DE3408347A1 - Verfahren zur herstellung von carbapenem-derivaten, dabei eingesetzte zwischenprodukte und verfahren zu deren herstellung - Google Patents

Verfahren zur herstellung von carbapenem-derivaten, dabei eingesetzte zwischenprodukte und verfahren zu deren herstellung

Info

Publication number
DE3408347A1
DE3408347A1 DE19843408347 DE3408347A DE3408347A1 DE 3408347 A1 DE3408347 A1 DE 3408347A1 DE 19843408347 DE19843408347 DE 19843408347 DE 3408347 A DE3408347 A DE 3408347A DE 3408347 A1 DE3408347 A1 DE 3408347A1
Authority
DE
Germany
Prior art keywords
group
alkyl
pyridinium
mmol
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19843408347
Other languages
German (de)
English (en)
Inventor
Pierre Laprairie Dextraze
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of DE3408347A1 publication Critical patent/DE3408347A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C07D213/20—Quaternary compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19843408347 1983-03-08 1984-03-07 Verfahren zur herstellung von carbapenem-derivaten, dabei eingesetzte zwischenprodukte und verfahren zu deren herstellung Withdrawn DE3408347A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47137883A 1983-03-08 1983-03-08
US49969183A 1983-06-07 1983-06-07
US55729583A 1983-12-01 1983-12-01

Publications (1)

Publication Number Publication Date
DE3408347A1 true DE3408347A1 (de) 1984-09-13

Family

ID=27413179

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19843408347 Withdrawn DE3408347A1 (de) 1983-03-08 1984-03-07 Verfahren zur herstellung von carbapenem-derivaten, dabei eingesetzte zwischenprodukte und verfahren zu deren herstellung

Country Status (31)

Country Link
JP (1) JPH05255250A (enExample)
KR (1) KR900002247B1 (enExample)
AR (1) AR241016A1 (enExample)
AT (1) AT387968B (enExample)
AU (2) AU572124B2 (enExample)
CA (1) CA1284324C (enExample)
CH (1) CH658248A5 (enExample)
CY (1) CY1546A (enExample)
DD (1) DD228258A5 (enExample)
DE (1) DE3408347A1 (enExample)
DK (1) DK140584A (enExample)
ES (2) ES8505205A1 (enExample)
FI (1) FI840863L (enExample)
FR (1) FR2542316B1 (enExample)
GB (1) GB2136802B (enExample)
GR (1) GR81871B (enExample)
HK (1) HK82990A (enExample)
HU (1) HU193895B (enExample)
IE (1) IE57098B1 (enExample)
IL (1) IL71149A (enExample)
IT (1) IT1178465B (enExample)
LU (1) LU85241A1 (enExample)
NL (1) NL8400702A (enExample)
NO (1) NO166038C (enExample)
NZ (1) NZ207346A (enExample)
OA (1) OA07674A (enExample)
PT (1) PT78211B (enExample)
SE (2) SE8401278L (enExample)
SG (1) SG35490G (enExample)
YU (2) YU46147B (enExample)
ZW (1) ZW3884A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0168707A1 (en) * 1984-07-02 1986-01-22 Merck & Co. Inc. 1-Methylcarbapenems having a 2-quaternary heteroarylalkylthio substituent
AT396472B (de) * 1985-09-11 1993-09-27 Bristol Myers Squibb Co Verfahren zur herstellung neuer carbapenem-antibiotika
AT397090B (de) * 1985-11-22 1994-01-25 Bristol Myers Squibb Co Verfahren zur herstellung von neuen carbapenemderivaten

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683301A (en) * 1982-04-08 1987-07-28 Bristol-Myers Company Carbapenem antibiotics
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics
CA1285940C (en) * 1984-07-02 1991-07-09 Merck & Co., Inc. Carbapenems having a 2-quaternary heteroarylalkylthio substituent
NZ219892A (en) * 1986-04-15 1991-02-26 Merck & Co Inc N-amino quaternised heteroarylium carbapenem derivatives and pharmaceutical compositions thereof
CA2036941A1 (en) * 1990-02-23 1991-08-24 Isao Kawamoto Carbapenem derivatives having antibiotic activity, their preparation and their use
US5712267A (en) * 1991-06-04 1998-01-27 Sankyo Company,. Limited Carbapenem derivatives, their preparation and their use as antibiotics
SI1631557T1 (sl) 2003-06-12 2007-06-30 Btg Int Ltd Cikličen hidroksilamin kot psihoaktivne spojine
FR2921258A1 (fr) * 2007-09-24 2009-03-27 Oreal Composition tinctoriale comprenant au moins un precurseur incolore disulfures/thiol, proced de coloration a partir de la composition

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55147284A (en) * 1979-04-17 1980-11-17 Sanraku Inc Novel beta-lactam derivative and its preparation
IE52147B1 (en) * 1980-03-27 1987-07-08 Merck & Co Inc 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation
EP0038869A1 (en) * 1980-04-30 1981-11-04 Merck & Co. Inc. Process for the preparation of 1-carbapenems, and intermediates for their preparation
EP0060612A1 (en) * 1981-02-04 1982-09-22 Beecham Group Plc Process for the preparation of azabicyclo(3.2.0)-hept-2-ene derivatives
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
EP0074599A1 (en) * 1981-09-09 1983-03-23 Takeda Chemical Industries, Ltd. 5,6-cis-Carbapenem derivatives, their production and use
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0168707A1 (en) * 1984-07-02 1986-01-22 Merck & Co. Inc. 1-Methylcarbapenems having a 2-quaternary heteroarylalkylthio substituent
AT396472B (de) * 1985-09-11 1993-09-27 Bristol Myers Squibb Co Verfahren zur herstellung neuer carbapenem-antibiotika
AT397090B (de) * 1985-11-22 1994-01-25 Bristol Myers Squibb Co Verfahren zur herstellung von neuen carbapenemderivaten

