JPS57176958A - 1-(2',6'-dichlorophenyl)-2-methylthioindole and its preparation - Google Patents
1-(2',6'-dichlorophenyl)-2-methylthioindole and its preparationInfo
- Publication number
- JPS57176958A JPS57176958A JP6124381A JP6124381A JPS57176958A JP S57176958 A JPS57176958 A JP S57176958A JP 6124381 A JP6124381 A JP 6124381A JP 6124381 A JP6124381 A JP 6124381A JP S57176958 A JPS57176958 A JP S57176958A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- agent
- methylthioindole
- dichlorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Indole Compounds (AREA)
Abstract
NEW MATERIAL:1-(2',6'-Dichlorophenyl-2-methylthioindole of formulaI.
USE: An intermediate which enables the industrially advantageous preparation of diclofenac sodium (general name) useful as an antiphlogistic agent, analgesic agent, antipyretic agent, etc. from an industrially easily available raw material using simple reaction procedures and a reduced number of reaction steps.
PROCESS: The compound of formulaIcan be prepared by reducing 1-[o-(2',6'- dichloroanilino)phenyl]-2-methylsulfinyl-2-methylthioethylene of formula II, and treating the product with an acid. Acid hydrolysis of the compound of formula Igives the compound of formula III, which can be converted to the compound of formula IV by hydrolyzing with an alkali. The sodium salt of the compound of formula IV is useful as the above pharmaceuticals.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6124381A JPS57176958A (en) | 1981-04-24 | 1981-04-24 | 1-(2',6'-dichlorophenyl)-2-methylthioindole and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6124381A JPS57176958A (en) | 1981-04-24 | 1981-04-24 | 1-(2',6'-dichlorophenyl)-2-methylthioindole and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57176958A true JPS57176958A (en) | 1982-10-30 |
Family
ID=13165590
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6124381A Pending JPS57176958A (en) | 1981-04-24 | 1981-04-24 | 1-(2',6'-dichlorophenyl)-2-methylthioindole and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57176958A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10266531B2 (en) | 2016-10-21 | 2019-04-23 | Novartis Ag | Naphthyridinone derivatives and their use in the treatment of arrhythmia |
-
1981
- 1981-04-24 JP JP6124381A patent/JPS57176958A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10266531B2 (en) | 2016-10-21 | 2019-04-23 | Novartis Ag | Naphthyridinone derivatives and their use in the treatment of arrhythmia |
US10844055B2 (en) | 2016-10-21 | 2020-11-24 | Novartis Ag | Naphthyridinone derivatives and their use in the treatment of arrhythmia |
US11530213B2 (en) | 2016-10-21 | 2022-12-20 | Novartis Ag | Naphthyridinone derivatives and their use in the treatment of arrhythmia |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS57183756A (en) | Preparation of 4-hydroxy-2-pyrrolidone | |
JPS57176958A (en) | 1-(2',6'-dichlorophenyl)-2-methylthioindole and its preparation | |
JPS5655359A (en) | Halogenated alpha-amino acid, and its preparation | |
JPS5524116A (en) | Preparation of o-(2, 6-dichloroanilino)-phenylacetic acid | |
JPS57158767A (en) | Antiulcer agent | |
JPS5764655A (en) | Novel benzoylaminophenylcarboxylic acid derivative, its preparation, and drug composition comprising it | |
JPS57144255A (en) | Alpha-methylthio(1-alkyl-2-pyrrolyl)acetamide derivative | |
JPS54128567A (en) | 1-substituted-4-acyl-2-pyrrolecarboxylic acid derivative | |
JPS57165382A (en) | Fluoro-pgi2 compound and its preparation | |
JPS57144252A (en) | Preparation of aminoalkylthiol | |
JPS5549396A (en) | Preparation of 17alpha-methylsteroid | |
JPS57176957A (en) | Preparation of 1-(2',6'-dichlorophenyl)-2-indolinone | |
JPS57176956A (en) | Preparation of 1-(2',6'-dichlorophenyl)-2-indolinone | |
JPS55118456A (en) | Method of collecting optically active d-alpha-methyl-beta- benzoyl-thiopropionic acid | |
JPS5699480A (en) | Preparation of pyridopyrimidine derivative | |
JPS5764647A (en) | 1-(o(2',6'-dichloroanilino)phenyl)-2,2-dihalogenoethylene | |
JPS5673064A (en) | Isoquinoline derivative | |
JPS57144289A (en) | Dioxaspiro ring compound and its preparation | |
JPS57140760A (en) | Production of mercaptoamine | |
JPS54128599A (en) | Pyrrolobenzazepin derivative | |
ES8307832A1 (en) | Anti-inflammatory, analgesic, antipyretic, water-soluble compound and process for its preparation | |
JPS5655373A (en) | Quinolinoneiminecarboxylic acid, its preparation, and antiphlogistic and analgesic composition containing said compound | |
JPS56115772A (en) | Novel preparation of substituted indolinone | |
JPS5677246A (en) | Production of substituted phenylacetic acid | |
JPS5463042A (en) | Substituted phenylacetic acid and its preparation |