JPS57176958A - 1-(2',6'-dichlorophenyl)-2-methylthioindole and its preparation - Google Patents

1-(2',6'-dichlorophenyl)-2-methylthioindole and its preparation

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Publication number
JPS57176958A
JPS57176958A JP6124381A JP6124381A JPS57176958A JP S57176958 A JPS57176958 A JP S57176958A JP 6124381 A JP6124381 A JP 6124381A JP 6124381 A JP6124381 A JP 6124381A JP S57176958 A JPS57176958 A JP S57176958A
Authority
JP
Japan
Prior art keywords
compound
formula
agent
methylthioindole
dichlorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6124381A
Other languages
Japanese (ja)
Inventor
Genichi Dobashi
Katsuyuki Ogura
Ryozo Sakota
Shuichi Fukushima
Kazuo Nagano
Ikuo Kawakami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Sagami Chemical Research Institute
Original Assignee
Nissan Chemical Corp
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp, Sagami Chemical Research Institute filed Critical Nissan Chemical Corp
Priority to JP6124381A priority Critical patent/JPS57176958A/en
Publication of JPS57176958A publication Critical patent/JPS57176958A/en
Pending legal-status Critical Current

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  • Indole Compounds (AREA)

Abstract

NEW MATERIAL:1-(2',6'-Dichlorophenyl-2-methylthioindole of formulaI.
USE: An intermediate which enables the industrially advantageous preparation of diclofenac sodium (general name) useful as an antiphlogistic agent, analgesic agent, antipyretic agent, etc. from an industrially easily available raw material using simple reaction procedures and a reduced number of reaction steps.
PROCESS: The compound of formulaIcan be prepared by reducing 1-[o-(2',6'- dichloroanilino)phenyl]-2-methylsulfinyl-2-methylthioethylene of formula II, and treating the product with an acid. Acid hydrolysis of the compound of formula Igives the compound of formula III, which can be converted to the compound of formula IV by hydrolyzing with an alkali. The sodium salt of the compound of formula IV is useful as the above pharmaceuticals.
COPYRIGHT: (C)1982,JPO&Japio
JP6124381A 1981-04-24 1981-04-24 1-(2',6'-dichlorophenyl)-2-methylthioindole and its preparation Pending JPS57176958A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6124381A JPS57176958A (en) 1981-04-24 1981-04-24 1-(2',6'-dichlorophenyl)-2-methylthioindole and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6124381A JPS57176958A (en) 1981-04-24 1981-04-24 1-(2',6'-dichlorophenyl)-2-methylthioindole and its preparation

Publications (1)

Publication Number Publication Date
JPS57176958A true JPS57176958A (en) 1982-10-30

Family

ID=13165590

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6124381A Pending JPS57176958A (en) 1981-04-24 1981-04-24 1-(2',6'-dichlorophenyl)-2-methylthioindole and its preparation

Country Status (1)

Country Link
JP (1) JPS57176958A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10266531B2 (en) 2016-10-21 2019-04-23 Novartis Ag Naphthyridinone derivatives and their use in the treatment of arrhythmia

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10266531B2 (en) 2016-10-21 2019-04-23 Novartis Ag Naphthyridinone derivatives and their use in the treatment of arrhythmia
US10844055B2 (en) 2016-10-21 2020-11-24 Novartis Ag Naphthyridinone derivatives and their use in the treatment of arrhythmia
US11530213B2 (en) 2016-10-21 2022-12-20 Novartis Ag Naphthyridinone derivatives and their use in the treatment of arrhythmia

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