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Zenyaku Kogyo KK
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Zenyaku Kogyo KK
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Priority to JP1742580ApriorityCriticalpatent/JPS56115772A/en
Publication of JPS56115772ApublicationCriticalpatent/JPS56115772A/en
PURPOSE: To obtain the titled compound useful as a synthetic intermediate for a medicine in a short preparation step in high yield, by hydrolyzing novel 1-[o-(2',6'- dichloroanilino)phenyl]-2,2-dihalogenoethylene as an intermediate.
CONSTITUTION: o-(2,6-Dichloroanilino)benzaldehyde of formula I obtained by the reaction of 2,6-dichloroaniline with o-iodobenzaldehyde is reacted with methylenephosphorane of formula II (R is alkyl, substituted amino, etc.; X and Y are halogen) to give novel 1-[o-(2',6'-dichloroanilino)phenyl]-2,2-dihalogenoethylene of formula III as an intermediate, which is then hydrolyzed under acidic conditions or basic and then acidic conditions to give the aimed 1-(2',6'-dichlorophenyl)-2-indolinone of formula IV.
USE: A synthetic intermediate for o-( 2,6-dichloroanilino )phenylacetic acid which is an analgesic and anti-inflammatory agent.
COPYRIGHT: (C)1981,JPO&Japio
JP1742580A1980-02-151980-02-15Novel preparation of substituted indolinone
PendingJPS56115772A
(en)
Improvements introduced in the object of the main patent by procedure for the production of hydroxylamins or rented. (Machine-translation by Google Translate, not legally binding)