DE3315467A1 - Azepinoindole, verfahren zu deren herstellung und diese enthaltende arzneimittel - Google Patents

Azepinoindole, verfahren zu deren herstellung und diese enthaltende arzneimittel

Info

Publication number
DE3315467A1
DE3315467A1 DE19833315467 DE3315467A DE3315467A1 DE 3315467 A1 DE3315467 A1 DE 3315467A1 DE 19833315467 DE19833315467 DE 19833315467 DE 3315467 A DE3315467 A DE 3315467A DE 3315467 A1 DE3315467 A1 DE 3315467A1
Authority
DE
Germany
Prior art keywords
addition salts
acid addition
alkyl
compounds
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19833315467
Other languages
German (de)
English (en)
Inventor
Fulvio Dr. 4127 Birsfelden Gadient
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Sandoz Patent GmbH
Original Assignee
Sandoz AG
Sandoz Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG, Sandoz Patent GmbH filed Critical Sandoz AG
Publication of DE3315467A1 publication Critical patent/DE3315467A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE19833315467 1982-05-06 1983-04-28 Azepinoindole, verfahren zu deren herstellung und diese enthaltende arzneimittel Withdrawn DE3315467A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH2806/82A CH649553A5 (de) 1982-05-06 1982-05-06 Azepinoindole und verfahren zu deren herstellung.

Publications (1)

Publication Number Publication Date
DE3315467A1 true DE3315467A1 (de) 1983-11-17

Family

ID=4242007

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19833315467 Withdrawn DE3315467A1 (de) 1982-05-06 1983-04-28 Azepinoindole, verfahren zu deren herstellung und diese enthaltende arzneimittel

Country Status (17)

Country Link
JP (1) JPS58203993A (hu)
AU (1) AU1425683A (hu)
BE (1) BE896590A (hu)
CH (1) CH649553A5 (hu)
DE (1) DE3315467A1 (hu)
DK (1) DK199883A (hu)
ES (1) ES522008A0 (hu)
FI (1) FI831475L (hu)
FR (1) FR2526434A1 (hu)
GB (1) GB2120662B (hu)
HU (1) HU189275B (hu)
IL (1) IL68576A0 (hu)
IT (1) IT1197644B (hu)
NL (1) NL8301552A (hu)
PT (1) PT76632B (hu)
SE (1) SE8302554L (hu)
ZA (1) ZA833266B (hu)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6583135B2 (en) * 2000-09-20 2003-06-24 Pharmacia & Upjohn Company Substituted azepino[4,5b]indole derivatives

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU193083B (en) * 1984-02-22 1987-08-28 Sandoz Ag Process for preparing diazepinoindole derivatives further pharmaceutical compositions containing such compounds
AU582564B2 (en) * 1985-02-20 1989-04-06 Sandoz Ltd. 2,3,4,5-tetrahydro-11-phenyl-1H-``1,4``diazepino``1,7-a`` indoles, their production and pharmaceutical compositions containing them
MXPA04001203A (es) * 2001-08-08 2004-05-20 Pharmacia & Upjhon Company 1-h-pirido[4,3-b] indoles terapeuticos.
AU2007207508B2 (en) * 2006-01-19 2011-08-18 Athersys, Inc. Thiophenyl and pyrrolyl azepines as serotonin 5-HT2c receptor ligands and uses thereof
JP5501251B2 (ja) 2008-01-11 2014-05-21 アルバニー モレキュラー リサーチ， インコーポレイテッド Ｍｃｈ拮抗薬としての（１−アジノン）置換ピリドインドール類
US9073925B2 (en) 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2011003007A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
EP2448585B1 (en) 2009-07-01 2014-01-01 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
US8697700B2 (en) 2010-12-21 2014-04-15 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE12641T1 (de) * 1979-11-02 1985-04-15 Sandoz Ag Azepinindole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6583135B2 (en) * 2000-09-20 2003-06-24 Pharmacia & Upjohn Company Substituted azepino[4,5b]indole derivatives
US6586421B2 (en) * 2000-09-20 2003-07-01 Pharmacia & Upjohn Company Substituted azepino[4,5b]indoline derivatives
US6828314B2 (en) 2000-09-20 2004-12-07 Pfizer Substituted azepino[4,5b]indoline derivatives
US6903090B2 (en) 2000-09-20 2005-06-07 Pfizer Substituted azepino[4,5b]indole derivatives

Also Published As

Publication number Publication date
FI831475L (fi) 1983-11-07
PT76632B (en) 1986-01-27
IT8348232A0 (it) 1983-05-06
GB8312159D0 (en) 1983-06-08
IT1197644B (it) 1988-12-06
BE896590A (fr) 1983-10-28
NL8301552A (nl) 1983-12-01
GB2120662B (en) 1985-09-11
DK199883D0 (da) 1983-05-04
FI831475A0 (fi) 1983-04-29
IL68576A0 (en) 1983-09-30
JPS58203993A (ja) 1983-11-28
ES8502440A1 (es) 1985-01-01
AU1425683A (en) 1983-11-10
SE8302554L (sv) 1983-11-07
FR2526434A1 (fr) 1983-11-10
ZA833266B (en) 1984-12-24
GB2120662A (en) 1983-12-07
SE8302554D0 (sv) 1983-05-04
PT76632A (en) 1983-06-01
HU189275B (en) 1986-06-30
ES522008A0 (es) 1985-01-01
CH649553A5 (de) 1985-05-31
DK199883A (da) 1983-11-07

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8139 Disposal/non-payment of the annual fee