225 A DE3411225 A DE 3411225A DE 3411225 C2 DE3411225 C2 DE 3411225C2
- Authority
- DE
- Germany
- Prior art keywords
- spironolactone
- cream
- acne
- weight
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 claims description 28
- 229960002256 spironolactone Drugs 0.000 claims description 28
- 239000006071 cream Substances 0.000 claims description 26
- 206010000496 acne Diseases 0.000 claims description 23
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 15
- -1 polyoxyethylene Polymers 0.000 claims description 12
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 9
- 238000009472 formulation Methods 0.000 claims description 9
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 5
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 229920006395 saturated elastomer Polymers 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 2
- 150000004671 saturated fatty acids Chemical class 0.000 claims description 2
- KRCMKUNIILUXPF-UHFFFAOYSA-N methyl 4-hydroxybenzoate;sodium Chemical compound [Na].COC(=O)C1=CC=C(O)C=C1 KRCMKUNIILUXPF-UHFFFAOYSA-N 0.000 claims 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 1
- 235000010268 sodium methyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 239000004290 sodium methyl p-hydroxybenzoate Substances 0.000 claims 1
- 239000003860 topical agent Substances 0.000 claims 1
- 210000003491 skin Anatomy 0.000 description 14
- 230000003902 lesion Effects 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 239000004480 active ingredient Substances 0.000 description 6
- 230000000699 topical effect Effects 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 102000011782 Keratins Human genes 0.000 description 3
- 108010076876 Keratins Proteins 0.000 description 3
- 206010033733 Papule Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 150000002334 glycols Chemical class 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 206010054107 Nodule Diseases 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 239000003246 corticosteroid Substances 0.000 description 2
- 208000031513 cyst Diseases 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 150000002596 lactones Chemical class 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- GQQQJYMOSMAOHU-UHFFFAOYSA-N 3-oxo-2-tetradecylicosanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)C(CCCCCCCCCCCCCC)C(=O)O GQQQJYMOSMAOHU-UHFFFAOYSA-N 0.000 description 1
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 1
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- PVNIQBQSYATKKL-UHFFFAOYSA-N Glycerol trihexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N Glycerol trioctadecanoate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- 102000006771 Gonadotropins Human genes 0.000 description 1
- 108010086677 Gonadotropins Proteins 0.000 description 1
- 206010020112 Hirsutism Diseases 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229940083712 aldosterone antagonist Drugs 0.000 description 1
- 239000002170 aldosterone antagonist Substances 0.000 description 1
- 230000001548 androgenic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000003842 bromide salts Chemical class 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 229960000258 corticotropin Drugs 0.000 description 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000002622 gonadotropin Substances 0.000 description 1
- 229940094892 gonadotropins Drugs 0.000 description 1
- 201000000079 gynecomastia Diseases 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000004694 iodide salts Chemical class 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910003002 lithium salt Inorganic materials 0.000 description 1
- 159000000002 lithium salts Chemical class 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 230000008384 membrane barrier Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229940127234 oral contraceptive Drugs 0.000 description 1
- 239000003539 oral contraceptive agent Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000037368 penetrate the skin Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT20435/83A IT1194185B (it) | 1983-04-01 | 1983-04-01 | Composizione per il trattamento dell'acne |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3411225A1 DE3411225A1 (de) | 1984-10-04 |
| DE3411225C2 true DE3411225C2 (en, 2012) | 1991-11-07 |
Family
ID=11166894
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19843466647 Expired DE3466647D1 (en, 2012) | 1983-04-01 | 1984-03-08 | |
| DE19843411225 Granted DE3411225A1 (de) | 1983-04-01 | 1984-03-27 | Verwendung von spironolacton zur bekaempfung von akne |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19843466647 Expired DE3466647D1 (en, 2012) | 1983-04-01 | 1984-03-08 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4543351A (en, 2012) |
| EP (1) | EP0124147B1 (en, 2012) |
| CA (1) | CA1204059A (en, 2012) |
| DE (2) | DE3466647D1 (en, 2012) |
| IT (1) | IT1194185B (en, 2012) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0410348A1 (en) * | 1989-07-26 | 1991-01-30 | G.D. Searle & Co. | Topical spironolactone composition |
| JPH05331066A (ja) * | 1992-05-25 | 1993-12-14 | Toko Yakuhin Kogyo Kk | 尋常性ざ瘡治療用組成物 |
| MX9303557A (es) * | 1992-08-06 | 1994-03-31 | Beta Pharm Co | Metodo para la administracion de un antiandrogeno, en particular, espironolactona, a traves de la piel. |
