JPS57176957A - Preparation of 1-(2',6'-dichlorophenyl)-2-indolinone - Google Patents
Preparation of 1-(2',6'-dichlorophenyl)-2-indolinoneInfo
- Publication number
- JPS57176957A JPS57176957A JP6124681A JP6124681A JPS57176957A JP S57176957 A JPS57176957 A JP S57176957A JP 6124681 A JP6124681 A JP 6124681A JP 6124681 A JP6124681 A JP 6124681A JP S57176957 A JPS57176957 A JP S57176957A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- acid
- formula
- raw material
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Indole Compounds (AREA)
Abstract
PURPOSE: To prepare the titled compound useful as an intermediate of pharmaceuticals such as antiphlogistic, analgesic and antipyretic agents, economically, by using a raw material which is easily available in an industrial scale, via a novel compound, 1-(2'.6'-dichlorophenyl)2,3-bis(methylthio)indole.
CONSTITUTION: The novel compound of formula II is prepared by the heat treatment or acid treatment of the compound of formulaI. The heat treatment is preferably carried out at ≥200°C in the absence of solvent, and the acid used in the acid treatment is preferably a mineral acid, a Lewis acid, or an acid halide. The compound of formula II can be converted to the objective compound of formula III by treating with a mineral acid in an aqueous medium preferably in the presence of an organic carboxylic acid compatible with water, e.g. acetic acid, etc. Hydrolysis of the objective compound yields the compound of formula IV whose Na salt is useful as the above-mentioned pharmaceutical. Since the compound of formulaIcan be prepared from a raw material which can be obtained easily in an industrial scale, the above pharmaceutical can be prepared by this process economically, in an industrial scale, using simple reaction procedures and reduced number of steps througout the whole process from an industrially available raw material.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6124681A JPS57176957A (en) | 1981-04-24 | 1981-04-24 | Preparation of 1-(2',6'-dichlorophenyl)-2-indolinone |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6124681A JPS57176957A (en) | 1981-04-24 | 1981-04-24 | Preparation of 1-(2',6'-dichlorophenyl)-2-indolinone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS57176957A true JPS57176957A (en) | 1982-10-30 |
Family
ID=13165677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6124681A Pending JPS57176957A (en) | 1981-04-24 | 1981-04-24 | Preparation of 1-(2',6'-dichlorophenyl)-2-indolinone |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57176957A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60220268A (en) * | 1984-04-13 | 1985-11-02 | カ−ル・フロイデンベルク | Built-up packing |
| US10266531B2 (en) | 2016-10-21 | 2019-04-23 | Novartis Ag | Naphthyridinone derivatives and their use in the treatment of arrhythmia |
-
1981
- 1981-04-24 JP JP6124681A patent/JPS57176957A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60220268A (en) * | 1984-04-13 | 1985-11-02 | カ−ル・フロイデンベルク | Built-up packing |
| JPH0469307B2 (en) * | 1984-04-13 | 1992-11-05 | Freudenberg Carl | |
| US10266531B2 (en) | 2016-10-21 | 2019-04-23 | Novartis Ag | Naphthyridinone derivatives and their use in the treatment of arrhythmia |
| US10844055B2 (en) | 2016-10-21 | 2020-11-24 | Novartis Ag | Naphthyridinone derivatives and their use in the treatment of arrhythmia |
| US11530213B2 (en) | 2016-10-21 | 2022-12-20 | Novartis Ag | Naphthyridinone derivatives and their use in the treatment of arrhythmia |
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