DE3263882D1 - 11-deoxoglycyrrhetinic acid hydrogen maleate, process for its production, and its use as a medicine - Google Patents
11-deoxoglycyrrhetinic acid hydrogen maleate, process for its production, and its use as a medicineInfo
- Publication number
- DE3263882D1 DE3263882D1 DE8282105994T DE3263882T DE3263882D1 DE 3263882 D1 DE3263882 D1 DE 3263882D1 DE 8282105994 T DE8282105994 T DE 8282105994T DE 3263882 T DE3263882 T DE 3263882T DE 3263882 D1 DE3263882 D1 DE 3263882D1
- Authority
- DE
- Germany
- Prior art keywords
- hydrogen maleate
- acid hydrogen
- deoxoglycyrrhetinic acid
- medicine
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- JZFSMVXQUWRSIW-BTJIZOSBSA-N 11-Deoxoglycyrrhetinic acid Chemical compound C([C@H]1C2=CC[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C JZFSMVXQUWRSIW-BTJIZOSBSA-N 0.000 title abstract 4
- JZFSMVXQUWRSIW-UHFFFAOYSA-N 3alpha-hydroxyolean-12-en-30-oic acid Natural products C12CC=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C JZFSMVXQUWRSIW-UHFFFAOYSA-N 0.000 title abstract 4
- FWWOWPGPERBCNJ-UHFFFAOYSA-N 2-hydroxy-4-(2-hydroxyethoxy)-4-oxobutanoic acid Chemical compound OCCOC(=O)CC(O)C(O)=O FWWOWPGPERBCNJ-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 230000007969 cellular immunity Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 abstract 1
- 231100000397 ulcer Toxicity 0.000 abstract 1
- 230000036269 ulceration Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/593—Dicarboxylic acid esters having only one carbon-to-carbon double bond
- C07C69/60—Maleic acid esters; Fumaric acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56104406A JPS588044A (ja) | 1981-07-06 | 1981-07-06 | １１−デオキソグリチルレチン酸水素マレ−ト及びそれを有効成分とする医薬 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3263882D1 true DE3263882D1 (en) | 1985-07-04 |
Family
ID=14379827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8282105994T Expired DE3263882D1 (en) | 1981-07-06 | 1982-07-05 | 11-deoxoglycyrrhetinic acid hydrogen maleate, process for its production, and its use as a medicine |
Country Status (5)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU553789B2 (en) * | 1982-06-30 | 1986-07-24 | Biorex Laboratories Ltd. | Glycyrrhetinic acid derivatives in cream compositions |
| IT1215626B (it) * | 1982-07-26 | 1990-02-22 | Isf Spa | Derivato dell'acido ursolico farmacologicamente attivo. |
| GB2140809A (en) * | 1983-06-01 | 1984-12-05 | Biorex Laboratories Ltd | New derivatives of glycyrrhetinic acid |
| JPS6058973A (ja) * | 1983-09-13 | 1985-04-05 | Mitsubishi Yuka Yakuhin Kk | γ−プチロラクトン誘導体及びそれを有効成分とする免疫調節剤 |
| JPS63135351A (ja) * | 1986-11-28 | 1988-06-07 | Sanwa Kagaku Kenkyusho Co Ltd | グリチルレチン酸誘導体、その製法及び該化合物を有効成分とする抗潰瘍剤 |
| US4987151A (en) * | 1989-06-19 | 1991-01-22 | The Trustees Of Columbia University In The City Of New York | Triterpene derivatives cholesterol acyltransferase inhibitors and methods of using same |
| US5519008A (en) * | 1992-09-10 | 1996-05-21 | Glycomed Incorporated | Derivatives of triterpenoid acids as inhibitors of cell-adhesion molecules ELAM-1 (E-selectin) and LECAM-1 (L-selectin) |
| US5527890A (en) * | 1993-04-16 | 1996-06-18 | Glycomed Incorporated | Derivatives of triterpenoid acids and uses thereof |
| GB0105772D0 (en) * | 2001-03-08 | 2001-04-25 | Sterix Ltd | Use |
| GB0604899D0 (en) * | 2006-03-10 | 2006-04-19 | York Pharma Plc | Derivatives of 18-glycyrrhetinic acid |
| CN101899081B (zh) * | 2009-05-31 | 2012-09-05 | 江苏正大天晴药业股份有限公司 | 甘草次酸酯类衍生物合成方法以及脱氧甘草次酸酯化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1051001B (it) * | 1971-08-06 | 1981-04-21 | Isf Spa | Processo per la preparazione dell acido 3 o beta carbossipropionil ibbeta glicirretico |
| GB1435622A (en) * | 1973-11-07 | 1976-05-12 | Biorex Laboratories Ltd | Erythrodiol derivatives |
| GB1475075A (en) * | 1974-09-11 | 1977-06-01 | Biorex Laboratories Ltd | Derivatives of glycyrrhetinic and oleanolic acids |
| GB1476053A (en) * | 1975-02-07 | 1977-06-10 | Biorex Laboratories Ltd | Glycyrrhetinic acid derivatives |
-
1981
- 1981-07-06 JP JP56104406A patent/JPS588044A/ja active Granted
-
1982
- 1982-07-01 US US06/394,114 patent/US4448788A/en not_active Expired - Fee Related
- 1982-07-05 EP EP82105994A patent/EP0069380B1/en not_active Expired
- 1982-07-05 AT AT82105994T patent/ATE13523T1/de not_active IP Right Cessation
- 1982-07-05 DE DE8282105994T patent/DE3263882D1/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0069380B1 (en) | 1985-05-29 |
| JPH0148254B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1989-10-18 |
| US4448788A (en) | 1984-05-15 |
| EP0069380A1 (en) | 1983-01-12 |
| ATE13523T1 (de) | 1985-06-15 |
| JPS588044A (ja) | 1983-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8339 | Ceased/non-payment of the annual fee |