DE3324532C2 - Verfahren zur Herstellung von (±)-4-Oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isochinolinderivaten - Google Patents

Verfahren zur Herstellung von (±)-4-Oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isochinolinderivaten

Info

Publication number
DE3324532C2
DE3324532C2 DE3324532A DE3324532A DE3324532C2 DE 3324532 C2 DE3324532 C2 DE 3324532C2 DE 3324532 A DE3324532 A DE 3324532A DE 3324532 A DE3324532 A DE 3324532A DE 3324532 C2 DE3324532 C2 DE 3324532C2
Authority
DE
Germany
Prior art keywords
radical
general formula
compounds
acid
pyrazino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3324532A
Other languages
German (de)
English (en)
Other versions
DE3324532A1 (de
Inventor
Chung Sup Kim
Jung Hyup Seoul Kim
Nam Jin Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea Advanced Institute of Science and Technology KAIST
Original Assignee
Korea Advanced Institute of Science and Technology KAIST
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR8203036A external-priority patent/KR840000250B1/ko
Priority claimed from KR1019830002418A external-priority patent/KR850001227B1/ko
Application filed by Korea Advanced Institute of Science and Technology KAIST filed Critical Korea Advanced Institute of Science and Technology KAIST
Publication of DE3324532A1 publication Critical patent/DE3324532A1/de
Application granted granted Critical
Publication of DE3324532C2 publication Critical patent/DE3324532C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE3324532A 1982-07-08 1983-07-07 Verfahren zur Herstellung von (±)-4-Oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isochinolinderivaten Expired DE3324532C2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR8203036A KR840000250B1 (ko) 1982-07-08 1982-07-08 4-옥소-1,3,4,6,7,11b-헥사히드로-4H-피라지노[2,1-a]이소퀴놀린유도체의 제조방법
KR1019830002418A KR850001227B1 (ko) 1983-05-31 1983-05-31 2-아실-4-옥소-1, 3, 4, 6, 7, 11b-헥사히드로-4H-피라지노[2, 1-a]이소퀴놀린 유도체의 제조방법

Publications (2)

Publication Number Publication Date
DE3324532A1 DE3324532A1 (de) 1984-01-19
DE3324532C2 true DE3324532C2 (de) 1986-07-24

Family

ID=26627177

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3324532A Expired DE3324532C2 (de) 1982-07-08 1983-07-07 Verfahren zur Herstellung von (±)-4-Oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isochinolinderivaten

Country Status (5)

Country Link
US (1) US4497952A (OSRAM)
DE (1) DE3324532C2 (OSRAM)
GB (1) GB2126212B (OSRAM)
IN (1) IN157936B (OSRAM)
IT (1) IT1193429B (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0134984B1 (en) * 1983-07-16 1988-07-13 Beecham Group Plc Benzazepine and benzoxazepine derivatives
DE102008015250A1 (de) * 2008-03-20 2009-09-24 Dömling, Alexander, Priv.-Doz. Dr. Neue Medikamenten Synthese
CN101691367B (zh) * 2009-08-31 2013-07-24 中国人民解放军第二军医大学 具有抗真菌活性的哌嗪并[2,1-a]异喹啉类化合物或其盐类
CN102786520A (zh) * 2011-05-17 2012-11-21 中国医学科学院药物研究所 吡喹酮晶a型物质及制备方法与在药品和保健品中应用
CN102786519B (zh) * 2011-05-17 2017-04-19 中国医学科学院药物研究所 吡喹酮晶b型物质及制备方法与在药品和保健品中应用
CN103333931B (zh) 2012-02-28 2014-12-03 苏州同力生物医药有限公司 一种左旋吡喹酮的合成方法
CN103044422B (zh) * 2012-12-27 2016-06-08 迪沙药业集团有限公司 一种吡喹酮的制备方法
CN105153157A (zh) * 2015-09-25 2015-12-16 浙江金伯士药业有限公司 一种吡喹酮的制备新方法
CN112645888A (zh) * 2020-12-24 2021-04-13 厦门优孚利生物医药科技有限公司 一种吡喹酮中间体的一锅合成法
CN114195783B (zh) * 2021-12-29 2022-11-25 河北嘉一药业有限公司 一种左旋吡喹酮的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2763652A (en) * 1954-02-01 1956-09-18 American Cyanamid Co Piperazinediones and methods for their preparation
US2927114A (en) * 1958-11-14 1960-03-01 American Cyanamid Co 3, 3-disubstituted-2, 6-piperazinediones
US3502679A (en) * 1967-05-31 1970-03-24 Sandoz Ag 10b-substituted 1,2,3,5,6,10b - hexahydropyrrolo(2,1-a)isoquinolines and process therefor
DE2331713A1 (de) * 1973-06-22 1975-01-23 Merck Patent Gmbh Pyrazinoisochinolin-derivat
DE2457971A1 (de) * 1974-12-07 1976-06-10 Merck Patent Gmbh Verfahren zur herstellung von 2-acyl4-oxo-pyrazino-isochinolin-derivaten
DE3006478A1 (de) * 1980-02-21 1981-09-24 Hoechst Ag, 6000 Frankfurt Pyrimido(2,1-a)isochinolin-4-onderivate
US7115551B2 (en) * 2002-06-07 2006-10-03 The Procter & Gamble Company Cleansing articles for skin or hair

Also Published As

Publication number Publication date
GB8318371D0 (en) 1983-08-10
IN157936B (OSRAM) 1986-07-26
IT8367737A0 (it) 1983-07-07
US4497952A (en) 1985-02-05
GB2126212A (en) 1984-03-21
IT1193429B (it) 1988-06-22
GB2126212B (en) 1986-07-02
DE3324532A1 (de) 1984-01-19
IT8367737A1 (it) 1985-01-07

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8128 New person/name/address of the agent

Representative=s name: HENKEL, G., DR.PHIL. FEILER, L., DR.RER.NAT. HAENZ

D2 Grant after examination
8381 Inventor (new situation)

Free format text: KIM, CHOONG SUP LEE, NAM JIN KIM, JOONG HYUP, SEOUL, KR

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee