JPS56152445A - Preparation of o- 2,6-dichloroanilino phenylacetic acid and its salt - Google Patents

Preparation of o- 2,6-dichloroanilino phenylacetic acid and its salt

Info

Publication number
JPS56152445A
JPS56152445A JP5562180A JP5562180A JPS56152445A JP S56152445 A JPS56152445 A JP S56152445A JP 5562180 A JP5562180 A JP 5562180A JP 5562180 A JP5562180 A JP 5562180A JP S56152445 A JPS56152445 A JP S56152445A
Authority
JP
Japan
Prior art keywords
formula
compound
dichloroanilino
salt
phenylacetic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5562180A
Other languages
Japanese (ja)
Inventor
Muneaki Takase
Toshiyuki Takezawa
Hajime Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zenyaku Kogyo KK
Original Assignee
Zenyaku Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenyaku Kogyo KK filed Critical Zenyaku Kogyo KK
Priority to JP5562180A priority Critical patent/JPS56152445A/en
Publication of JPS56152445A publication Critical patent/JPS56152445A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the titled compound generally named dichlofenac in high yield, having anti-inflammatory, pain-killing, and antipyretic actions, by hydrolyzing a corresponding 2,2-dihalogenoethylene compound.
CONSTITUTION: A 1- [o'- (2'.6'-dichloroanilino) phenyl ]-2, 2-dihalogenoethylene shown by the formula II (X and Y are halogen) is hydrolyzed with ≥75wt% sulfuric acid, to give o-(2,6-dichloroanilino) phenylacetic acid shown by the formula I and its salt. The reaction is carried out at temperature preferably ≤40°C. The compound shown by the formula II is obtained by reacting 2,6-dichloroaniline with o- iodobenzaldehyde to give a compound shown by the formula III, followed by reacting this compound with a methylene phosphorante shown by the formula R3= CXY (R is alkyl, substituted amino, etc.).
COPYRIGHT: (C)1981,JPO&Japio
JP5562180A 1980-04-26 1980-04-26 Preparation of o- 2,6-dichloroanilino phenylacetic acid and its salt Pending JPS56152445A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5562180A JPS56152445A (en) 1980-04-26 1980-04-26 Preparation of o- 2,6-dichloroanilino phenylacetic acid and its salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5562180A JPS56152445A (en) 1980-04-26 1980-04-26 Preparation of o- 2,6-dichloroanilino phenylacetic acid and its salt

Publications (1)

Publication Number Publication Date
JPS56152445A true JPS56152445A (en) 1981-11-26

Family

ID=13003844

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5562180A Pending JPS56152445A (en) 1980-04-26 1980-04-26 Preparation of o- 2,6-dichloroanilino phenylacetic acid and its salt

Country Status (1)

Country Link
JP (1) JPS56152445A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4544766A (en) * 1981-03-06 1985-10-01 Otsuka Kagaku Yakuhin Kabushiki Kaisha Process for preparing aryl acetic acid derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4544766A (en) * 1981-03-06 1985-10-01 Otsuka Kagaku Yakuhin Kabushiki Kaisha Process for preparing aryl acetic acid derivatives

Similar Documents

Publication Publication Date Title
JPS56152445A (en) Preparation of o- 2,6-dichloroanilino phenylacetic acid and its salt
JPS55139375A (en) Production of hydroxyflavan
JPS5524116A (en) Preparation of o-(2, 6-dichloroanilino)-phenylacetic acid
JPS56115772A (en) Novel preparation of substituted indolinone
JPS5520727A (en) Preparation of 2-anilinophenyl acetate
JPS557222A (en) Preparation of aletheine derivative
JPS5566550A (en) Preparation of o-(2,6-dichloroanilino)-phenylacetic acid
JPS55126514A (en) Production of hydrazine sulfate
JPS5295653A (en) Preparation of o-sulfobenzoic acid imide
JPS57156449A (en) Preparation of alpha-amino acid or n-acyl amino acid
JPS5798243A (en) Preparation of 5-(n-methylaminoethoxy)carvacrol
JPS5748960A (en) Novel cyclohexanecarboxylic acid derivative and its preparation
JPS55157572A (en) Preparation of 2-mercapto-4,6-dimethylpyrimidine hydrochloride
JPS56156256A (en) Preparation of n-substituted aletheine
JPS52136134A (en) Preparation of #-phenylenediamine
JPS5318521A (en) Preparation of 3,5-dichloronitrogenzene
JPS5686142A (en) Preparation of threo-3-amino-2-hydroxybutanoylamino- acetic acids
JPS54125633A (en) 4-chloro-3,5-diaminophenyl acetate, its preparation, and hardeners for preparing polyurethane elastomers
JPS5436257A (en) Substituted benzoic acid amide
JPS5714593A (en) Nitro-beta-trialkylsilystyrene oxide and its preparation
JPS572268A (en) Preparation of 5- p-chlorobenzoyl -1,4-dimethylpyrrole- 2-acetic acid
JPS56123964A (en) 1- n-benzyl-o- 2,6-dichloroanilino phenyl -2-methylsulfinyl- 2-methylthioethylene
JPS5562050A (en) Preparation of substituted phenylacetohydroxamic acid
JPS5626851A (en) Preparation of alpha-halogeno-beta-alanine or its mineral acid salt
JPS56127378A (en) 2-alkoxyindolizine derivative and its preparation