JPS56152445A - Preparation of o- 2,6-dichloroanilino phenylacetic acid and its salt - Google Patents
Preparation of o- 2,6-dichloroanilino phenylacetic acid and its saltInfo
- Publication number
- JPS56152445A JPS56152445A JP5562180A JP5562180A JPS56152445A JP S56152445 A JPS56152445 A JP S56152445A JP 5562180 A JP5562180 A JP 5562180A JP 5562180 A JP5562180 A JP 5562180A JP S56152445 A JPS56152445 A JP S56152445A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- dichloroanilino
- salt
- phenylacetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To obtain the titled compound generally named dichlofenac in high yield, having anti-inflammatory, pain-killing, and antipyretic actions, by hydrolyzing a corresponding 2,2-dihalogenoethylene compound.
CONSTITUTION: A 1- [o'- (2'.6'-dichloroanilino) phenyl ]-2, 2-dihalogenoethylene shown by the formula II (X and Y are halogen) is hydrolyzed with ≥75wt% sulfuric acid, to give o-(2,6-dichloroanilino) phenylacetic acid shown by the formula I and its salt. The reaction is carried out at temperature preferably ≤40°C. The compound shown by the formula II is obtained by reacting 2,6-dichloroaniline with o- iodobenzaldehyde to give a compound shown by the formula III, followed by reacting this compound with a methylene phosphorante shown by the formula R3= CXY (R is alkyl, substituted amino, etc.).
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5562180A JPS56152445A (en) | 1980-04-26 | 1980-04-26 | Preparation of o- 2,6-dichloroanilino phenylacetic acid and its salt |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5562180A JPS56152445A (en) | 1980-04-26 | 1980-04-26 | Preparation of o- 2,6-dichloroanilino phenylacetic acid and its salt |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56152445A true JPS56152445A (en) | 1981-11-26 |
Family
ID=13003844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5562180A Pending JPS56152445A (en) | 1980-04-26 | 1980-04-26 | Preparation of o- 2,6-dichloroanilino phenylacetic acid and its salt |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56152445A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4544766A (en) * | 1981-03-06 | 1985-10-01 | Otsuka Kagaku Yakuhin Kabushiki Kaisha | Process for preparing aryl acetic acid derivatives |
-
1980
- 1980-04-26 JP JP5562180A patent/JPS56152445A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4544766A (en) * | 1981-03-06 | 1985-10-01 | Otsuka Kagaku Yakuhin Kabushiki Kaisha | Process for preparing aryl acetic acid derivatives |
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