DE3390563T1 - 8,10-Dideazaminopterins - Google Patents

8,10-Dideazaminopterins

Info

Publication number
DE3390563T1
DE3390563T1 DE19833390563 DE3390563T DE3390563T1 DE 3390563 T1 DE3390563 T1 DE 3390563T1 DE 19833390563 DE19833390563 DE 19833390563 DE 3390563 T DE3390563 T DE 3390563T DE 3390563 T1 DE3390563 T1 DE 3390563T1
Authority
DE
Germany
Prior art keywords
dideazaminopterin
ethyl
methyl
acid
tumor growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19833390563
Other languages
German (de)
English (en)
Other versions
DE3390563C2 (enExample
Inventor
Joseph I. Sunnyvale Calif. DeGraw
Lawrence F. Australia Kelly
Francis M. New York N.Y. Sirotnak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Publication of DE3390563T1 publication Critical patent/DE3390563T1/de
Application granted granted Critical
Publication of DE3390563C2 publication Critical patent/DE3390563C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE19833390563 1983-12-27 1983-12-27 8,10-Dideazaminopterins Granted DE3390563T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1983/002065 WO1985002844A1 (en) 1983-12-27 1983-12-27 8,10-dideazaminopterins

Publications (2)

Publication Number Publication Date
DE3390563T1 true DE3390563T1 (de) 1985-11-14
DE3390563C2 DE3390563C2 (enExample) 1992-04-09

Family

ID=22175656

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19833390563 Granted DE3390563T1 (de) 1983-12-27 1983-12-27 8,10-Dideazaminopterins

Country Status (6)

Country Link
EP (1) EP0166726B1 (enExample)
JP (1) JPS61500845A (enExample)
AU (1) AU559561B2 (enExample)
DE (1) DE3390563T1 (enExample)
GB (1) GB2160525B (enExample)
WO (1) WO1985002844A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5140104A (en) * 1982-03-09 1992-08-18 Cytogen Corporation Amine derivatives of folic acid analogs
ZA861235B (en) * 1985-03-08 1986-10-29 Univ Princeton Pyrido(2,3-d)pyrimidine derivatives
US4818819A (en) * 1986-10-20 1989-04-04 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
US4902796A (en) * 1986-10-20 1990-02-20 The Trustees Of Princeton University 6-alkenyl and ethynyl derivatives of 2-amino-4-hydroxypyrido[2,3-d]pyrimidines
US4996206A (en) * 1989-12-11 1991-02-26 The Trustees Of Princeton University N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
US5159079A (en) * 1991-12-20 1992-10-27 Eli Lilly And Company 2-piperidones as intermediates for 5-deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acids
US5374726A (en) * 1992-03-03 1994-12-20 Degraw; Joseph I. Process for preparing 10-deazaaminopterins and 5,10-and 8,10-dideazaaminopterins from pteroic dicarboxylic acid diesters
US5196424A (en) * 1992-03-24 1993-03-23 Eli Lilly And Company N-[2-amino-4-substituted[[(pyrrollo or pyrido)[2,3-d]pyrimidinyl]-alkyl]benzoyl]-L-glutamic acids
CN106115745B (zh) * 2011-08-16 2018-01-12 蒂艾克思股份有限公司 多晶金属氧化物、其制备方法以及包括该多晶金属氧化物的制品

Also Published As

Publication number Publication date
EP0166726A1 (en) 1986-01-08
JPS61500845A (ja) 1986-05-01
AU559561B2 (en) 1987-03-12
WO1985002844A1 (en) 1985-07-04
GB2160525B (en) 1987-08-26
EP0166726B1 (en) 1988-11-17
DE3390563C2 (enExample) 1992-04-09
AU2435784A (en) 1985-07-12
GB8518606D0 (en) 1985-08-29
GB2160525A (en) 1985-12-24

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee