DE3370325D1 - 1-phenyl-2(1h,3h)-indolone psycho-therapeutic agents - Google Patents

1-phenyl-2(1h,3h)-indolone psycho-therapeutic agents

Info

Publication number
DE3370325D1
DE3370325D1 DE8383305484T DE3370325T DE3370325D1 DE 3370325 D1 DE3370325 D1 DE 3370325D1 DE 8383305484 T DE8383305484 T DE 8383305484T DE 3370325 T DE3370325 T DE 3370325T DE 3370325 D1 DE3370325 D1 DE 3370325D1
Authority
DE
Germany
Prior art keywords
phenyl
indolone
psycho
indolones
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383305484T
Other languages
German (de)
English (en)
Inventor
Harry R Howard
Reinhard Sarges
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE3370325D1 publication Critical patent/DE3370325D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Dental Preparations (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE8383305484T 1982-09-20 1983-09-19 1-phenyl-2(1h,3h)-indolone psycho-therapeutic agents Expired DE3370325D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/420,544 US4476307A (en) 1982-09-20 1982-09-20 Heteroylidene indolone compounds

Publications (1)

Publication Number Publication Date
DE3370325D1 true DE3370325D1 (en) 1987-04-23

Family

ID=23666904

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383305484T Expired DE3370325D1 (en) 1982-09-20 1983-09-19 1-phenyl-2(1h,3h)-indolone psycho-therapeutic agents

Country Status (24)

Country Link
US (1) US4476307A (https=)
EP (1) EP0104860B1 (https=)
JP (1) JPS5976058A (https=)
KR (1) KR860001270B1 (https=)
AT (1) ATE25972T1 (https=)
AU (1) AU543115B2 (https=)
CA (1) CA1194871A (https=)
DD (1) DD213211A5 (https=)
DE (1) DE3370325D1 (https=)
DK (1) DK157010C (https=)
ES (3) ES8503328A1 (https=)
FI (1) FI77446C (https=)
GR (1) GR79732B (https=)
HU (1) HU189747B (https=)
IE (1) IE55923B1 (https=)
IL (1) IL69758A (https=)
NO (1) NO161557C (https=)
NZ (1) NZ205638A (https=)
PH (1) PH18297A (https=)
PL (3) PL141876B1 (https=)
PT (1) PT77360B (https=)
SU (1) SU1272983A3 (https=)
YU (4) YU189283A (https=)
ZA (1) ZA836933B (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879391A (en) * 1982-09-20 1989-11-07 Pfizer Inc. 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents
US4760083A (en) * 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
WO1990008146A1 (en) * 1989-01-10 1990-07-26 Pfizer Inc. Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides
US5078756A (en) * 1990-01-12 1992-01-07 Major Thomas O Apparatus and method for purification and recovery of refrigerant
US5158969A (en) * 1991-08-21 1992-10-27 Neurosearch A/S Indole derivatives as potassium channel blockers
US5760250A (en) * 1991-11-05 1998-06-02 Zeneca Limited Process for the preparation of 3-(α-methoxy)methylenebenzofuranones and intermediates therefor
DE19949209A1 (de) * 1999-10-13 2001-04-19 Boehringer Ingelheim Pharma In 5-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
AU2002341881B2 (en) * 2001-09-27 2008-05-08 Allergan, Inc. 3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
MXPA04009365A (es) * 2002-03-27 2005-01-25 Lundbeck & Co As H Metodo para la manufactura de sertindol.
FR2847811B1 (fr) * 2002-11-29 2005-01-07 Oreal Composition filtrante contenant au moins un derive du dibenzoylmethane et au moins un derive de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one;procede de photostabilisation
FR2847813A1 (fr) * 2002-11-29 2004-06-04 Oreal Compositions cosmetiques photoprotectrices contenant des derives de 3-(2-azacycloalkylidene)-1,3-dihydro-indol-2-one et utilisations
ES2600460T3 (es) 2005-05-10 2017-02-09 Intermune, Inc. Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés
CN102099036B (zh) 2008-06-03 2015-05-27 英特芒尼公司 用于治疗炎性疾患和纤维化疾患的化合物和方法
US8222430B2 (en) 2008-12-19 2012-07-17 Nippon Soda Co., Ltd. 1-heterodiene derivative and harmful organism control agent
KR101376443B1 (ko) 2009-11-12 2014-03-19 닛뽕소다 가부시키가이샤 1-헤테로디엔 유도체 및 유해 생물 방제제
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
MX382781B (es) 2014-04-02 2025-03-13 Intermune Inc Piridinonas anti-fibroticas.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506683A (en) * 1963-10-07 1970-04-14 Upjohn Co 3-(2-pyrrolidinylidene)-3h-indoles
GB1237008A (en) * 1968-12-18 1971-06-30 Pfizer Ltd Novel indoline derivatives
US3723457A (en) * 1969-09-30 1973-03-27 Eisai Co Ltd Indoline-2-one derivatives and preparation thereof
GB1374414A (en) * 1972-06-12 1974-11-20 Sterling Drug Inc 1-acyl-3-amino-alkyl-indoles and their preparation
DE2557342A1 (de) * 1975-12-19 1977-06-30 Hoechst Ag Basisch substituierte indolderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
ES8505950A1 (es) 1985-06-01
DK157010B (da) 1989-10-30
PL141609B1 (en) 1987-08-31
NO161557B (no) 1989-05-22
PH18297A (en) 1985-05-24
DK425383D0 (da) 1983-09-19
PL250769A1 (en) 1985-07-02
KR840006239A (ko) 1984-11-22
NO161557C (no) 1989-08-30
JPS6241711B2 (https=) 1987-09-04
PT77360A (en) 1983-10-01
YU169286A (en) 1987-10-31
NO833367L (no) 1984-03-21
IE55923B1 (en) 1991-02-27
EP0104860A1 (en) 1984-04-04
DK425383A (da) 1984-05-03
EP0104860B1 (en) 1987-03-18
DK157010C (da) 1990-03-26
PL141876B1 (en) 1987-09-30
PL243826A1 (en) 1985-04-24
CA1194871A (en) 1985-10-08
YU169186A (en) 1987-10-31
AU543115B2 (en) 1985-04-04
DD213211A5 (de) 1984-09-05
SU1272983A3 (ru) 1986-11-23
FI77446B (fi) 1988-11-30
YU189283A (en) 1987-10-31
ES531907A0 (es) 1985-06-01
ZA836933B (en) 1985-05-29
PL250768A1 (en) 1985-07-02
FI833335A7 (fi) 1984-03-21
GR79732B (https=) 1984-10-31
ES8505951A1 (es) 1985-06-01
JPS5976058A (ja) 1984-04-28
PL141370B1 (en) 1987-07-31
FI77446C (fi) 1989-03-10
HU189747B (en) 1986-07-28
ES525737A0 (es) 1985-02-16
AU1925283A (en) 1984-03-29
NZ205638A (en) 1986-12-05
IE832193L (en) 1984-03-20
ATE25972T1 (de) 1987-04-15
ES8503328A1 (es) 1985-02-16
FI833335A0 (fi) 1983-09-19
YU169386A (en) 1987-10-31
PT77360B (en) 1986-05-19
IL69758A0 (en) 1983-12-30
ES531908A0 (es) 1985-06-01
US4476307A (en) 1984-10-09
KR860001270B1 (ko) 1986-09-04
IL69758A (en) 1986-12-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee