DE3382616T2 - Vermittler des durchdringungsvermoegens zur transdermalen verabreichung systemischer wirkstoffe. - Google Patents

Vermittler des durchdringungsvermoegens zur transdermalen verabreichung systemischer wirkstoffe.

Info

Publication number
DE3382616T2
DE3382616T2 DE8383105041T DE3382616T DE3382616T2 DE 3382616 T2 DE3382616 T2 DE 3382616T2 DE 8383105041 T DE8383105041 T DE 8383105041T DE 3382616 T DE3382616 T DE 3382616T DE 3382616 T2 DE3382616 T2 DE 3382616T2
Authority
DE
Germany
Prior art keywords
penetentiality
mediator
active substances
transdermal administration
systemic active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8383105041T
Other languages
English (en)
Other versions
DE3382616D1 (de
Inventor
Vithal J Rajadhyaksha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Whitby Research Inc
Original Assignee
Whitby Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whitby Research Inc filed Critical Whitby Research Inc
Application granted granted Critical
Publication of DE3382616D1 publication Critical patent/DE3382616D1/de
Publication of DE3382616T2 publication Critical patent/DE3382616T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/41—Devices for promoting penis erection
    • A61F2005/415—Devices for promoting penis erection by inflatable means
DE8383105041T 1982-05-20 1983-05-20 Vermittler des durchdringungsvermoegens zur transdermalen verabreichung systemischer wirkstoffe. Expired - Fee Related DE3382616T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/380,161 US4405616A (en) 1975-06-19 1982-05-20 Penetration enhancers for transdermal drug delivery of systemic agents

Publications (2)

Publication Number Publication Date
DE3382616D1 DE3382616D1 (de) 1992-10-15
DE3382616T2 true DE3382616T2 (de) 1993-03-11

Family

ID=23500123

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383105041T Expired - Fee Related DE3382616T2 (de) 1982-05-20 1983-05-20 Vermittler des durchdringungsvermoegens zur transdermalen verabreichung systemischer wirkstoffe.

Country Status (7)

Country Link
US (1) US4405616A (de)
EP (1) EP0095169B1 (de)
JP (1) JPS58210026A (de)
AT (1) ATE80312T1 (de)
AU (1) AU568590B2 (de)
DE (1) DE3382616T2 (de)
ZA (1) ZA833442B (de)

Families Citing this family (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5449670A (en) * 1983-05-20 1995-09-12 Skinner; Wilfred A. Composition and method for the transdermal delivery of bioactive peptides
US4557934A (en) * 1983-06-21 1985-12-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
US4931283A (en) * 1983-12-22 1990-06-05 American Home Products Corp. (Del) Menthol enhancement of transdermal drug delivery
US4933184A (en) * 1983-12-22 1990-06-12 American Home Products Corp. (Del) Menthol enhancement of transdermal drug delivery
JPH0627074B2 (ja) * 1984-07-25 1994-04-13 日東電工株式会社 医薬組成物
US4626539A (en) * 1984-08-10 1986-12-02 E. I. Dupont De Nemours And Company Trandermal delivery of opioids
US4927687A (en) * 1984-10-01 1990-05-22 Biotek, Inc. Sustained release transdermal drug delivery composition
US4568343A (en) * 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
DE3570598D1 (en) * 1984-11-15 1989-07-06 Nitto Denko Corp Composition for percutaneous administration
JPS61130207A (ja) * 1984-11-30 1986-06-18 Sunstar Inc 養毛剤
US4706676A (en) * 1985-02-11 1987-11-17 The United States Of America As Represented By The Secretary Of The Army Dermal substance collection device
CA1288698C (en) * 1985-08-30 1991-09-10 Yie W. Chien Transdermal anti-anginal pharmaceutical dosage
DE3531545A1 (de) * 1985-09-04 1987-03-05 Goedecke Ag Arzneimittel mit einem gehalt an calcium-antagonisten und deren verwendung
US4837026A (en) * 1985-10-03 1989-06-06 Rajakhyaksha Vithal J Transdermal and systemic preparation and method
US5023252A (en) * 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
JPS63502282A (ja) * 1986-01-31 1988-09-01 ホイットビ−・リサ−チ・インコ−ポレ−テッド １−置換アザシクロアルカン類より成る組成物とその用法
US5204339A (en) * 1986-01-31 1993-04-20 Whitby Research, Inc. Penetration enhancers for transdermal delivery of systemic agents
US5256647A (en) * 1986-01-31 1993-10-26 Whitby Research, Inc. Compositions comprising 1-substituted azacycloalkanes
US4992422A (en) * 1986-01-31 1991-02-12 Whitby Research, Inc. Compositions comprising 1-substituted azacycloalkanes
AU599964B2 (en) * 1986-01-31 1990-08-02 Nelson Research & Development Company Topical pharmaceuticals dye compositions, and plant nutrient compositions comprising 1-substituted azacycloalkanes as penetration enhancers
US4755535A (en) * 1986-04-23 1988-07-05 Nelson Research & Development Co. Compositions comprising 1-substituted azacycloalkenes
US4801586A (en) * 1986-04-23 1989-01-31 Nelson Research & Development Co. Penetration enhancers for transdermal delivery of systemic agents
US5142044A (en) * 1986-04-23 1992-08-25 Whitby Research, Inc. Penetration enhancers for transdermal delivery of systemic agents
CH666621A5 (de) * 1986-06-27 1988-08-15 Ciba Geigy Ag Topisch applizierbare pharmazeutische zusammensetzungen mit systemischer wirkung.
CA1319613C (en) * 1986-10-07 1993-06-29 Gevork Minaskanian Penetration enhancers for transdermal delivery of systemic agents
US5196410A (en) * 1986-10-31 1993-03-23 Pfizer Inc. Transdermal flux enhancing compositions
US4959365A (en) * 1986-10-31 1990-09-25 Pfizer Inc. Topical compositions of lipophilic pharmaceuticals agents
MY102980A (en) * 1986-10-31 1993-03-31 Pfizer Transdermal flux enhancing compositions
US4873266A (en) * 1987-01-16 1989-10-10 American Home Products Corp. Menthone enhancement of transdermal drug delivery
US4888362A (en) * 1987-01-16 1989-12-19 American Home Products Corp. Eugenol enhancement of transdermal drug delivery
US4888360A (en) * 1987-01-16 1989-12-19 American Home Products Corporation Carvone enhancement of transdermal drug delivery
US4746515A (en) * 1987-02-26 1988-05-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolaurate
US4940586A (en) * 1987-02-26 1990-07-10 Alza Corporation Skin permeation enhancer compositions using sucrose esters
US4865848A (en) * 1987-02-26 1989-09-12 Alza Corporation Skin permeation enhancer compositions using sucrose esters
US5051260A (en) * 1987-07-16 1991-09-24 The Regents Of The University Of California Method and composition for enhancing the cutaneous penetration of pharmacologically active agents
US5045317A (en) * 1987-07-16 1991-09-03 The Regents Of The University Of California Enhancing the cutaneous penetration of pharmacologically active agents
US4971800A (en) * 1988-07-08 1990-11-20 The Regents Of The University Of California Method and compositions for enhancing the cutaneous penetration of pharmacologically active agents
US4764379A (en) * 1987-08-24 1988-08-16 Alza Corporation Transdermal drug delivery device with dual permeation enhancers
US4820720A (en) * 1987-08-24 1989-04-11 Alza Corporation Transdermal drug composition with dual permeation enhancers
DE3871464D1 (de) * 1987-08-28 1992-07-02 Lilly Co Eli Die permeation verbessernde zusammensetzung.
US5196416A (en) * 1987-08-28 1993-03-23 Eli Lilly And Company Transdermal flux-enhancing pharmaceutical compositions comprising azone, ethanol and water
US4879275A (en) * 1987-09-30 1989-11-07 Nelson Research & Development Co. Penetration enhancers for transdermal delivery of systemic agent
US4920101A (en) * 1987-09-30 1990-04-24 Nelson Research & Development Co. Compositions comprising 1-oxo- or thiohydrocarbyl substituted azacycloaklkanes
US4863738A (en) * 1987-11-23 1989-09-05 Alza Corporation Skin permeation enhancer compositions using glycerol monooleate
US4906475A (en) * 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
US5641504A (en) * 1988-06-09 1997-06-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolinoleate
US5378730A (en) * 1988-06-09 1995-01-03 Alza Corporation Permeation enhancer comprising ethanol and monoglycerides
US4960771A (en) * 1988-07-12 1990-10-02 Rajadhyaksha Vithal J Oxazolidinone penetration enhancing compounds
US4975271A (en) * 1988-12-19 1990-12-04 Vipont Pharmaceutical, Inc. Muscosal delivery systems for treatment of periodontal disease
DE3843557A1 (de) * 1988-12-23 1990-06-28 Beiersdorf Ag Transdermales therapeutisches system zur verabreichung von clenbuterol
DE3905050A1 (de) 1989-02-18 1990-08-30 Lohmann Therapie Syst Lts Therapeutisches system zur verzoegerten und gesteuerten transdermalen oder transmucosalen verabreichung von wirkstoffen (ii)
US5059426A (en) * 1989-03-22 1991-10-22 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US4973468A (en) * 1989-03-22 1990-11-27 Cygnus Research Corporation Skin permeation enhancer compositions
US5053227A (en) * 1989-03-22 1991-10-01 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US4958032A (en) * 1989-04-05 1990-09-18 Lenick Jr Anthony J O N-alkoxylated ether 2-pyrrolidones
US6028105A (en) * 1989-04-06 2000-02-22 Nigra; Thomas P. Topical drug delivery composition and method
JP2831030B2 (ja) * 1989-05-12 1998-12-02 学校法人城西大学 ３’‐アジド‐３’デオキシチミジンを有効成分とする経皮投与製剤用組成物
US5023085A (en) * 1989-11-29 1991-06-11 Pfizer Inc. Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals
US5221254A (en) * 1991-04-02 1993-06-22 Alza Corporation Method for reducing sensation in iontophoretic drug delivery
DE4115849A1 (de) * 1991-05-15 1992-11-19 Lohmann Therapie Syst Lts Penetrationsfoerdernde substanz
US5229130A (en) * 1991-12-20 1993-07-20 Cygnus Therapeutics Systems Vegetable oil-based skin permeation enhancer compositions, and associated methods and systems
AU666735B2 (en) * 1992-05-13 1996-02-22 Alza Corporation Transdermal administration of oxybutynin
US5900250A (en) * 1992-05-13 1999-05-04 Alza Corporation Monoglyceride/lactate ester permeation enhancer for oxybutnin
DE69407061T2 (de) * 1992-06-02 1998-06-04 Alza Corp Abgabevorrichtung zur elektrischen übertragung von arzneimitteln
GB2273044B (en) * 1992-12-02 1997-04-09 Pacific Chem Co Ltd Medicinal patches for percutaneous administration
US5776923A (en) * 1993-01-19 1998-07-07 Endorecherche, Inc. Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone
WO1994016709A2 (en) * 1993-01-19 1994-08-04 Endorecherche Inc. Therapeutic uses and delivery systems of dehydroepiandrosterone
US5451407A (en) * 1993-06-21 1995-09-19 Alza Corporation Reduction or prevention of skin irritation or sensitization during transdermal administration of a irritating or sensitizing drug
EP0705097B2 (de) * 1993-06-25 2004-01-14 Alza Corporation Einarbeitung eines poly-n-vinylamids in ein transdermales system
EP0721348B1 (de) * 1993-09-29 1999-09-01 Alza Corporation Hautpermeabilitaetserhöher bestehend aus monoglycerid/laktat estern
AU695170B2 (en) * 1994-12-21 1998-08-06 Theratech, Inc. Transdermal delivery system with adhesive overlay and peel seal disc
US5837281A (en) 1995-03-17 1998-11-17 Takeda Chemical Industries, Ltd. Stabilized interface for iontophoresis
US5785991A (en) * 1995-06-07 1998-07-28 Alza Corporation Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
US5703104A (en) * 1995-07-07 1997-12-30 Durham Pharmaceuticals Llc Cyclic amides and derivatives thereof
US5707612A (en) * 1996-04-08 1998-01-13 Alzo, Inc. Use urethane polymers of castor oil skin and personal care product compositiions
US20030045492A1 (en) * 1997-08-13 2003-03-06 Tang De-Chu C. Vaccination by topical application of recombinant vectors
US6706693B1 (en) 1997-08-13 2004-03-16 The Uab Research Foundation Vaccination by topical application of genetic vectors
US6348450B1 (en) 1997-08-13 2002-02-19 The Uab Research Foundation Noninvasive genetic immunization, expression products therefrom and uses thereof
US20030125278A1 (en) * 1997-08-13 2003-07-03 Tang De-Chu C. Immunization of animals by topical applications of a salmonella-based vector
US6716823B1 (en) 1997-08-13 2004-04-06 The Uab Research Foundation Noninvasive genetic immunization, expression products therefrom, and uses thereof
US6267984B1 (en) 1997-12-22 2001-07-31 Alza Corporation Skin permeation enhancer compositions comprising a monoglyceride and ethyl palmitate
US6454681B1 (en) 1998-01-05 2002-09-24 Thomas Brassil Hand rehabilitation glove
US20070087901A1 (en) * 1998-01-05 2007-04-19 Brassil Thomas W Therapy system
US20040009936A1 (en) * 1999-05-03 2004-01-15 Tang De-Chu C. Vaccine and drug delivery by topical application of vectors and vector extracts
US6544541B1 (en) 1999-06-02 2003-04-08 Cardiovascular Solutions, Inc. Devices and compounds for treating arterial restenosis
US7029694B2 (en) 2000-04-26 2006-04-18 Watson Laboratories, Inc. Compositions and methods for transdermal oxybutynin therapy
US7179483B2 (en) * 2000-04-26 2007-02-20 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
US7198801B2 (en) * 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
AU2001282064B2 (en) * 2000-08-03 2007-02-01 Antares Pharma Ipl Ag Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
US20070225379A1 (en) * 2001-08-03 2007-09-27 Carrara Dario Norberto R Transdermal delivery of systemically active central nervous system drugs
US20020119187A1 (en) * 2000-09-29 2002-08-29 Cantor Adam S. Composition for the transdermal delivery of fentanyl
EP1390084B1 (de) 2001-05-01 2011-03-23 A.V. Topchiev Institute of Petrochemical Synthesis Zweiphasige, wasserabsorbierende bioadhäsive zusammenstezung
US20090162342A1 (en) * 2001-06-07 2009-06-25 Sanomune Inc. Therapeutic uses of glandular kallikrein
WO2003000158A1 (en) * 2001-06-22 2003-01-03 Bentley Pharmaceuticals, Inc. Pharmaceutical composition
US20040033253A1 (en) * 2002-02-19 2004-02-19 Ihor Shevchuk Acyl opioid antagonists
MY139721A (en) * 2002-04-19 2009-10-30 Cpex Pharmaceuticals Inc Pharmaceutical composition
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
KR101407131B1 (ko) 2002-06-10 2014-06-19 유로-셀티크 소시에떼 아노뉨 경피 전달 장치에 포함된 활성 성분의 오용을 방지하는 경피 전달 장치의 처리 시스템
ES2294344T3 (es) * 2002-08-02 2008-04-01 Ab Science 2-(3-aminoaril)amino-4-aril-tiazoles y su utilizacion como inhibidores de c-kit.
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
US20030049307A1 (en) * 2002-08-15 2003-03-13 Gyurik Robert J. Pharmaceutical composition
WO2004017941A2 (en) * 2002-08-20 2004-03-04 Euro-Celtique, S.A. Transdermal dosage form comprising an active agent and a salt and free-baseform of an antagonist
US20080020028A1 (en) * 2003-08-20 2008-01-24 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent
PT1670433E (pt) 2003-10-10 2012-02-08 Ferring Bv Fórmula farmacológica transdérmica para a minimização de resíduos na pele
CN1950347B (zh) * 2003-10-23 2012-04-04 Ab科学公司 作为酪氨酸激酶抑制剂的2-氨基芳基噁唑化合物
PT1682537E (pt) 2003-11-05 2012-06-20 Sarcode Bioscience Inc Moduladores de adesão celular
US7105263B2 (en) * 2003-12-30 2006-09-12 Samsung Electronics Company Dry toner comprising encapsulated pigment, methods and uses
US8658201B2 (en) 2004-01-30 2014-02-25 Corium International, Inc. Rapidly dissolving film for delivery of an active agent
WO2005097083A2 (en) * 2004-03-30 2005-10-20 Dermatrends,Inc. Transdermal administration of proton pump inhibitors
WO2005110418A2 (en) 2004-05-07 2005-11-24 Phytotox Limited Transdermal administration of phycotoxins
US20060008432A1 (en) * 2004-07-07 2006-01-12 Sebastiano Scarampi Gilsonite derived pharmaceutical delivery compositions and methods: nail applications
JP2008531581A (ja) * 2005-02-23 2008-08-14 ユーエービー リサーチ ファウンデーション アルキル−グリコシドで増強されたワクチン接種
US20080242704A1 (en) 2005-04-04 2008-10-02 Ab Science Substituted Oxazole Derivatives and their Use as Tyrosine Kinase Inhibitors
WO2006125642A1 (en) 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
TWI366460B (en) 2005-06-16 2012-06-21 Euro Celtique Sa Cannabinoid active pharmaceutical ingredient for improved dosage forms
US8153162B2 (en) 2005-09-27 2012-04-10 Tissuetech, Inc. Purified amniotic membrane compositions and methods of use
US8187639B2 (en) 2005-09-27 2012-05-29 Tissue Tech, Inc. Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
CA2646667C (en) 2006-04-21 2014-03-11 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
US7879344B2 (en) * 2006-06-29 2011-02-01 Kimberly-Clark Worldwide, Inc. Transdermal delivery of oleocanthal for relief of inflammation
WO2008067991A2 (en) * 2006-12-08 2008-06-12 Antares Pharma Ipl Ag Skin-friendly drug complexes for transdermal administration
WO2008141176A1 (en) * 2007-05-11 2008-11-20 The Trustees Of The University Of Pennsylvania Methods of treatment of skin ulcers
US9511016B2 (en) * 2007-06-12 2016-12-06 Epicentrx, Inc. Topical composition for treating pain
US20080311058A1 (en) * 2007-06-18 2008-12-18 Connopco, Inc., D/B/A Unilever Stable high internal phase emulsions and compositions comprising the same
RU2472539C2 (ru) 2007-08-06 2013-01-20 Аллерган, Инк. Способы и устройства для доставки препарата десмопрессина
CA2866527C (en) 2007-10-10 2018-07-03 Bryan B. Fuller Use of isoeugenol esters in treating hyperpigmentation
ES2830024T3 (es) 2007-10-19 2021-06-02 Novartis Ag Composiciones y métodos para el tratamiento del edema macular
US20090123504A1 (en) * 2007-11-12 2009-05-14 Kimberly-Clark Worldwide, Inc. Olive oil formulation for pain relief
US8425882B2 (en) * 2008-04-01 2013-04-23 Conopco, Inc. In-shower and bath compositions
ES2763703T3 (es) * 2008-04-15 2020-05-29 Sarcode Bioscience Inc Antagonistas de LFA-1 tópicos utilizados en el tratamiento localizado de trastornos inmunes
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
PT3085381T (pt) 2008-05-21 2018-05-18 Ferring Bv Desmopressina orodispersível para aumentar o período inicial de sono não perturbado pela noctúria
US20090304776A1 (en) * 2008-06-06 2009-12-10 Totada Shantha Transmucosal delivery of therapeutic agents and methods of use thereof
US7883487B2 (en) * 2008-06-16 2011-02-08 Shantha Totada R Transdermal local anesthetic patch with injection port
GB0819594D0 (en) 2008-10-24 2008-12-03 Univ Coimbrra Process
US8299127B2 (en) * 2009-03-11 2012-10-30 Conopco, Inc. Method and composition for evenly applying water soluble actives
US8241614B2 (en) * 2009-11-30 2012-08-14 Conopco, Inc Compositions and methods for imparting a sunless tan
AR079993A1 (es) 2010-01-12 2012-03-07 Ab Science Derivados de azol, composiciones farmaceuticas y sus usos para tratar trastornos mediados por una sobreactividad de quinasas
US20120302577A1 (en) 2010-01-28 2012-11-29 Ab Science Treatment of gist with masitinib
CA2797033C (en) 2010-04-22 2021-10-19 Longevity Biotech, Inc. Highly active polypeptides and methods of making and using the same
US8821839B2 (en) 2010-10-22 2014-09-02 Conopco, Inc. Compositions and methods for imparting a sunless tan with a vicinal diamine
US8398959B2 (en) 2010-12-06 2013-03-19 Conopco, Inc. Compositions and methods for imparting a sunless tan with functionalized adjuvants
WO2012116452A1 (en) 2011-03-03 2012-09-07 Denovamed Inc. Antimicrobial/adjuvant compounds and methods
ES2822301T3 (es) 2011-06-10 2021-04-30 Tissuetech Inc Métodos de procesamiento de tejidos de soporte fetal
CN103764150A (zh) 2011-06-29 2014-04-30 阿勒根公司 阿卡他定在治疗荨麻疹中的用途
MX2014001079A (es) 2011-07-27 2014-09-12 Ab Science Derivados de oxazoly tiazol como inhibidores de la proteina quinasa selectiva (c-kit).
WO2013032938A1 (en) 2011-08-26 2013-03-07 Tissuetech, Inc. Methods of sterilizing fetal support tissues
US8961942B2 (en) 2011-12-13 2015-02-24 Conopco, Inc. Sunless tanning compositions with adjuvants comprising sulfur comprising moieties
US20130315891A1 (en) 2012-05-25 2013-11-28 Matthew Charles Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
CA2880085C (en) 2012-06-04 2021-09-07 Diamedica Inc. Human tissue kallikrein 1 glycosylation isoforms
EP2968469A4 (de) 2013-03-15 2016-08-31 Longevity Biotech Inc Peptide mit nichtnatürlichen aminosäuren und verfahren zur herstellung und verwendung davon
DK3024474T3 (da) 2013-07-23 2022-03-28 Serenity Pharmaceuticals Llc Sammensætninger omfattende desmopressin i kombination med en beta-3-adrenoreceptor-agonist
CN106414433A (zh) 2014-03-24 2017-02-15 Ab科学有限公司 作为脾酪氨酸激酶抑制剂的二氮杂螺烷酮取代的噁唑衍生物
KR20170070008A (ko) 2014-08-15 2017-06-21 더 존스 홉킨스 유니버시티 조직 복원용 복합 재료
WO2016081599A1 (en) 2014-11-18 2016-05-26 Rutgers, The State University Of New Jersey Novel mitochondrial uncouplers for treatment of metabolic diseases and cancer
KR20170097045A (ko) 2014-11-20 2017-08-25 알레간 인코포레이티드 알파-아드레날린성 수용체 길항제와 조합된 데스모프레신을 포함하는 방법 및 조성물
EP3053920B1 (de) 2015-02-05 2020-04-08 AB Science Verbindungen mit antitumoraktivität
ES2919964T3 (es) 2015-08-17 2022-07-29 Univ Johns Hopkins Material compuesto que se forma in situ para la restauración de tejido
EP3144307A1 (de) 2015-09-18 2017-03-22 AB Science Neue oxazol derivaten als syk kinasehemmer
TW201733600A (zh) 2016-01-29 2017-10-01 帝聖工業公司 胎兒扶持組織物及使用方法
CA3024610A1 (en) 2016-05-18 2017-11-23 David J. Augeri Novel mitochondrial uncouplers for treatment of metabolic diseases and cancer
EP3592377A4 (de) 2017-03-09 2021-02-17 Diamedica Inc. Darreichungsformen von gewebekallikrein 1
ES2942848T3 (es) 2018-03-05 2023-06-07 Denovamed Inc Derivados de tiofeno-2-amida sustituidos con difenilo y composiciones farmacéuticas de los mismos útiles como antimicrobiano
AU2019265839A1 (en) 2018-05-09 2020-12-03 The Johns Hopkins University Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration
CN112384258A (zh) 2018-05-09 2021-02-19 约翰·霍普金斯大学 用于细胞和组织递送的纳米纤维-水凝胶复合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4316893A (en) * 1975-06-19 1982-02-23 Nelson Research & Development Co. Vehicle composition containing 1-substituted azacycloalkan-2-ones
FR2314731A1 (fr) * 1975-06-19 1977-01-14 Nelson Res & Dev Azacycloalcan-2-ones 1-substituees et compositions pharmaceutiques contenant ces composes a titre d'excipients
US3989816A (en) * 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones

Also Published As

Publication number Publication date
AU568590B2 (en) 1988-01-07
ATE80312T1 (de) 1992-09-15
AU1439383A (en) 1983-11-24
EP0095169A2 (de) 1983-11-30
ZA833442B (en) 1984-01-25
JPS58210026A (ja) 1983-12-07
EP0095169B1 (de) 1992-09-09
EP0095169A3 (en) 1985-07-31
US4405616A (en) 1983-09-20
DE3382616D1 (de) 1992-10-15

Similar Documents

Publication Publication Date Title
DE3382616T2 (de) Vermittler des durchdringungsvermoegens zur transdermalen verabreichung systemischer wirkstoffe.
EP0268220A3 (en) Penetration enhancers for transdermal delivery of systemic agents
EP0164998A3 (de) Mittel und Verfahren zur Erhöhung der transdermalen und transmembranen Penetration topischer und systemischer Wirkstoffe
DZ1067A1 (fr) Nouvelles préparations pharmaceutiques à emission prolongée.
ATE149349T1 (de) Einarbeitung eines poly-n-vinylamids in ein transdermales system
ES550011A0 (es) Un metodo de administracion de una cantidad terapeuticamenteefectiva de timolol
RU94045259A (ru) Увлажняющая композиция и способ увлажнения кожи
ATE218868T1 (de) Hustenhemmende, theobromine enthaltende zusammensetzungen
KR870005646A (ko) 수술후 유착형성 억제방법
SE8101374L (sv) Kompositioner innehallande n,n-dietyl-m-toluamid
ES2038154T3 (es) Un procedimiento para preparar una composicion para potenciar la penetracion de membranas de al menos un agente sistematicamente activo.
DE69113437T2 (de) Therapeutische Mittel für diabetisches Gangrän.
KR900016130A (ko) 2-피리딜메틸티오 유도체 및 궤양 치료제
IE38967L (en) 16-cyano-pregnene compounds.
KR920019349A (ko) 불안을 치료하기 위한 r(+)-3-아미노-1-하이드록시-피롤리딘-2-온의 용도
KR880005929A (ko) 전신 약품의 경피 투여용 침투 증강제
KR927003530A (ko) 이온삼투요법용 제약 제제의 제조에 있어서의 국소 마취제의 용도
ATE79277T1 (de) Eine pharmazeutische zusammensetzung angepasst an die transdermale applikation eines opioids.
JPS5261217A (en) Method for increasing absorption of novel penicillin at rectal infusio n
DE3577838D1 (de) Fluessige, biologisch wirksame zusammensetzungen.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee