DE3330699A1 - Verfahren zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasma - Google Patents
Verfahren zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasmaInfo
- Publication number
- DE3330699A1 DE3330699A1 DE19833330699 DE3330699A DE3330699A1 DE 3330699 A1 DE3330699 A1 DE 3330699A1 DE 19833330699 DE19833330699 DE 19833330699 DE 3330699 A DE3330699 A DE 3330699A DE 3330699 A1 DE3330699 A1 DE 3330699A1
- Authority
- DE
- Germany
- Prior art keywords
- fibrinogen
- plasma
- enzyme
- thrombin
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108010049003 Fibrinogen Proteins 0.000 title claims abstract description 43
- 102000008946 Fibrinogen Human genes 0.000 title claims abstract description 43
- 229940012952 fibrinogen Drugs 0.000 title claims abstract description 43
- 238000000034 method Methods 0.000 title claims abstract description 41
- 230000004992 fission Effects 0.000 title abstract description 8
- FBPFZTCFMRRESA-ZXXMMSQZSA-N D-iditol Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-ZXXMMSQZSA-N 0.000 title 2
- 108090000790 Enzymes Proteins 0.000 claims abstract description 21
- 102000004190 Enzymes Human genes 0.000 claims abstract description 21
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 9
- 239000003998 snake venom Substances 0.000 claims abstract description 8
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 8
- 230000002345 thrombinlike Effects 0.000 claims abstract description 7
- 239000000872 buffer Substances 0.000 claims abstract description 5
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 4
- 239000003599 detergent Substances 0.000 claims abstract description 4
- 241000270295 Serpentes Species 0.000 claims abstract description 3
- 229910001424 calcium ion Inorganic materials 0.000 claims abstract description 3
- 229940088598 enzyme Drugs 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 13
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 239000002435 venom Substances 0.000 claims description 4
- 210000001048 venom Anatomy 0.000 claims description 4
- 231100000611 venom Toxicity 0.000 claims description 4
- 108010027612 Batroxobin Proteins 0.000 claims description 3
- 229960002210 batroxobin Drugs 0.000 claims description 3
- 230000015556 catabolic process Effects 0.000 claims description 3
- 238000003776 cleavage reaction Methods 0.000 claims description 3
- 230000007017 scission Effects 0.000 claims description 3
- 241000271510 Agkistrodon contortrix Species 0.000 claims description 2
- 241000271064 Calloselasma rhodostoma Species 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 241000271897 Viperidae Species 0.000 claims description 2
- 239000007853 buffer solution Substances 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- 210000002381 plasma Anatomy 0.000 description 17
- 108090000190 Thrombin Proteins 0.000 description 12
- 229960004072 thrombin Drugs 0.000 description 12
- 230000015271 coagulation Effects 0.000 description 8
- 238000005345 coagulation Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 4
- 239000004019 antithrombin Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000001900 immune effect Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 238000007430 reference method Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- IEQAICDLOKRSRL-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO IEQAICDLOKRSRL-UHFFFAOYSA-N 0.000 description 2
- 108010039627 Aprotinin Proteins 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- 108010023197 Streptokinase Proteins 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 230000002429 anti-coagulating effect Effects 0.000 description 2
- 229960004405 aprotinin Drugs 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 229960005202 streptokinase Drugs 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 208000015294 blood coagulation disease Diseases 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 1
- 239000001639 calcium acetate Substances 0.000 description 1
- 229960005147 calcium acetate Drugs 0.000 description 1
- 235000011092 calcium acetate Nutrition 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- -1 calcium halides Chemical class 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 230000009852 coagulant defect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 230000003480 fibrinolytic effect Effects 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 239000002607 heparin antagonist Substances 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000009666 routine test Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/4609—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates from reptiles
- G01N2333/4613—Snake venom
- G01N2333/462—Snake venom from Agkistrodon sp., e.g. acutase, ACTE
- G01N2333/4623—Snake venom from Agkistrodon sp., e.g. acutase, ACTE from Agkistrodon rhodostama (Malayan pit viper); Arvin (R); Batroboxin; Ancrod
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/4609—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates from reptiles
- G01N2333/4613—Snake venom
- G01N2333/462—Snake venom from Agkistrodon sp., e.g. acutase, ACTE
- G01N2333/4626—Snake venom from Agkistrodon sp., e.g. acutase, ACTE from Agkistrodon contortrix contortrix (copperhead snake); Protac (R)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/75—Fibrin; Fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833330699 DE3330699A1 (de) | 1983-08-25 | 1983-08-25 | Verfahren zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasma |
| US06/642,421 US4692406A (en) | 1983-08-25 | 1984-08-20 | Process and a reagent for the simultaneous determination of fibrinogen and fibrinogen fission products in plasma |
| ES535372A ES8504940A1 (es) | 1983-08-25 | 1984-08-23 | Procedimiento para la determinacion simultanea de fibrinogeno y de productos de disociacion de fibrinogeno en el plasma |
| DD84266560A DD222043A5 (de) | 1983-08-25 | 1984-08-23 | Verfahren und reagens zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasma |
| DE8484110145T DE3462699D1 (en) | 1983-08-25 | 1984-08-24 | Process for the simultaneous determination of fibrinogen and cleavage products of fibrinogen in plasma |
| JP59175310A JPS6066996A (ja) | 1983-08-25 | 1984-08-24 | 血漿中のフイブリノゲン及びフイブリノゲン分解生成物を同時に測定する方法及び試薬 |
| EP84110145A EP0137269B1 (de) | 1983-08-25 | 1984-08-24 | Verfahren zur gleichzeitigen Bestimmung von Fibrinogen und Fibrinogen-Spaltprodukten im Plasma |
| AT84110145T ATE26002T1 (de) | 1983-08-25 | 1984-08-24 | Verfahren zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasma. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833330699 DE3330699A1 (de) | 1983-08-25 | 1983-08-25 | Verfahren zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3330699A1 true DE3330699A1 (de) | 1985-03-07 |
Family
ID=6207432
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19833330699 Withdrawn DE3330699A1 (de) | 1983-08-25 | 1983-08-25 | Verfahren zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasma |
| DE8484110145T Expired DE3462699D1 (en) | 1983-08-25 | 1984-08-24 | Process for the simultaneous determination of fibrinogen and cleavage products of fibrinogen in plasma |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8484110145T Expired DE3462699D1 (en) | 1983-08-25 | 1984-08-24 | Process for the simultaneous determination of fibrinogen and cleavage products of fibrinogen in plasma |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4692406A (enrdf_load_stackoverflow) |
| EP (1) | EP0137269B1 (enrdf_load_stackoverflow) |
| JP (1) | JPS6066996A (enrdf_load_stackoverflow) |
| AT (1) | ATE26002T1 (enrdf_load_stackoverflow) |
| DD (1) | DD222043A5 (enrdf_load_stackoverflow) |
| DE (2) | DE3330699A1 (enrdf_load_stackoverflow) |
| ES (1) | ES8504940A1 (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4203980A1 (de) * | 1992-02-11 | 1993-08-12 | Max Planck Gesellschaft | Verfahren zur bestimmung von hirudin und synthetischen thrombininhibitoren |
| US9213035B2 (en) | 2008-05-22 | 2015-12-15 | Ethicon, Inc. | Protein assay |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3502878A1 (de) * | 1985-01-29 | 1986-07-31 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur bestimmung des fibrinolytischen zustands von plasma |
| US4849403A (en) * | 1985-05-29 | 1989-07-18 | Pentapharm Ag | Protein C activator, methods of preparation and use thereof |
| GB2178533B (en) * | 1985-07-22 | 1989-07-19 | Asahi Chemical Ind | Analytical method of enzyme precursors and device therefor |
| DE3607559A1 (de) * | 1986-03-07 | 1987-09-10 | Boehringer Mannheim Gmbh | Verfahren zur photometrischen bestimmung der protein c- und/oder protein s-aktivitaet |
| DD261844A1 (de) * | 1986-07-09 | 1988-11-09 | Adw Ddr | Verfahren zur praezipitation von fibrinmonomeren |
| DE3900493A1 (de) * | 1989-01-10 | 1990-07-12 | Thomae Gmbh Dr K | Verfahren zur bestimmung der fibrinolytischen gesamtaktivitaet im plasma |
| JP3180824B2 (ja) * | 1991-08-30 | 2001-06-25 | シスメックス株式会社 | 血液凝固試薬 |
| DE4133946A1 (de) * | 1991-10-14 | 1993-04-15 | Behringwerke Ag | Funktioneller test und reagenz zur bestimmung von fibrinogen |
| ATE138478T1 (de) * | 1992-02-17 | 1996-06-15 | Akzo Nobel Nv | Kalibrator und verwendung davon in einer immuntest |
| AT399055B (de) * | 1992-05-15 | 1995-03-27 | Immuno Ag | Verfahren zur bestimmung von fibrinogen |
| JP2776488B2 (ja) * | 1992-09-09 | 1998-07-16 | 株式会社トクヤマ | フィブリノゲン定量乾燥試薬 |
| US5441892A (en) * | 1992-10-15 | 1995-08-15 | Medtronic Hemptec, Inc. | Blood clot mass measuring technique |
| ES2119165T5 (es) * | 1993-01-29 | 2004-07-01 | T.A.C. Thrombosis And Coagulation Aktiebolag | Nueva actividad de cofactor anticoagulante. |
| JP2994557B2 (ja) | 1994-09-02 | 1999-12-27 | 株式会社アズウェル | フィブリノゲン測定方法およびその測定試薬 |
| US5780255A (en) * | 1995-06-09 | 1998-07-14 | Instrumentation Laboratory, S.P.A. | Protein C pathway screening test |
| US6379975B1 (en) | 1996-11-27 | 2002-04-30 | T.A.C. Thrombosis And Coagulation Aktiebolag | Methods and reagents for determining protein S |
| JP2000070241A (ja) | 1998-08-31 | 2000-03-07 | Nissho Corp | 急速凝固用真空採血管 |
| WO2001023536A1 (fr) * | 1999-09-27 | 2001-04-05 | International Reagents Corporation | Stabilisation de la thrombine et compositions |
| US6261820B1 (en) * | 1999-10-01 | 2001-07-17 | Amgen Inc. | Fibronolytically active polypeptide |
| DE10046187A1 (de) * | 2000-09-13 | 2002-03-21 | Univ Schiller Jena | Verfahren zur Messung der Aktivität von Gerinnungsfaktor XIIIa |
| US6855509B2 (en) * | 2000-12-19 | 2005-02-15 | Instrumentation Laboratory Company | Protein S functional assay and kit therefor |
| DE10362199B4 (de) * | 2003-06-04 | 2009-09-10 | Stief, Thomas, Dr.med. | Nachweisverfahren für Fibrinogen |
| CA2567137A1 (en) * | 2004-05-17 | 2005-12-08 | Medtronic, Inc. | Point of care heparin determination system |
| US20210071229A1 (en) * | 2018-01-25 | 2021-03-11 | Dsm Ip Assets B.V. | Fibrinogen test |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2525804B2 (de) * | 1975-06-10 | 1980-04-03 | Behringwerke Ag, 3550 Marburg | Stabiler Clumping-Faktor, Verwendung desselben zum Nachweis von Fibrinogen- und Fibrinspaltprodukten und Herstellung desselben |
| DE2615844A1 (de) * | 1976-04-10 | 1977-10-20 | Knoll Ag | Fibrinogen spaltendes enzymsystem |
| US4289498A (en) * | 1979-01-08 | 1981-09-15 | Ortho Diagnostics, Inc. | One-stage prothrombin assay and compositions useful therein |
| DE3017707A1 (de) * | 1980-05-08 | 1981-11-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und reagens zum nachweis von fibrinmonomer |
-
1983
- 1983-08-25 DE DE19833330699 patent/DE3330699A1/de not_active Withdrawn
-
1984
- 1984-08-20 US US06/642,421 patent/US4692406A/en not_active Expired - Lifetime
- 1984-08-23 DD DD84266560A patent/DD222043A5/de not_active IP Right Cessation
- 1984-08-23 ES ES535372A patent/ES8504940A1/es not_active Expired
- 1984-08-24 EP EP84110145A patent/EP0137269B1/de not_active Expired
- 1984-08-24 AT AT84110145T patent/ATE26002T1/de not_active IP Right Cessation
- 1984-08-24 DE DE8484110145T patent/DE3462699D1/de not_active Expired
- 1984-08-24 JP JP59175310A patent/JPS6066996A/ja active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4203980A1 (de) * | 1992-02-11 | 1993-08-12 | Max Planck Gesellschaft | Verfahren zur bestimmung von hirudin und synthetischen thrombininhibitoren |
| US5547850A (en) * | 1992-02-11 | 1996-08-20 | Max-Planck-Gesellschaft | Process for determining hirudin and synthetic thrombin inhibitors |
| US9213035B2 (en) | 2008-05-22 | 2015-12-15 | Ethicon, Inc. | Protein assay |
| US9896716B2 (en) | 2008-05-22 | 2018-02-20 | Ethicon, Inc. | Protein assay |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6066996A (ja) | 1985-04-17 |
| US4692406A (en) | 1987-09-08 |
| DE3462699D1 (en) | 1987-04-23 |
| ES535372A0 (es) | 1985-05-16 |
| ATE26002T1 (de) | 1987-04-15 |
| EP0137269A1 (de) | 1985-04-17 |
| DD222043A5 (de) | 1985-05-08 |
| JPH0368680B2 (enrdf_load_stackoverflow) | 1991-10-29 |
| ES8504940A1 (es) | 1985-05-16 |
| EP0137269B1 (de) | 1987-03-18 |
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