Also Published As

Publication number Publication date
SE8401278D0 (sv) 1984-03-07
KR840008157A (ko) 1984-12-13
IL71149A0 (en) 1984-06-29
IT8419945A0 (it) 1984-03-07
NO166038B (no) 1991-02-11
KR900002247B1 (ko) 1990-04-07
ATA76984A (de) 1988-09-15
AU605491B2 (en) 1991-01-17
ES530337A0 (es) 1985-05-16
HK82990A (en) 1990-10-19
CH658248A5 (de) 1986-10-31
YU42084A (en) 1986-08-31
SG35490G (en) 1990-07-13
OA07674A (fr) 1985-05-23
PT78211A (en) 1984-04-01
CY1546A (en) 1991-03-22
FI840863A7 (fi) 1984-09-09
LU85241A1 (fr) 1984-11-14
AU572124B2 (en) 1988-05-05
GB8405984D0 (en) 1984-04-11
IE840549L (en) 1984-09-08
FR2542316B1 (fr) 1988-10-07
AR241016A2 (es) 1991-04-30
PT78211B (en) 1986-08-12
SE8901162L (sv) 1989-04-03
DK140584A (da) 1984-09-09
DD228258A5 (de) 1985-10-09
FI840863L (fi) 1984-09-09
HUT34980A (en) 1985-05-28
SE8901162D0 (sv) 1989-04-03
JPH05255250A (ja) 1993-10-05
IT1178465B (it) 1987-09-09
AU7592487A (en) 1987-10-22
YU46147B (sh) 1993-05-28
NO166038C (no) 1991-05-22
GB2136802B (en) 1987-05-20
DK140584D0 (da) 1984-02-29
IL71149A (en) 1990-03-19
ZW3884A1 (en) 1984-10-10
CA1284324C (en) 1991-05-21
ES8505205A1 (es) 1985-05-16
NO840865L (no) 1984-09-10
ES8507145A1 (es) 1985-08-16
YU49486A (en) 1987-12-31
FR2542316A1 (fr) 1984-09-14
ES537349A0 (es) 1985-08-16
HU193895B (en) 1987-12-28
AU2536084A (en) 1984-09-13
NL8400702A (nl) 1984-10-01
FI840863A0 (fi) 1984-03-05
NZ207346A (en) 1987-01-23
SE8401278L (sv) 1984-09-09
GB2136802A (en) 1984-09-26
YU46305B (sh) 1993-05-28
IE57098B1 (en) 1992-04-22
AT387968B (de) 1989-04-10
GR81871B (enExample) 1984-12-12
AR241016A1 (es) 1991-04-30

Similar Documents

Publication Publication Date Title
DE3321864C2 (enExample)
DE3785163T2 (de) 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-en-2-carbonsaeurederivate und verfahren zu deren herstellung.
CH657853A5 (de) Carbapenemderivate, deren herstellung und solche verbindungen enthaltende praeparate.
DE2950913A1 (de) Neue substituierte penemverbindungen, verfahren zu deren herstellung und arzneimittel
DE69129175T2 (de) 1-Methylcarbapenemderivate und Verfahren zu ihrer Herstellung
DE69612374T2 (de) Derivate des carbapenem-3-carbonsäureesters
DE3109086C2 (enExample)
DE3312533C2 (enExample)
DD228258A5 (de) Verfahren zur herstellung von carbapenem-derivaten
DE3334937C2 (enExample)
DE69322188T2 (de) Antimikrobielle Carbapenem-Derivate, ihre Herstellung und ihre therapeutische Verwendung
DE68916908T2 (de) Carbapenemderivate.
DE2652676A1 (de) N-alkylierte derivate von thienamycin, verfahren zu deren herstellung und diese enthaltende arzneimittel
CH651037A5 (de) Penem-3-carbonsaeurederivate und verfahren zu deren herstellung.
DE3317742C2 (enExample)
CH640236A5 (en) 3-(2-Aminoethylthio)-6-ethyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2 -carboxylic acid and process for its preparation
CH661729A5 (de) Fluoralkylierte carbapenemverbindungen.
US4880922A (en) Carbapenems with quaternized heterothioalkylthio substitution at position 2
DE2652679A1 (de) Substituierte n-methylenderivate von thienamycin, verfahren zu deren herstellung und diese enthaltende arzneimittel
KR910009270B1 (ko) 카바펜엠 항생제의 제조방법
DE3630857C2 (de) Carbapenem-Antibiotika, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Mittel
DD237507A5 (de) Verfahren zur herstellung von quaternaeren aminthiol.-zwischenverbindungen
AT387574B (de) Verfahren zur herstellung neuer carbapenem-derivate
DE3880660T2 (de) In 2-stellung substituierte (1r,5s,6s)-2-thio-6-((r)-1-hydroxyethyl)-1-methyl-carbapenem-carbonsaeure-derivate.
AT381942B (de) Verfahren zur herstellung neuer carbapenem-derivate

Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: BRISTOL-MYERS SQUIBB CO. (N.D.GES.D.STAATES DELAWA

8128 New person/name/address of the agent

Representative=s name: KINZEBACH, W., DIPL.-CHEM. DR.PHIL. RIEDL, P., DIP

8110 Request for examination paragraph 44
8125 Change of the main classification

Ipc: C07D213/20

8139 Disposal/non-payment of the annual fee