| US10343436B2 (en) | 2006-02-27 | 2019-07-09 | Viavi Solutions Inc. | Security device formed by printing with special effect inks |
| US8102389B2 (en) * | 2007-02-14 | 2012-01-24 | International Business Machines Corporation | Box casting using an integrated acceleration data structure |
| CA2689507C (en) | 2007-06-06 | 2016-07-26 | The Hospital For Sick Children | Aldosterone induced elastin production |
| US20090203628A1 (en) * | 2008-02-12 | 2009-08-13 | Jan Marini | Composition, Method And Kit For Treating Skin Disorders And Improving Skin Condition |
| CA2726377A1 (en) | 2008-06-06 | 2009-12-10 | Human Matrix Sciences Llc | Aldosterone induced vascular elastin production |
| US20100247693A1 (en) * | 2009-03-24 | 2010-09-30 | Marini Jan L | Cosmetic formulation to treat rosacea telangiectasia |
| US9023399B2 (en) | 2012-11-16 | 2015-05-05 | NU Technology, LLC | Water-soluble anti-inflammatory cream with natural ingredients base |
| US8613961B1 (en) | 2013-01-09 | 2013-12-24 | NU Technology, LLC | Dermatological cream with natural ingredients base |
| CN104055781A (zh) * | 2014-06-16 | 2014-09-24 | 南充市中心医院 | 替硝唑螺内酯乳膏及其制备方法 |
| WO2016141182A1 (en) | 2015-03-03 | 2016-09-09 | Yee Richard W | Compositions and methods for treating ocular diseases |
| US10792293B2 (en) * | 2015-07-31 | 2020-10-06 | Hamidreza Kelidari | Topical nanodrug formulation |
| US11524016B2 (en) | 2020-07-17 | 2022-12-13 | Amy Thorne | Compositions and methods for the topical administration of spironolactone for the treatment of cutaneous signs of excess androgen and chronic stress response |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4177267A (en) * | 1963-12-09 | 1979-12-04 | Crown Zellerbach | Enhancing tissue penetration of physiologically active steroidal agents with DMSC |
| DE2744826A1 (de) * | 1976-10-06 | 1978-04-13 | Marques Brev Soc Et Exploit | Therapeutische zubereitung |
| FR2379285A2 (fr) * | 1977-02-08 | 1978-09-01 | Expl Marques Brevets Et | Nouvelle composition a base d'acide salicylique et de corticoide |
| FR2366840A1 (fr) * | 1976-10-06 | 1978-05-05 | Expl Marques Brevets Et | Nouvelle composition a base d'acide salicylique et de betamethasone |
| FI59534C (fi) * | 1979-10-31 | 1981-09-10 | Orion Yhtymae Oy | Vaordmedel foer fraemjande av haorvaext och hindrande av mjaell |
| US4347245A (en) * | 1981-05-26 | 1982-08-31 | German Shapiro | Spironolactone-containing composition and use thereof |
| AU556817B2 (en) * | 1982-02-03 | 1986-11-20 | Efamol Limited | Topical application of a lithium salt and dihomo-alpha- linolenic acid |
-
1983
- 1983-04-01 IT IT20435/83A patent/IT1194185B/it active
-
1984
- 1984-03-08 DE DE19843466647 patent/DE3466647D1/de not_active Expired
- 1984-03-08 EP EP84200329A patent/EP0124147B1/en not_active Expired
- 1984-03-27 US US06/593,926 patent/US4543351A/en not_active Expired - Lifetime
- 1984-03-27 DE DE19843411225 patent/DE3411225A1/de active Granted
- 1984-03-30 CA CA000450953A patent/CA1204059A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE3466647D1 (en, 2012) | 1987-11-12 |
| IT8320435A0 (it) | 1983-04-01 |
| US4543351A (en) | 1985-09-24 |
| CA1204059A (en) | 1986-05-06 |
| EP0124147A1 (en) | 1984-11-07 |
| IT1194185B (it) | 1988-09-14 |
| DE3411225A1 (de) | 1984-10-04 |
| EP0124147B1 (en) | 1987-10-07 |
| IT8320435A1 (it) | 1984-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69827929T2 (de) | Hautpflegemittel | |
| DE69919863T2 (de) | Stabilgelmischung in form einer mischung eines öligen gels und eines wässrigen gels | |
| DE69029804T2 (de) | VEHIKEL MIT LANGSAMER FREISETZUNG ZUR VERMINDERUNG DER HAUTREIZUNG TOPISCHER retinoidhaltiger MITTEL | |
| DE69733086T2 (de) | Pharmazeutische zusammensetzungen welche kukui nuss öl enthalten | |
| DE3411225C2 (en, 2012) | ||
| DE3111767A1 (de) | Mittel zur behandlung der haut | |
| DE2046119A1 (de) | Mitte) zur Behandlung der Akne | |
| EP0037011A2 (de) | Salbengrundlagen für dermatologische und kosmetische Zwecke | |
| EP0367103B1 (de) | Topische Salbe | |
| WO2007118653A2 (de) | Nanopartikel, enthaltend nicotin und/oder cotinin, dispersionen und die verwendung derselben | |
| WO1994003156A1 (de) | Pharmazeutische und/oder kosmetische zubereitung sowie die verwendung einer derartigen zubereitung | |
| DE69912760T2 (de) | Verwendung von topischen formulierungen des öl-in-wasser typs, enthaltend galaktolipid material als emulsionsmittel, um eine länger anhaltende wirkung eines darin enthaltenen aktiven wirkstoffs zu vermitteln | |
| DE2747631B2 (de) | Salbe | |
| DE60004786T2 (de) | Verfahren und zusammensetzung zur behandlung von akne | |
| DE19534209A1 (de) | Hormonales Mittel zur Behandlung der Haut | |
| DE2818827C2 (de) | Mittel zur Behandlung von Psoriasis | |
| DE2601489A1 (de) | Tretinoin enthaltende gelpraeparate | |
| DE1804801C3 (de) | Mittel zur Aknebehandlung | |
| DE69919597T2 (de) | Topische formulierungen, die hautpenetrations-mittel enthalten, und ihre verwendung | |
| DE69904567T2 (de) | Lipidmischung sowie ihre verwendung | |
| DE69705968T2 (de) | Zubereitung auf der basis von kokosöl und ihre verwendung | |
| DE3020616C2 (en, 2012) | ||
| DE2654743C2 (de) | Verwendung eines Gemisches als Therapeutikum zur externen Behandlung von Schuppenflechte (Psoriasis), Flechten und Ekzemen | |
| DE2751391A1 (de) | Zubereitung zur prophylaxe und behandlung von akne | |
| DE2851544C2 (de) | Fluocortolon-haltige Creme |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |